Aimovig (erenumab-aooe)

Zoo Siab

• Aimovig yog dab tsi?
• Ib yam tshiab ntawm cov tshuaj
• Aimovig ntau
• Aimovig phiv
• Ntau cov kev mob tshwm sim
• Cov kev mob tshwm sim hnyav heev
• Kev fab tshuaj tiv thaiv
• Kev yuag poob / qhov hnyav nce
• Lub sij hawm ntev cov teebmeem
• Cem quav
• Cov plaub hau poob lawm
• Xeev siab
• Nkees
• Zawv plab
• Insomnia
• Mob leeg
• Khaus
• Aimovig tus nqi
• Kev pab nyiaj txiag
• Aimovig siv
• Aimovig rau mob taub hau heev
• Kev siv uas tsis pom zoo
• Aimovig ntau npaum
• Cov ntawv thiab lub zog
• Muab kom tsawg rau kev mob taub hau
• Yog tias kuv plam koob tshuaj?
• Kuv puas yuav tau siv cov tshuaj no ntev?
• Xaiv rau Aimovig
• CGRP cov thaiv kev
• Aimovig vs. lwm cov tshuaj
• Aimovig vs Ajovy
• Aimovig vs Botox
• Aimovig vs Emgality
• Aimovig vs Topamax
• Aimovig thiab cawv
• Aimovig kev sib cuam tshuam
• Yuav ua li cas Aimovig yog metabolized
• Cov lus qhia ntawm yuav ua li cas noj Aimovig
• Yuav txhaj li cas
• Sijhawm
• Noj Aimovig nrog zaub mov noj
• Cia
• Aimovig ua haujlwm licas
• Yuav siv sijhawm ntev npaum li cas ua haujlwm?
• Aimovig thiab cev xeeb tub
• Aimovig thiab noj mis
• Cov lus nug uas nquag muaj txog Aimovig
• Siv ceev xwmphem Aimovig ua rau rho tawm?
• Aimovig puas yog roj ntsha?
• Koj puas tuaj yeem siv Aimovig kho qhov mob tob hau?
• Puas yog Aimovig kho mob tob hau?
• Aimovig txawv li cas ntawm lwm cov tshuaj migraine?
• Yog tias kuv noj Aimovig, kuv puas tuaj yeem tsum tsis noj kuv cov tshuaj tiv thaiv lwm tus ntxiv?
• Aimovig overdose
• Tshuav cov tsos mob
• Dab tsi yog qhov ua txhaum cai dhau
• Aimovig cov lus ceeb toom
• Aimovig tas sijhawm thiab cia khoom
• Cov ntaub ntawv tshaj lij rau Aimovig
• Mechanism ntawm kev ua
• Pharmacokinetics thiab cov metabolism
• Cov Yuav Tsum Tau Ua
• Cia

Aimovig yog dab tsi?

Aimovig yog ib hom tshuaj muaj npe rau kev noj tshuaj uas siv los tiv thaiv mob taub hau rau cov neeg laus. Nws los nyob rau hauv ib tug xaum autoinjector cwj mem. Koj siv tus kws tsav tsheb txhawm rau muab tshuaj rau koj tus kheej hauv tsev ib hlis ib zaug. Aimovig tuaj yeem muab rau hauv ib qho ntawm ob koob tshuaj: 70 mg rau ib hlis lossis 140 mg rau ib hlis.

Aimovig muaj cov tshuaj erenumab. Erenumab yog ib qho tshuaj monoclonal antibody, uas yog ib hom tshuaj tsim nyob hauv chav kuaj. Cov tshuaj tiv thaiv monoclonal yog cov tshuaj tsim los ntawm cov tshuaj tiv thaiv kab mob hauv lub cev. Lawv ua haujlwm los ntawm kev thaiv cov kev ua ntawm qee cov protein hauv koj lub cev.

Aimovig tuaj yeem siv los tiv thaiv ob leeg mob taub hau thiab mob tob hau mob taub hau heev. Lub koom haum American Headache xav kom Aimovig rau cov neeg uas:

• tsis tuaj yeem txo lawv tus naj npawb ntawm mob taub hau ib hlis ib zaug txaus nrog lwm cov tshuaj
• tsis tuaj yeem noj lwm yam tshuaj mob taub hau vim muaj kev phiv lossis tshuaj sib cuam tshuam

Aimovig tau pom tias muaj txiaj ntsig zoo hauv kev tshawb fawb. Rau cov neeg muaj mob migraine, ntawm 40 feem pua ​​thiab 50 feem pua ​​ntawm cov neeg uas tau siv Aimovig rau rau lub hlis txiav lawv tus naj npawb ntawm hnub migraine tsawg kawg yog ib nrab. Thiab rau cov neeg muaj mob migraine ntev, kwv yees li 40 feem pua ​​ntawm cov neeg uas tau siv Aimovig txiav lawv cov lej hnub migraine ib nrab lossis ntau dua.

