FLT3 Kev Sib Hloov thiab Mob Ntshav Mob Myeloid: Cov kev txiav txim siab, dhau los, thiab Kho

Zoo Siab

• FLT3 hloov tau yog dab tsi?
• FLT3 cuam tshuam li cas rau AML?
• Cov tsos mob zoo li cas?
• Kev kuaj rau FLT3 hloov pauv
• Kev kho rau FLT3 hloov pauv
• Nqa Nyiaj

FLT3 hloov tau yog dab tsi?

Mob myeloid mob ntshav dawb (AML) tau muab faib ua subtypes raws qhov yuav ua li cas cov qog nqaij hlav cancer saib, thiab cov noob hloov pauv twg lawv muaj. Qee hom AML yog nruj dua li lwm tus thiab xav tau kev kho mob sib txawv.

FLT3 yog kev hloov pauv ntawm cov noob, lossis hloov pauv, hauv cov qe ntshav muaj qog ntshav. Nruab nrab ntawm cov neeg nrog AML muaj qhov hloov no.

FLT3 cov lej noob rau cov protein hu ua FLT3 uas pab cov qe ntshav dawb loj tuaj. Kev hloov pauv hauv cov gene no txhawb txoj kev loj hlob ntawm cov qog ntshav muaj ntshav ntau dhau.

Cov neeg muaj tus kab mob FLT3 hloov pauv muaj cov ntshav siab mob heev uas yuav rov muaj mob dua tuaj tom qab kho tau.

Yav dhau los, kev kho mob AML tsis muaj txiaj ntsig zoo tiv thaiv qog nqaij hlav nrog FLT3 kev sib hloov. Tab sis cov tshuaj tshiab uas tshwj xeeb phiaj rau kev hloov pauv no yog kev txhim kho qhov pom ntawm cov neeg muaj mob AML subtype.

FLT3 cuam tshuam li cas rau AML?

FLT3 lub cev pab tswj cov ciaj sia ntawm tes thiab kev rov tsim tawm. Lub noob hloov tau ua rau cov qe ntshav tsis txaus uas muaj ntau yam tsis tuaj yeem tswj tau.

Raws li qhov tshwm sim, cov neeg mob FLT3 hloov pauv tau muaj hom mob hnyav dua ntawm AML. Lawv tus kab mob yuav ntxim rov qab los, lossis rov huam mob tuaj, tom qab kho tas. Lawv kuj muaj cov nyiaj poob qis dua cov tib neeg tsis muaj kev hloov pauv.

Cov tsos mob zoo li cas?

Cov tsos mob ntawm AML suav nrog:

• yooj yim bruising los yog los ntshav
• taub ntswg
• cov pos hniav los ntshav
• nkees nkees
• tsis muaj zog
• ua npaws
• piav tsis hnyav poob
• mob taub hau
• daj ntseg tawv nqaij

Kev kuaj rau FLT3 hloov pauv

Lub Tsev Kawm Qib Siab ntawm American Pathologist thiab American Society of Hematology pom zoo tias txhua tus neeg kuaj mob tus mob AML raug kuaj rau FLT3 noob hloov pauv.

Koj tus kws kho mob yuav ntsuas koj hauv ib ntawm ob txoj kev:

• Kuaj ntshav: Ntshav tau coj los ntawm cov leeg hauv koj txhais caj npab thiab xa mus rau qhov chaw kuaj ntshav.
• Mob hlwb pob txha rau siab: Ib rab koob tau ntxig rau hauv koj lub pob txha. Lub rab koob tshem tawm me me ntawm cov kua pob txha kua.

Cov ntshav los yog txha pob txha coj pob txha los soj ntsuam seb koj puas muaj tus kab mob FLT3 hloov hauv koj cov ntshav muaj ntshav. Qhov kev ntsuas no yuav qhia seb koj puas yog tus neeg sib tw zoo rau cov tshuaj uas tsom mus rau hom AML no.

