Pancreatic islet cell qog

Tus mob qog nqaij hlav tawv (pancreatic islet cell tumor) yog qog qog ntshav uas pom tshwm sim los ntawm ib hom cell hu ua islet cell.

Hauv cov ntoo ua kom muaj kev noj qab haus huv, lub hlwb hu ua islet cell tsim cov tshuaj hormones uas tswj ntau lub cev ua haujlwm. Cov no suav nrog qib ntshav qab zib cov ntshav thiab ua kom muaj cov kua qaub.

Cov qog uas tshwm sim los ntawm cov islet hlwb ntawm lub txiav yuav ua tau ntau yam tshuaj hormones, uas tuaj yeem ua rau muaj cov tsos mob tshwj xeeb.

Lub qog nqaij hlav hauv Pancreatic islet tuaj yeem ua kom mob tsis yooj yim (benign) lossis mob qog nqaij hlav (malignant).

Islet hlav hlav xws li:

• Gastrinoma (Zollinger-Ellison syndrome)
• Glucagonoma
• Tshuaj insulinoma
• Somatostatinoma
  
• VIPoma (Verner-Morrison syndrome)

Tsev neeg keeb kwm ntawm ntau tus kab mob endocrine neoplasia, hom I (MEN I) yog qhov muaj kev pheej hmoo rau kev txhim kho islet cell hlav.

Cov tsos mob nyob ntawm seb yam tshuaj twg yog tsim los ntawm cov qog noj.

Piv txwv, insulinomas tsim cov tshuaj insulin, uas ua rau cov ntshav qab zib kom qis. Cov tsos mob tuaj yeem suav nrog:

• Xis nkees los sis tsis muaj zog
• Tuav los yog tawm hws
• Mob taub hau
• Kev tshaib plab
• Tsom muag, ntxhov siab, lossis xav txob taws
• Tsis paub xav lossis hnov ​​tsis meej
• Pom ob lossis dig muag
• Lub plawv dhia ceev lossis dhia ceev

Yog tias koj cov piam thaj hauv ntshav qis dhau lawm, koj yuav tsaus muag, qaug dab peg, lossis tseem poob mus rau hauv txoj kev tsis nco qab lawm.

Gastrinomas ua rau lub plab gastrin, uas qhia lub cev ua kom lub plab ua haujlwm. Cov tsos mob tuaj yeem suav nrog:

• Mob plab
• Zawv plab
• Cov nqaij mob hauv plab thiab plab hnyuv me
• Ntuav ntshav (qee zaus)

Glucagonomas ua rau lub cev glucagon, uas pab lub cev nce cov ntshav qab zib. Cov tsos mob tuaj yeem suav nrog:

• Mob ntshav qab zib
• Liab, tawm pob liab vog hauv puab tais lossis pob tw
• Lub cev yuag
• Nquag tso zis thiab nqhis dej

Somatostatinomas ua rau cov tshuaj somatostatin. Cov tsos mob tuaj yeem suav nrog:

• Ntshav qab zib siab
• Gallstones
• Cov tsos daj ua kom tawv nqaij, thiab qhov muag
• Lub cev yuag
• Mob plab zawv nrog quav ua pa tsw phem

VIPomas ua rau lub cev vasoactive plab hnyuv peptide (VIP) uas koom nrog tswj kev tshuav nyiaj ntsev, sodium, potassium thiab lwm yam minerals nyob rau hauv GI huam. VIPomas yuav ua rau:

• Kev mob raws plab uas tuaj yeem ua kom lub cev qhuav dej
• Cov ntshav poov tshuaj tsis muaj ntshav ntau ntau, thiab cov ntshav calcium ntau ntau
• Mob plab zom mov
• Lub cev yuag

Koj tus kws kho mob yuav siv koj li keeb kwm kho mob thiab kuaj ib ce.

Kuaj ntshav yuav txawv, nyob ntawm cov tsos mob, tab sis yuav muaj:

• Kev yoo mov qib qabzib
• Gastrin qib
• Kuaj ntshav qab zib kuaj
• Kev kuaj xyuas zais cia zais cia rau cov kab mob ua paug
• Qib ntshav qib glucagon
• Ntshav insulin C-peptide
• Ntshav cov ntshav insulin theem
• Kev yoo mov cov ntshiab somatostatin qib
• Ntshav vasoactive plab hnyuv peptide (VIP) qib

Kev ntsuas cov duab yuav tau:

• Mob plab hauv TV
• Mob plab hauv ultrasound
• Endoscopic ultrasound
• MRI ntawm lub plab mog

Kev kuaj ntshav kuj tseem tuaj yeem nqa los ntawm txoj hlab ntshav hauv cov leeg ntshav coj los kuaj.

