Tus Sau: Clyde Lopez
Hnub Kev Tsim: 24 Lub Xya Hli Ntuj 2021
Hloov Hnub: 11 Lub Ib Hli Ntuj 2025
Anonim
How does Niacin (B3) Work? (+ Pharmacology)
Daim Duab: How does Niacin (B3) Work? (+ Pharmacology)

Zoo Siab

Niacin yog ib hom tshuaj vitamin B3. Nws muaj nyob hauv cov zaub mov xws li poov xab, nqaij, ntses, mis nyuj, qe, zaub ntsuab, thiab cov noob taum. Niacin tseem tsim tawm hauv lub cev los ntawm tryptophan, uas pom nyob hauv cov zaub mov muaj protein. Thaum noj raws li kev pab ntxiv, niacin feem ntau pom muaj kev sib xyaw nrog lwm cov vitamins B.

Tsis txhob yuam kev niacin nrog NADH, niacinamide, inositol nicotinate, IP-6, lossis tryptophan. Saib cov npe cais rau cov ncauj lus no.

Cov foos tshuaj niacin tau txais kev pom zoo los ntawm Asmeskas Cov Khoom Noj thiab Tshuaj (FDA) rau cov roj (cholesterol) siab thiab kom nce qib ntawm qee hom qib roj (cholesterol) zoo, hu ua HDL. Cov tshuaj pab Niacin thiab cov tshuaj yuav tom lub qhov ncauj txhawm rau tiv thaiv cov vitamin B3 tsis txaus thiab cov cuam tshuam xws li pellagra.

Cov Tshuaj Kho Kom Zoo Database cov txiaj ntsig raws li cov pov thawj tshawb fawb tau raws li cov teev hauv qab no: Siv tau zoo, Yuav muaj txiaj ntsig zoo, Muaj txiaj ntsig zoo, Muaj txiaj ntsig zoo, tsis muaj txiaj ntsig zoo, tsis muaj txiaj ntsig, tsis muaj txiaj ntsig, thiab tsis muaj pov thawj txaus rau tus nqi.

Cov hauj lwm zoo rau NIACIN muaj raws li nram no:


Yuav zoo rau ...

  • Qib ntshav tsis zoo los yog cov rog (dyslipidemia)Cov. Qee cov khoom lag luam niacin tau txais kev pom zoo los ntawm Asmeskas Cov Khoom Noj thiab Tshuaj (FDA) ua cov khoom kho mob rau kev kho cov qib rog hauv cov ntshav. Cov tshuaj niacin no feem ntau tuaj hauv lub siab muaj zog 500 mg lossis siab dua ntawd. Kev noj zaub mov ntxiv ntawm niacin feem ntau tuaj hauv lub zog ntawm 250 mg los yog tsawg dua. Txij li cov koob tshuaj niacin ntau kawg yog yuav tsum tau txhawm rau txhim kho cov qib roj cholesterol, kev noj zaub mov muaj zog niacin feem ntau tsis tsim nyog. Niacin tej zaum yuav xyaw nrog lwm cov tshuaj roj ntshav muaj txiaj ntsig thaum kev noj zaub mov noj thiab kev siv tshuaj ib leeg tsis txaus. Niacin txhim kho cov qib roj cholesterol ntau dua, tab sis tsis txhim kho cov txiaj ntsig ntsig txog hlab plawv xws li mob plawv nres thiab hlab ntshav tawg.
  • Ib tus kab mob tshwm sim los ntawm tus neeg tsis txaus niacin (pellagra)Cov. Niacin tau pom zoo los ntawm U.S. Food and Drug Administration (FDA) rau qhov kev siv no. Txawm li cas los xij, niacin tuaj yeem ua rau "yaug" (liab, khaus, thiab tingling). Yog li lwm cov khoom lag luam, hu ua niacinamide, qee zaum muaj kev nyiam vim tias nws tsis ua rau muaj qhov tshwm sim no.

Tejzaum nws zoo rau ...

  • Qib ntshav tsis zoo nyob hauv cov neeg mob HIV / AIDSCov. Kev noj cov tshuaj niacin zoo li txhim kho qib roj thiab ntshav rog hu ua triglycerides hauv cov neeg mob uas muaj tus mob no.
  • Ib pawg ntawm cov tsos mob uas ua rau muaj kev pheej hmoo mob ntshav qab zib, mob plawv, thiab mob stroke (metabolic syndrome)Cov. Kev noj cov tshuaj niacin zoo li nce qib ntawm lipoprotein ntau (high-density lipoprotein (HDL lossis "zoo") cov roj cholesterol thiab txo cov ntshav rog hu ua triglycerides hauv cov neeg muaj metabolic syndrome. Noj cov niacin nrog rau cov tshuaj omega-3 fatty acid zoo li ua haujlwm zoo dua.

Kev tsis zoo rau ...

  • Kab mob plawvCov. Kev tshawb nrhiav zoo qhia tau tias niacin tsis tiv thaiv lub plawv lossis mob hlab ntsha tawg hauv cov neeg uas noj niacin tiv thaiv lossis kho kab mob plawv. Niacin kuj tseem tsis tau pom muaj txo qis kev tuag. Niacin yuav tsum tsis txhob noj tshuaj los tiv thaiv kab mob plawv.

Cov pov thawj tsis txaus ntseeg kom ntsuas kev ua haujlwm rau ...

  • Kev ua haujlwm ntawm cov hlab ntsha (atherosclerosis)Cov. Kev noj niacin ntawm qhov ncauj nrog rau cov tshuaj hu ua bile acid sequestrants yuav txo qis ntawm txoj hlab ntshav khov hauv cov txiv neej nrog tus mob no. Nws zoo nkaus li ua haujlwm zoo tshaj plaws rau cov txiv neej uas muaj ntshav siab ntau cov rog hu ua triglycerides. Tab sis kev noj niacin tsis zoo li txo qis ntawm cov hlab ntsha hauv cov neeg mob uas muaj lub npe hu ua peripheral arterial (PAD). Tsis tas li, niacin tsis tiv thaiv cov kab mob plawv xws li mob plawv lossis mob hlab ntsha tawg.
  • Alzheimer tus kab mobCov. Cov neeg uas haus cov niacin ntau dua los ntawm cov zaub mov thiab multivitamins zoo li muaj feem tsawg dua ntawm kev muaj mob Alzheimer dua li cov neeg uas haus tsawg niacin. Tab sis tsis muaj pov thawj qhia tias kev noj cov tshuaj niacin pab tiv thaiv kom tsis txhob muaj mob Alzheimer.
  • CataractsCov. Cov tib neeg uas noj zaub mov noj ntau nyob rau hauv niacin yuav muaj kev pheej hmoo tsawg zuj zus ntawm kev tsim muaj cov hlab ntaws nuclear. Tus mob no puas muaj qhov cataract uas nquag muaj tshaj. Cov nyhuv ntawm kev noj cov tshuaj niacin yog tsis paub.
  • Muaj mob ntawm cov hnyuv uas ua rau raws plab (raws plab)Cov. Kev noj tshuaj niacin los ntawm qhov ncauj zoo li ua rau txo plab zom mov hauv cov neeg mob raws plab.
  • Erectile kawg (ED)Cov. Kev noj tshuaj ncua-tso niacin thaum mus pw rau 12 lub lis piam zoo li pab tau cov txiv neej uas muaj ED thiab lipid ntau ntau tuav ib qho erection thaum sib deev.
  • Theem siab ntawm phosphate nyob rau hauv cov ntshav (hyperphosphatemia)Cov. Cov neeg uas lub raum tsis ua haujlwm lawm yuav muaj ntshav phosphate ntau dua. Qee qhov kev tshawb nrhiav thaum ntxov qhia tias kev noj cov tshuaj niacin tuaj yeem txo cov ntshav phosphate ntau dua hauv cov neeg muaj kab mob raum theem kawg thiab ntshav phosphate ntau ntxiv. Tab sis lwm txoj kev tshawb fawb qhia tau hais tias kev noj cov tshuaj niacin tsis txo cov ntshav phosphate ntau ntau hauv cov neeg uas tseem noj tshuaj uas siv txo cov ntshav phosphate.
  • Kev txhaws ntawm txoj hlab ntsha hauv qhov muag (retinal hlab ntsha occlusion): Kev tshawb fawb ntxov qhia tias kev noj cov niacin yuav ua rau kom pom kev zoo rau cov neeg muaj tus mob no.
  • Cov kab mob cell: Cov kev tshawb fawb thaum ntxov qhia tau hais tias kev noj niacin tsis txhim kho cov qib ntawm cov rog hauv cov neeg muaj kab mob cell sickle.
  • Pob txuv.
  • Kev siv dej cawv muaj teeb meem.
  • Kev ua kis las.
  • Ntsuam xyuas kev tsis txaus siab-hyperactivity tsis meej (ADHD).
  • Kev Nyuaj Siab.
  • Kiv taub hau.
  • Kev quav yeeb quav tshuaj.
  • Mob taub hau.
  • Mob taub hau.
  • Schizophrenia.
  • Lwm yam mob.
Xav tau cov pov thawj ntxiv los ntsuas niacin rau kev siv no.

Niacin yog nqus los ntawm lub cev thaum yaj hauv dej thiab coj los ntawm qhov ncauj. Nws hloov pauv mus rau niacinamide yog tias noj ntau dua qhov uas lub cev xav tau.

Niacin raug tso cai rau kev ua haujlwm kom zoo ntawm cov rog thiab suab thaj hauv lub cev thiab tswj cov hlwb zoo. Ntawm cov koob tshuaj ntau, niacin yuav pab cov neeg muaj kab mob plawv vim nws cov txiaj ntsig zoo los ntawm txhaws. Nws kuj tseem tuaj yeem txhim kho qib ntawm qee yam muaj roj hu ua triglycerides hauv cov ntshav.

Niacin tsis tuaj yeem ua rau mob hu ua pellagra, uas ua rau tawv nqaij ua paug, raws plab, thiab dementia. Pellagra tau tshwm sim nyob rau thaum ntxov thib nees nkaum xyoo, tab sis tam sim no tsis tshua pom, txij li qee cov zaub mov muaj hmoov nplej muaj tam sim no muaj zog nrog niacin. Pellagra tau zoo tshaj plaws tau tshem tawm hauv cov kab lis kev cai sab hnub poob.

Cov neeg uas tsis noj zaub mov tsis zoo, haus dej cawv, thiab qee yam qog uas hlav qeeb qeeb hu ua carcinoid qog yuav ua rau muaj kev pheej hmoo rau niacin tsis txaus. Thaum noj ntawm qhov ncauj: Niacin yog ZOO KAWG rau cov neeg feem coob thaum noj khoom haum. Cov tshuaj uas kws kho mob niacin muaj kev nyab xeeb thaum noj raws li qhia. Niacin-cov zaub mov muaj txiaj ntsig lossis cov tshuaj niacin muaj kev nyab xeeb thaum noj hauv koob tshuaj qis dua 35 mcg txhua hnub.

Ib qho kev mob tshwm sim ntawm niacin yog ib cov tshuaj tiv thaiv flushing. Qhov no tuaj yeem ua rau hlawv, tingling, khaus, thiab liab ntawm lub ntsej muag, caj npab, thiab hauv siab, ntxiv rau mob taub hau. Pib nrog kev noj tshuaj me me ntawm niacin thiab noj tshuaj 325 mg ntawm tshuaj aspirin ua ntej txhua koob ntawm niacin yuav pab txo qhov yaug tshwm sim. Feem ntau, qhov kev tawm tsam no ploj mus vim tias lub cev tau txais los siv rau noj tshuaj. Cawv yuav ua rau cov tshuaj tiv thaiv yaug sai dua. Zam txhob haus dej cawv ntau thaum noj cov tshuaj niacin.

