Mob Lymphocytic Mob Hlav (CLL)

Zoo Siab

• Cov roj ntsha lymphocytic uas mob ntev (CLL) yog dab tsi?
• Cov tsos mob ntawm CLL zoo licas?
• Yuav kho tus mob CLL li cas?
• Kws khomob
• Kev tawg
• Cov hom phiaj kho
• Mob hlwb pob txha los yog txha ntshav ntshav hloov ntshav ntawm tes
• Qhov txhab ntshav ntxiv
• Kev phais mob
• Yuav kuaj li cas thiaj paub tau?
• Ua kom tiav cov ntshav suav (CBC) nrog cov qe ntshav dawb (WBC) plawg
• Kev sim tshuaj Immunoglobulin
• Nqaij pob txha caj dab
• Iav scan
• Ntws cytometry thiab cytochemistry
• Kev tshuaj ntsuam Genomic thiab molecular
• Tus ciaj sia taus rau cov neeg uas muaj CLL yog dab tsi?
• CLL staged li cas?
• Dab tsi ua rau muaj tus mob CLL, thiab puas muaj kev pheej hmoo txaus rau tus kabmob no?
• Puas muaj lwm yam kev phom sij ntxiv nrog txoj kev kho tau?
• Qhov ntev ntawm kev txheeb xyuas qhov tseeb rau CLL yog dab tsi?

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Cov roj ntsha lymphocytic uas mob ntev (CLL) yog dab tsi?

Leukemia yog ib hom mob cancer uas cuam tshuam nrog tib neeg cov qe ntshav thiab cov ntshav tsim. Muaj ntau cov ntshav qog ntshav, txhua yam cuam tshuam rau ntau cov qe ntshav sib txawv. Mob ntsws lymphocytic uas mob ntev, los yog CLL, cuam tshuam rau lymphocytes.

Lymphocytes yog ib hom qe ntshav dawb (WBC). CLL cuam tshuam B lymphocytes, uas tseem hu ua B cell.

Cov kab mob B mus nyob rau hauv koj cov ntshav thiab pab koj lub cev tua kab mob. Cov kab mob cancer B tsis tua cov kab mob sib xws li cov B B ua ib txwm muaj. Raws li tus naj npawb ntawm cov qog nqaij hlav hlwb B nce siab zuj zus, lawv faib tawm cov lymphocytes li qub.

CLL yog hom leukemia uas tseem pom muaj tshaj rau ntawm cov laus. National Cancer Institute (NCI) kwv yees tias 21,040 kis mob tshiab yuav tshwm sim hauv Tebchaws Asmeskas thaum xyoo 2020.

Cov tsos mob ntawm CLL zoo licas?

Qee tus neeg mob CLL yuav tsis muaj tsos mob dab tsi, thiab lawv tsuas pom mob cancer thaum kuaj ntshav tas li xwb.

Yog tias koj muaj cov tsos mob, lawv feem ntau suav nrog:

• nkees
• ua npaws
• mob heev heev los yog mob
• piav tsis poob lossis tsis poob ceeb thawj
• tsaus ntuj tawm hws
• ua daus no
• o cov qog ntshav o

Thaum kuaj lub cev, koj tus kws kho mob kuj yuav pom tias koj tus hnoos qeev, mob siab, lossis cov qog ntshav nce. Cov no tuaj yeem yog cov cim qhia tias mob cancer tau kis rau cov kabmob no. Qhov no feem ntau tshwm sim hauv kev kis mob siab ntawm CLL.

Yog tias qhov no tshwm sim rau koj, koj yuav hnov ​​zoo li qog mob hauv koj lub caj dab lossis qhov hnov ​​ntawm tag nrho lossis o hauv koj lub plab.

Yuav kho tus mob CLL li cas?

Yog tias koj tus mob CLL pheej hmoo tsawg, koj tus kws kho mob yuav qhia koj kom tos thiab saib xyuas cov tsos mob tshiab. Koj tus mob yuav tsis ua kom tsis zoo lossis yuav tsum kho ntau xyoo. Qee tus neeg tsis tas kho los kho.

