Dab Tsi Ua Rau Mantle Cell Lymphoma Txawv Los ntawm Lwm Cov Lymphomas?

Zoo Siab

• MCL yog B-cell tsis-Hodgkin's lymphoma
• MCL nyhav rau cov txiv neej laus dua
• MCL tsis tshua muaj feem ntau tag nrho
• Nws kis ntawm mantle cheeb tsam
• Nws tau cuam tshuam nrog kev hloov caj dab tshwj xeeb
• Nws muaj kev txhoj puab heev thiab kho tau yooj yim
• Nws tuaj yeem kho nrog cov hom phiaj kho
• Cov nqa mus

Lymphoma yog cancer ntshav uas tsim los ntawm lymphocytes, yog ib hom qe ntshav dawb. Lymphocytes ua lub luag haujlwm tseem ceeb hauv koj lub cev tiv thaiv kab mob. Thaum lawv dhau los ua mob cancer, lawv ntau hlav tuaj yeem tswj tsis tau thiab hlav mus ua qog.

Muaj ntau hom mob qog ua kua. Cov kev xaiv khomob thiab kev saib xyuas sib txawv ntawm ib hom rau ib hom. Siv sijhawm me me los kawm seb mantle cell lymphoma (MCL) piv rau lwm hom mob no li cas.

MCL yog B-cell tsis-Hodgkin's lymphoma

Muaj ob hom qog tshwj xeeb: Hodgkin's lymphoma thiab tsis-Hodgkin's lymphoma. Muaj ntau tshaj 60 qhov subtypes ntawm tsis-Hodgkin's lymphoma. MCL yog ib tus ntawm lawv.

Nws muaj ob hom lymphocytes: T lymphocytes (T cell) thiab B lymphocytes (B hlwb). MCL cuam tshuam B cell.

MCL nyhav rau cov txiv neej laus dua

Raws li American Cancer Society, Hodgkin's lymphoma feem ntau cuam tshuam rau cov neeg hluas, tshwj xeeb cov neeg hauv lawv 20s. Los ntawm kev sib piv, MCL thiab lwm yam hom tsis-Hodgkin's lymphoma muaj ntau rau cov neeg laus. Lymphoma tshawb fawb Foundation qhia tias feem ntau cov neeg uas muaj MCL yog cov txiv neej hnub nyoog 60 xyoo.

Zuag qhia tag nrho, kab mob ntsws yog ib hom mob khees-xaws feem ntau cuam tshuam rau menyuam yaus thiab tub ntxhais hluas. Tab sis tsis zoo li qee hom kev mob qog, MCL yog qhov tsis tshua muaj rau cov neeg hluas.

MCL tsis tshua muaj feem ntau tag nrho

MCL muaj ntau tsawg dua li qee hom mob qog. Nws sau txog kwv yees li 5 feem pua ​​ntawm tag nrho cov mob lymphoma, raws li American Cancer Society. Qhov no txhais tau tias MCL sawv cev kwv yees li 1 hauv 20 lymphomas.

Piv rau, hom feem ntau ntawm qhov tsis-Hodgkin's lymphoma yog diffuse loj B-cell lymphoma, uas muaj kwv yees li ntawm 1 ntawm 3 lymphomas.

Vim tias qhov mob no tsis tshua muaj, ntau tus kws kho mob yuav tsis paub txog cov kev tshawb nrhiav thiab kho tshiab rau MCL. Thaum tsim nyog, nws yog qhov zoo tshaj plaws mus ntsib kws kho mob kws paub tshwj xeeb txog cov qog ntshav lossis MCL.

Nws kis ntawm mantle cheeb tsam

MCL tau txais nws lub npe los ntawm qhov tseeb tias nws tsim hauv mantle cheeb tsam ntawm ib lub lymph node. Qhov chaw ua mantle yog lub nplhaib ntawm lymphocytes uas nyob ib puag ncig ntawm lub lymph node.

Txog thaum kuaj pom tus mob, MCL feem ntau kis mus rau lwm cov qog ntshav, thiab lwm yam nqaij thiab kabmob. Piv txwv, nws yuav kis tau tus kab mob rau koj cov pob txha, txha caj qaum, thiab plab hnyuv. Muaj qee zaus, nws yuav cuam tshuam koj lub hlwb thiab tus txha caj qaum.

Nws tau cuam tshuam nrog kev hloov caj dab tshwj xeeb

Cov qog ntshav o ua ke yog cov tsos mob feem ntau ntawm MCL thiab lwm yam mob qog. Yog tias koj tus kws kho mob xav tias koj muaj mob qog nqaij hlav, lawv yuav ua ib qho qauv ntawm cov qog ntshav lossis lwm qhov chaw ntawm koj lub cev mus kuaj.