Lwm qhov kev mob tshwm sim me me ntawm niacin yog mob plab, ua pa hauv plab, kiv taub hau, mob hauv qhov ncauj, thiab lwm yam teeb meem.

Thaum kev noj tshuaj ntau dua 3 gram ib hnub twg ntawm niacin noj, cov kev mob tshwm sim hnyav tuaj yeem tshwm sim. Cov no suav nrog teeb meem mob siab, mob gout, mob ntawm lub plab zom mov, tsis pom kev, ntshav qab zib hauv siab, lub plawv dhia tsis xwm yeem, thiab lwm yam teeb meem loj.

Cov kev ceev faj & cov lus ceeb toom:

Cev xeeb tub thiab pub niam mis: Niacin yog ZOO KAWG rau cov poj niam cev xeeb tub thiab pub niam mis thaum noj ntawm qhov ncauj raws li cov lus pom zoo. Cov tshuaj noj ntau tshaj plaws ntawm niacin rau cov poj niam cev xeeb tub lossis pub niam mis yog 30 mg rau ib hnub rau cov poj niam hnub nyoog qis dua 18 xyoo, thiab 35 mg rau cov poj niam tshaj 18 xyoo.

Cov menyuam: Niacin yog ZOO KAWG thaum noj ntawm qhov ncauj hauv cov lus pom zoo rau txhua pawg hnub nyoog. Tab sis cov menyuam yaus yuav tsum tsis txhob noj cov tshuaj niacin ntau tshaj qhov txwv niaj hnub, uas yog 10 mg rau menyuam hnub nyoog 3 xyoos, 15 mg rau menyuam hnub nyoog 4-8 xyoo, 20 mg rau menyuam yaus hnub nyoog 9-13 xyoos, thiab 30 mg rau me nyuam 14-18 xyoo.

Kev ua xua: Niacin yuav ua rau muaj kev tsis haum tshuaj ntau dua los ntawm kev ua rau histamine, tshuaj raug rau kev ua xua, raug tso tawm.

Mob plawv / tsis zoo nkauj angina: Loj heev ntawm niacin tuaj yeem ua rau muaj kev pheej hmoo ntawm lub plawv dhia tsis xwm yeem. Siv nrog ceev faj.

Crohn kab mob: Cov neeg mob Crohn yuav muaj cov tshuaj niacin tsawg thiab xav tau kev pab ntxiv thaum lub sijhawm ua pa tuaj.

Mob ntshav qab zib: Niacin yuav nce ntshav qab zib. Cov neeg mob ntshav qab zib uas noj niacin yuav tsum kuaj lawv cov ntshav qab zib kom zoo.

Gallbladder muaj tus kab mob: Niacin yuav ua kom cov mob gallbladder muaj qhov tsis zoo.

Gout: Cov niacin ntau yuav ua rau mob gout.

Mob raum: Niacin yuav muaj ntau ntxiv nrog cov neeg muaj raum. Qhov no tuaj yeem tsim kev puas tsuaj.

Mob siab: Niacin yuav ua rau daim siab puas. Tsis txhob siv nyiaj ntau yog tias koj muaj kab mob siab.

Mob plab lossis mob hnyuv: Niacin yuav ua rau mob kiav txhab tsis zoo. Tsis txhob siv nyiaj ntau yog tias koj muaj mob txhab.

Tsawg ntshav siab: Niacin yuav txo cov ntshav siab thiab ua kom muaj cov mob no.

Kev phais mob: Niacin yuav cuam tshuam nrog tswj ntshav qab zib thaum lub sijhawm thiab tom qab phais tas. Tsum noj cov tshuaj niacin tsawg kawg 2 lub lis piam ua ntej kev phais mob.

Cov rog ua ke nyob ib ncig ntawm cov leeg (tendon xanthomas): Niacin yuav ua rau muaj kev pheej hmoo kis mob ntxiv hauv xanthomas.

Lub qog ua kom mob siab: Thyroxine yog yam tshuaj tsim los ntawm cov thyroid caj pas. Niacin yuav txo qis cov ntshav muaj koj cov thyroxine. Qhov no yuav paug cov tsos mob ntawm qee cov thyroid ntshawv siab.

Ntsawv
Ceev faj nrog txoj kev sib xyaw ua ke no.
Cawv (Ethanol)
Niacin tuaj yeem ua rau yaug tawm thiab khaus. Kev haus dej haus cawv nrog rau niacin yuav ua rau yaug dej thiab khaus. Kuj tseem muaj qee qhov kev txhawj xeeb uas haus cawv nrog niacin yuav ua rau muaj kev pheej hmoo ua mob rau daim siab.
Allopurinol (Zyloprim)
Allopurinol (Zyloprim) yog siv los kho gout. Kev noj cov tshuaj niacin ntau dua tuaj yeem ua rau muaj kev phom sij rau gout thiab txo cov txiaj ntsig ntawm allopurinol (Zyloprim).
Clonidine (Catapres)
Clonidine thiab niacin ob leeg txo qis ntshav siab. Noj niacin nrog clonidine yuav ua rau koj cov ntshav siab poob qis.
Gemfibrozil (Lopid)
Noj niacin nrog rau gemfibrozil tej zaum yuav ua rau mob leeg rau qee tus neeg. Siv nrog ceev faj.
Noj tshuaj kho mob ntshav qab zib (Tshuaj tiv thaiv ntshav qab zib)
Kev siv cov koob tshuaj loj ntawm niacin (txog 3-4 grams txhua hnub) yuav nce ntshav qab zib. Los ntawm kev ua kom cov ntshav qab zib, niacin yuav txo qis cov ntshav qab zib ua kom siv tshuaj. Saib xyuas koj cov ntshav qab zib kom zoo. Cov koob tshuaj koj cov tshuaj ntshav qab zib yuav tau hloov pauv.

Qee cov tshuaj siv rau ntshav qab zib muaj xws li glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), metformin (Glucophage), nateglinide (Starlix), repaglinide (Prandin), Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), thiab lwm yam.
Cov tshuaj rau ntshav siab (Cov tshuaj tiv thaiv ntshav siab)
Siv cov niacin nrog cov tshuaj uas txo cov ntshav siab tuaj yeem ua rau cov teebmeem ntawm cov tshuaj no thiab txo qis ntshav siab ntau dhau.

Qee cov tshuaj rau cov ntshav siab muaj xws li captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), thiab lwm yam. Cov.
Cov tshuaj uas tuaj yeem cuam tshuam rau lub siab (Cov tshuaj Hepatotoxic)
Niacin yuav tuaj yeem ua mob rau lub siab. Cov neeg npaj-tso niacin kev npaj zoo li muaj kev pheej hmoo loj tshaj. Kev noj tshuaj niacin nrog rau kev noj tshuaj uas tuaj yeem tsim kev puas tsuaj rau daim siab tuaj yeem ua rau muaj kev pheej hmoo mob siab. Tsis txhob noj niacin yog tias koj noj tshuaj uas tuaj yeem cuam tshuam rau daim siab.

Qee cov tshuaj uas tuaj yeem cuam tshuam rau daim siab muaj xws li acetaminophen (Tylenol thiab lwm tus), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporan) erythromycin (Erythrocin, Ilosone, lwm tus), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), thiab lwm yam.
Cov tshuaj noj kom ntshav txhaws (Anticoagulant / Antiplatelet tshuaj)
Niacin yuav ua rau cov ntshav txhaws. Noj niacin nrog rau cov tshuaj uas ua rau txhaws qeeb yuav ua rau muaj qhov txhaws thiab los ntshav.

Qee cov tshuaj uas ua rau cov ntshav txhaws qeeb muaj xws li tshuaj aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, indomethacin (Indocin), ticlopidine (Ticlid), warfarin (Coumadin), thiab lwm yam.
Cov tshuaj siv rau txo qis roj (Bile acid sequestrants)
Qee cov tshuaj rau txo qis roj hu ua bile acid sequestrants tuaj yeem txo qis niacin lub cev npaum li cas. Qhov no tuaj yeem txo qis kev ua haujlwm ntawm niacin. Noj cov tshuaj niacin thiab cov tshuaj tsawg kawg yog 4-6 teev sib nrug.

Qee cov tshuaj uas siv los txo cov roj (cholesterol) muaj xws li cholestyramine (Questran) thiab colestipol (Colestid).
Cov tshuaj siv rau txo cov roj (Statins)
Niacin tuaj yeem cuam tshuam rau cov leeg. Qee cov tshuaj siv rau txo qis roj hu ua statins tseem tuaj yeem cuam tshuam rau cov leeg. Kev noj tshuaj niacin nrog rau cov tshuaj no yuav ua rau muaj kev pheej hmoo mob leeg.