Muaj qee kis CLL pheej hmoo, koj tus kws kho mob yuav hais kom kho. Piv txwv li, lawv yuav qhia seb yuav kho yog tias koj muaj:

• muaj mob pheej, rov kis tau dua
• cov ntshav ntshav tsawg hauv lub cev
• qaug zog lossis tawm hws hmo ntuj
• cov mob ua mob ntshav siab

Yog tias koj nyob nruab nrab - lossis pheej hmoo tsis txaus siab CLL, koj tus kws kho mob yuav qhia koj kom kho tam sim ntawd.

Hauv qab no yog qee qhov kev kho mob uas koj tus kws kho mob yuav pom zoo.

Kws khomob

Kev siv tshuaj khomob yog kev kho mob tus thawj xibfwb rau CLL. Nws suav txog kev siv tshuaj los tua cov kabmob kheesxaws. Nyob ntawm cov tshuaj uas koj tus kws kho mob sau yuav, koj tuaj yeem siv tshuaj pleev hauv qhov ncauj lossis qhov ncauj.

Kev tawg

Nyob rau hauv txoj kev ua no, cov khoom siv hluav taws xob loj los yog cov nthwv dej tau siv los tua cov qog noj ntshav. Kev xoo hluav taws xob feem ntau tsis yog siv rau CLL, tab sis yog tias koj muaj qhov mob o, cov qog ntshav tuaj, kev siv hluav taws xob yuav pab ua kom lawv xoob thiab daws koj qhov mob.

Cov hom phiaj kho

Cov hom phiaj kho mob tsom mus rau ib qho tshwj xeeb caj ces, protein, lossis cov nqaij uas pab txhawb txoj kev mob qog nqaij hlav hlwb. Cov no tuaj yeem suav nrog:

• cov kab mob monoclonal, uas txuas rau cov protein
• kinase inhibitors uas tuaj yeem rhuav tshem cov qog ntshav mob los ntawm kev thaiv cov kinase enzymes

Mob hlwb pob txha los yog txha ntshav ntshav hloov ntshav ntawm tes

Yog tias koj muaj qhov mob siab CLL, qhov kev kho mob no yuav yog ib qho kev xaiv. Nws cuam tshuam txog kev noj cov hlwb pob txha los ntawm cov pob txha los yog ntshav ntawm tus neeg pub nyiaj - feem ntau yog cov neeg hauv tsev neeg - thiab hloov lawv mus rau hauv koj lub cev kom pab tsim cov hlwb pob txha tsis muaj mob.

Qhov txhab ntshav ntxiv

Yog koj cov qe ntshav muaj tsawg, tej zaum koj yuav tau txhaj ntshav ntxiv los ntawm txoj hlab ntshav (IV) kom ntxiv rau lawv.

Kev phais mob

Muaj qee kis, koj tus kws kho mob yuav pom zoo kom phais txhawm rau tshem tus po tawm yog tias qhov cuam tshuam nce vim yog CLL.

Yuav kuaj li cas thiaj paub tau?

Yog tias koj tus kws kho mob xav tias koj muaj CLL, lawv yuav siv ntau yam kev kuaj mob kom paub meej tias kuaj mob. Piv txwv li, lawv yuav xaj ib lossis ntau qhov kev ntsuam xyuas hauv qab no.

Ua kom tiav cov ntshav suav (CBC) nrog cov qe ntshav dawb (WBC) plawg

Koj tus kws kho mob tuaj yeem siv cov kev kuaj ntshav no los ntsuas tus lej ntawm ntau hom qe ntshav hauv koj cov ntshav, suav nrog ntau hom WBCs.

Yog tias koj muaj CLL, koj yuav muaj cov lymphocytes ntau dua li ib txwm.

Kev sim tshuaj Immunoglobulin

Koj tus kws kho mob tuaj yeem siv cov kev kuaj ntshav no kom paub yog tias koj muaj tshuaj tiv thaiv kom txaus rau kev tua kab mob.

Nqaij pob txha caj dab

Nyob hauv txoj kev ua no, koj tus kws kho mob ntxig ib rab koob nrog lub raj tshwj xeeb rau koj lub pob txha ntawm lub duav lossis lub mis nqa kom tau ib qho piv txwv ntawm koj cov pob txha pob txha los kuaj.