Ib yam tshiab ntawm cov tshuaj

Aimovig yog ib feem ntawm chav kawm tshiab ntawm cov tshuaj noj hu ua calcitonin cov noob ntsig txog peptide (CGRP) antagonists. Hom tshuaj no tau tsim los rau kev tiv thaiv mob taub hau.

Aimovig tau txais kev pom zoo ntawm Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) thaum lub Tsib Hlis 2018. Nws yog thawj cov tshuaj tau pom zoo hauv CGRP chav thaiv kev ntawm cov tshuaj.

Ob qho tshuaj ntxiv rau hauv cov tshuaj no tau pom zoo tom qab Aimovig: Emgality (galcanezumab) thiab Ajovy (fremanezumab). Ib qho tshuaj thib plaub, hu ua eptinezumab, tam sim no tau kawm hauv kev sim tshuaj.

Aimovig ntau

Aimovig tsis muaj nyob rau hauv daim ntawv foos. Nws tsuas yog los ua cov tshuaj uas muaj npe zoo.

Aimovig muaj cov tshuaj erenumab, uas tseem hu ua erenumab-aooe. Qhov xaus ntawm "-aooe" qee zaus ntxiv los qhia tias cov tshuaj noj txawv ntawm cov tshuaj zoo sib xws uas tsim tau yav tom ntej. Lwm cov tshuaj monoclonal antibody kuj tseem muaj npe hom zoo li no.

Aimovig phiv

Aimovig tuaj yeem ua rau mob hnyav los sis mob hnyav. Cov npe hauv qab no muaj qee qhov kev mob tshwm sim thaum yuav noj Aimovig. Daim ntawv teev npe no tsis suav tag nrho cov kev mob tshwm sim.

Yog xav paub ntxiv txog cov kev mob tshwm sim ntawm Aimovig, lossis cov lus qhia txog kev yuav ua li cas nrog cov kev mob tshwm sim, tham nrog koj tus kws kho mob lossis kws muag tshuaj.

Nco tseg: Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) taug qab cov kev phiv los ntawm cov tshuaj uas lawv tau pom zoo. Yog tias koj xav ceeb toom mus rau FDA txog qhov tshwm sim uas koj tau ntsib nrog Aimovig, koj tuaj yeem ua li ntawd dhau ntawm MedWatch.

Ntau cov kev mob tshwm sim

Cov kev mob tshwm sim heev dua ntawm Aimovig tuaj yeem suav nrog:

• Qhov chaw txhaj tshuaj cuam tshuam (liab, khaus ntawm daim tawv nqaij, mob)
• cem quav
• mob leeg
• mob leeg pob txha

Feem ntau ntawm cov kev mob tshwm sim no yuav ploj mus tom qab ob peb hnub lossis ob peb lub lis piam. Hu rau koj tus kws kho mob lossis kws muag tshuaj yog tias koj muaj cov kev mob tshwm sim loj heev los sis cov tshwm sim uas tsis ploj mus.

Cov kev mob tshwm sim hnyav heev

Cov kev mob tshwm sim hnyav los ntawm Aimovig tuaj yeem tshwm sim, tab sis lawv tsis muaj. Qhov mob tshwm sim loj ntawm Aimovig yog kev fab tshuaj tsis haum. Saib hauv qab cov ncauj lus kom ntxaws.

Kev fab tshuaj tiv thaiv

Qee tus neeg muaj kev fab tshuaj tom qab siv Aimovig. Txoj kev xav tiv thaiv zoo li no muaj peev xwm ua tau nrog kev kho mob feem ntau. Cov tsos mob ntawm kev txhaum fab hnyav tuaj yeem suav nrog:

• muaj pob nyob ntawm koj cov tawv nqaij
• hnov khaus
• ua yaug (muaj qhov sov thiab liab nyob hauv koj cov tawv nqaij)

Tsis tshua muaj, kev tsis haum tshua loj dua tuaj yeem tshwm sim. Cov tsos mob ntawm kev txhaum fab hnyav muaj xws li:

• o o ntawm koj cov tawv nqaij (feem ntau hauv koj daim tawv muag, daim di ncauj, tes, lossis ko taw)
• ua pa luv los yog muaj teeb meem ua pa
• muaj o ntawm koj tus nplaig, qhov ncauj, lossis caj pas

Hu rau koj tus kws kho mob tam sim ntawd yog tias koj xav tias koj muaj qhov tsis haum tshuaj loj rau Aimovig. Hu 911 yog tias koj tus mob hnov ​​lub neej tsis zoo lossis yog koj muaj mob kub ntxhov.