Kev kho rau FLT3 hloov pauv

Txog thaum nyuam qhuav dhau los, cov neeg muaj FLT3 hloov pauv tau feem ntau yog kho cov tshuaj khomob, uas ua tsis tau zoo ntawm kev txhim kho cov kev ua neej nyob ntxiv. Ib pawg tshiab ntawm cov tshuaj hu ua FLT3 inhibitors yog txhim kho qhov pom kev rau cov neeg uas muaj kev sib hloov.

Midostaurin (Rydapt) yog thawj cov tshuaj pom zoo rau FLT3, thiab thawj cov tshuaj tshiab tau txais kev pom zoo los kho AML hauv 40 xyoo. Cov kws kho mob muab Rydapt ua ke nrog kev siv tshuaj kho mob xws li cytarabine thiab daunorubicin.

Koj noj Rydapt los ntawm qhov ncauj ob zaug ib hnub. Nws ua haujlwm los ntawm thaiv cov FLT3 thiab lwm cov protein ntawm cov roj ntsha leukemia uas pab lawv loj hlob.

Kev tshawb nrhiav ntawm 717 tus neeg uas muaj cov kab mob FLT3 luam tawm nyob rau hauv phau ntawv Askiv Cov Tshuaj Tshiab tau saib txog kev cuam tshuam ntawm kev kho nrog cov tshuaj tshiab no. Cov kws tshawb nrhiav tau pom tias ntxiv Rydapt rau cov kws khomob siv sijhawm ntev dua li piv rau kev kho mob tsis siv tshuaj (placebo) ntxiv rau kev siv tshuaj kho.

Tus nqi nyob hauv plaub-xyoo yog 51 feem pua ​​ntawm cov neeg uas coj Rydapt, piv rau ntau tshaj li 44 feem pua ​​hauv cov pab pawg. Qhov nruab nrab ntev ntawm kev muaj sia nyob ntau dua rau xyoo hauv pawg kho mob, piv txwv li tsuas yog ntau dua ob xyoos hauv pawg placebo.

Rydapt tuaj yeem ua rau phiv xws li:

• ua npaws thiab cov qe ntshav dawb (febrile neutropenia)
• xeev siab
• ntuav
• qhov ncauj tawm lossis daim tawv liab ntawm lub qhov ncauj
• mob taub hau
• leeg mob lossis pob txha mob
• doog ntshav
• taub ntswg
• ntshav qab zib kom ntau ntau

Koj tus kws kho mob yuav soj qab xyuas koj cov kev mob tshwm sim thaum koj tseem noj cov tshuaj no, thiab muab kev kho koj los pab tswj hwm lawv.

Ob peb lwm FLT3 inhibitors tseem nyob hauv qhov chaw sim tshuaj saib seb lawv puas ua haujlwm. Cov no suav nrog:

• crenolanib
• gilteritinib
• xeem ntawv

Cov kws tshawb nrhiav tseem tab tom kawm seb qog cell qog hloov kho tom qab kho nrog tus FLT3 inhibitor yuav txo qhov muaj feem ntawm kev mob qog rov qab los. Lawv kuj tseem xyuas seb cov tshuaj sib txawv ntawm cov tshuaj yuav ua tau zoo dua rau cov neeg uas muaj qhov hloov no.

Nqa Nyiaj

Muaj lub FLT3 hloov tau yog tias koj muaj AML siv los txhais tau tias muaj qhov tshwm sim tsis zoo. Tam sim no, cov tshuaj zoo ib yam li Rydapt yog pab txhawm rau txhim kho qhov pom. Cov tshuaj tshiab thiab kev sib txuas ntawm cov tshuaj yuav txuas ntxiv kom muaj txoj sia nyob ntev dua nyob rau xyoo tom ntej.

Yog tias koj kuaj pom tias muaj mob AML, koj tus kws kho mob yuav kuaj koj tus mob cancer rau FLT3 thiab lwm yam kev hloov pauv ntawm cov noob. Paub kom ntau li ntau tau txog koj cov qog yuav pab koj tus kws kho mob nrhiav kev kho kom zoo tshaj rau koj.