Tus Sau: Gregory Harris
Hnub Kev Tsim: 10 Lub Plaub Hlis Ntuj 2021
Hloov Hnub: 20 Lub Kaum Ib Hli Ntuj 2024
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Alpha-1 antitrypsin tsis muaj peev xwm - Tshuaj Kho Mob
Alpha-1 antitrypsin tsis muaj peev xwm - Tshuaj Kho Mob

Alpha-1 antitrypsin (AAT) qhov tsis txaus yog ib qho mob uas lub cev ua tsis tau txaus ntawm AAT, yog ib qho protein uas tiv thaiv lub ntsws thiab daim siab los ntawm kev puas tsuaj. Tus mob tuaj yeem ua rau mob COPD thiab kab mob siab (mob ntsws).

AAT yog ib hom protein uas hu ua protease inhibitor. AAT tsim nyob rau hauv daim siab thiab nws ua haujlwm tiv thaiv lub ntsws thiab lub siab.

AAT deficiency txhais tau tias tsis muaj cov protein txaus hauv lub cev. Nws tshwm sim los ntawm kev tshuaj ntsuam caj ces. Tus mob yog feem ntau muaj rau cov neeg Europe thiab North Asmeskas ntawm haiv neeg European.

Cov neeg laus uas muaj mob tsis txaus ntawm AAT yuav ua mob emphysema, qee zaum ua ntej 40 xyoo. Kev haus luam yeeb tuaj yeem ua rau muaj kev pheej hmoo rau mob hawb pob thiab ua rau nws tshwm sim thaum ntxov.

Cov tsos mob tuaj yeem suav nrog ib qho hauv qab no:

  • Ua tsis taus pa nrog thiab tsis ntxo, thiab lwm cov tsos mob ntawm COPD
  • Cov tsos mob ntawm daim siab ua haujlwm
  • Poob phaus yam tsis tau sim
  • Hawb pob

Qhov tshuaj xyuas lub cev yuav qhia lub hauv siab zoo li lub hauv siab, hawb pob, lossis tsis hnov ​​pa nrov. Cov kev ntsuam xyuas hauv qab no kuj tseem yuav pab nrog kev kuaj mob:


  • AAT kev kuaj ntshav
  • Arterial ntshav roj
  • Kev ntsuas hluav taws xob xoo
  • CT scan ntawm lub hauv siab
  • Kev tshuaj ntsuam caj ces
  • Lub ntsws muaj nuj nqi kuaj

Koj tus kws kho mob yuav xav tias koj muaj tus mob no yog tias koj muaj:

  • COPD ua ntej hnub nyoog 45 xyoos
  • COPD tab sis koj tsis tau haus luam yeeb lossis tau co toxins
  • COPD thiab koj muaj keeb kwm tsev neeg ntawm tus mob no
  • Kab mob ntsws thiab tsis muaj lwm yam laj thawj yuav pom
  • Kab mob ntsws thiab koj muaj tsev neeg muaj kab mob siab

Kev kho mob rau AAT qhov tsis txaus cuam tshuam nrog kev hloov cov AAT protein uas ploj lawm. Cov protein muab los ntawm txoj hlab ntshav txhua lub lis piam lossis txhua 4 asthiv. Qhov no tsuas yog ua tau zoo me ntsis ntawm kev tiv thaiv kev mob ntsws ntau dua rau cov neeg tsis muaj tus kab mob thaum kawg. Txoj kev ua no yog hu ua kev kho mob ntxiv.

Yog tias koj haus luam yeeb, koj yuav tsum txiav luam yeeb.

Lwm txoj kev kho mob kuj tseem siv rau COPD thiab mob ntsws.

Lub ntsws loj tuaj yeem siv rau kev mob ntsws hnyav, thiab lub siab hloov pauv tuaj yeem siv rau mob ntsws hnyav.


Qee cov neeg uas lub cev tsis txaus siab yuav tsis ua mob rau daim siab lossis mob ntsws. Yog koj txiav luam yeeb, koj tuaj yeem ua rau qeeb ntawm kev mob ntsws ntsws.

COPD thiab mob hlab ntshaws tuaj yeem yog txoj sia txo.

Teeb meem ntawm AAT tsis muaj zog suav nrog:

  • Bronchiectasis (kev puas tsuaj ntawm cov hlab pa loj)
  • Mob Hlwb Mob Hlwb Ntev (COPD)
  • Daim siab ua haujlwm lossis mob qog noj ntshav

Hu rau koj tus kws kho mob yog tias koj muaj cov tsos mob ntawm AAT tsis txaus.

AAT tsis muaj peev xwm; Alpha-1 tiv thaiv tsis muaj zog; COPD - alpha-1 antitrypsin tsis muaj peev xwm; Cirrhosis - alpha-1 antitrypsin tsis txaus

  • Lub ntsws
  • Nplooj siab anatomy

Han MK, Laxalaus SC. COPD: kev kuaj mob thiab chaw tswj xyuas. Hauv: Broaddus VC, Mason RJ, Ernst JD, li al, eds. Murray thiab Nadel Cov Ntawv Phau Ntawv Qhia Txog Cov Pa. 6 tus ed. Philadelphia, PA: Elsevier Saunders; 2016: chaaj 44.


Hatipoglu U, Stoller JK. a1 -antitrypsin tsis muaj peev xwm. Clin Hauv Siab Med. 2016; 37 (3): 487-504. PMID: 27514595 www.pubmed.ncbi.nlm.nih.gov/27514595/.

Winnie GB, Boas SR. a1 -antitrypsin tsis muaj zog thiab emphysema. Hauv: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Phau Ntawv ntawm Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020: cha 421.

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