Dendritic cells yog dab tsi thiab lawv yog dab tsi rau

Zoo Siab

• Dab tsi tsim nyog rau
• Hom dendritic hlwb
• Lawv yuav pab kho mob cancer tau li cas

Dendritic cells, lossis DC, yog cov qe tsim nyob rau hauv cov pob txha pob txha uas tuaj yeem nrhiav hauv cov ntshav, tawv nqaij thiab lub plab thiab lub plab ua pa, piv txwv, thiab uas yog ib feem ntawm kev tiv thaiv kab mob, ua lub luag haujlwm txhawm rau txheeb xyuas tus mob thiab txhim kho lub cev tiv thaiv kab mob. teb.

Yog li, thaum lub cev tiv thaiv kab mob ua rau muaj kev hem thawj, cov kab mob no tau ua haujlwm kom paub tseeb tias tus neeg kis tau tus kab mob thiab txhawb nws txoj kev tshem tawm. Yog li, yog cov dendritic cells ua haujlwm tsis zoo, lub cev tiv thaiv kab mob muaj teeb meem ntau dua rau kev tiv thaiv lub cev, muaj ntau dua los ntawm kev tsim kab mob lossis mob cancer.

Dab tsi tsim nyog rau

Dendritic cells muaj lub luag haujlwm rau kev ua kom cov kab mob ntxeem tau thiab nthuav tawm cov tshuaj tua kabmob (antigens), uas muaj nyob ntawm nws cov nplaim, rau T lymphocytes, pib ua lub cev tiv thaiv kab mob los tiv thaiv tus kabmob kis, tiv thaiv tus kabmob.

Vim tias qhov tseeb uas lawv ntes thiab nthuav tawm cov tshuaj antigens rau lawv thaj chaw, uas yog qhov chaw ntawm tus neeg sawv cev sib kis, dendritic cells hu ua Antigen-Presenting Cells, lossis APCs.

Ntxiv nrog rau kev txhawb nqa thawj zaug ntawm kev tiv thaiv kab mob ntawm ib tus neeg muaj mob thiab tiv thaiv kev tiv thaiv kab mob hauv lub cev, dendritic hlwb yog qhov tseem ceeb rau kev txhim kho ntawm kev tiv thaiv kev tiv thaiv, uas yog ib qho uas lub hlwb nco tau tsim, tiv thaiv nws los ntawm kev tshwm sim dua lossis hauv txoj kev sib zog. muaj tus kab mob los ntawm tib lub cev.

Nkag siab txog qhov ua haujlwm tiv thaiv kabmob ntawm lub cev ua haujlwm.

Hom dendritic hlwb

Dendritic cells tuaj yeem muab cais ua raws li lawv qhov txav chaw nyob, qhia cov cim ntawm lawv cov nplaim, thaj chaw thiab kev ua haujlwm. Yog li, dendritic cells tuaj yeem muab cais ua ob hom:

• Plasmocytoid dendritic cov hlwb, uas yog nyob rau feem ntau hauv cov ntshav thiab lymphoid plab hnyuv siab raum, piv txwv li hnoos qeev, thymus, mob pob txha thiab cov qog ntshav, piv txwv. Cov kab mob no ua tshwj xeeb tshaj tawm rau cov kab mob thiab, vim lawv lub peev xwm los tsim Interferon alpha thiab beta, uas yog cov protein ua lub luag haujlwm rau cov kev cai ntawm lub cev tiv thaiv kab mob, tseem muaj cov khoom tiv thaiv qog hauv qee kis, ntxiv rau lub peev xwm tiv thaiv kab mob.
• Myeloid dendritic hlwb, uas nyob ntawm daim tawv nqaij, ntshav thiab mucosa. Cov kab mob hauv cov ntshav yog hu ua inflammatory DC, uas tsim TNF-alpha, uas yog ib hom cytokine lub luag haujlwm rau kev tuag ntawm cov qog thiab cov txheej txheem inflammatory. Hauv cov ntaub so ntswg, cov hlwb no yuav raug hu ua interstitial lossis mucosal DC thiab, thaum muaj nyob rau hauv daim tawv nqaij, lawv hu ua Langerhans hlwb lossis cov qog hlwb, txij li tom qab lawv ua haujlwm, lawv khiav los ntawm daim tawv nqaij mus rau lymph nodes, qhov chaw uas lawv nthuav qhia tshuaj antigens. rau T lymphocytes.

Lub hauv paus pib ntawm dendritic cov hlwb tseem tau kawm dav dav, tab sis nws tau txiav txim siab tias nws yuav muaj keeb kwm los ntawm ob qho lymphoid thiab myeloid caj ces. Ib qho ntxiv, nws muaj ob qhov kev xav uas sim piav qhia lub keeb kwm ntawm cov hlwb no:

1. Tej Qauv Yas Muaj Qauv, leej twg txiav txim siab hais tias ntau hom dendritic hlwb sawv cev rau ntau theem ntawm kev loj hlob ntawm ib tus xovtooj ntawm tes, cov haujlwm sib txawv ua tau muaj txiaj ntsig ntawm qhov chaw nyob uas lawv muaj;
2. Tus Qauv Tshwj Xeeb Tus Qauv, leej twg txiav txim siab hais tias ntau hom dendritic hlwb tau los ntawm cov xovtooj ntawm sib txawv, uas yog qhov laj thawj rau cov haujlwm sib txawv.

Nws ntseeg tau tias ob qhov theories muaj lub hauv paus thiab tias nyob hauv kev muaj sia nws muaj peev xwm tias ob qhov theories yuav tshwm sim ib txhij.

Lawv yuav pab kho mob cancer tau li cas

Vim nws lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob thiab muaj peev xwm tswj tau txhua yam txheej txheem ntsig txog kev tiv thaiv kab mob, kev tshawb fawb tau ua tiav nrog lub hom phiaj ntawm kev txheeb xyuas nws cov txiaj ntsig hauv kev kho mob qog noj ntshav, feem ntau yog siv tshuaj tiv thaiv.

Hauv chav kuaj, dendritic cells tau muab tso rau hauv kev sib cuag nrog cov qog ntawm cov qog thiab lawv lub peev xwm tshem tawm cov qog nqaij hlav mob yog tshawb xyuas qhov tseeb. Yog tias nws pom tias cov txiaj ntsig ntawm kev sim ntawm cov qauv sim thiab cov tsiaj muaj txiaj ntsig, nws yog qhov tuaj yeem ua rau kev sim tshuaj tiv thaiv kabmob kheesxaws nrog cov hlwb dendritic yuav ua rau muaj rau cov pejxeem. Txawm hais tias tau cog lus tseg, xav tau kev kawm ntxiv rau kev tsim cov tshuaj tiv thaiv no, nrog rau hom mob cancer uas cov tshuaj tiv thaiv no tuaj yeem tiv thaiv.

Ntxiv nrog rau qhov muaj peev xwm siv tau los tiv thaiv mob qog noj ntshav, daim ntawv thov ntawm dendritic cell tseem tau kawm txog kev kho mob tiv thaiv AIDS thiab systemic sporotrichosis, uas yog cov kab mob loj thiab ua rau lub cev txo qis hauv lub cev. Nov yog qee qhov kev txhim kho thiab ntxiv dag zog rau koj lub cev.