Kev yuag poob / qhov hnyav nce

Kev poob phaus thiab kev hnyav tsis qhia nyob rau hauv kev tshawb fawb soj ntsuam ntawm Aimovig. Txawm li cas los xij, qee tus neeg tuaj yeem pom cov kev hloov pauv hauv lawv qhov hnyav thaum kho Aimovig. Qhov no tej zaum yog vim mob taub hau nws tus kheej es tsis yog rau Aimovig.

Qee tus neeg yuav tsis hnov ​​tshaib plab ua ntej, thaum, lossis tom qab mob taub hau. Yog tias qhov no tshwm sim ntau txaus, nws tuaj yeem ua rau kom poob phaus. Yog tias koj poob qab los thaum koj muaj mob taub hau mob taub hau, ua haujlwm nrog koj tus kws kho mob tsim kho phiaj xwm kev noj zaub mov kom paub tseeb tias koj tau txais txhua yam khoom noj uas koj xav tau.

Ntawm lwm qhov kawg ntawm cov spectrum, qhov hnyav nce lossis rog dhau ntawm cov neeg muaj migraine. Thiab cov kev tshawb fawb soj ntsuam pom tau tias kev rog rog tuaj yeem yog qhov phom sij ua kom mob taub hau heev lossis mob taub hau ntau dua.

Yog tias koj txhawj xeeb txog koj qhov hnyav li cas cuam tshuam rau koj kev mob taub hau, nrog koj tus kws kho mob tham txog cov hauv kev los tswj koj qhov hnyav.

Lub sij hawm ntev cov teebmeem

Aimovig yog kev pom zoo tsis ntev los no hauv kev siv tshuaj hauv cov chav kawm tshuaj tshiab. Raws li qhov tshwm sim, muaj kev tshawb nrhiav mus sij hawm ntev me ntsis muaj nyob ntawm Aimovig qhov kev nyab xeeb, thiab paub me ntsis txog nws cov kev cuam tshuam mus ntev.

Hauv ib txoj kev kawm txog kev nyab xeeb mus ntev uas nyob ib puag ncig peb xyoos, feem ntau cov kev mob tshwm sim nrog Aimovig yog:

• rov qab mob
• cov mob ua pa sab sauv (xws li mob khaub thuas lossis mob hauv qhov ntswg)
• cov tsos mob khaub thuas zoo li

Yog tias koj muaj cov kev mob tshwm sim no thiab nws hnyav lossis tsis ploj, nrog koj tus kws kho mob tham.

Cem quav

Cem quav muaj tshwm sim txog li 3 feem pua ​​ntawm cov neeg uas tau siv Aimovig hauv kev tshawb fawb soj ntsuam.

Qhov kev mob tshwm sim no yuav yog vim li cas Aimovig cuam tshuam rau calcitonin ntsig txog peptide gene-ntsig txog (CGRP) hauv koj lub cev. CGRP yog cov protein uas tuaj yeem pom nyob hauv txoj hnyuv thiab lub luag haujlwm ua haujlwm ntawm lub cev li qub. Aimovig thaiv kev ua haujlwm ntawm CGRP, thiab qhov kev txiav txim no tuaj yeem tiv thaiv kev quav ib txwm tsis tshwm sim.

Yog tias koj muaj cem quav thaum kho nrog Aimovig, tham nrog koj tus kws kho mob lossis kws muag tshuaj txog cov kev kho uas yuav pab tau kom zoo.

Cov plaub hau poob lawm

Cov plaub hau poob tsis yog kev phiv los txuas nrog Aimovig. Yog tias koj pom tias koj poob plaub hau, tham nrog koj tus kws kho mob txog cov peev txheej thiab kev kho mob.

Xeev siab

Xeev siab tsis yog kev mob tshwm sim uas tau tshaj tawm nrog kev siv Aimovig. Txawm li cas los xij, ntau tus neeg uas muaj mob taub hau tuaj yeem xav tias xeev siab thaum lub sij hawm mob taub hau me.

Yog tias koj xav tias xeev siab thaum mob taub hau, nws yuav pab nyob hauv chav tsaus nti, ntsiag to, lossis tawm mus sab nraum cov huab cua ntshiab. Koj tseem tuaj yeem nug koj tus kws kho mob lossis kws muag tshuaj txog cov tshuaj uas tuaj yeem pab tiv thaiv lossis kho qhov xeev siab.

Nkees

Qaug zog (tsis muaj lub zog) tsis yog lub txiaj ntsig uas tau cuam tshuam nrog Aimovig. Tab sis mloog zoo li nkees yog cov tsos mob tshwm sim ntawm migraine uas ntau tus neeg hnov ​​ua ntej, thaum, lossis tom qab mob taub hau tshwm sim.

Ib txoj kev tshawb nrhiav pom tau hais tias cov neeg mob taub hau uas mob taub hau ntau dua yuav ua rau lub cev qaug zog.

Yog tias koj muaj mob siab rau nkees, tham nrog koj tus kws kho mob txog cov hau kev los txhim kho koj cov zog ntau ntau.

