Mob ntsws mob myelogenous ntev (CML)

Mob myelogenous mob ntshav dawb (CML) yog mob qog nqaij hlav uas pib hlav hlwb pob txha. Nov yog cov nqaij mos hauv nruab nrab ntawm cov pob txha uas pab tsim txhua cov qe ntshav.

CML ua rau muaj kev loj hlob tsis paub tswj ntawm lub hlwb tsis paub qab hau thiab hlob uas ua rau qee hom qe ntshav dawb hu ua myeloid cells. Cov kabmob muaj kabmob ua rau cov hlwb pob txha thiab cov ntshav.

Qhov ua rau CML muaj feem xyuam rau chromosome txawv txav hu ua Philadelphia chromosome.

Kev raug hluav taws xob yuav ua rau muaj kev pheej hmoo ntawm kev tsim CML. Kev siv hluav taws xob hluav taws xob tuaj yeem yog los ntawm kev siv hluav taws xob siv yav dhau los los kho tus mob qog nqaij hlav cancer lossis Hodgkin lymphoma lossis los ntawm kev tsim kev puas tsuaj nuclear.

Nws siv ntau xyoo los tsim kev mob qog ntshav los ntawm kev raug hluav taws xob. Feem ntau cov neeg kho mob qog noj cancer nrog hluav taws xob tsis ua mob leukemia. Thiab feem ntau cov neeg nrog CML tsis tau raug hluav taws xob.

CML ntau zaus tshwm sim rau cov neeg laus hnub nyoog thiab cov menyuam yaus.

Ntev ntshav mob myelogenous tau muab sau ua tej qib:

• Mob sib kho
• Ua nrawm
• Moj tej tawg ntsoog

Qeb mob tau ntev rau lub hlis lossis xyoo. Tus kabmob yuav muaj ob peb lossis tsis muaj tsos mob rau lub sijhawm no. Feem ntau ntawm cov neeg tau kuaj pom nyob rau theem no, thaum lawv tau kuaj ntshav rau lwm yam.

Qeb nrawm nrawm yog qib siab dua. Ntshav cov qe ntshav tau loj hlob sai dua. Cov tsos mob tshwm sim suav nrog ua npaws (txawm tias tsis muaj mob), mob pob txha, thiab hnoos qeev.

Kev tsis kho CML ua rau cov theem daws teebmeem. Los ntshav thiab kis tau tus mob tshwm sim vim pob txha tsis ua haujlwm.

Lwm cov tsos mob tshwm sim ntawm kev tawg tsoo muaj xws li:

• Nqaij ntuag
• Tawm hws ntau heev (tsaus ntuj tawm hws)
• Nkees
• Ua npaws
• Siab hauv qab nqaj sab sauv los ntawm tus txha caj ntshav o
• Pob xoo - ua cim me me ua pob liab liab ntawm daim tawv nqaij (petechiae)
• Neeg tsis muaj zog

Kev kuaj lub cev ib ce feem ntau qhia tias qhov o o tuaj. Ib qho kev ua tiav ntawm cov ntshav (CBC) qhia tias muaj cov qe ntshav dawb muaj ntau ntxiv uas tsis paub ntau lub sijhawm tam sim no thiab nce cov platelets. Cov no yog ib feem ntawm cov ntshav uas pab cov ntshav txhaws.

Lwm yam kev xeem uas yuav muaj xws li:

• Nqaij pob txha caj dab
• Kev kuaj ntshav thiab cov pob txha txha rau kev muaj cov Philadelphia chromosome
• Platelet suav

Cov tshuaj uas tsom rau cov protein tsis zoo uas tau tsim los ntawm Philadelphia chromosome feem ntau yog qhov kev kho mob thawj zaug rau CML. Cov tshuaj no tuaj yeem siv los ua tshuaj. Cov neeg tau kho cov tshuaj no feem ntau mus rau hauv kev daws sai sai thiab tuaj yeem nyob hauv kev so ntau xyoo.

Qee zaum, kev siv tshuaj kho mob yuav siv thawj zaug los txo cov qe ntshav dawb yog tias nws muaj ntau heev thaum kuaj pom.

Qhov kev tawg pob tawg theem yog qhov nyuaj rau kev kho tau. Qhov no yog vim muaj qhov ntau kawg ntawm cov ntshav dawb tsis paub qab hau (kab mob hlwb leukemia) uas tiv taus kev kho mob.