Qee cov tshuaj siv rau cov roj (cholesterol) siab muaj xws li rosuvastatin (Crestor), atorvastatin (Lipitor), lovastatin (Mevacor), pravastatin (Pravachol), fluvastatin (Lescol), thiab simvastatin (Zocor).
Probenecid (Benemid)
Probenecid yog siv los kho gout. Kev noj cov tshuaj niacin ntau dua tuaj yeem ua rau gout zuj zus thiab txo cov txiaj ntsig ntawm probenecid.
Sulfinpyrazone (Anturane)
Sulfinpyrazone (Anturane) yog siv los kho gout. Kev noj cov tshuaj niacin ntau dua tuaj yeem ua rau muaj kev phom sij rau gout thiab txo cov txiaj ntsig sulfinpyrazone (Anturane).
Cov thyroid hormones
Lub cev ib txwm ua rau cov thyroid hormones. Niacin yuav txo cov thyroid hormones txaus lawm. Kev noj cov tshuaj niacin nrog cov tshuaj ua cov thyroid hormones txaus yuav txo qis kev phiv thiab phiv los ntawm cov thyroid hormone.
Menyuam yaus
Ceev faj ntawm qhov sib xyaw ua ke no.
Tshuaj aspirin
Cov tshuaj aspirin feem ntau siv nrog niacin txhawm rau txo cov dej ntws tawm los ntawm niacin. Kev noj cov tshuaj aspirin ntau tuaj yeem ua rau lub cev ploj sai npaum li cas ntawm niacin. Qhov no tuaj yeem ua rau muaj niacin ntau dhau hauv lub cev thiab ua rau muaj kev phiv. Txawm li cas los xij, kev noj cov tshuaj aspirin tsawg kawg yog siv rau qhov tso dej tsis haum rau niacin tsis zoo li muaj teeb meem.
Nicotine thaj (Nicoderm)
Qee zaum Niacin tuaj yeem ua rau yaug thiab kiv taub hau. Qhov thaj chaw muaj nicotine kuj tseem tuaj yeem ua rau yaug thiab kiv taub hau. Kev noj tshuaj niacin lossis niacinamide thiab siv daim npog nicotine tuaj yeem ua rau muaj peev xwm ua kom yaug thiab kiv taub hau.
Beta-carotene
Kev sib xyaw ua ke ntawm niacin thiab cov tshuaj simvastatin (Zocor) nce HDL (cov roj lipoprotein ntau) cov roj ("cov roj (cholesterol)" zoo) hauv cov neeg muaj mob plawv thiab muaj HDL tsawg. Txawm li cas los xij, kev noj niacin nrog rau kev sib xyaw ua ke ntawm cov tshuaj tiv thaiv kab mob, nrog rau beta-carotene, zoo li tsis meej qhov no nce hauv HDL. Kuj tsis paub meej tias cov yam ntxwv no tshwm sim rau cov neeg uas tsis muaj mob plawv.
Chromium
Kev noj tshuaj niacin thiab chromium ua ke yuav txo cov ntshav qab zib. Yog tias koj muaj ntshav qab zib thiab noj tshuaj chromium thiab niacin ua ke, saib xyuas koj cov piam thaj hauv ntshav kom paub tseeb tias nws yuav tsis poob qis heev.
Tshuaj ntsuab thiab tshuaj ntxiv uas yuav ua mob rau lub siab
Niacin, tshwj xeeb tshaj yog nyob rau hauv cov koob tshuaj ntau dua tuaj yeem ua rau daim siab puas. Kev noj tshuaj niacin nrog rau lwm yam tshuaj ntsuab los yog tshuaj ntxiv uas tuaj yeem cuam tshuam rau daim siab tuaj yeem ua rau muaj kev pheej hmoo. Qee cov khoom lag luam suav nrog androstenedione, nplooj tawv muag daj, chaparral, comfrey, dehydroepiandrosterone (DHEA), tus kabmob me, kava, roj pennyroyal, liab poov xab, thiab lwm yam.
Tshuaj ntsuab thiab tshuaj ntxiv uas txo qis ntshav siab
Niacin yuav txo cov ntshav siab. Kev noj tshuaj niacin nrog lwm cov tshuaj ntsuab thiab tshuaj ntxiv uas ua rau txo cov ntshav siab tuaj yeem ua rau cov ntshav siab poob qis. Lwm yam tshuaj ntsuab thiab tshuaj ntxiv uas tuaj yeem txo cov ntshav siab muaj xws li andrographis, casein peptides, miv claw, coenzyme Q10, L-arginine, lycium, stinging nettle, theanine, thiab lwm yam.
Tshuaj ntsuab thiab tshuaj uas yuav ua rau ntshav txhaws
Niacin yuav ua rau cov ntshav txhaws. Siv cov niacin nrog rau lwm cov tshuaj ntsuab thiab cov tshuaj ntxiv uas ua rau cov ntshav txhaws me me tuaj yeem ua rau muaj kev pheej hmoo los ntshav hauv qee leej neeg. Qee lwm yam tshuaj ntsuab ntawm hom no suav nrog angelica, clove, danshen, qij, qhiav, Panax ginseng, thiab lwm tus.
Kombucha tshuaj yej
Muaj qee qhov kev txhawj xeeb uas cov tshuaj yej kombucha yuav txo qis niacin nqus. Txawm li cas los xij, qhov no yuav tsum tau kawm ntxiv.
Selenium
Kev sib xyaw ua ke ntawm niacin thiab cov tshuaj simvastatin (Zocor) nce HDL (cov roj lipoprotein ntau) cov roj ("cov roj (cholesterol)" zoo) hauv cov neeg muaj mob plawv thiab muaj HDL tsawg. Txawm li cas los xij, kev noj niacin nrog rau kev sib xyaw ua ke ntawm cov tshuaj tiv thaiv kab mob, nrog rau selenium, zoo li tsis meej qhov no nce hauv HDL. Kuj tsis paub meej tias cov yam ntxwv no tshwm sim rau cov neeg uas tsis muaj mob plawv.
Tryptophan
Qee cov tryptophan los ntawm kev noj haus yuav hloov mus rau hauv niacin hauv lub cev. Kev noj niacin thiab tryptophan ua ke yuav nce qib thiab phiv ntawm niacin.
Vitamin C
Kev sib xyaw ua ke ntawm niacin thiab cov tshuaj simvastatin (Zocor) nce HDL (cov roj lipoprotein ntau) cov roj ("cov roj (cholesterol)" zoo) hauv cov neeg muaj mob plawv thiab muaj HDL tsawg. Txawm li cas los xij, kev noj niacin nrog rau kev sib xyaw ua ke ntawm cov tshuaj tiv thaiv kab mob, nrog rau cov vitamin C, zoo li tsis meej qhov no nce hauv HDL. Kuj tsis paub meej tias cov yam ntxwv no tshwm sim rau cov neeg uas tsis muaj mob plawv.
Vitamin E
Kev sib xyaw ua ke ntawm niacin thiab cov tshuaj simvastatin (Zocor) nce HDL (cov roj lipoprotein ntau) cov roj ("cov roj (cholesterol)" zoo) hauv cov neeg muaj mob plawv thiab muaj HDL tsawg. Txawm li cas los xij, kev noj niacin nrog rau kev sib xyaw ua ke ntawm cov tshuaj tiv thaiv kab mob, nrog rau cov vitamin E, zoo li tsis meej qhov no nce hauv HDL. Kuj tsis paub meej tias cov yam ntxwv no tshwm sim rau cov neeg uas tsis muaj mob plawv.
Zinc
Lub cev tuaj yeem ua rau niacin. Cov neeg uas noj zaub mov tsis zoo thiab muaj niacin tsis muaj peev xwm, xws li kev haus dej cawv ntev, ua rau niacin ntxiv yog tias lawv noj zinc. Tej zaum yuav muaj kev pheej hmoo ntxiv ntawm cov kev mob tshwm sim ntawm niacin xws li tso dej tawm thiab khaus yog tias niacin thiab zinc raug sib koom ua ke.
Haus dej kub
Niacin tuaj yeem ua rau yaug thiab khaus. Cov teebmeem no yuav nce ntxiv yog tias niacin noj nrog haus kub.
Cov koob tshuaj nram no tau kawm hauv kev tshawb fawb:

COV LAUS

BY MOUTH:
  • Dav: Qee cov khoom noj khoom noj ntxiv teev cov tshuaj niacin ntawm cov npe hauv niacin sib npaug (NE). 1 mg ntawm niacin yog tib yam li 1 mg NE. Thaum niacin tau teev nyob rau ntawm daim ntawv lo ua NE, nws yuav suav nrog lwm cov ntawv ntawm niacin ib yam nkaus, suav nrog niacinamide, inositol nicotinate, thiab tryptophan. Cov kev noj zaub mov uas tau pom zoo txhua hnub (RDAs) rau niacin hauv cov neeg laus yog 16 mg NE rau cov txiv neej, 14 mg rau cov poj niam, 18 mg NE rau cov poj niam cev xeeb tub, thiab 17 mg NE rau cov pojniam muaj menyuam.
  • Rau roj siab: Qhov cuam tshuam ntawm niacin yog koob tshuaj-siv. Cov koob tshuaj ntawm niacin tsawg li 50 mg thiab ntau npaum li 12 gram ib hnub twg tau siv. Txawm li cas los xij, qhov loj tshaj nce hauv HDL thiab txo qis hauv cov triglycerides tshwm sim ntawm 1200 txog 1500 mg / hnub. Niacin qhov muaj txiaj ntsig zoo tshaj plaws ntawm LDL tshwm sim thaum 2000 txog 3000 mg / hnub. Niacin feem ntau siv nrog lwm cov tshuaj rau kev txhim kho cov qib roj cholesterol.
  • Txog kev tiv thaiv thiab kho vitamin B3 qhov tsis txaus thiab cuam tshuam txog cov mob xws li pellagra: 300-1000 mg txhua hnub hauv kev faib faib.
  • Rau kev kho cov tawv nqaij tawv tawv: Kuaj cov tshuaj niacin tau ntau npaum li 12 grams txhua hnub. Txawm li cas los xij, txoj kev siv tshuaj ntau npaum li 1 txog 4 gram ntawm niacin txhua hnub, ib leeg lossis nrog rau statins lossis kua tsib cov kua qaub (cov tshuaj ua kom cov roj (cholesterol) txo qis), tau siv ntev txog 6.2 xyoo.
  • Txog kev txo cov kua qog ua kom mob los ntawm cholera toxin: 2 gram txhua hnub tau siv.
  • Txog rau cov ntshav rog lub cev tsis xwm yeem vim kev kho mob rau HIV / AIDS: Txog li 2 gram ib hnub twg tau siv.
  • Rau cov metabolic syndrome: 2 gram ntawm niacin tau noj txhua hnub rau 16 lub lis piam. Qee qhov xwm txheej, niacin 2 grams txhua hnub, ib leeg lossis ntawm kev noj ntau npaum li no, noj nrog 4 gram ntawm tshuaj omega-3 ethyl esters (Lovaza, GlaxoSmithKline Cov Tshuaj).
BY IV:
  • Txog kev tiv thaiv thiab kho vitamin B3 qhov tsis txaus thiab cuam tshuam txog cov mob xws li pellagra: 60 mg ntawm niacin tau siv lawm.
AS RAWS:
  • Txog kev tiv thaiv thiab kho vitamin B3 qhov tsis txaus thiab cuam tshuam txog cov mob xws li pellagra: 60 mg ntawm niacin tau siv lawm.
TUS ME NYUAM

BY MOUTH:
  • Dav: Cov tshuaj pom zoo noj zaub mov zoo noj txhua hnub (RDAs) rau niacin hauv menyuam yaus yog 2 mg rau cov menyuam hnub nyoog 6 txog 6 hlis, 4 mg NE rau cov menyuam mos hnub nyoog 7-12 hlis, 6 mg rau cov menyuam hnub nyoog 1-3 xyoos, 8 mg NE rau cov menyuam hnub nyoog 4-8 xyoos, 12 mg rau cov menyuam hnub nyoog 9-13 xyoo, 16 mg rau cov tub hnub nyoog 14-18 xyoo, thiab 14 mg rau cov menyuam hnub nyoog 14-18 xyoo.
  • Txog kev tiv thaiv thiab kho vitamin B3 qhov tsis txaus thiab cuam tshuam txog cov mob xws li pellagra: 100-300 mg ib hnub twg ntawm niacin, muab txhaj tshuaj faib rau.
3-Pyridinecarboxylic Acid, Acide Nicotinique, Acide Pyridine-Carboxylique-3, Anti-Blacktongue Factor, Antipellagra Factor, B Complex Vitamin, Complexe de Vitamines B, Facteur Anti-Pellagre, Niacina, Niacine, Nicosedine, Nicotinic Acid, Pellagor, Tshuaj Tiv Thaiv, Vitamin B3, Vitamin PP, Vitamina B3, Vitamine B3, Vitamine PP.

Xav paub ntau ntxiv txog yuav sau li cas cov lus tau sau, thov saib cov Cov Tshuaj Kho Kom Zoo Database kev qhia txujci.


