Dab Tsi Txhua Tus Neeg Uas Muaj Psoriasis Yuav Tsum Paub Txog PDE4 Cov Tshuaj Hauv Paus

Zoo Siab

• Txheej txheem cej luam
• PDE4 inhibitors yog dab tsi?
• Yuav ua li cas lawv ua hauj lwm rau psoriasis?
• PDE4 inhibitor kev kho mob vs lwm cov kev kho mob psoriasis
• Cov txiaj ntsig muaj txiaj ntsig
• Phiv pob thiab lus ceeb toom
• Cov nqa mus

Txheej txheem cej luam

Cov quav hniav psoriasis yog mob autoimmune mob. Ntawd yog, lub cev tiv thaiv kab mob ntawm lub cev tsis raug. Nws ua rau thaj chaw liab, maim txaij tsim tawm ntawm daim tawv. Tej zaum qhov no ua rau me nyuam pheej khaus lossis hnov ​​mob.

Cov kev xaiv kho mob txhawm rau txo cov tsos mob no. Vim tias qhov mob o yog lub hauv paus ntawm cov quav hniav psoriasis, lub hom phiaj ntawm ntau yam tshuaj kho yog txo qis hauv lub cev tiv thaiv kab mob thiab tsim kom muaj kev sib npaug.

Yog tias koj nyob nrog kev sib tw mob sib khuav sib thooj rau cov quav hniav, cov tshuaj tiv thaiv PDE4 tuaj yeem yog cov cuab yeej zoo hauv kev tswj cov tsos mob.

Txawm li cas los xij, cov tshuaj tsis yog rau txhua tus. Koj yuav tsum nrog koj tus kws kho mob sib tham txog kev kho mob.

PDE4 inhibitors yog dab tsi?

PDE4 inhibitors yog qhov kev kho mob tshiab. Lawv ua haujlwm rau cov kab mob ua kom tsis muaj zog, uas yog txo cov mob. Lawv ua rau qib theem ntawm tes los nres qhov kev tsim cov enzyme hu ua PDE4.

Cov kws tshawb nrhiav paub tias phosphodiesterases (PDEs) cuam tshuam cyclic adenosine monophosphate (cAMP). cAMP pab txhawb ntau qhov kom pom kev ntawm cov hlwb.

Los ntawm kev txiav tseg PDE4s, cAMP nce ntxiv.

Raws li kev tshawb nrhiav xyoo 2016, qhov feem pua ​​ntawm cov CAMP ntau dua tuaj yeem muaj cov kev tiv thaiv kev cuam tshuam, tshwj xeeb hauv cov neeg nyob nrog psoriasis thiab atopic dermatitis.

Yuav ua li cas lawv ua hauj lwm rau psoriasis?

PDE4 inhibitors, zoo li apremilast (Otezla), ua haujlwm sab hauv lub cev kom tiv thaiv o.

Raws li kev tiv thaiv kab mob, nws yuav muaj txiaj ntsig zoo rau cov neeg muaj mob psoriasis los tswj kev mob o. Txo qhov mob o tuaj yeem ua rau muaj kev tawm tsam tsawg dua thiab ua rau muaj mob hnyav.

Nws tseem yuav nres lossis tiv thaiv tus mob kev loj hlob kom ua rau mob psoriatic mob caj dab (PsA).

Ntawm cov neeg uas nyob nrog txhua yam kev sib txawv ntawm tus mob psoriasis, kwv yees li 30 feem pua ​​nws pib mob PsA, uas ua rau mob sib khuav xwb los ntawm mob tej pob txha. PsA tuaj yeem txo koj lub neej zoo.

PDE4 inhibitor kev kho mob vs lwm cov kev kho mob psoriasis

Apremilast, PDE4 inhibitor, yog noj ntawm qhov ncauj. Nws kuj tseem ua txoj hauv kev tseem ceeb los ntawm kev cuam tshuam los ntawm cov lus teb inflammatory uas ua rau muaj cov tsos mob ntawm cov quav hniav psoriasis.

Kev kho mob biologic xws li adalimumab (Humira), etanercept (Enbrel), thiab infliximab (Remicade) yog txhaj rau hauv lub cev.

