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Andreas Hochhaus: Asciminib vs. Bosutinib in Chronic Myeloid Leukemia
Daim Duab: Andreas Hochhaus: Asciminib vs. Bosutinib in Chronic Myeloid Leukemia

Zoo Siab

Bosutinib yog siv los kho qee yam mob myeloid leukemia (CML; ib hom mob cancer ntawm cov qe ntshav dawb), suav nrog kev kho mob rau cov neeg uas nyuam qhuav pom muaj tus mob no thiab cov uas tsis tuaj yeem tau txais txiaj ntsig los ntawm lwm cov tshuaj ntxiv rau CML lossis cov uas tsis tuaj yeem noj cov tshuaj no vim tias muaj kev phiv. Bosutinib nyob hauv chav kawm ntawm cov tshuaj hu ua kinase inhibitors. Nws ua haujlwm los ntawm kev thaiv qhov kev txiav txim ntawm cov protein tsis txaus uas ua rau muaj hlwb hlav hlav. Qhov no yuav pab kom tsis txhob kis mob hlwb.

Bosutinib los ua ib ntsiav tshuaj noj ntawm qhov ncauj. Feem ntau nws tau noj nrog zaub mov ib hnub. Siv bosutinib nyob ib ncig ntawm tib lub sijhawm txhua txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Siv bosutinib raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Nqos cov ntsiav tshuaj tag nrho; tsis txhob sib faib, zom, lossis tsoo lawv. Yog tias ib qho ntawm cov ntsiav tshuaj tawg lossis tsoo, tsis txhob kov lawv nrog koj txhais tes dawb.


Koj tus kws kho mob tuaj yeem txiav kho lossis kho koj cov tshuaj ntawm bosutinib ib ntus los yog tas mus li nyob ntawm koj cov lus teb rau kev kho mob thiab kev phiv uas koj ntsib. Tham nrog koj tus kws kho mob txog saib koj xav li cas thaum kho koj tus mob. Txuas ntxiv noj bosutinib txawm hais tias koj tus kheej yuav zoo siab. Tsis txhob tsum noj bosutinib yam tsis tham nrog koj tus kws kho mob.

Nug koj tus kws muag tshuaj lossis tus kws kho mob txog cov ntawv luam ntawm cov ntaub ntawv tsim tawm rau tus neeg mob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj bosutinib,

  • qhia rau koj tus kws kho mob thiab kws muag tshuaj yog tias koj muaj kev fab tshuaj rau bosutinib lossis ib yam ntawm cov khoom xyaw hauv cov ntsiav tshuaj bosutinib. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
  • qhia rau koj tus kws kho mob thiab kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob thiab cov tshuaj uas tsis yog kws kho mob sau, tshuaj vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais qhov ib qho ntawm cov hauv qab no: qee yam antifungals xws li ketoconazole thiab itraconazole (Sporanox); aprepitant (Hloov Kho); qee cov tshuaj siv los kho tib neeg cov tshuaj tiv thaiv kab mob (HIV) xws li indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), thiab saquinavir (Invirase); cov tshuaj noj kom txo cov mob plab (proton-twj tso kua mis inhibitors) xws li esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), thiab rabeprazole (AcipHex); diltiazem (Cardizem, Cartia, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); nefazodone; rifabutin (Mycobutin); thiab rifampin (Rifadin, Rimactane hauv Rifamate, hauv Rifater). Ntau lwm yam tshuaj kuj tseem tuaj yeem cuam tshuam nrog bosutinib, yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv, txawm tias tsis tshwm nyob hauv daim ntawv no.
  • yog tias koj noj tshuaj antacids, xws li aluminium hydroxide / magnesium hydroxide (Maalox), calcium carbonate (Tums) lossis calcium carbonate thiab magnesium (Rolaids) lossis tshuaj noj kom txo cov plab kua qaub, xws li cimetidine (Tagamet), famotidine (Pepcid), lossis ranitidine (Zantac), coj lawv 2 teev ua ntej lossis 2 teev tom qab koj noj bosutinib.
  • qhia koj tus kws kho mob tias yam tshuaj ntsuab koj noj, tshwj xeeb tshaj yog St. John wort.
  • qhia rau koj tus kws kho mob yog tias koj tau lossis tau muaj mob raum, mob siab, lossis mob plawv.
  • qhia rau koj tus kws kho mob yog tias koj cev xeeb tub los yog npaj yuav cev xeeb tub. Koj yuav tsum tau mus kuaj cev xeeb tub ua ntej koj pib kho thiab koj yuav tsum tsis txhob cev xeeb tub thaum koj noj bosutinib. Koj yuav tsum siv txoj kev tswj kom tsis txhob muaj menyuam yaus thaum lub sijhawm kho nrog bosutinib thiab rau 2 lub lis piam tom qab koj zaum kawg. Tham nrog koj tus kws kho mob txog kev tiv thaiv kev xeeb tub uas yuav ua haujlwm rau koj. Yog tias koj cev xeeb tub thaum noj bosutinib, hu rau koj tus kws kho mob. Bosutinib tuaj yeem tsim kev puas tsuaj rau tus menyuam hauv plab.
  • qhia rau koj tus kws kho mob yog tias koj pub mis niam rau menyuam. Koj yuav tsum tsis txhob pub niam mis thaum koj noj bosutinib thiab rau 2 lub lis piam tom qab koj li kev noj tshuaj kawg.
  • koj yuav tsum paub tias cov tshuaj no tuaj yeem txo qis kev muaj menyuam hauv txivneej thiab pojniam. Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev noj bosutinib.

Tsis txhob noj txiv kab ntxwv qaub, haus kua txiv kab ntxwv qaub, lossis noj lwm yam ntxiv uas muaj cov txiv kab ntxwv qaub thaum koj noj cov tshuaj no.


Noj cov koob tshuaj uas ploj lawm nrog zaub mov kom sai li sai raws li koj nco qab nws.Txawm li cas los xij, yog tias nws tau ntau dua 12 teev txij li koj cov tshuaj kawg, hla cov koob tshuaj uas tsis nco qab thiab ua ntxiv rau koj cov caij nyoog noj tshuaj tas li. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Bosutinib yuav ua rau muaj kev phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

  • mob taub hau
  • tsis qab los noj mov
  • nkees lossis qaug zog
  • hloov lub peev xwm los saj cov khoom noj
  • coov hauv pob ntseg

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob no, hu rau koj tus kws kho mob:

  • xeev siab
  • ntuav
  • zawv plab
  • mob plab thaj tsam ib ce
  • piav qhia ntshav los ntshav
  • cov ntshav nyob rau hauv cov zis lossis cov quav
  • hloov pauv qhov tso zis heev
  • nce lossis txo qis rau hauv cov zis
  • kiv taub hau
  • kub taub hau, mob caj pas, ua daus no, los yog lwm yam cim ntawm tus kab mob
  • txog siav thiab hnoos
  • mob hauv siab
  • o ntawm lub ntsej muag, tes, pob taws, ko taw, lossis ceg qis
  • nce ceeb thawj sai
  • daj ntawm daim tawv nqaij thiab qhov muag
  • tsaus nti lossis zas zis
  • khaus
  • ua pob
  • khaus
  • ua pa nyuaj lossis nqos

Bosutinib tuaj yeem ua lwm cov kev mob tshwm sim. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.


Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws khomob yuav xaj qee yam kev kuaj sim kuaj saib koj lub cev teb li cas rau bosutinib.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

  • Bosulif®
Kawg Kho - 12/15/2019

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