Zawv plab

Qhov raws plab tsis yog qhov tshwm sim uas tau qhia tawm nrog kev siv Aimovig. Txawm li cas los xij, nws yog ib qho tshwm sim tsawg kawg ntawm kev mob taub hau. Tej zaum yuav muaj qhov txuas ntawm mob taub hau thiab mob plab hnyuv thiab lwm yam mob plab hnyuv.

Yog tias koj muaj mob raws plab uas ua ntev dua li ob peb hnub, nrog koj tus kws kho mob tham.

Insomnia

Insomnia (teeb meem tsaug zog) tsis yog phiv uas tau pom nyob rau hauv kev tshawb fawb soj ntsuam ntawm Aimovig. Txawm li cas los xij, ib qhov kev tshawb fawb soj ntsuam pom tias cov neeg mob taub hau uas muaj insomnia zoo li yuav muaj kev mob taub hau ntau dua. Qhov tseeb, tsis muaj kev pw tsaug zog yuav yog qhov ua rau mob tob hau thiab ua rau muaj kev pheej hmoo ntawm kev tsim mob mob taub hau ntev.

Yog tias koj muaj mob insomnia thiab xav tias nws yuav muaj kev cuam tshuam rau koj kev mob taub hau, nrog koj tus kws kho mob tham txog yuav ua kom pw tsaug zog zoo dua.

Mob leeg

Hauv cov kev tshawb fawb soj ntsuam, cov neeg uas tau txais Aimovig tsis hnov ​​mob nqaij pob txha li. Qee tus tau mob leeg nqaij thiab pob ib ce, thiab hauv kev tshawb fawb txog kev nyab xeeb ntev, cov neeg noj Aimovig hnov ​​mob nraub qaum.

Yog tias koj muaj mob leeg thaum noj Aimovig, nws yuav yog vim lwm yam ua. Piv txwv, mob leeg hauv caj dab tuaj yeem yog cov tsos mob ntawm migraine rau qee tus neeg. Kuj, qhov kev txhaj tshuaj ntawm thaj chaw, suav nrog qhov mob ntawm thaj tsam ib ncig ntawm kev txhaj tshuaj, tuaj yeem xav qhov mob leeg. Hom mob no yuav tsum ploj mus li ntawm ob peb hnub ntawm kev txhaj tshuaj.

Yog tias koj mob leeg uas tsis ploj lossis cuam tshuam rau koj lub neej zoo, tham nrog koj tus kws kho mob txog cov kev xaiv ua kom tsis txhob mob.

Khaus

Cov pob khaus khaus tsis yog kev mob tshwm sim uas tau pom hauv kev tshawb fawb soj ntsuam ntawm Aimovig. Txawm li cas los xij, cov tawv nqaij khaus nyob rau thaj chaw uas Aimovig tau txhaj tshuaj yog ib txwm qhia ntau.

Cov tawv nqaij khaus nyob ze ntawm thaj chaw txhaj tshuaj yuav tsum ploj mus li ntawm ob peb hnub. Yog koj muaj khaus khaus es nws tsis tas li, lossis yog tias qhov khaus khaus ntawd yog mob hnyav, tham nrog koj tus kws kho mob.

Aimovig tus nqi

Ib yam li txhua yam tshuaj, cov nqi rau Aimovig tuaj yeem sib txawv.

Koj tus nqi yuav yog nyob ntawm koj cov nyiaj pov hwm, koj qhov chaw nyob, thiab lub tsev muag tshuaj uas koj tau siv.

Kev pab nyiaj txiag

Yog tias koj xav tau kev txhawb nqa nyiaj txiag los them rau Aimovig, kev pabcuam yeej muaj.

Amgen thiab Novartis, cov tuam txhab tsim khoom ntawm Aimovig, muaj qhov kev pabcuam Aimovig Ally Access Card uas tuaj yeem pab koj them tsawg dua rau txhua daim ntawv yuav tshuaj. Yog xav paub cov ntaub ntawv ntau ntxiv thiab saib seb koj puas tsim nyog tau txais, hu 833-246-6844 lossis mus saib lub vev xaib website.

Aimovig siv

Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) tau pom zoo rau cov tshuaj xws li Aimovig kho lossis tiv thaiv qee yam mob.

Aimovig rau mob taub hau heev

Aimovig yog FDA-pom zoo rau kev tiv thaiv mob taub hau rau cov neeg laus. Cov mob taub hau hnyav no yog cov tsos mob feem ntau ntawm tus mob migraine, uas yog tus mob neurological.