Lwm yam kev siv tshuaj lom neeg muaj xws li:

• Ustekinumab (IL-12/23 inhibitor)
• secukinumab (IL-17A inhibitor)
• ixekizumab (IL-17A inhibitor)
• guselkumab (IL-23 inhibitor)
• risankizumab (IL-23 inhibitor)

Tofacitinib yog Janus kinase (JAK) inhibitor uas tau pom zoo ua kev kho mob hauv qhov ncauj.

Abatacept yog T-cell ua kom inhibitor uas tau muab los ua kev tso leeg ntshav (IV) lossis txhaj tshuaj.

Cov txiaj ntsig muaj txiaj ntsig

Apremilast tau pom zoo rau cov neeg nyob nrog kev muaj mob tsis txaus mus rau qhov hnyav ntawm cov quav hniav psoriasis uas tseem yog cov neeg sib tw rau kev kho mob ib puag ncig lossis kev kho duab.

Hauv, ntau dua qhov feem pua ​​ntawm cov neeg uas siv tshuaj apremilast tau qhab nia zoo rau ob qho Tag nrho Kws Kho Mob Kev Ntsuam Xyuas Thoob Ntiaj Teb (sPGA) thiab Psoriasis Thaj Tsam thiab Severity Index (PASI) piv rau cov uas tau noj cov placebo.

Phiv pob thiab lus ceeb toom

Txawm hais tias PDE4 inhibitors qhia tau cov lus cog tseg zoo heev, nws tsis yog rau txhua tus. Apremilast tsis tau sim rau cov poj niam cev xeeb tub lossis pub niam mis. Tam sim no, nws tsuas yog pom zoo rau cov laus xwb.

Nws kuj tseem ceeb kom luj qhov muaj peev xwm thiab cov txiaj ntsig zoo ntawm PDE4 inhibitors.

Apremilast los nrog qee qhov kev paub txaus ntshai.

Cov neeg noj tshuaj apremilast yuav muaj kev tsis haum tshuaj xws li:

• xeev siab
• zawv plab
• sab sauv ntawm txoj hlab ua pa tuaj
• mob taub hau

Qee tus neeg kuj ntsib poob ceeb thawj.

Apremilast tseem tuaj yeem nce cov kev xav txog kev ntxhov siab thiab kev xav txog kev tua tus kheej.

Rau cov tib neeg muaj keeb kwm ntawm kev nyuaj siab lossis tus kheej txoj sia, nws raug nquahu kom lawv tham nrog lawv tus kws kho mob kom pab lawv ua tib zoo ntsuas qhov muaj txiaj ntsig zoo ntawm cov tshuaj tiv thaiv cov kev pheej hmoo.

Yog tias koj tau ntsib kev mob tshwm sim, koj tus kws kho mob yuav pom zoo kom tsis txhob noj cov tshuaj.

Cov nqa mus

Psoriasis yog mob ntev - tab sis tswj tau - tus mob. Lub luag haujlwm hloov kho yog qhov tseem ceeb ntawm kev kho thiab tshawb nrhiav.

Yog tias koj tus kws kho mob txiav txim siab koj cov quav hniav psoriasis mob ntsws me lossis tswj tau zoo, lawv tuaj yeem pom zoo rau cov tshuaj tiv thaiv tsis muaj kabmob (NSAIDs). Tej zaum lawv tseem yuav pom zoo cov kev kho mob saum toj no.

Lawv feem ntau yuav sim ob qho ntawm cov lus pom zoo no ua ntej xav txog kev siv PDE4 inhibitor lossis lwm yam tshuaj tiv thaiv kab mob hauv lub cev.

Cov kws tshawb nrhiav tau tshawb pom ntau ntxiv txog cov txheej txheem nyob rau hauv lub cev uas ua rau muaj mob. Cov ntaub ntawv no tau pab hauv kev tsim cov tshuaj tshiab uas tej zaum yuav muab kev pab rau cov neeg nyob nrog psoriasis.

PDE4 inhibitors yog kev hloov tshiab tshaj plaws, tab sis lawv tuaj nrog kev pheej hmoo. Koj thiab koj tus kws kho mob yuav tsum ua tib zoo xav txog cov xwm txheej no ua ntej pib kho ib hom tshuaj tshiab.