  1. Anderson TJ, Grégoire J, Pearson GJ, li al. 2016 Cov Neeg Koom Tes Hauv Lub Plawv Kev Noj Qab Haus Huv Hauv Phau Ntawv Qhia rau Kev Tswj Xyuas Dyslipidemia rau kev tiv thaiv kab mob plawv hauv cov neeg laus. Tau J Cardiol. 2016; 32: 1263-1282. Saib daws teeb meem.
  2. Pob zeb NJ, Robinson JG, Lichtenstein AH, li al. Xyoo 2013 ACC / AHA cov lus qhia txog kev kho mob ntshav siab txhawm rau txo atherosclerotic mob plawv rau cov neeg laus: ib tsab ntawv tshaj tawm ntawm American College of Cardiology / American Heart Association txoj haujlwm ua haujlwm ntawm cov lus qhia xyaum. J Am Coll Cardiol 2014; 63: 2889-934. Saib daws teeb meem.
  3. Lloyd-Jones DM, Morris PB, Ballantyne CM, li al. 2016 ACC Tus kws tshaj lij pom zoo kev txiav txim siab txog lub luag haujlwm ntawm kev kho mob tsis yog statin rau LDL-cholesterol qis dua hauv kev tswj hwm ntawm atherosclerotic mob plawv txaus ntshai: cov ntawv tshaj tawm ntawm American College ntawm Cardiology ua haujlwm ntawm cov kws tshaj lij kev pom zoo cov ntaub ntawv. J Am Coll ntawm Cardiol 2016; 68: 92-125. Saib daws teeb meem.
  4. Montserrat-de la Paz S, Lopez S, Bermudez B, li al. Qhov cuam tshuam ntawm kev tso tawm sai sai ntawm niacin thiab kev noj haus cov roj ntsha ntawm cov tshuaj insulin thiab lipid hauv cov tib neeg muaj mob metabolic. J Sci Zaub Mov Noj 2018; 98: 2194-200. Saib daws teeb meem.
  5. Jenkins DJA, Spence JD, Giovannucci EL, li al. Cov tshuaj vitamins thiab minerals ntxiv rau CVD kev tiv thaiv thiab kho. J Am Coll Cardiol 2018; 71: 2570-84. Saib daws teeb meem.
  6. Sahebkar A, Reiner Z, Simental-Mendia LE, Ferretti G, Cicero AF. Qhov cuam tshuam ntawm kev tso tawm niacin ntawm plasma lipoprotein (a) qib: Kev tshuaj xyuas lub hauv paus thiab kev tsom xam ntawm kev siv cov tshuaj placebo. Kev zom zaub mov. 2016 Nov; 65: 1664-78. Saib daws teeb meem.
  7. Gyan MW, Paulus YM, Rahimy E, Alexander JL, Mansour SE. Cov nyhuv ntawm qhov ncauj niacin ntawm central retinal leeg leeg occlusion. Cim Rau Nruab Nrab Clin Exp Ophthalmol. 2017 Lub Rau Hli; 255: 1085-92. Saib daws teeb meem.
  8. Schandelmaier S, Briel M, Saccilotto R, Olu KK, Arpagaus A, Hemkens LG, Nordmann AJ. Niacin rau kev tiv thaiv kab mob plawv thiab theem nrab ntawm kev mob plawv. Cochrane Cov Ntawv Pov Tseg Syst Rev. 2017 Jun 14; 6: CD009744. Saib daws teeb meem.
  9. Lin C, Grandinetti A, Shikuma C, li al. Qhov cuam tshuam ntawm kev nthuav tawm niacin ntawm lipoprotein sub-particle ntau nyob rau hauv cov neeg mob HIV. Hawaii J Med Cov Noj Qab Haus Huv. Xyoo 2013 Lub Plaub Hlis; 72: 123-7. Saib daws teeb meem.
  10. Scoffone HM, Krajewski M, Zorca S, li al. Cov nyhuv ntawm ncua-tso niacin rau cov ntshav lipids thiab cov kev ua haujlwm endothelial hauv cov neeg laus uas muaj ntshav ntsa ntshav tsis txaus thiab muaj cov roj lipoprotein ntau ntau. Am J Cardiol. 2013 Nov 1; 112: 1499-504. Saib daws teeb meem.
  11. Brunner G, Yang EY, Kumar A, li al. Cov nyhuv ntawm kev hloov kho lipid ntawm cov kab mob peripheral artery tom qab endovascular kev cuam tshuam kev sim (ELIMIT). Atherosclerosis. 2013 Dec; 213: 371-7. Saib daws teeb meem.
  12. Goldie C, Taylor AJ, Nguyen P, McCoy C, Zhao XQ, Preiss D. Niacin kev kho mob thiab qhov kev pheej hmoo ntawm kev pib mob ntshav qab zib tshiab: kev soj ntsuam meta-kev soj ntsuam ntawm kev sim kho cov kev sim. Plawv. 2016 Lub Ob Hlis; 102: 198-203. Saib daws teeb meem.
  13. PL Cov Lus Qhia-Cov Ntawv Sau Tseg, Lub Luag Haujlwm ntawm Tsis yog Statins rau Dyslipidemia. Daim Ntawv / Tus Kws Tshuaj Tshuaj Daim Ntawv Tshuaj. Rau Hli 2016; 32: 320601.
  14. Teo KK, Goldstein LB, Chaitman BR, Grant S, Weintraub WS, Anderson DC, Sila CA, Cruz-Flores S, Padley RJ, Kostuk WJ, Boden PEB; AIM-SIAB Neeg Soj Ntsuam. Kev nthuav dav-tso tawm kev kho mob niacin thiab kev pheej hmoo ntawm ischemic mob hlab ntsha hauv cov neeg mob mob plawv: kev tiv thaiv kab mob Atherothrombosis hauv Metabolic Syndrome nrog HDL tsawg / High Triglycerides: Muaj feem cuam tshuam ntawm Kev Noj Qab Haus Huv Ntiaj Teb (AIM-HIGH). Mob stroke. 2013 Oct; 44: 2688-93. Saib daws teeb meem.
  15. Txiab GC, Pottala JV, Hansen SN, Brandenburg V, Harris WS. Qhov cuam tshuam ntawm cov tshuaj niacin thiab omega-3 fatty acids ntawm lipids thiab vascular muaj nuj nqi nyob rau hauv metabolic syndrome: kev tswj hwm kev sim. J Lipid Res. 2012 Nov; 53: 2429-35. Saib daws teeb meem.
  16. Sazonov V, Maccubbin D, Sisk CM, Canner PL. Qhov cuam tshuam ntawm niacin ntawm kev tshwm sim ntawm qhov pib tshiab mob ntshav qab zib thiab cov hlab plawv cov txheej xwm hauv cov neeg mob uas muaj cov ntshav nruab nrog cev thiab tsis ua haujlwm sai. Int J Clin Kev Xyaum. Xyoo 2013 Apr; 67: 297-302. Saib daws teeb meem.
  17. Philpott AC, Hubacek J, Hnub YC, Hillard D, Anderson TJ. Niacin txhim kho lipid profile tab sis tsis muaj endothelial muaj nuj nqi nyob rau hauv cov neeg mob mob ua mob rau cov hlab ntshav ntawm txoj kev kho mob siab statin. Atherosclerosis. 2013 Lub Ob Hlis; 226: 453-8. Saib daws teeb meem.
  18. Loebl T, Raskin S. Cov ntaub ntawv tshiab tshiab: mob tsis txaus ntseeg sai sai tom qab kho nrog niacin. J Neuropsychiatry Clin Neurosci. Xyoo 2013 Poob; 25: E14. Saib daws teeb meem.
  19. Lavigne PM, Karas RH. Tam sim no lub xeev ntawm niacin hauv kev tiv thaiv kab mob plawv: kev soj ntsuam cov kab mob hauv lub cev thiab meta-regression. J Am Coll Cardiol. 2013 Jan 29; 61: 440-6. Saib daws teeb meem.
  20. Lakey WC, Greyshock N, Guyton JR. Cov kev phiv tshuaj ntawm Achilles leeg xanthomas hauv peb tus neeg mob hypercholesterolemic tom qab kev kho mob sib zog nrog niacin thiab kua tsib cov kua qaub ua kom muaj zog. J Clin Lipidol. 2013 Mar-Apr; 7: 178-81. Saib daws teeb meem.
  21. Kei A, Liberopoulos EN, Mikhailidis DP, Elisaf M. Kev sib piv ntawm kev hloov pauv mus rau qhov siab tshaj plaws ntawm rosuvastatin vs. ntxiv rau ntawm nicotinic acid thiab sib ntxiv ntawm fenofibrate rau kev sib xyaw dyslipidaemia. Int J Clin Kev Xyaum. Xyoo 2013 Lub Tsib Hlis; 67: 412-9. Saib daws teeb meem.
  22. Keene D, Nqe C, Suav-Shin MJ, Francis DP. Kev cuam tshuam rau cov kev mob plawv ntawm cov ntshav qab zib siab lipoprotein tsom cov tshuaj kho niacin, fibrates, thiab CETP inhibitors: meta-tsom xam ntawm cov kev tswj hwm uas tsis suav nrog suav nrog 117,411 tus neeg mob. BMJ. 2014 Jul 18; 349: g4379. Saib daws teeb meem.
  23. Nws YM, Feng L, Huo DM, Yang ZH, Liao YH. Cov txiaj ntsig zoo thiab kev phom sij ntawm niacin thiab nws cov lus sib piv rau cov neeg mob ntshav hlab plawv: kev tshuaj xyuas kab mob hauv nruab nrog cev thiab tshuaj xyuas kab mob kev ntsuas. Rau Cov Hluav Taws Xob Nerol. 2014 Lub Ob Hlis; 46: 433-42. Saib daws teeb meem.
  24. Guyton JR, Fazio S, Adewale AJ, Jensen E, Tomassini JE, Shah A, Tershakovec AM. Qhov cuam tshuam ntawm ncua-tso niacin rau kev pib mob ntshav qab zib tshiab ntawm cov neeg mob hyperlipidemic kho nrog ezetimibe / simvastatin nyob rau hauv kev sim tswj kev sim. Ntshav Qab Zib Kho Mob. Xyoo 2012 Lub Plaub Hlis; 35: 857-60. Saib daws teeb meem.
  25. Davidson MH, Rooney M, Pollock E, Drucker J, Choy Y. Qhov cuam tshuam ntawm colesevelam thiab niacin ntawm cov roj lipoprotein tsawg cov roj ntsha thiab glycemic tswj hauv cov ncauj lus nrog dyslipidemia thiab ua rau cov ntshav qabzib sai. J Clin Lipidol. 2013 Sep-Kaum Hlis; 7: 423-32. Saib daws teeb meem.
  26. Bassan M. Ib rooj plaub rau kev tso tawm sai sai niacin. Lub Plawv. 2012 Lub Ib Hlis-Lub Ob Hlis; 41: 95-8. Saib daws teeb meem.
  27. Aramwit P, Srisawadwong R, Supasyndh O. Ua tau zoo thiab muaj kev nyab xeeb ntawm kev tso tawm cov nicotinic acid rau txo cov ntshiab phosphorus hauv cov neeg mob hemodialysis. J Nifaisrol. 2012 Tsib Hlis-Jun; 25: 354-62. Saib daws teeb meem.
  28. Ali EH, McJunkin B, Jubelirer S, Hood W. Niacin ntxias coagulopathy ua rau muaj kev tiv thaiv kab mob siab. W V Med J. 2013 Jan-Feb; 109: 12-4 Saib cov duab abstract.
  29. Urberg, M., Benyi, J., thiab John, R. Hypocholesterolemic cuam tshuam ntawm nicotinic acid thiab chromium ntxiv. J Fam.Pract. 1988; 27: 603-606. Saib daws teeb meem.