Lwm cov tsos mob tuaj yeem tshwm sim nrog mob taub hau, xws li:

• xeev siab
• ntuav
• rhiab nkag mus rau lub teeb thiab suab
• teeb meem hais lus

Mob taub hau tuaj yeem tau muab cais ua ntu lossis mob nyhav, raws li International Headache Society. Aimovig tau txais kev pom zoo txhawm rau txhawm rau txhawm rau txhawm rau mob tob tob thiab mob tob hau mob taub hau heev. Qhov sib txawv ntawm cov mob migraine no yog:

• kev mob taub hau episodic ua rau muaj tsawg dua 15 mob taub hau lossis mob taub hau ib hnub nyob rau ib hlis
• mob taub hau ntev ua rau 15 lossis ntau dua mob taub hau ib hlis nyob rau ib lub sijhawm tsawg kawg peb lub hlis, tsawg kawg yog yim ntawm hnub nyob rau hnub migraine

Kev siv uas tsis pom zoo

Aimovig kuj tseem siv tau daim ntawv lo-off rau lwm yam mob. Kev siv tshuaj tua (label-label) yog thaum siv tshuaj uas raug pom zoo los kho ib yam mob yog tsim los kho ib yam mob.

Aimovig rau pawg ua si tob hau

Aimovig tsis tau pom zoo los ntawm FDA los tiv thaiv kev mob taub hau, tab sis nws yuav siv cov ntawv no rau lub hom phiaj no. Tamsis no nws tseem tsis tau paub yog tias Aimovig siv tau rau ntawm kev tiv thaiv mob taub hau.

Cluster mob taub hau yog mob mob taub hau uas tshwm sim hauv tej pawg ua ke (ntau mob taub hau ntev ib ntus). Lawv tuaj yeem yog mob ntu lossis mob ntev. Qaug mob taub hau mob taub hau tau ntev dua lub sijhawm ntawm pawg ntawm mob taub hau. Mob taub hau ntev tau ua ntu luv ntawm pawg mob taub hau.

Aimovig tsis tau soj ntsuam rau kev tiv thaiv pawg mob taub hau hauv cov kev tshawb fawb soj ntsuam. Txawm li cas los xij, lwm yam tshuaj uas zwm rau tib chav tshuaj uas yog Aimovig, suav nrog Emgality thiab Ajovy, tau sim.

Hauv ib qhov kev tshawb fawb soj ntsuam, Emgality tau pom los pab tiv thaiv kev mob taub hau pawg. Tab sis kev sim tshuaj ntawm Ajovy, cov chaw tsim tshuaj paus nres qhov kev kawm ntxov vim tias Ajovy tsis ua haujlwm kom txo tsawg cov mob taub hau mob rau cov neeg hauv txoj kev tshawb no.

Aimovig rau mob taub hau vestibular

Aimovig tsis pom zoo FDA tsis pom zoo tiv thaiv lossis kho kev mob taub hau. Vestibular mob taub hau txawv ntawm classic mob taub hau mob taub hau vim tias lawv feem ntau tsis mob. Cov neeg uas muaj mob taub hau me me tuaj yeem hnov ​​kiv tob hau lossis hnov ​​tus yees. Cov tsos mob no tuaj yeem siv sijhawm ntev mus rau ntau teev.

Cov kev tshawb fawb soj ntsuam tsis tau ua tiav los qhia yog tias Aimovig ua tau zoo ntawm kev tiv thaiv lossis kho mob taub hau vestibular. Tab sis qee tus kws kho mob tseem yuav xaiv ua lub npe tshuaj noj rau ntawm tus mob no.

Aimovig ntau npaum

Qhov Aimovig ntau npaum koj tus kws kho mob sau yuav yog nyob ntawm ntau yam. Cov no suav nrog qhov mob hnyav ntawm cov mob uas koj tau siv Aimovig kho.

Feem ntau, koj tus kws kho mob yuav pib koj li qhov noj tsawg kawg thiab kho nws kom dhau sijhawm mus cuag cov tshuaj uas haum rau koj. Lawv kawg yuav tsum tau muab qhov kev noj tshuaj tsawg tshaj plaws uas muab rau yam xav tau.

Cov ntaub ntawv hauv qab no piav qhia ntau npaum li cas cov tshuaj uas feem ntau siv los yog ua kom siv. Txawm li cas los xij, nco ntsoov siv qhov ntau npaum koj tus kws kho mob sau rau koj. Koj tus kws kho mob yuav txiav txim siab muab qhov zoo tshaj plaws kom haum koj cov kev xav tau.

Cov ntawv thiab lub zog

Aimovig yog los ntawm kev txhaj ib koob tshuaj, cov kws kho mob pib txhaj tshuaj uas tau siv los txhaj tshuaj subcutaneous (kev txhaj tshuaj uas nkag hauv qab daim tawv). Tus kws kho tsheb tuaj hauv ib lub zog: 70 mg rau ib koob. Txhua tus tsav tsheb txhais tau tias siv ib zaug nkaus xwb ces muab pov tseg.