Tsuas paub kho tus mob CML yog hloov hlwb pob txha, lossis qog hloov ntshav ntawm pob txha. Cov neeg feem coob, txawm li cas los xij, tsis tas yuav hloov ntshav vim hais tias cov tshuaj tiv thaiv muaj kev vam meej. Sib tham txog koj cov kev xaiv nrog koj tus kws kho mob.

Koj thiab koj tus kws kho mob yuav xav tswj ntau lwm yam teeb meem lossis kev txhawj xeeb thaum koj mus kho mob ntshav siab, nrog rau:

• Tswj koj cov tsiaj kom nruj thaum siv tshuaj
• Los ntshav teeb meem
• Noj zaub mov kom txaus thaum koj muaj mob
• Kev o thiab kev mob hauv koj lub qhov ncauj
• Muaj kev nyab xeeb noj thaum kho mob cancer

Koj tuaj yeem daws kev ntxhov siab ntawm kev muaj mob los ntawm kev koom nrog pawg pab txhawb mob qog noj ntshav. Faib qhia rau lwm tus uas muaj kev paub thiab teeb meem ntau yam tuaj yeem pab koj tsis txhob xav tias yog ib leeg.

Cov tshuaj tseem ceeb tau txhim kho kev pom zoo rau cov neeg uas muaj CML. Thaum cov tsos mob thiab cov tsos mob ntawm CML ploj mus thiab kev suav cov ntshav thiab cov pob txha mob ntawm cev nqaij hlav zoo li qub, tus neeg yuav tau txiav txim siab rau hauv kev zam txim. Cov neeg feem coob tseem tuaj yeem nyob hauv kev zam nyob ntau xyoo thaum siv cov tshuaj no.

Lub cev qog lossis pob txha hloov hlwb feem ntau yog xam rau cov neeg uas muaj kab mob rov qab los yog mob heev dua thaum noj thawj cov tshuaj. Kuj yuav pom zoo kom muaj kev hloov mus rau cov neeg uas tau kuaj pom sai sai los yog tawg kev tawg.

Kev puas ntsoog ntawm pob zeb tuaj yeem ua rau muaj teeb meem, nrog rau kev kis mob, los ntshav, qaug zog, ua npaws tsis paub, thiab muaj teeb meem lub raum. Kev siv tshuaj kho mob tuaj yeem muaj qhov mob tshwm sim loj heev, nyob ntawm cov tshuaj siv.

Tsis txhob raug hluav taws xob thaum muaj peev xwm.

CML; Ntev ntshav mob myeloid; CGL; Mob ntsws (granulocytic) mob daj ntseg ntev; Mob ntshav roj - mob ntev granulocytic

• Hloov cev pob txha - hloov ntshav tawm

• Mob hlwb pob txha tsis muaj kev cia siab
• Mob myelocytic mob ntshav qab zib ntev - kuaj me me
• Ntev ntshav mob myelocytic
• Ntev ntshav mob myelocytic

Kantarjian H, Cortes J. Ntev mob ntshav txha caj qaum. Hauv: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical OncologyCov. 6 tus ed. Philadelphia, PA: Elsevier; 2020: cha 98.

Lub koom haum Cancer National website. Cov mob ntshav qab zib myelogenous kho mob (PDQ) muaj txuj ci kho mob. www.cancer.gov/types/leukemia/hp/cml-nyuj-pdq. Hloov kho Lub Ob Hlis 8, 2019. Nkag mus rau Lub Peb Hlis 20, 2020.

Lub Tebchaws National Comprehensive Cancer Network lub vev xaib. NCCN kev soj ntsuam kev coj ua hauv oncology: (NCCN cov txheej txheem) .Cov tshuaj tiv thaiv myeloid cov ntshav muaj kab mob. Daim Ntawv 3.2020. www.nccn.org/professionals/physician_gls/pdf/cml.pdf. Hloov kho Lub Ib Hlis 30, 2020. Nkag mus rau Lub Peb Hlis 23, 2020.

Radich J. Ntev mob ntshav txha caj qaum ntev ntev. Hauv: Goldman L, Schafer AI, eds. Goldman-Cecil TshuajCov. 26th ed. Philadelphia, PA: Elsevier; 2020: cha 175.