  30. Hendrix, CR, Housh, TJ, Mielke, M., Zuniga, JM, Camic, CL, Johnson, GO, Schmidt, RJ, thiab Housh, DJ Mob los ntawm kev muaj caffeine-ntxiv ntxiv rau ntawm lub rooj ntev zaum thiab ceg txuas ntxiv dag zog thiab lub sijhawm rau qhov kev ua kom dhau los thaum lub voj voog ergometry. J Lub Zog.Cond.Res 2010; 24: 859-865. Saib daws teeb meem.
  31. Daim duab HL, Daim Duab J, Souney PF, li al. Kev sib piv ntawm kev nthuav tawm ntawm nicotinuric acid tom qab kev noj ntawm ob lub tshuaj tswj kev tso tawm nicotinic acid npaj rau hauv tus txiv neej. J Clin Tshuaj Kho Mob. 1988 Kev Txiav Txim; 28: 1136-40. Saib daws teeb meem.
  32. Mrochek JE, Jolley RL, Young DS, Turner WJ. Kev ntsuas ntawm tib neeg rau kev noj ntawm nicotinic acid thiab nicotinamide. Clin Chem. Xyoo 1976; 22: 1821-7. Saib daws teeb meem.
  33. Neuvonen PJ, Roivas L, Laine K, Sundholm O. Qhov kev nyab xeeb ntawm kev saib xyuas kev tso cov nicotinic acid formulations. Br J Clin Tshuaj Kho Mob. Xyoo 1991; 32: 473-6. Saib daws teeb meem.
  34. Menon RM, Adams MH, González MA, Tolbert DS, Leu JH, Cefali EA. Plasma thiab tso zis pharmacokinetics ntawm niacin thiab nws cov metabolites los ntawm kev nthuav dav tso tawm niacin. Int J Clin Pharmacol Ther. 2007; 45: 448-54. Saib daws teeb meem.
  35. Karpe F, Frayn KN. Cov nicotinic acid receptor - qhov kev hloov kho rau cov tshuaj tshiab. Kev Looj Mem. Xyoo 2004; 363: 1892-44. Saib daws teeb meem.
  36. Tus neeg S, Smith SJ, Zheng YW, li al. Kev txheeb xyuas ntawm cov gene encoding ancyl CoA: diacylglycerol acyltransferase, qhov tseem ceeb enzyme hauv triacylglycerol synthesis. Proc Natl Acad Sci U S A. 1998; 95: 13018-23. Saib daws teeb meem.
  37. Ganji SH, Tavintharan S, Zhu D, Xing Y, Kamanna VS, Kashyap ML. Niacin noncompetitively inhibits DGAT2 tab sis tsis DGAT1 kev ua haujlwm hauv HepG2 hlwb. J Lipid Res. Xyoo 2004; 45: 1835-45. Saib daws teeb meem.
  38. Tornvall P, Hamsten A, Johansson J, Carlson LA. Kev hloov kho ib txwm muaj pes tsawg leeg ntawm lipoprotein ntau hauv hypertriglyceridemia los ntawm nicotinic acid. Atherosclerosis. 1990; 84 (2-3): 219-27. Saib daws teeb meem.
  39. Morgan JM, Capuzzi DM, Baksh RI, li al. Qhov cuam tshuam ntawm ncua-tso tawm niacin ntawm lipoprotein subclass faib. Am J Cardiol. Xyoo 2003; 91: 1432-6. Saib daws teeb meem.
  40. Jin FY, Kamanna VS, Kashyap ML. Niacin txo qis kev tshem tawm cov lipoprotein ntau-apolipoprotein A-I tab sis tsis muaj cov roj (cholesterol) ester yog Hep G2 hlwb. Kev siv rau kev thauj rov qab cov roj cholesterol. Arterioscler Thromb Vasc Biol. 1997; 17: 2020-8. Saib daws teeb meem.
  41. Vincent JE, Zijlstra FJ. Nicotinic acid inhibits thromboxane synthesis hauv platelets. Prostaglandins. Xyoo 1978; 15: 629-36. Saib daws teeb meem.
  42. Datta S, Das DK, Engelman RM, li al. Txhim khu myocardial khaws cia los ntawm nicotinic acid, antilipolytic compound: mechanism ntawm kev nqis tes ua. Yeem Res Cardiol. Xyoo 1989; 84: 63-76. Saib daws teeb meem.
  43. Turjman N, Cardamone A, Gotterer GS, Hendrix TR. Cov nyhuv ntawm nicotinic acid ntawm cov teeb meem raws kev mob qa muaj zog thiab unidirectional sodium fluxes hauv luav jejunum. Johns Hopkins Med J. 1980; 147: 209-11. Saib daws teeb meem.
  44. Unna K. Kev tshawb fawb txog kev ua kom muaj tshuaj lom thiab chaw muag tshuaj ntawm nicotinic acid. J Pharmacol Exp Ther 1939; 65: 95-103.
  45. Brazda FG thiab Coulson RA. Toxicity ntawm nicotinic acid thiab qee qhov nws cov derivatives. Proc Soc Exp Biol Med 1946; 62: 19-20.
  46. Chen KK, Rose CL, Robbins EB. Toxicity ntawm nicotinic acid. Proc Soc Exp Biol Med 1938; 38: 241-245.
  47. Fraunfelder FW, Fraunfelder FT, Illingworth DR. Kev phiv tshuaj ntau ntxiv cuam tshuam nrog kev kho niacin. Br J Ophthalmol 1995; 79: 54-56.
  48. Litin SC, Anderson CF. Nicotinic acid-txuam nrog myopathy: ib daim ntawv qhia ntawm peb kis. Am J Med. 1989; 86: 481-3. Saib daws teeb meem.
  49. Gharavi AG, Pob Zeb Diamond JA, Smith DA, Phillips RA. Niacin-ntxias cov myopathy. Am J Cardiol. Xyoo 1994; 74: 841-2. Saib daws teeb meem.
  50. OO POOS PO, CALLBECK MJ, HOFFER A. Muaj kev tiv thaiv-tso cov nicotinic acid (nicospan); cuam ​​tshuam rau cov qib roj cholesterol thiab leukocytes. Yuav Med Assoc J. 1959; 80: 359-62. Saib daws teeb meem.
  51. Earthman TP, Odom L, Mullins CA. Lactic acidosis cuam tshuam nrog kev txhaj tshuaj niacin ntau. Sab Qab Teb Med J. 1991; 84: 496-7. Saib daws teeb meem.
  52. Xim av WV. Niacin rau kev mob plab tsis zoo. Kev ntsuas, qhov ua tau zoo, thiab kev nyab xeeb. Hloov kho Med. Xyoo 1995 Lub Yim Hli; 98: 185-9, 192-3. Saib daws teeb meem.
  53. Windler E, Zyriax BC, Bamberger C, Rinninger F, Beil FU. Cov tswv yim tam sim no thiab cov kev hloov kho tshiab tsis ntev los no hauv kev kho mob ntawm hypercholesterolemia. Atheroscler Khoom Siv. 2009; 10: 1-44. Saib daws teeb meem.
  54. Kaijser L, Eklund B, Olsson AG, Carlson LA. Kev cuam tshuam ntawm cov teebmeem ntawm nicotinic acid rau vasodilatation thiab lipolysis los ntawm prostaglandin synthesis inhibitor, indomethacin, hauv tus txiv neej. Med Biol. Xyoo 1979; 57: 114-7. Saib daws teeb meem.
  55. Eklund B, Kaijser L, Tam Sim No J, Wennmalm A. Prostaglandins pab rau vasodilation ntxias los ntawm nicotinic acid. Prostaglandins. Xyoo 1979; 17: 821-30. Saib daws teeb meem.
  56. Andersson RG, Aberg G, Brattsand R, Ericsson E, Lundholm L. Kev tshawb nrhiav ntawm cov tshuab ntawm yaug tawm los ntawm nicotinic acid. Acta Pharmacol Toxicol (Copenh). Xyoo 1977 Jul; 41: 1-10. Saib daws teeb meem.
  57. Morgan JM, Capuzzi DM, Guyton JR, li al. Kev Kho Mob Ntxim Ntxim ntawm Niaspan, Tshuaj Tswj-tso tawm Niacin, hauv Cov Neeg Mob Nrog hypercholesterolemia: Ib qho chaw tshuaj uas tsis yog tshuaj Placebo. J Cardiovasc Pharmacol Ther. Xyoo 1996; 1: 195-202. Saib daws teeb meem.
  58. Aronov DM, Keenan JM, Akhmedzhanov NM, li al. Soj ntsuam kev sim ntawm ciab-matrix txhawb-tso niacin nyob rau hauv ib tug pej xeem Lavxias teb sab nrog hypercholesterolemia. Koov Tooj Med. Xyoo 1996; 5: 567-75. Saib daws teeb meem.
  59. Goldberg A, Alagona P Jr, Capuzzi DM, li al. Ntau yam tshuaj tiv thaiv kab mob ua tau zoo thiab kev nyab xeeb ntawm kev ncua daim ntawv niacin hauv kev tswj hwm ntawm hyperlipidemia. Am J Cardiol. 2000; 85: 1100-5. Saib daws teeb meem.
  60. Smith DT, Ruffin JM, thiab Smith SG. Pellagra tau zoo kho nrog nicotinic acid: cov ntaub ntawv qhia. JAMA 1937; 109: 2054-2055.
  61. Fouts PJ, Helmer OM, Lepkovsky S, thiab li al. Kev kho mob ntawm tib neeg pellagra nrog nicotinic acid. Proc Soc Exp Biol Med 1937; 37: 405-407.
  62. Xim av BG, Bardsley J, Poulin D, li al. Kev noj tshuaj ib nrab, peb-tshuaj kho mob nrog niacin, lovastatin, thiab colestipol txhawm rau txo cov roj lipoprotein tsawg roj <100 mg / dl hauv cov neeg mob hyperlipidemia thiab mob ntshav siab. Am J Cardiol. 1997; 80: 111-5. Saib daws teeb meem.
  63. Ban TA. Kev kawm siab ntsws thiab txuj ci kev lag luam. Kev Puas Hlwb Neuropsychopharmacol Biol. Xyoo 2006 Lub Tsib Hlis; 30: 429-41.Qhov paub daws teeb.
  64. Lanska DJ. Tshooj 30: keeb kwm sib nrauj ntawm cov loj ntawm cov neurological vitamin tsis txaus siab: dej-soluble B vitamins. Tes Tes Taw Neurol. Xyoo 2010; 95: 445-76. Saib daws teeb meem.
  65. Berge KG, Canner PL. Txoj kev mob rau txoj hlab ntshav: kev paub nrog niacin. Coronary Tshuaj Kho Mob Tshawb Nrhiav Haujlwm Pawg. Eur J Clin Tshuaj Kho Mob. Xyoo 1991; 40 Tus Neeg Muag Khoom 1: S49-51. Saib daws teeb meem.
  66. Tsis muaj tus sau phau ntawv. Clofibrate thiab niacin hauv kev mob plawv hauv plawv. JAMA. 1975 Jan 27; 231: 360-81. Saib daws teeb meem.
  67. Henkin Y, Oberman A, Hurst DC, Segrest JP. Niacin rov xyuas dua: kev soj ntsuam tshuaj rau ib qho tseem ceeb tab sis siv tshuaj tsis raug. Am J Med. Xyoo 1991; 91: 239-46. Saib daws teeb meem.
  68. Henkin Y, Johnson KC, Segrest JP. Rov qab kho dua nrog crystalline niacin tom qab tshuaj tiv thaiv kab mob siab los ntawm kev mob siab tso tawm niacin. JAMA. 1990; 264: 241-3. Saib daws teeb meem.