Muab kom tsawg rau kev mob taub hau

Aimovig tuaj yeem muab tshuaj rau ob koob: 70 mg lossis 140 mg. Ib koob tshuaj twg ib hlis ib zaug.

Yog tias koj tus kws kho mob tau sau ntawv li 70 mg, koj yuav muab koj tus kheej txhaj ib hlis ib zaug (siv ib tus kws kho mob lub cev). Yog tias koj tus kws kho mob tau sau 140 mg, koj yuav tau txhaj tshuaj rau koj tus kheej ob hlis ib zaug, ib zaug ntxiv tom qab sib ntxiv (siv ob lub tshuaj kho tsheb).

Koj tus kws kho mob yuav pib kho koj li 70 mg rau ib hlis. Yog tias qhov tshuaj no tsis txo koj cov hnub migraine ntau txaus, koj tus kws kho mob yuav nce koj qhov ntau npaum rau 140 mg rau ib hlis.

Yog tias kuv plam koob tshuaj?

Noj tshuaj kom sai li sai tau thaum koj paub tias koj ploj lawm. Koj cov koob tshuaj txuas ntxiv yuav tsum yog ib hlis tom qab txhaj koob tshuaj ntawd. Nco ntsoov hnub tim tshiab yog li koj tuaj yeem npaj rau koj cov koob tshuaj tom ntej.

Kuv puas yuav tau siv cov tshuaj no ntev?

Yog tias Aimovig siv tau zoo los tiv thaiv kev mob taub hau rau koj, koj thiab koj tus kws kho mob yuav txiav txim siab txuas ntxiv kev kho mob nrog Aimovig ntev.

Xaiv rau Aimovig

Muaj lwm yam tshuaj rau siv los pab tiv thaiv mob tob hau. Qee tus kuj ua haujlwm zoo dua rau koj dua li lwm tus. Yog tias koj xav ua qhov kev kho mob uas tsis yog Aimovig, tham nrog koj tus kws kho mob kom paub ntxiv txog lwm cov tshuaj uas yuav ua haujlwm zoo rau koj.

Piv txwv ntawm lwm cov tshuaj uas FDA pom zoo rau kev tiv thaiv mob taub hau xws li:

• lwm cov calcitonin cov noob-hais txog peptide (CGRP) antagonists:
• fremanezumab-vrfm (Ajovy)
• galcanezumab-gnlm (Emgality)
• qee yam tshuaj chua leeg, xws li:
• divalproex sodium (Depakote)
• cov tshuaj topiaxate (Topamax, Trokendi XR)
• cov neurotoxin onabotulinumtoxinA (Botox)
• cov beta-blocker propranolol (Inderal, Inderal LA)

Qee cov tshuaj siv tawm ntawm daim ntawv lo txhawm rau tiv thaiv mob taub hau mob taub hau. Cov tshuaj no suav nrog:

• qee cov tshuaj tiv thaiv kev kub ntxhov, xws li amitriptyline lossis venlafaxine (Effexor XR)
• qee qhov qaug dab peg tshuaj, xws li valproate sodium
• qee qhov beta-blockers, xws li metoprolol (Lopressor, Toprol XL) lossis atenolol (Tenormin)

CGRP cov thaiv kev

Aimovig yog ib feem ntawm cov chav kawm tshiab hauv cov tshuaj hu ua calcitonin gene-ntsig txog peptide (CGRP) antagonists. Aimovig tau pom zoo los ntawm FDA xyoo 2018 txhawm rau tiv thaiv mob taub hau. Ob lwm lwm tus neeg lub cev tiv thaiv CGRP hu ua Ajovy thiab Emgality kuj tau pom zoo tsis ntev los no. Ib qho tshuaj thib plaub hauv cov hoob no (eptinezumab) yuav tsum pom zoo sai sai.

Lawv ua haujlwm li cas

Kev pom zoo rau CGRP kev thaiv kev ua haujlwm ua haujlwm zoo sib xws los tiv thaiv kev mob taub hau.

CGRP yog cov protein nyob hauv koj lub cev uas tau txuas rau kev mob thiab mob ntsws (nthuav dav ntawm cov hlab ntshav) hauv lub hlwb. Qhov mob no thiab vasodilation tuaj yeem ua rau mob mob los ntawm mob taub hau. Txhawm rau ua rau cov teebmeem no, CGRP yuav tsum khi (txuas) rau nws cov receptors, uas yog cov chaw nyob rau qee qhov ntawm koj lub hlwb hlwb.

Ajovy thiab Emgality ob leeg ua haujlwm los ntawm khi rau CGRP nws tus kheej. Yog li ntawd, CGRP tsis tuaj yeem khi rau nws cov neeg txais. Tsis zoo li lwm qhov tshuaj nyob hauv chav kawm no, Aimovig ua haujlwm los ntawm kev khi rau lub hlwb ntawm tes txais. Qhov no thaiv cov CGRP los ntawm kev ua qhov no.

