Dab tsi Tshiab nrog Kev Kho Mob PPMS? Phau Ntawv Qhia Cov Lus Qhia

Zoo Siab

• Tshawb nrhiav tshuaj los ntawm NINDS
• Tshuaj kho mob
• Kev hloov kho Gene
• Cov lus pom zoo kom rov zoo
• Kev kho lub cev thiab tshawb fawb hauv kev tawm dag zog
• Kev nrhav kev nyob hauv txoj kev kho kom zoo
• Cov chaw kuaj mob rau PPMS
• Kev kho yav tom ntej ntawm PPMS

Kev Tsim Kho Hauv Ntau Hom Sclerosis Kho

Thawj qhov muaj mob ntau yam sclerosis (PPMS) tsis muaj kev kho mob, tab sis muaj ntau txoj kev xaiv los tswj tus mob. Cov kev kho mob tsom rau kev txo cov tsos mob thaum txo qis ntawm txoj kev tsis taus mus ib txhis.

Koj tus kws kho mob yuav tsum yog thawj qhov kev kho mob rau PPMS. Lawv tuaj yeem muab cov lus qhia kev tswj hwm rau koj raws li lawv soj qab xyuas qhov nce ntawm tus kab mob.

Txawm li cas los xij, koj tseem yuav txaus siab tshawb nrhiav cov peev txheej ntxiv rau kev kho PPMS Kawm paub txog cov peev txheej nyob ntawm no.

Tshawb nrhiav tshuaj los ntawm NINDS

Lub koom haum National of Neurological Disorder thiab Stroke (NINDS) tau tshawb fawb txuas mus ntxiv rau txhua hom mob txha caj qaum (MS).

Lub NINDS yog ib ceg ntawm National Institutes of Health (NIH), thiab tau txais kev pab nyiaj los ntawm tsoomfwv. NINDS tseem tab tom tshawb xyuas cov tshuaj uas tuaj yeem hloov kho myelin thiab cov noob caj dab uas tuaj yeem tiv thaiv qhov pib ntawm PPMS.

Tshuaj kho mob

Hauv 2017, ocrelizumab (Ocrevus) tau pom zoo los ntawm Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) rau kev kho mob ntawm PPMS thiab rov huam dua MS (RRMS). Cov tshuaj no yog thawj zaug thiab tsuas yog tshuaj PPMS nyob rau ntawm lub khw.

Raws li NINDS, lwm yam tshuaj nyob hauv kev txhim kho kuj qhia tau cog lus. Cov tshuaj kho mob no yuav ua haujlwm los ntawm kev tiv thaiv cov myelin cell los ntawm kev ua paug thiab tig mus rau qhov txhab. Lawv tuaj yeem tiv thaiv myelin cov hlwb lossis pab kho lawv tom qab muaj mob.

Kev noj tshuaj hauv qhov ncauj cladribine (Mavenclad) yog ib qho piv txwv.

Lwm cov tshuaj uas tau tshawb nrhiav tuaj yeem yuav txhawb nqa kev txhim kho ntawm oligodendrocytes. Oligodendrocytes yog cov hlwb ua tshwj xeeb uas yuav pab tsim cov hlwb tshiab myelin.

Kev hloov kho Gene

Qhov tseem ceeb ua rau PPMS - thiab MS tag nrho - tsis paub. Kev tshuaj ntsuam caj ces xav tias yuav pab ua kom muaj kab mob loj hlob. Cov kws tshawb nrhiav kawm txuas ntxiv txog lub luag haujlwm ntawm cov caj ces hauv PPMS.

NINDS hais txog cov noob caj noob ces uas tej zaum yuav ua rau muaj kev pheej hmoo rau MS li "kev muaj lub cev raug taus." Lub koom haum tab tom nrhiav rau cov tshuaj uas tuaj yeem hloov kho cov noob no ua ntej MS txhim kho.

Cov lus pom zoo kom rov zoo

National Ntau yam Sclerosis Society yog lwm lub koom haum uas muaj kev hloov tshiab ntawm kev nrhav hauv kev kho.

Tsis zoo li NINDS, lub Koom Haum yog lub koom haum ua haujlwm tsis yeem. Lawv lub luag haujlwm yog mus tshaj tawm kev paub txog MS thaum tseem khaws nyiaj los txhawb rau kev tshawb fawb.

Raws li ib feem ntawm nws lub luag haujlwm los txhawb kev tawm dag zog rau cov neeg mob, lub Koom Haum nquag hloov kho cov peev txheej ntawm nws lub vev xaib. Vim tias cov kev xaiv tshuaj muaj tsawg, tej zaum koj yuav pom cov khoom siv hauv lub zej zog txog kev rov txhim kho kom zoo dua. Ntawm no lawv teev:

• kev pab kho lub cev
• kev kho kom lub cev
• kev nkag ua kom txawj ntse
• qhia kho mob (rau cov haujlwm)
• hais lus-kev pathology

Kev kho lub cev thiab kev ua haujlwm yog cov hom kev nyiam kho kom zoo tshaj plaws hauv PPMS. Nram qab no yog qee qhov kev nrhav kev tshiab uas suav nrog ob txoj kev kho no.