  69. Etchason JA, Miller TD, Squires RW, li al. Kab mob siab siab Niacin-hle: qhov muaj feem tshwm sim nrog tsawg-lub sij hawm tso tawm niacin. Mayo Clin Proc. 1991; 66: 23-8. Saib daws teeb meem.
  70. Shakir KM, Kroll S, Aprill BS, Drake AJ 3, Eisold JF. Nicotinic acid txo cov ntshav cov thyroid hormones txaus thaum tswj kev tiv thaiv lub xeev euthyroid. Mayo Clin Proc. Xyoo 1995; 70: 556-8. Saib daws teeb meem.
  71. Drinka PJ. Kev hloov pauv ntawm cov thyroid thiab cov kev ua rau kabmob hepatic muaj feem cuam tshuam nrog kev npaj ntawm kev txhawb nqa-niacin tso tawm. Mayo Clin Proc. Xyoo 1992; 67: 1206. Saib daws teeb meem.
  72. Cashin-Hemphill L, Spencer CA, Nicoloff JT, li al. Cov kev hloov pauv hauv cov ntshav cov thyroid cov tshuaj hormones hormonal nrog colestipol-niacin txoj kev kho. Ann Intern Med. Xyoo 1987; 107: 324-9. Saib daws teeb meem.
  73. Dunn RT, Ford MA, Rindone JP, Kwiecinski FA. Kev Noj Tshuaj Qis Rau Me thiab Aspirin thiab Ibuprofen Txo qhov Txiav Txim Siab Ua Raws Li Niacin Kev Tswj Xyuas. Am J Ther. Xyoo 1995; 2: 478-480. Saib daws teeb meem.
  74. Litin SC, Anderson CF. Nicotinic acid-txuam nrog myopathy: ib daim ntawv qhia ntawm peb kis. Am J Med. Xyoo 1989; 86: 481-3. Saib daws teeb meem.
  75. Hexeberg S, Retterstøl K. [Hypertriglyceridemia - kuaj mob, phom sij thiab kho]. Tidsskr Tsis Laegeforen. Xyoo 2004; 124: 2746-9. Saib daws teeb meem.
  76. Garnett WR. Kev sib cuam tshuam nrog hydroxymethylglutaryl-coenzyme A reductase inhibitors. Am J Noj Qab Haus Huv Syst Pharm. Xyoo 1995; 52: 1639-45. Saib daws teeb meem.
  77. Gadegbeku CA, Dhandayuthapani A, Shrayyef MZ, Egan BM. Hemodynamic cuam tshuam ntawm nicotinic acid Txoj kev lis ntshav hauv cov ntsiab lus tsis hais siab thiab kub siab. Am J Hypertens. Xyoo 2003; 16: 67-71. Saib daws teeb meem.
  78. O'Brien T, Silverberg JD, Nguyen TT. Nicotinic acid-ntxias cov tshuaj lom cuam tshuam nrog cytopenia thiab txo qis ntawm thyroxine-binding globulin. Mayo Clin Proc. Xyoo 1992; 67: 465-8. Saib daws teeb meem.
  79. Txog rau BD, Lavie CJ, Lohmann TP, Genton E. Niacin hob cov ntshav txhaws ua rau muaj kev cuam tshuam nrog coagulopathy. Kob Kawm Med. Xyoo 1992; 152: 861-3. Saib daws teeb meem.
  80. Sampathkumar K, Selvam M, Sooraj YS, Gowthaman S, Ajeshkumar RN. Ncua tso tawm nicotinic acid - tus neeg sawv cev qhov ncauj tshiab rau kev tswj hwm phosphate. Rau Cov Hluav Taws Xob Nerol. 2006; 38: 171-4. Saib daws teeb meem.
  81. Ng CF, Lee CP, Ho AL, Lee VW. Cov nyhuv ntawm niacin ntawm kev ua haujlwm erectile rau tus txiv neej raug mob erectile kawg thiab dyslipidemia. J Sib deev. 2011; 8: 2883-93. Saib daws teeb meem.
  82. Duggal JK, Singh M, Attri N, li al. Cov nyhuv ntawm niacin kho rau cov txiaj ntsig ntawm lub plawv nyob rau hauv cov neeg mob uas mob rau cov hlab ntshav ntawm lub cev. J Cardiovasc Pharmacol Ther. Xyoo 2010; 15: 158-66. Saib daws teeb meem.
  83. Carlson LA, Rosenhamer G. Kev txo qis kev tuag ntawm cov neeg hauv Stockholm Ischemic Lub Plawv Hnyav Tiv Thaiv Kab Mob Hlawv Ntxiv Kev kawm los ntawm kev kho ua ke nrog clofibrate thiab nicotinic acid. Acta Med Scand. 1988; 223: 405-18. Saib daws teeb meem.
  84. Blankenhorn DH, Nessim SA, Johnson RL, li al. Muaj txiaj ntsig zoo ntawm kev sib koom ua ke ntawm colestipol-niacin kho rau kev mob ntshav ntawm txoj hlab ntshav leeg txoj hlab ntshav ntawm txoj hlab ntshav ntawm txoj hlab ntshav leeg txoj hlab ntshav ntawm txoj hlab ntshav txoj hlab ntshav. JAMA. 1987; 257: 3233-40. Saib daws teeb meem.
  85. Mack WJ, Selzer RH, Hodis HN, li al. Ib-xyoo kev txo qis thiab kev tshawb xyuas qhov ntev ntawm cov carotid intima-media thickness cuam tshuam nrog kev kho mob colestipol / niacin. Mob stroke. Xyoo 1993; 24: 1779-83. Saib daws teeb meem.
  86. Blankenhorn DH, Selzer RH, Crawford DW, li al. Muaj txiaj ntsig zoo ntawm kev siv tshuaj colestipol-niacin rau ntawm cov leeg carotid leeg. Ob- thiab plaub-xyoo txo ​​ntawm intima-media tuab ntsuas los ntawm ultrasound. Kev ncig. Xyoo 1993; 88: 20-8. Saib daws teeb meem.
  87. Xim av BG, Zambon A, Poulin D, li al. Kev siv cov niacin, statins, thiab resins hauv cov neeg mob ua ke ua ke hyperlipidemia. Am J Cardiol. 1998; 81 (4A): 52B-59B. Saib daws teeb meem.
  88. Xim av G, Albers JJ, Fisher LD, li al. Regression ntawm kev mob ntshav siab vim los ntawm kev kho lipid-txo qis kev kho mob hauv cov txiv neej muaj qib apolipoprotein B. N Engl J Med. 1990; 323: 1289-98. Saib daws teeb meem.
  89. Bruckert E, Labreuche J, Amarenco P. Meta-tsom xam ntawm cov nyhuv ntawm nicotinic acid ib leeg lossis hauv kev sib xyaw ntawm cov kev mob plawv thiab cov ntshav atherosclerosis. Atherosclerosis. Xyoo 2010; 210: 353-61. Saib daws teeb meem.
  90. Spies TD, Grant JM, Pob Zeb RE, li al. Cov kev soj ntsuam tsis ntev los no txog kev kho rau pua pellagrins nrog kev tshwj xeeb qhia txog kev siv cov nicotinic acid hauv prophylaxis. Sab Qab Teb Med J 1938; 31: 1231.
  91. Malfait P, Moren A, Dillon JC, li al. Muaj pellagra cuam tshuam txog kev hloov pauv ntawm kev noj haus niacin ntawm cov neeg tawg rog Mozambican hauv Malawi. Int J Epidemiol. Xyoo 1993; 22: 504-11. Saib daws teeb meem.
  92. Gerber MT, Mondy KE, Yarasheski KE, li al. Niacin hauv cov neeg muaj tus kabmob HIV nrog hyperlipidemia tau txais kev kho mob muaj zog. Clin Kab Mob Tsis Zoo. Xyoo 2004; 39: 419-25. Saib daws teeb meem.
  93. Dubé MP, Wu JW, Aberg JA, li al. Kev Nyab Xeeb thiab kev ua tau zoo ntawm kev tso tawm niacin ntxiv rau kev kho mob ntawm dyslipidaemia rau cov neeg mob uas muaj tus kab mob HIV: AIDS Clinical Trial Group Pawg Kawm A5148. Antivir Ther. 2006; 11: 1081-9. Saib daws teeb meem.
  94. Balasubramanyam A, Coraza I, Smith EO, li al. Kev sib xyaw ua ke ntawm niacin thiab fenofibrate nrog kev hloov pauv hauv kev ua neej txhim kho dyslipidemia thiab hypoadiponectinemia hauv cov neeg mob HIV ntawm kev siv tshuaj tiv thaiv kab mob: cov txiaj ntsig ntawm "lub siab zoo," ib qho kev sim, tswj kev sim. J Clin Endocrinol Metab. Xyoo 2011; 96: 2236-47. Saib daws teeb meem.
  95. Elam MB, Hunninghake DB, Davis KB, li al. Cov nyhuv ntawm niacin ntawm lipid thiab lipoprotein ntau ntau thiab glycemic tswj nyob rau hauv cov neeg mob ntshav qab zib thiab peripheral arterial kab mob: ADMIT txoj kev tshawb fawb: Kev sim kev pheej hmoo. Arterial Kab Mob Ntau Yam Kev Tiv Thaiv. JAMA. 2000; 284: 1263-70. Saib daws teeb meem.
  96. Charland SL, Malone DC. Kev twv ua ntej ntawm cov hlab plawv kev pheej hmoo txo ​​los ntawm lipid hloov txuam nrog siab potency dyslipidemia therapy. Curr Med Res Opin. Xyoo 2010; 26: 365-75. Saib daws teeb meem.
  97. Goldberg AC. Kev tshawb xyuas meta-tsom xam ntawm cov kev tshawb fawb uas tau tshawb xyuas txog cov teebmeem ntawm ncua-tso niacin hauv cov poj niam Am J Cardiol. Xyoo 2004; 94: 121-44. Saib daws teeb meem.
  98. Maes BD, Hiele MI, Geypens BJ, li al. Pharmacological cov kev hloov kho ntawm lub plab zom cov nqi khib nyiab raws li ntsuas los ntawm cov pa roj carbon uas sau tias octanoic acid ua pa ntsuas: cawv ntawm erythromycin thiab propantheline. Lub plab xyoo 1994; 35: 333-7. Saib daws teeb meem.
  99. FDA cov lus ntawm AIM-HIGH mus sib hais. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm256841.htm. (Nkag mus rau 3 Lub Rau Hli 2011).
  100. NIH Xov Xwm. NIH nres cov ntawv sib ntxiv rau kev kho mob sib xyaw ua ke. Tsib Hlis 26, 2011.http://www.nih.gov/news/health/may2011/nhlbi-26.htm. (Nkag mus rau 3 Lub Rau Hli 2011).
  101. PL Cov Lus Qhia-Daim Ntawv, Niacin Ntxiv Statin kom txo cov hlab plawv: Txoj kev tshawb nrhiav AIM-HIGH. Daim Ntawv / Tus Kws Tshuaj Tshuaj Daim Ntawv Tshuaj. Lub 7 hli 2011.
  102. Karthikeyan K, Thappa DM. Pellagra thiab tawv nqaij. Int J Dermatol 2002; 41: 476-81. Saib daws teeb meem.
  103. Hendricks WM. Pellagra thiab pellagralike dermatoses: etiology, kev kuaj mob txawv, dermatopathology, thiab kho mob. Semin Dermatol 1991; 10: 282-92. Saib daws teeb meem.