Los ntawm kev thaiv CGRP los ntawm kev cuam tshuam nrog nws cov receptor, tag nrho peb cov tshuaj yuav pab kom tsis txhob muaj mob thiab vasodilation. Qhov no tuaj yeem pab tiv thaiv mob tob hau.

Sab ua ke

Daim duab hauv qab no muab sib piv cov ntsiab lus hais txog peb FDA kev pom zoo tshuaj hauv chav kawm no uas siv los tiv thaiv mob taub hau. Yog xav paub ntxiv txog yuav ua li cas Aimovig piv nrog lwm cov tshuaj no, saib sab lus nram qab no (“Aimovig thiab lwm cov tshuaj”).

* Cov nqi tuaj yeem sib txawv raws li koj qhov chaw nyob, lub tsev muag tshuaj tau siv, koj cov nyiaj tuav pov hwm, thiab cov phiaj xwm kev pab tsim khoom.

Aimovig vs. lwm cov tshuaj

Koj tuaj yeem xav paub yuav ua li cas Aimovig piv rau lwm cov tshuaj uas tau sau tseg rau kev siv zoo sib xws. Hauv qab no yog cov sib piv ntawm Aimovig thiab ntau yam tshuaj noj.

Aimovig vs Ajovy

Aimovig muaj cov tshuaj erenumab, uas yog lub tshuaj tiv thaiv monoclonal. Ajovy muaj cov tshuaj fremanezumab, uas tseem yog lub npe tshuaj monoclonal. Cov tshuaj tiv thaiv monoclonal yog cov tshuaj tsim nyob hauv ib chav kuaj. Cov tshuaj no yog tsim los ntawm cov tshuaj tiv thaiv kab mob hauv lub cev. Lawv ua haujlwm los ntawm kev thaiv cov kev ua ntawm qee cov protein hauv koj lub cev.

Aimovig thiab Ajovy ob leeg nres qhov kev ua haujlwm ntawm cov protein hu ua calcitonin gene-ntsig txog peptide (CGRP). CGRP ua rau mob o thiab txhaws (nthuav dav hlab ntsha) hauv lub hlwb, uas tuaj yeem ua rau mob taub hau me. Thaiv cov hlab ntsws CGRP pab tiv thaiv mob taub hau heev.

Kev Siv

Aimovig thiab Ajovy ob leeg tau pom zoo FDA-pom zoo tiv thaiv kev mob taub hau rau cov neeg laus.

Cov ntawv thiab cov thawj coj

Aimovig thiab Ajovy ob leeg tuaj txog hauv daim ntawv txhaj tshuaj uas tau siv hauv qab koj cov tawv nqaij (tawv nqaij). Koj tuaj yeem muab kev txhaj tshuaj rau koj tus kheej hauv tsev. Ob yam tshuaj tuaj yeem hno tshuaj rau tus kheej ntawm qee qhov chaw, xws li:

• koj lub plab
• sab xub ntiag ntawm koj tus ncej puab
• sab nraub qaum koj sab caj npab

Aimovig yog xa khoom raws li qhov kev txhaj tshuaj ib zaug xwb prefilled autoinjector. Feem ntau nws muab 70-mg txhaj ib hlis ib zaug. Txawm li cas los xij, qee tus neeg tau raug muab tshuaj ntau dua 140 mg txhua hli.

Ajovy tau muab los ua qhov koob txhaj ib koob xav tau ib zaug. Nws tuaj yeem raug muab txhaj ib zaug nrog 225 mg ib hlis ib zaug. Lossis nws tuaj yeem raug muab raws li peb koob tshuaj 225 mg ib zaug txhua txhua peb lub hlis.

Phiv thiab txaus ntshai

Aimovig thiab Ajovy ua haujlwm zoo sib xws thiab ua rau muaj qee qhov kev phiv tib yam. Cov tshwm sim uas ib txwm muaj thiab loj heev ntawm ob cov tshuaj hauv qab no.

Ntau cov kev mob tshwm sim

Cov npe no muaj cov piv txwv ntawm ntau cov kev mob tshwm sim uas tuaj yeem tshwm sim nrog Aimovig, nrog Ajovy, lossis nrog ob qho tshuaj (thaum noj ib leeg).

• Yuav tshwm sim nrog Aimovig:
• cem quav
• mob pob ntseg los yog txha nqaj qaum
• kis mob sab saud (xws li mob khaub thuas lossis mob hauv cov hlab ntshav)
• cov tsos mob khaub thuas zoo li
• rov qab mob
• Yuav tshwm sim nrog Ajovy:
• tsis muaj cov kev mob tshwm sim tshwj xeeb
• Yuav tshwm sim nrog ob Aimovig thiab Ajovy:
• Kev txhaj tshuaj ntawm thaj chaw xws li mob, khaus, lossis liab

Cov kev mob tshwm sim hnyav heev

Qhov tshwm sim loj rau ob qho Aimovig thiab Ajovy yog kev fab tshuaj tsis haum. Qhov kev tawm tsam no tsis yog ib txwm muaj, tab sis nws muaj peev xwm ua tau. (Yog xav paub ntxiv, saib "Kev tsis haum tshuaj" raws li "Aimovig phiv" saum toj).

