Klinefelter syndrome

Klinefelter syndrome yog qhov muaj raws caj ces uas tshwm sim hauv cov txivneej thaum lawv muaj tus xoo hluav taws xob ntxiv.

Cov neeg feem coob muaj 46 chromosomes. Cov chromosomes muaj tag nrho koj cov caj ces thiab DNA, cov tsev lag luam ntawm lub cev. Tus 2 tus txiv neej poj niam (X thiab Y) txiav txim siab yog tias koj los ua tus tub lossis ib tus ntxhais. Cov ntxhais feem ntau muaj 2 lub chromosomes. Cov tub hluas ib txwm muaj 1 X thiab 1 Y chromosome.

Klinefelter syndrome tshwm sim thaum tus tub yug los nrog tsawg kawg 1 ntawm cov xoos xoo hluav taws xob. Qhov no yog sau ua XXY.

Klinefelter syndrome tshwm sim hauv kwv yees li ib ntawm 500 rau 1,000 tus menyuam tub. Cov poj niam cev xeeb tub tom qab hnub nyoog 35 yog me ntsis tus tub hluas nrog tus mob no ntau dua li cov poj niam yau.

Ntxiv lawm tshob yog cov tsos mob feem ntau ntawm Klinefelter syndrome.

Cov tsos mob tuaj yeem suav nrog ib qho hauv qab no:

• Kev txawv txav ntawm lub cev (cov ceg ntev, lub cev luv, lub xub pwg sib npaug ntawm lub duav loj)
• Mis loj hauv lub mis (gynecomastia)
• Ntxiv lawm tshob
• Teeb meem kev sib deev
• Tsawg dua cov nyiaj pub dawb, cov qhov tso rau hauv, thiab ntsej muag
• Me me, cov noob qes ua noob
• Siab siab
• Me noov loj
  
  

Klinefelter syndrome yuav xub nrhiav tus txiv neej thaum tus txiv neej mus rau kws kho mob vim tias muaj menyuam. Cov kev xeem hauv qab no tuaj yeem ua:

• Karyotyping (khij cov chromosomes)
• Kua phev suav

Kev kuaj ntshav yuav ua kom tiav cov qib theem hauv hom hormone, suav nrog:

• Estradiol, ib hom tshuaj estrogen
• Follicle stimulating hormone
• Luteinizing cov tshuaj hormones
• Testosterone

Tej zaum yuav siv tshuaj testosterone. Qhov no tuaj yeem pab tau:

• Loj hlob lub cev plaub hau
• Txhim kho qhov zoo ntawm cov leeg
• Txhim kho kev kub siab
• Txhim kho kev xav thiab tus kheej
• Ua kom muaj zog ntau dua thiab ua kom muaj kev sib deev
• Ntxiv dag zog

Feem coob ntawm cov txiv neej uas muaj tus mob no yuav ua tsis taus poj niam lub cev. Tus kws kho mob ntxiv lawm tshob tuaj yeem pab tau. Mus ntsib tus kws kho mob hu ua endocrinologist kuj tseem pab tau thiab.

Cov peev txheej no tuaj yeem muab cov ntaub ntawv qhia ntxiv ntawm Klinefelter syndrome:

• Koom Haum Rau X thiab Y Chromosome Cov Kev Hloov - genetic.org
• Teb Chaws Chaw Tshuaj ntawm Tshuaj, Tshuaj Txhim Tsev Hauv Tsev - medlineplus.gov/klinefelterssyndrome.html

Nus hniav nrog ib txheej nto yog tshwm sim heev hauv Klinefelter syndrome. Qhov no yog hu ua taurodontism. Qhov no tuaj yeem pom ntawm xoo hluav taws xob.

Klinefelter syndrome kuj ua rau muaj kev pheej hmoo:

• Mloog tsis txaus hyperactivity tsis meej (ADHD)
• Cov kab mob autoimmune, xws li mob lupus, mob caj dab, thiab Sjögren syndrome
• Tus mob cancer mis rau tus txiv neej
• Kev Nyuaj Siab
• Kev kawm tsis taus, suav nrog dyslexia, uas cuam tshuam rau kev nyeem ntawv
• Muaj tsawg hom mob qog hu ua extragonadal cell cell hlav
• Mob ntsws
• Kab mob hauv
• Varicose leeg

Hu rau koj tus kws khomob yog tias koj tus tub tsis tau coj tus cwjpwm sib deev thaum tseem tiav nkauj tiav nraug. Qhov no suav nrog kev loj hlob ntawm lub ntsej muag plaub hau thiab lub suab sib sib zog nqus.

Tus kws pab tswv yim txog noob caj noob ces tuaj yeem muab cov ntaub ntawv hais txog tus mob no thiab qhia koj kom pab pawg nyob hauv koj thaj chaw.

47 X-X-Y mob; XXY mob ntsws; XXY trisomy; 47, XXY / 46, XY; Mos syndrome; Poly-X Klinefelter syndrome

Allan CA, McLachlan RI. Androgen tsis muaj qhov tsis txaus. Hauv: Jameson JL, De Groot LJ, de Kretser DM, li al, eds. Endocrinology: Cov Neeg Loj thiab Pediatric. 7 tus ed. Philadelphia, PA: Elsevier Saunders; 2016: cha 139.

Matsumoto AM, Anawalt BD, Kev tsis ncaj ncees rau lub cev. Hauv: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Phau Ntawv ntawm Endocrinology. Xab 14th. Philadelphia, PA: Elsevier; 2020: chap 19.

Nussbaum RL, McInnes RR, Willard HF. Lub chromosomal thiab genomic hauv paus ntawm tus kab mob: muaj kev cuam tshuam ntawm cov autosomes thiab poj niam txiv neej chromosomes. Hauv: Nussbaum RL, McInnes RR, Willard HF, eds. Thompson & Thompson Genetics hauv Tshuaj. 8 tus ed. Philadelphia, PA: Elsevier; 2016: chap 6.