Dab tsi yog qhov tseem ceeb thrombocythemia, tsos mob, kuaj mob thiab yuav kho li cas

Zoo Siab

• Cov tsos mob tseem ceeb
• Puas yog qhov tseem ceeb kabmob thrombocythemia?
• Yuav kuaj li cas
• Kev kho mob rau qhov tseem ceeb thrombocythemia

Qhov tseem ceeb thrombocythemia, los yog TE, yog ib qho kev mob hematological los ntawm kev nce ntxiv ntawm cov plasmaets hauv cov ntshav, uas ua rau muaj kev pheej hmoo ntawm thrombosis thiab los ntshav.

Tus kab mob no feem ntau asymptomatic, tau nrhiav pom tsuas yog tom qab ua cov ntshav ib txwm ua. Txawm li cas los xij, kev kuaj mob tsuas yog paub tseeb los ntawm tus kws kho mob tom qab tsis suav lwm qhov laj thawj uas ua rau kev nce platelets, xws li ntshav tsis muaj zog, piv txwv.

Kev kho feem ntau yog ua nrog cov tshuaj uas tuaj yeem txo cov platelets hauv cov ntshav thiab txo qhov kev pheej hmoo ntawm thrombosis, thiab yuav tsum siv raws li cov kws kho mob lossis hematologist tau qhia.

Cov tsos mob tseem ceeb

Qhov tseem ceeb thrombocythemia feem ntau yog asymptomatic, tau pom tsuas yog tom qab ua tiav cov ntshav suav, piv txwv. Txawm li cas los xij, nws tuaj yeem ua rau qee qhov tsos mob, lub ntsiab yog:

• Kev hnov ​​mob hauv lub taw thiab txhais tes;
• Splenomegaly, uas yog tus txha nqaj txhim kho;
• Kev mob hauv siab;
• Tawm hws;
• Tsis muaj zog;
• Mob taub hau;
• Cov dig muag tsis pom kev, uas tej zaum yuav tiav lossis tag;
• Lub cev yuag.

Ntxiv rau, cov tib neeg thiaj kuaj pom tias qhov tseem ceeb thrombocythemia yog cov muaj feem yuav ua kom mob thrombosis thiab los ntshav. Tus kab mob no muaj feem ntau rau cov neeg muaj hnub nyoog tshaj 60 xyoo, tab sis nws kuj tseem tuaj yeem tshwm sim hauv cov neeg muaj hnub nyoog 40 dua.

Puas yog qhov tseem ceeb kabmob thrombocythemia?

Qhov tseem ceeb thrombocythemia tsis yog mob qog nqaij hlav, vim tias tsis muaj qhov loj hlob ntawm cov hlwb tsis zoo, tab sis cov hlwb zoo li qub, hauv qhov no, platelets, yam ntxwv ntawm tus mob thrombocytosis lossis thrombocytosis. Tus kab mob no tseem nyob ruaj khov yog li ntawm 10 txog 20 xyoo thiab muaj tus nqi kho mob hloov kho tsawg, tsawg dua 5%.

Yuav kuaj li cas

Kev kuaj mob yog tsim los ntawm tus kws kho mob tshwj xeeb lossis hematologist raws li cov cim qhia thiab cov tsos mob qhia los ntawm tus neeg mob, ntxiv rau cov txiaj ntsig ntawm kev sim kuaj. Nws tseem yog ib qho tseem ceeb uas yuav tsum tau cais tawm lwm qhov ua rau muaj cov platelets nce ntxiv, xws li mob voos, myelodysplasia thiab hlau tsis muaj peev xwm, piv txwv. Paub cov laj thawj tseem ceeb ntawm cov ntshav plau plhu.

Kev kuaj pom ntawm qhov tseem ceeb thrombocythemia yog tsim thaum pib los ntawm kev txheeb xyuas cov ntshav suav, hauv kev pom tias kev nce ntshav hauv platelets, muaj tus nqi siab dua 450,000 platelets / mm³ ntawm cov ntshav. Nquag, cov platelet concentration tau rov ua dua rau hnub sib txawv los saib seb tus nqi tseem nce ntxiv.

Yog tias platelets muaj kev mob siab, kev tshuaj ntsuam genetic tau ua tiav los soj ntsuam seb puas muaj kev hloov pauv uas yog qhov qhia tau tias qhov tseem ceeb thrombocythemia, kev hloov pauv JAK2 V617F, uas muaj nyob hauv ntau dua 50% ntawm cov neeg mob. Yog tias qhov pom ntawm qhov kev sib hloov no tau txheeb xyuas qhov tseeb, nws yog ib qho tsim nyog yuav tsum tau tshem tawm qhov tshwm sim ntawm lwm cov kab mob siab thiab tshawb xyuas cov khoom noj muaj hlau.

Hauv qee kis, kev hloov cov pob txha ntawm lub cev tuaj yeem ua tau, uas qhov nce ntawm cov concentration ntawm megakaryocytes, uas yog lub qe ntshav ua ntej ntawm platelets, tuaj yeem ua raws cai.

Kev kho mob rau qhov tseem ceeb thrombocythemia

Txoj kev kho mob rau qhov tseem ceeb thrombocythemia tsom rau txo qis kev mob plab thiab mob ntshav siab, thiab nws feem ntau yog tus kws kho mob tau siv cov tshuaj los txo cov platelets hauv cov ntshav, piv txwv li Anagrelide thiab Hydroxyurea, piv txwv.

Hydroxyurea yog cov tshuaj uas ib txwm pom zoo rau cov neeg uas pom tias muaj kev pheej hmoo siab heev, uas yog, uas muaj hnub nyoog tshaj 60 xyoo, tau muaj mob ntu ntawm qhov mob plab thiab muaj ntshav tawm ntau dua 1500000 / mm³ ntawm cov ntshav. Txawm li cas los xij, cov tshuaj no muaj qee qhov tshwm sim, xws li hyperpigmentation ntawm daim tawv nqaij, xeev siab thiab ntuav.

Kev kho mob ntawm cov neeg mob yog cov tsis tshua muaj kev pheej hmoo, uas yog cov hnub nyoog qis dua 40 xyoo, feem ntau yog ua nrog acetylsalicylic acid raws li kev taw qhia ntawm cov kws kho mob feem ntau lossis hematologist.

Ib qho ntxiv, txhawm rau txo cov pheej hmoo ntawm thrombosis nws yog ib qho tseem ceeb kom tsis txhob haus luam yeeb thiab kho cov kab mob tseem ceeb, xws li kub siab, rog thiab ntshav qab zib, vim lawv nce txoj kev pheej hmoo ntawm thrombosis. Yuav tsum paub dab tsi los txhawm rau tiv thaiv thrombosis.