Iav scan

Koj tus kws kho mob tuaj yeem siv cov duab tsim los ntawm CT scan txhawm rau saib rau qog ntshav hauv koj lub hauv siab lossis lub plab.

Ntws cytometry thiab cytochemistry

Nrog rau cov kev sim no, cov tshuaj khes mis lossis cov kua roj looj cov khoom siv txhawm rau pom cov cim ntaus cim tshwj xeeb ntawm cov qog nqaij hlav cancer los pab txiav txim seb hom ntshav muaj ntshav dab tsi. Cov ntshav ntsuas yog txhua yam uas xav tau rau qhov kev ntsuas no.

Kev tshuaj ntsuam Genomic thiab molecular

Cov kev kuaj no yog saib cov caj ces, qog nqaij hlav, thiab xoos qog txawv txav uas tej zaum yuav txawv rau qee hom mob ntshav leukemia. Lawv tseem pab txiav txim seb tus kab mob no yuav loj hlob mus li cas thiab pab koj tus kws kho mob xaiv yam kev kho mob uas yuav siv.

Kev tshuaj ntsuam caj nrhiav kom pom cov kev hloov pauv lossis hloov pauv tuaj yeem suav nrog fluorescence hauv situ hybridization (FISH) tshaj tawm thiab polymerase saw cov tshuaj tiv thaiv.

Tus ciaj sia taus rau cov neeg uas muaj CLL yog dab tsi?

Qhov kev nyob nrog 5 xyoo rau cov neeg Asmeskas nrog CLL yog 86.1 feem pua, raws li NCI. Lub koom haum tseem twv tias CLL yuav ua rau 4,060 tus neeg tuag hauv Tebchaws Meskas thaum 2020.

Ciaj sia nyob tus nqi tsawg dua rau cov neeg laus uas muaj tus mob no.

CLL staged li cas?

Yog tias koj tus kws kho mob txiav txim siab tias koj muaj mob CLL, lawv yuav xaj mus kuaj ntxiv los ntsuas seb tus kabmob zoo li cas. Qhov no yuav pab koj tus kws kho mob txheeb xyuas theem ntawm cov qog noj ntshav, uas yuav qhia koj txoj kev kho mob.

Txhawm rau sim koj qhov CLL, koj tus kws kho mob yuav xaj kuaj ntshav mus kuaj koj lub qe ntshav liab (RBC) suav thiab suav cov ntshav lymphocyte suav. Lawv kuj tseem yuav tshuaj xyuas yog tias koj lub qog ntshav, ntshav lossis lub siab.

Raws li Rai kev faib tawm, CLL yog staged ntawm 0 txog 4. Rai theem 0 CLL yog qhov tsawg tshaj plaws, thaum Rai theem 4 yog qhov ua tau zoo tshaj plaws.

Rau cov hom phiaj kho, cov theem kuj tau muab faib ua pawg uas muaj kev pheej hmoo. Rai theem 0 yog qhov pheej hmoo tsawg, Rai theem 1 thiab 2 yog qhov pheej hmoo nruab nrab, thiab Rai theem 3 thiab 4 muaj kev pheej hmoo siab, piav qhia Cov Neeg Asmeskas Cov Kab Mob Cancer.

Ntawm no yog qee qhov tsos mob CLL ntawm txhua qib:

• Theem 0: theem siab ntawm lymphocytes
• Theem 1: theem siab ntawm lymphocytes; tsam mob txhab ntshav
• Theem 2: theem siab ntawm lymphocytes; cov qog ntshav kuj yuav loj tuaj; tsam raug hnoos qeev; muaj feem mob siab
• theem 3: theem siab ntawm lymphocytes; anemia; cov qog ntshav, qog ntshav, lossis mob siab
• theem 4: theem siab ntawm lymphocytes; cov qog ntshav, qog, lossis daim siab yuav ua kom dav; muaj peev xwm ua tau ntshav; theem qis ntawm platelets

Dab tsi ua rau muaj tus mob CLL, thiab puas muaj kev pheej hmoo txaus rau tus kabmob no?