Qee zaum, yuav tsum muaj kev phais mob txhawm rau kuaj thiab kho tus mob no. Thaum txoj kev ua no, tus kws phais mob kuaj cov txiav txiav los ntawm txhais tes thiab nrog ultrasound.

Txoj kev kho yog nyob ntawm hom mob qog thiab yog tias nws mob qog.

Mob qog yuav hlav loj sai thiab kis mus rau lwm yam kabmob. Lawv yuav tsis tuaj yeem kho tus mob. Cov nqaij hlav feem ntau raug tshem tawm nrog kev phais mob, yog tias ua tau.

Yog tias cov qog nqaij hlav cancer kis mus rau lub siab, ib feem ntawm daim siab kuj tuaj yeem rho tawm, yog ua tau. Yog tias mob qog nthuav dav, kev kho tshuaj yuav siv tau los sim thiab ua kom cov qog.

Yog tias cov tshuaj hormones tsis zoo txaus ua rau cov tsos mob, koj yuav tau txais tshuaj los kho nws cov teebmeem. Piv txwv, nrog gastrinomas, kev ua haujlwm ntau dhau ntawm gastrin ua rau cov kua qaub ntau dhau hauv lub plab. Cov tshuaj uas thaiv lub plab cov kua qaub tawm tuaj yeem txo cov tsos mob.

Koj tuaj yeem daws kev ntxhov siab ntawm kev muaj mob los ntawm kev koom nrog pawg pab txhawb mob qog noj ntshav. Faib qhia rau lwm tus uas muaj kev paub thiab teeb meem ntau yam tuaj yeem pab koj tsis txhob xav tias yog ib leeg.

Koj tuaj yeem yuav kho tau yog tias cov qog tshem tawm phais ua ntej lawv kis mus rau lwm yam kabmob. Yog tias cov qog mob cancer, kev siv tshuaj kho mob, tab sis feem ntau nws kho tsis tau tib neeg.

Teeb meem kev phom sij txog lub neej (xws li cov piam thaj hauv ntshav qis heev) tuaj yeem tshwm sim vim dhau lawm ntau lawm cov khoom lag luam, lossis yog tias mob cancer kis thoob plaws lub cev.

Lwm yam mob hauv cov qog suav nrog:

• Mob ntshav qab zib
• Cov qog ntshav (yog tias cov qog tawm qee cov tshuaj hormones)
• Mob ntshav qab zib tsawg heev (los ntawm insulinomas)
• Kev mob rau hauv lub plab thiab cov hnyuv me me (los ntawm gastrinomas)
• Kev xa tawm ntawm cov qog mus rau nplooj siab

Hu rau koj tus kws kho mob yog tias koj muaj cov tsos mob ntawm cov qog, tshwj xeeb yog tias koj muaj keeb kwm tsev neeg ntawm MEN Kuv.

Kuj tsis paub kom tiv thaiv tau cov qog no.

Kab Mob Cancer - txiav; Kab Mob Cancer - pancreatic; Pancreatic mob cancer; Cov hlav hlav Islet; Islet of Langerhans hlav; Cov hlav hlav neuroendocrine; Mob rwj - islet cell qog; Kev mob hypoglycemia - islet cell qog; Zollinger-Ellison syndrome; Verner-Morrison syndrome; Gastrinoma; Insulinoma; VIPoma; Somatostatinoma; Glucagonoma

• Cov qog endocrine
• Qos Yis

Foster DS, Norton JA. Kev tswj ntawm pancreatic islet cell hlav tawm tsis suav nrog gastrinoma. Hauv: Cameron AM, Cameron JL, eds. Kev Kho Mob Tam Sim NoCov. 13th ed. Philadelphia, PA: Elsevier; 2020: 581-584.

Lub koom haum Cancer National website. Kev kho mob qog noj ntshav (PDQ) - kev noj qab haus huv cov qauv. www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq. Hloov kho Lub Ib Hlis 2, 2020. Nkag mus siv Lub Ob Hlis 25, 2020.

Lub Tebchaws National Comprehensive Cancer Network lub vev xaib. NCCN kev soj ntsuam kev coj ua hauv oncology (Cov txheej txheem NCCN). Neuroendocrine thiab cov qog adrenal. Version 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. Hloov kho Lub Peb Hlis 5, 2019. Nkag mus rau Lub Ob Hlis 25, 2020.

Lub Tebchaws National Comprehensive Cancer Network lub vev xaib. NCCN cov lus qhia rau cov neeg mob. Cov hlav hlav neuroendocrine. 2018. www.nccn.org/patients/guidelines/content/PDF/neuroendocrine-patient.pdf.