Hauv lub tshuab kuaj kab mob me me, MCL cov hlwb zoo sib xws li qee yam lymphoma. Tab sis feem ntau, cov qog muaj cov cim caj ces uas tuaj yeem pab koj tus kws kho mob kawm txog hom qog ntshav uas lawv muaj. Txhawm rau kuaj mob kom paub tseeb, koj tus kws kho mob yuav xaj kom kuaj xyuas seb puas muaj cim caj ces tshwj xeeb thiab cov protein.

Koj tus kws kho mob tej zaum yuav xaj lwm yam kev kuaj, xws li thaij duab CT, kom paub seb tus kabmob puas tau kis mob. Lawv kuj tuaj yeem tso me me rau ntawm koj cov pob txha pob txha, plab hnyuv lossis lwm yam nqaij.

Nws muaj kev txhoj puab heev thiab kho tau yooj yim

Qee hom tsis-Hodgkin's lymphoma yog qib qis lossis tsis tuaj yeem. Qhov no txhais tau tias lawv zoo li maj mam loj hlob, tab sis feem ntau lawv tsis tuaj yeem ua rau. Txoj kev kho tuaj yeem pab txo tus mob qog, tab sis cov qib qog qis feem ntau yuav rov huam dua, lossis rov qab los.

Lwm hom kev tsis-Hodgkin's lymphoma yog qib-siab lossis nruj. Lawv zoo li loj hlob sai, tab sis lawv muaj peev xwm kho tau. Thaum cov kev kho mob thawj zaug muaj kev vam meej, cov qib high-qib qog ntshav yuav tsis rov huam mob dua.

MCL yog qhov txawv txav hauv qhov ntawd nws pom cov yam ntxwv ntawm ob qho tib si-qib siab thiab qib qis cov lymphomas. Zoo li lwm yam lymphomas siab, nws feem ntau loj hlob sai. Tab sis zoo li cov lymphomas qis, nws feem ntau tsis tuaj yeem ua tau. Cov neeg feem ntau uas muaj MCL mus rau hauv kev zam txim tom qab lawv pib kho mob, tab sis tus mob cancer yuav luag pheej rov huam hauv ob peb xyoos.

Nws tuaj yeem kho nrog cov hom phiaj kho

Zoo li lwm yam mob qog, MCL tuaj yeem kho nrog ib lossis ntau txoj hauv kev hauv qab no:

• saib ntsoov tos
• kev siv tshuaj kho mob
• monoclonal cov tshuaj tiv thaiv
• kev sib xyaw ua ke ntawm kev kho mob thiab tshuaj tua kab mob hu ua chemoimmunotherapy
• hluav taws xob kho
• hloov raum

Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) tau pom zoo plaub yam tshuaj uas tshwj xeeb rau MCL:

• bortezomib (Velcade)
• lenalidomide (Revlimid)
• ibrutinib (Imbruvica)
• acalabrutinib (Calquence)

Tag nrho cov tshuaj no tau txais kev pom zoo rau kev siv thaum rov huam mob, tom qab lwm yam kev kho mob twb tau sim ua. Bortezomib kuj tau pom zoo raws li kev kho mob thawj zaug, tuaj yeem siv ua ntej lwm txoj hauv kev. Ntau cov chaw kuaj mob tseem tabtom kawm txog kev siv lenalidomide, ibrutinib, thiab acalabrutinib yog thawj cov kev khomob, ib yam nkaus.

Txhawm rau paub ntau ntxiv txog koj cov kev kho mob, tham nrog koj tus kws kho mob. Lawv cov phiaj xwm kev kho mob uas pom zoo yuav nce nyob ntawm koj lub hnub nyoog thiab kev noj qab haus huv tag nrho, nrog rau qhov chaw twg thiab yuav kho mob cancer hauv koj lub cev li cas.

Cov nqa mus

MCL kuj tsis tshua muaj thiab nyuaj kho kho. Tab sis nyob rau xyoo tas los no, cov kev kho mob tshiab tau tsim thiab tau pom zoo los tsom cov hom mob cancer no. Cov kev kho tshiab no tau pab txuas ntxiv lub neej ntawm cov neeg uas muaj MCL.

Yog tias tsim nyog, nws yog qhov zoo tshaj rau mus ntsib tus kws paub txog mob qog noj ntshav uas tau kho tus mob qog nqaij hlav, suav nrog MCL. Tus kws tshaj lij no tuaj yeem pab koj nkag siab thiab hnyav koj cov kev xaiv kho.