  104. Bingham LG, Verma SB. Photodistributed ua pob. (Txoj kev ntsuas tus kheej qhov ntsuas ntawm American Academy ntawm Dermatology). J Am Acad Dermatol 2005; 52: 929-32.
  105. Nahata MC. Chloramphenicol. Hauv: Evans PEB, Schentag JJ, Jusko WJ (eds). Kev Siv Tshuaj Pharmacokinetics: Cov Ntsiab Cai ntawm Kev Tshuaj Ntsuam Xyuas Yeeb Tshuaj. 3rd ed., Vancouver, WA: Kev Siv Tshuaj, Inc, 1992.
  106. Ding RW, Kolbe K, Merz B, li al. Pharmacokinetics ntawm nicotinic acid-salicylic acid sib cuam tshuam. Tuam Txhab Nyiaj Tuam Tsev Kho Mob 1989; 46: 642-7. Saib daws teeb meem.
  107. Lyon VB, Fairley JA. Anticonvulsant-pined pellagra. J Am Acad Dermatol 2002; 46: 597-9. Saib daws teeb meem.
  108. Kaur S, Goraya JS, Thami GP, Kanwar AJ. Pellagrous dermatitis ntxias los ntawm phenytoin (tsab ntawv). Pediatr Derm 2002; 19: 93. Saib daws teeb meem.
  109. Ntoo B, Rademaker M, Oakley A, Wallace J. Pellagra hauv tus poj niam siv cov tshuaj kho dua tshiab. Australia J Dermatol 1998; 39: 42-4. Saib daws teeb meem.
  110. Bender DA, Russell-Jones R. Isoniazid-raug ntxias pellagra txawm hais tias muaj vitamin B6 ntxiv (tsab ntawv). Lancet 1979; 2: 1125-6. Saib daws teeb meem.
  111. Stevens H, Ostlere L, Begent R, li al. Pellagra theem nrab txog 5-fluorouracil. Br J Dermatol 1993; 128: 578-80. Saib daws teeb meem.
  112. Swash M, Roberts AH. Reversible pellagra-zoo li encephalopathy nrog ethionamide thiab cycloserine. Tubercle 1972; 53: 132. Saib daws teeb meem.
  113. Brooks-Hill RW, Npis Sov ME, Vellend H. Pellagra-zoo li encephalopathy ua rau muaj kev cuam tshuam ntau yam tshuaj rau cov tshuaj tiv thaiv kab mob ntsws vim tias mob Mycobacterium avium-intracellulare (tsab ntawv). Am Rev Teb Dis 1985; 131: 476. Saib daws teeb meem.
  114. Bender DA, Earl CJ, Lees AJ. Kev noj qab haus huv Niacin hauv Parkinsonian cov neeg mob kho nrog L-dopa, benserazide thiab carbidopa. Clinical Sci 1979; 56: 89-93. Cov. Saib daws teeb meem.
  115. Ludwig GD, Dawb DC. Pellagra ntxias los ntawm 6-mercaptopurine. Clin Res 1960; 8: 212.
  116. Stratigos JD, Katsambas A. Pellagra: tseem muaj kab mob. Br J Dermatol 1977; 96: 99-106. Saib daws teeb meem.
  117. Jarrett P, Duffill M, Oakley A, Smith A. Pellagra, azathioprine thiab mob hnyuv tiv thaiv kab mob. Clin Exp Dermatol 1997; 22: 44-5. Saib daws teeb meem.
  118. Cov ntaub ntawv khoom: Niaspan. Kos Cov Tshuaj Phim. Cranbury, NJ. 2005. Muaj nyob ntawm www.niaspan.com/ koom tes pab / saib tsis taus / tswjfwm / ua qauv ntaub ntawv. (Nkag mus 3 Lub Peb Hlis 2006).
  119. Schwab RA, Bachhuber BH. Delirium thiab lactic acidosis tshwm sim los ntawm ethanol thiab niacin coingestion. Am J Emerg Med 1991; 9: 363-5. Saib daws teeb meem.
  120. Ito MK. Kev nce qib hauv kev nkag siab thiab kev tswj hwm ntawm dyslipidemia: siv cov kev kho mob niacin-based. Am J Kev Noj Qab Haus Huv-Syst Xyoo 2003; 60 (muab 2): s15-21. Saib daws teeb meem.
  121. Reaven P, Witztum JL. Lovastatin, nicotinic acid thiab rhabdomyolysis (tsab ntawv). Ann Int Med 1988; 109: 597-8. Saib daws teeb meem.
  122. Rockwell KA. Muaj peev xwm sib cuam tshuam ntawm niacin thiab transdermal nicotine (tsab ntawv). Ann Pharmacother Xyoo 1993; 27: 1283-4. Saib daws teeb meem.
  123. Gillman MA, Sandyk R. Nicotinic acid tsis txaus los ntawm sodium valproate (tsab ntawv). S Afr Med J 1984; 65: 986. Saib daws teeb meem.
  124. Papa CM. Niacinamide thiab acanthosis nigricans (tsab ntawv). Arch Dermatol 1984; 120: 1281. Saib daws teeb meem.
  125. Morris MC, Evans DA, Bianias JL, li al. Kev noj haus niacin thiab qhov xwm txheej tshwm sim Alzheimer tus kab mob thiab kev txawj ntse poob qis. J Neurol Neurosurg Kev Puas Siab Ntsws 2004; 75: 1093-99. Saib daws teeb meem.
  126. McKenney J. Cov kev xav tshiab rau kev siv niacin hauv kev kho lipid kev puas tsuaj. Arch Intern Med 2004; 164: 697-705. Saib daws teeb meem.
  127. Raising HDL thiab Niacin Siv. Tsab Ntawv / Tus Kws Kho Mob Tsab Ntawv 2004; 20: 200504.
  128. Hoskin PJ, Stratford MR, Saunders MI, li al. Kev tswj hwm ntawm nicotinamide thaum daim duab: pharmacokinetics, koob tshuaj nce ntxiv, thiab tshuaj lom neeg hauv chaw kho mob. Int J Radiat Oncol Biol Phys 1995; 32: 1111-9. Saib daws teeb meem.
  129. Miralbell R, Mornex F, Greiner R, li al. Kev siv tshuaj tua hluav taws xob sai sai, carbogen, thiab nicotinamide hauv glioblastoma multiforme: tsab ntawv ceeb toom ntawm European Lub Koom Haum rau Kev Tshawb Nrhiav thiab Kev Kho Kab Mob Cancer 22933. J Clin Oncol 1999; 17: 3143-9. Saib daws teeb meem.
  130. Anon. Niacinamide Monograph. Alt Med Rev 2002; 7: 525-9. Saib daws teeb meem.
  131. Schwartz ML. Kev rov thim rov qab hyperglycemia yog qhov muaj txiaj ntsig ntawm kev kho niacin. Arch Int Med 1993; 153: 2050-2. Saib daws teeb meem.
  132. Kahn SE, Hwj txwv JC, Schwartz MW, li al. Nce B-cell zais cia muaj peev xwm ua mechanism rau islet hloov mus rau nicotinic acid-ntxias insulin tsis kam. Mob Ntshav Qab Zib 1989; 38: 562-8. Saib daws teeb meem.
  133. Rader JI, Calvert RJ, Hathcock JN. Hepatic toxicity ntawm kev ua haujlwm tsis zoo thiab lub sij hawm tso tawm ntawm niacin. Am J Med 1992; 92: 77-81. Saib daws teeb meem.
  134. Daim duab HL, Daim Duab J, Souney PF, li al. Nicotinic acid: tshuaj xyuas nws txoj kev siv tshuaj kho rau kev mob lipid. Kws Kho Mob 1988; 8: 287-94. Saib daws teeb meem.
  135. Bays HE, Dujovne CA. Kev sib cuam tshuam yeeb tshuaj ntawm lipid-hloov cov tshuaj. Tshuaj Kev Nyab Xeeb 1998; 19: 355-71. Saib daws teeb meem.
  136. Vannucchi H, Moreno FS. Kev sib cuam tshuam ntawm niacin thiab zinc metabolism hauv cov neeg mob uas muaj cawv pellagra. Am J Clin Nutr 1989; 50: 364-9. Saib daws teeb meem.
  137. Urberg M, Zemel MB. Cov ntaub ntawv pov thawj rau synergism ntawm chromium thiab nicotinic acid nyob rau hauv kev tswj hwm kev tso kua nplaum nyob rau hauv cov neeg laus. Kev Metabolism 1987; 36: 896-9. Saib daws teeb meem.
  138. Cheung MC, Zhao XQ, Tsab A, li al. Cov tshuaj pab tiv thaiv kab mob pab tiv thaiv kev teb ntawm HDL rau kev simvastatin-niacin kev kho mob hauv cov neeg mob uas muaj mob rau cov hlab ntshav liab thiab HDL tsawg. Arterioscler Thromb Vasc Biol 2001; 21: 1320-6. Saib daws teeb meem.
  139. Chesney CM, Elam MB, Herd JA, li al. Cov nyhuv ntawm niacin, warfarin, thiab tshuaj tua kab mob antioxidant rau kev coagulation tsis raug rau cov neeg mob uas muaj kabmob txha caj qaum nyob rau hauv Arterial Disease Ntau Cov Kev Pabcuam Sib Tw (ADMIT). Am Lub Siab J 2000; 140: 631-6 .. Saib kom paub daws teeb.
  140. Wink J, Giacoppe G, Vaj Ntxwv J. Ntxim li cov tshuaj naicin tsawg kawg ntawm kev noj cov lipoprotein ntau hauv cov neeg mob niaj hnub siv cov tshuaj statin ntev ntev. Am Lub Ncauj J 2002; 143: 514-8 .. Saib kev paub daws teeb.
  141. Wolfe ML, Vartanian SF, Ross JL, li al. Kev Nyab Xeeb thiab kev ua haujlwm ntawm Niaspan thaum ntxiv rau qhov xwm txheej kom zoo rau kev kho mob ntawm dyslipidemia. Am J Cardiol 2001; 87: 476-9, A7 .. Saib cov duab abstract.
  142. Xim av BG, Zhao XQ, Chait A, li al. Simvastatin thiab niacin, antioxidant vitamins, los yog kev sib txuam rau kev tiv thaiv kab mob rau cov hlab ntshav. N Engl J Med 2001; 345: 1583-93. Saib daws teeb meem.
  143. Cumming RG, Mitchell P, Smith W. Kev Noj Haus thiab Kab Ntsig Zoo: Xiav Toj Roob Hauv Qhov Muag Pom. Ophthalmology 2000; 10: 450-6. Saib daws teeb meem.
  144. Kuroki F, Iida M, Tominaga M, li al. Ntau hom kab mob vitamin hauv Crohn's kab mob. Sib txheeb nrog cov haujlwm kev kis kab mob. Khawb Dis Disi Xyoo 1993; 38: 1614-8. Saib daws teeb meem.
  145. Pawg Tswj Xyuas Khoom Noj thiab Khoom Noj, Lub Chaw Tshuaj. Kev Noj Qab Haus Huv Cov Khoom Noj rau Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, thiab Choline. Washington, DC: National Academy Xovxwm, 2000. Muaj nyob ntawm: http://books.nap.edu/books/0309065542/html/.
  146. Miskas koom Kev Noj Haus Lub Vev Xaib. Muaj nyob ntawm: www.eatright.org/adap1097.html (Mus Saib 16 Lub Xya Hli 1999).