Cov kws tshaj lij tsis paub meej tias dab tsi ua rau CLL. Txawm li cas los xij, muaj qee qhov kev pheej hmoo uas ua rau ib tus neeg muaj txoj kev txhim kho CLL.

Nov yog qee qhov kev pheej hmoo uas muaj peev xwm los txhawb tus tib neeg txoj kev txhim kho CLL:

• Lub hnub nyoog. CLL tsis tshua pom muaj rau cov neeg muaj hnub nyoog 40 xyoos. Feem ntau ntawm cov mob CLL raug kuaj rau cov neeg muaj hnub nyoog tshaj 50 xyoo. Cov hnub nyoog nruab nrab ntawm cov neeg kuaj mob CLL yog 71.
• Poj niam txiv neej. Nws cuam tshuam rau ntau dua cov txiv neej.
• Haiv Neeg. Nws yog ib txwm muaj rau cov neeg ntawm haiv neeg Lavxias thiab European thiab tsis tshua pom muaj nyob rau hauv cov neeg ntawm cov neeg Esxias sab hnub tuaj thiab cov neeg Esxias yav qab teb.
• Monoclonal B-cell lymphocytosis. Muaj qhov kev pheej hmoo me me uas tus mob no, uas ua rau muaj ntau dua li ib txwm ntawm lymphocytes, tuaj yeem hloov mus rau hauv CLL.
• Ib puag ncig. Tsoomfwv Meskas Lub Tsev Haujlwm Qub Tub Rog Lub Chaw Saib Xyuas muaj feem cuam tshuam nrog Tus Sawv Cev Orange, lub tshuaj siv tshuaj tua rog thaum Nyablaj Tebchaws Nyab Laj, yog qhov muaj kev pheej hmoo rau CLL
• Keeb kwm tsev neeg. Cov neeg uas muaj txheeb ze tam sim nrog kuaj mob CLL muaj qhov pheej hmoo siab dua rau CLL.

Puas muaj lwm yam kev phom sij ntxiv nrog txoj kev kho tau?

Kev siv tshuaj kho kom lub cev tsis muaj zog tiv thaiv koj lub cev, ua rau koj muaj mob kis yooj yim dua. Koj kuj tseem yuav tsim cov qib ntawm cov tshuaj tiv thaiv kab mob ntshav thiab ntshav qis hauv lub cev thaum kho tshuaj.

Lwm yam kev phiv los ntawm kev siv tshuaj kho mob suav nrog:

• nkees
• plaub hau poob
• qhov ncauj tawm
• tsis qab los noj mov
• xeev siab thiab ntuav

Hauv qee kis, kev siv tshuaj kho mob tuaj yeem pab txhawb kev txhim kho ntawm lwm cov qog nqaij hlav.

Kev xoo hluav taws xob, kev hloov ntshav, thiab mob pob txha lossis mob hlab ntsha hauv pob ntawm tes tuaj yeem cuam tshuam nrog kev phiv.

Txhawm rau daws qee yam kev phiv, koj tus kws kho mob yuav sau ntawv:

• IV immunoglobulin
• corticosteroids
• spleen tshem tawm
• cov tshuaj rituximab

Tham nrog koj tus kws kho mob txog qhov kev cia siab uas yuav tshwm sim ntawm koj txoj kev kho mob. Lawv tuaj yeem qhia koj tias cov tsos mob thiab cov kev mob tshwm sim twg xav tau kev kho mob.

Qhov ntev ntawm kev txheeb xyuas qhov tseeb rau CLL yog dab tsi?

Ciaj sia taus feem rau CLL sib txawv. Koj lub hnub nyoog, kev sib deev, kev xoos qog, thiab cov qog nqaij hlav cancer tuaj yeem cuam tshuam koj lub zeem muag ntev. Tus kab mob no tsis tshua kho, tab sis neeg feem coob nyob tau ntau xyoo nrog CLL.

Nug koj tus kws kho mob txog koj kis tshwj xeeb. Lawv tuaj yeem pab koj nkag siab txog koj li mob cancer tau nce mus deb npaum li cas. Lawv kuj tuaj yeem sib tham txog koj cov kev kho mob thiab qhov pom ntawm lub hom phiaj ntev.