Kev kho lub cev thiab tshawb fawb hauv kev tawm dag zog

Kev kho lub cev (PT) yog siv los ua cov qauv kev txum tim rov qab los hauv PPMS. Cov hom phiaj ntawm PT tuaj yeem sib txawv raws qhov hnyav ntawm koj cov tsos mob. Nws yog siv rau:

• pab cov neeg nrog PPMS ua haujlwm txhua hnub
• txhawb kom muaj kev ywj pheej
• txhim kho kev nyab xeeb - piv txwv, kev qhia kev ntsuas lub peev xwm uas tuaj yeem txo kev ntog ntog
• txo txoj kev pheej hmoo ntawm txoj kev tsis taus
• muab kev pab txhawb txoj kev xav
• txiav txim siab qhov xav tau rau cov khoom siv pabcuam hauv tsev
• txhim kho tag nrho muaj lub neej zoo

Koj tus kws kho mob yuav pom zoo kom kho lub cev sai sai tom qab koj kuaj pom thawj zaug. Ua tib zoo hais txog cov kev kho mob no tseem ceeb - tsis txhob tos kom txog thaum koj cov tsos mob zoo zuj zus.

Kev tawm dag zog yog qhov tseem ceeb ntawm PT. Nws pab txhim kho koj txoj kev txav chaw, lub zog, thiab ntau yam ntawm cov lus tsa suab kom koj tuaj yeem tswj kev ywj pheej.

Cov kws tshawb nrhiav kuj tseem niaj hnub saib cov txiaj ntsig ntawm kev tawm dag zog hauv aerobic ce txhua hom MS. Raws li National National Sclerosis Society, kev tawm dag zog tsis tau pom zoo kom txog rau thaum ib nrab xyoo 1990. Qhov no yog thaum txoj kev xav hais tias kev tawm dag zog tsis tau zoo rau MS thaum kawg tau ua txhaum.

Koj tus kws kho mob lub cev tuaj yeem qhia kev tawm dag zog rau koj txoj kev tawm dag zog uas koj tuaj yeem ua - nyab xeeb - nyob rau ntawm kev teem sijhawm txhawm rau txhim kho koj cov tsos mob thiab txhim kho koj lub zog.

Kev nrhav kev nyob hauv txoj kev kho kom zoo

Kev kho txoj haujlwm yog nce raug lees paub tias yog khoom muaj nqis hauv PPMS kev kho mob. Nws tuaj yeem muaj txiaj ntsig rau kev saib xyuas tus kheej thiab thaum ua haujlwm, thiab nws kuj tseem tuaj yeem pab nrog:

• kev ua si lom zem
• kev ua si
• ua phooj ywg
• kev pab dawb
• kev tswj hwm tsev

OT feem ntau pom tau tias yog tib yam li PT. Txawm hais tias cov kev kho no ua kom tiav ib leeg, lawv txhua tus muaj lub luag haujlwm rau kev sib txawv ntawm kev kho PPMS.

PT tuaj yeem txhawb koj lub zog tag nrho thiab kev mus ncig, thiab OT tuaj yeem pab nrog cov haujlwm uas cuam tshuam rau koj txoj kev ywj pheej, xws li da dej thiab hnav khaub ncaws ntawm koj tus kheej. Nws raug nquahu kom cov neeg PPMS nrhiav kev ntsuam xyuas ob qho PT thiab OT thiab kev kho mob tom qab.

Cov chaw kuaj mob rau PPMS

Koj tseem tuaj yeem nyeem txog kev kho PPMS tam sim no thiab tawm ntawm ClinicalTrials.gov. Nov yog lwm ceg ntawm tus NIH. Lawv lub luag haujlwm yog muab "cov ntaub ntawv khaws cia ntawm kev kawm tshawb fawb thiab ntiav nyiaj txiag thoob ntiaj teb."

Ntaus “PPMS” rau “Kev mob lossis kab mob” dab tsi. Koj yuav pom ntau cov kev tshawb fawb nquag thiab ua tiav nrog kev siv tshuaj thiab lwm yam uas tuaj yeem cuam tshuam tus kab mob.

Ib qho ntxiv, koj yuav txiav txim siab koom nrog kev sim kho mob koj tus kheej. Nov yog qhov kev cog lus tiag tiag. Txhawm rau kom ntseeg tau tias koj tus kheej muaj kev nyab xeeb, koj yuav tsum sib tham txog kev kuaj mob nrog koj tus kws kho mob ua ntej.

Kev kho yav tom ntej ntawm PPMS

Tsis muaj kev kho rau PPMS, thiab cov kev xaiv tshuaj muaj cwj ciam. Kev tshawb fawb tseem tab tom tshawb nrhiav tshuaj lwm yam li ocrelizumab uas tuaj yeem pab tswj cov kev mob tshwm sim.

Ntxiv nrog rau kev tshuaj xyuas nrog koj tus kws kho mob tsis tu ncua, siv cov peev txheej no kom paub txog cov kev hloov tshiab tom ntej hauv PPMS tshawb nrhiav. Kev ua haujlwm ntau yog ua tiav kom nkag siab zoo txog PPMS thiab kho tib neeg kom zoo dua ntxiv.