  147. Lal SM, Hewett JE, Petroski GF, li al. Qhov cuam tshuam ntawm nicotinic acid thiab lovastatin hauv cov neeg mob raum hloov pauv: muaj kev cia siab, muaj kev sib tw, qhib cov ntawv cim sau hla. Am J Lub Raum Dis 1995; 25: 616-22. Saib daws teeb meem.
  148. Guyton JR, Goldberg AC, Kreisberg RA, li al. Kev ua tau zoo ntawm kev noj ib zaug ib hmos ntawm ncua kev tso tawm niacin ib leeg thiab ua ke rau hypercholesterolemia. Am J Cardiol 1998; 82: 737-43. Saib daws teeb meem.
  149. Vega GL, Grundy SM. Lipoprotein cov lus teb rau kev kho mob nrog lovastatin, gemfibrozil, thiab nicotinic acid hauv cov neeg mob hypolalidemic uas muaj hypoalphalipoproteinemia. Arch Intern Med 1994; 154: 73-82. Saib daws teeb meem.
  150. Vacek JL, Dittmeier G, Chiarelli T, li al. Kev sib piv ntawm lovastatin (20 mg) thiab nicotinic acid (1.2 g) nrog ib qho tshuaj ib leeg rau hom II hyperlipoproteinemia. Am J Cardiol 1995; 76: 182-4. Saib daws teeb meem.
  151. Illingworth DR, Stein EA, Mitchel YB, li al. Sib piv cov teebmeem ntawm lovastatin thiab niacin hauv thawj hypercholesterolemia. Ib qho kev txiav txim siab yav tom ntej. Arch Intern Med 1994; 154: 1586-95. Saib daws teeb meem.
  152. Pozzilli P, Browne PD, Kolb H. Meta-tsom xam ntawm kev kho mob nicotinamide hauv cov neeg mob nrog IDDM tsis ntev los no. Cov Neeg Txiav Txim Siab Nicotinamide. Mob Ntshav Qab Zib 1996; 19: 1357-63. Saib daws teeb meem.
  153. Johansson JO, Egberg N, Asplund-Carlson A, Carlson LA. Kev kho mob Nicotinic acid hloov cov tshuaj fibrinolytic kom zoo thiab txo cov ntshav fibrinogen hauv cov txiv neej hypertriglyceridaemic. J Cardiovasc Kev Raug Mob 1997; 4: 165-71. Saib daws teeb meem.
  154. Rabbani GH, Butler T, Bardhan PK, Islam A. Txo cov kua-poob ua kom mob raws plab los ntawm nicotinic acid: kev sim mus los. Phau Ntawv Teev Npe 1983; 2: 1439-42. Saib daws teeb meem.
  155. Kev Qhia Txog Cholesterol Tuaj Rau Hauv Tebchaws. Cov Roj (Cholesterol) Txo hauv Tus Neeg Mob Ntau Tshaj Plaws Lub Plawv. 1997. Muaj nyob ntawm: http://www.vidyya.com/pdfs/1225cholesterol.pdf. (Mus saib tau 26 May 2016).
  156. Darvay A, Basarab T, McGregor JM, Russell-Jones R. Isoniazid tau ntxias pellagra txawm hais tias pyridoxine ntxiv. Clin Exp Dermatol Xyoo 1999; 24: 167-9. Saib daws teeb meem.
  157. Ishii N, Nishihara Y. Pellagra encephalopathy ntawm cov neeg mob tuberculous: nws muaj feem xyuam rau isoniazid txoj kev kho. J Neurol Neurosurg Kev Puas Siab Ntsws 1985; 48: 628-34. Saib daws teeb meem.
  158. Miskas Lub Koom Haum ntawm Cov Tshuaj Noj Qab Haus Huv-System Tshuaj. ASHP Cov Lus Qhia Txog Kev Kho Mob nyob rau kev siv nyab xeeb ntawm niacin hauv kev tswj hwm ntawm dyslipidemias. Am J Kev Noj Qab Haus Huv Syst Pharm 1997; 54: 2815-9. Saib daws teeb meem.
  159. Leighton RF, Gordon NF, Me GS, li al. Hniav thiab gingival mob raws li kev phiv los ntawm kev kho niacin. Chest 1998; 114: 1472-4. Saib daws teeb meem.
  160. Garg A, Grundy SM. Nicotinic acid ua kev kho mob rau dyslipidemia nyob rau hauv cov ntshav qab zib tsis muaj tshuaj tiv thaiv kev mob ntshav qab zib mellitus. JAMA 1990; 264: 723-6. Saib daws teeb meem.
  161. Qhwv JR III. Kev tsim kho tshiab hauv kev siv cov niacin rau kev kho mob hyperlipidemia: qhov kev xav tshiab hauv kev siv ib qho tshuaj qub. Coron Artery Dis 1996; 7: 321-6. Saib daws teeb meem.
  162. Pob Tsuas RH. Soj ntsuam cov ntaub ntawv ntawm tiaj tiv tiag tiv thaiv-tso tawm niacin (Niaspan) thiab lub cev kev paub txog kev txhaj tshuaj rau yav hmo ntuj. Am J Cardiol 1998; 82: 24U-28U; sib tham 39U-41U. Saib daws teeb meem.
  163. Knopp RH, Alagona P, Davidson M, li al. Sib txig sib luag ntawm lub sijhawm tso tawm ntawm niacin (Niaspan) muab ib zaug-ib-hmo ntuj piv rau cov niacin dawb hauv kev tswj hwm hyperlipidemia. Kev Metabolism 1998; 47: 1097-104. Saib daws teeb meem.
  164. McKenney JM, Kws Ua Yeeb Yam JD, Harris S, Chinchili VM. Kev sib piv ntawm kev ua tau zoo thiab muaj tshuaj lom cuam tshuam los ntawm kev pab cuam-vs tam sim ntawd-tso tawm niacin hauv cov neeg mob hypercholesterolemic. JAMA 1994; 271: 672-7. Saib daws teeb meem.
  165. Grey DR, Morgan T, Chretien SD, Kashyap ML. Kev ua tau zoo thiab kev nyab xeeb ntawm kev tswj hwm-tso tawm niacin hauv dyslipoproteinemic cov qub tub rog. Ann Intern Med 1994; 121: 252-8. Saib daws teeb meem.
  166. Capuzzi DM, Guyton JR, Morgan JM, li al. Kev ua tau zoo thiab kev nyab xeeb ntawm kev tso tawm ntev niacin (Niaspan): kev tshawb xyuas mus ntev. Am J Cardiol 1998; 82: 74-81; disc. 85U-6U. Saib daws teeb meem.
  167. Jungnickel PW, Maloley PA, Vander Tuin EL, li al. Cov txiaj ntsig ntawm ob qho tshuaj aspirin pretreatment regimens on niacin hob cutaneous tshua. J Gen Intern Med 1997; 12: 591-6. Saib daws teeb meem.
  168. Whelan AM, Nqe SO, Fowler SF, Hainer BL. Cov nyhuv ntawm cov tshuaj aspirin nyob rau niacin-raug txiav cutaneous kev txiav txim siab. J Fam Pract 1992; 34: 165-8. Saib daws teeb meem.
  169. Gibbons LW, Gonzalez V, Gordon N, Grundy S. Qhov tshwm sim ntawm cov kev mob tshwm sim nrog kev tsis tu ncua thiab muaj kev tiv thaiv kev tso tawm nicotinic acid. Am J Med 1995; 99: 378-85. Saib daws teeb meem.
  170. Chaw Ua Si YK, Sempos CT, Barton CN, li al. Kev ua haujlwm ntawm kev ua noj ua haus hauv Tebchaws Meskas: rooj plaub ntawm pellagra. Am J Kev Noj Qab Haus Huv Xyoo 2000; 90: 727-38. Saib daws teeb meem.
  171. Zhao XQ, Xim av BG, Hillger L, li al. Qhov cuam tshuam ntawm kev kho mob lipid-txo qis rau kev kho cov ntshav ntawm cov leeg asymptomatic nrog kev nce siab apolipoprotein B. Kev Ua Haujlwm 1993; 88: 2744-53. Saib daws teeb meem.
  172. Canner PL, Berge KG, Wenger NK, li al. Kaum tsib xyoo kev tuag nyob hauv Cov Neeg Mob Tshuaj Coronary Project: cov txiaj ntsig mus sij hawm ntev nrog niacin. J Am Coll Cardiol 1986; 8: 1245-55. Saib daws teeb meem.
  173. Guyton JR, Blazing MA, Hagar J, li al. Ntev-tso tawm niacin vs gemfibrozil rau kev kho mob ntawm theem qis ntawm high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Kawm Pab Pawg. Arch Intern Med 2000; 160: 1177-84. Saib daws teeb meem.
  174. Zema MJ. Gemfibrozil, nicotinic acid thiab kev sib txuas ua ke hauv kev kho mob hauv cov neeg mob uas raug rho tawm hypoalphalipoproteinemia: ib qho randomized, qhib-daim ntawv lo, kawm hla kev kawm. J Am Coll Cardiol 2000; 35: 640-6. Saib daws teeb meem.
  175. Knodel LC, Talbert RL. Cov tshuaj tiv thaiv tsis zoo ntawm cov tshuaj hypolipidaemic. Med Toxicol 1987; 2: 10-32. Saib daws teeb meem.
  176. Yates AA, Schlicker SA, Suitor CW. Cov lus qhia txog kev noj zaub mov noj: yog lub hauv paus tshiab rau cov lus pom zoo rau calcium thiab cov as-ham zoo, B vitamins, thiab choline. J Am Noj Assoc 1998; 98: 699-706. Saib daws teeb meem.
  177. Shils ME, Olson JA, Shike M, Ross AC, eds. Niaj hnub nimno Noj Qab Haus Huv hauv Kev Noj Qab Haus Huv thiab Kab Mob. 9le ed. Baltimore, MD: Williams & Wilkins, 1999.
  178. Reimund E. Pw tsaug zog tsis txaus tsim cov tawv nqaij: ntxiv kev txhawb nqa ntawm nicotinic acid depletion hauv kev pw tsaug zog. Med Hypotheses 1991; 36: 371-3. Saib daws teeb meem.
  179. Ioannides-Demos LL, Christophidis N, li al. Kev noj tshuaj muaj feem cuam tshuam nrog kev soj ntsuam mob cuam tshuam los ntawm kev ua kua txiv kab ntxwv qaub thiab cyclosporine thiab cov tshuaj metabolite ntau nyob hauv cov neeg mob autoimmune. J Rheumatol 1997; 24: 49-54. Saib daws teeb meem.
  180. Hardman JG, Limbird LL, Molinoff PB, eds. Tus Neeg Zoo thiab Gillman's Qhov Chaw Muag Tshuaj Kho Mob, 9 ed. New York, NY: McGraw-Toj, 1996.
  181. Garg R, Malinow MR, Pettinger M, li al. Kev kho mob Niacin nce qib ntshav homocysteine ​​ntau ntau. Am Lub Siab J 1999; 138: 1082-7. Saib daws teeb meem.
  182. Gruenwald J, Brendler T, Jaenicke C. Tebchaws rau Tshuaj ntsuab Tshuaj ntsuab 1lub ed. Montvale, NJ: Kev Lag Luam Kho Mob Lag Luam, Inc., 1998.
  183. McEvoy GK, ed. AHFS Ntaub Ntawv Yeeb Tshuaj. Bethesda, MD: Asmeskas Cov Koom Haum ntawm Kev Noj Qab Haus Huv Kev Noj Qab Haus Huv-System Pharmacists, 1998.
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