Kev siv tshuaj tiv thaiv

Hauv kev soj ntsuam sim ua rau ob qho tib si Aimovig thiab Ajovy, muaj qee leej neeg muaj cov tshuaj tiv thaiv tsis haum cov tshuaj. Cov tshuaj tiv thaiv ua rau lawv lub cev tsim cov tshuaj tiv thaiv kev tawm tsam cov tshuaj.

Cov tshuaj tua kab mob yog cov protein ua los ntawm lub cev tiv thaiv kab mob mus tua cov tshuaj txawv teb chaws hauv koj lub cev. Koj lub cev tuaj yeem txhim kho cov tshuaj tiv thaiv rau ib qho tshuaj txawv teb chaws, suav nrog cov tshuaj tiv thaiv monoclonal. Yog tias koj lub cev ua cov tshuaj tiv thaiv rau Aimovig lossis Ajovy, cov tshuaj yuav tsis ua haujlwm rau koj ntxiv lawm.

Hauv kev sim kho mob rau Aimovig, ntau dua 6 feem pua ​​ntawm tib neeg tsim cov tshuaj tiv thaiv rau cov tshuaj. Hauv cov kev tshawb fawb soj ntsuam tsis tu ncua, tsawg dua 2 feem pua ​​ntawm tib neeg tsim cov tshuaj tiv thaiv rau Ajovy.

Vim tias Aimovig thiab Ajovy tau pom zoo rau xyoo 2018, nws tseem ntxov dhau los paub txog cov teebmeem no yuav cuam tshuam licas thiab nws yuav cuam tshuam li cas rau tib neeg siv cov tshuaj no rau yav tom ntej.

Txij nkawm

Aimovig thiab Ajovy puav leej muaj txiaj ntsig zoo rau kev tiv thaiv kev mob taub hau, tab sis lawv tsis tau muab piv rau hauv kev sim tshuaj.

Txawm li cas los xij, kev qhia txog kev kho mob rau mob taub hau pom zoo tias ib qho tshuaj yog qhov kev xaiv rau qee tus neeg. Cov no suav cov neeg uas:

• tsis tuaj yeem txo lawv lub hli ib hnub zuj zus txaus nrog lwm yam tshuaj
• tsis tuaj yeem zam lwm cov tshuaj vim muaj kev phiv los sis cuam tshuam nrog kev siv yeeb tshuaj

Kev mob taub hau ntu

Kev tshawb fawb sib txawv ntawm Aimovig thiab Ajovy pom tias muaj txiaj ntsig zoo rau kev tiv thaiv mob taub hau mob taub hau mob ib ce.

• Hauv cov kev tshawb fawb soj ntsuam ntawm Aimovig, kwv yees li 40 feem pua ​​ntawm cov neeg muaj mob pob qij txha uas tau txais 70 mg ntawm cov tshuaj txhua hli txiav lawv cov hnub migraine tsawg kawg yog ib nrab dhau rau lub hlis. Txog li 50 feem pua ​​ntawm cov neeg uas tau txais 140 mg muaj cov txiaj ntsig zoo sib xws.
• Hauv kev soj ntsuam kev soj ntsuam ntawm Ajovy, nyob ib ncig ntawm 48 feem pua ​​ntawm cov neeg muaj mob pob qij txha uas tau txais kev kho mob txhua hli nrog cov tshuaj txiav lawv cov hnub migraine tsawg kawg yog ib nrab dhau peb lub hlis. Kwv yees li 44 feem pua ​​ntawm cov neeg uas tau txais Ajovy txhua peb lub hlis puav leej muaj cov txiaj ntsig zoo sib xws.

Mob taub hau ntev

Cov kev tshawb fawb sib txawv ntawm Aimovig thiab Ajovy kuj qhia tau tias muaj txiaj ntsig zoo rau kev tiv thaiv kev mob taub hau ntev.

• Hauv kev tshawb nrhiav 3 lub hlis ntawm Aimovig, kwv yees li 40 feem pua ​​ntawm cov neeg muaj mob migraine uas tau txais 70 mg lossis 140 mg ntawm cov tshuaj txhua hli muaj ib nrab ntawm ntau hnub migraine lossis tsawg dua.
• Hauv kev tshawb nrhiav peb lub hlis dhau los ntawm Ajovy, yuav luag 41 feem pua ​​ntawm cov neeg muaj mob migraine uas tau txais kev kho txhua hli Ajovy muaj ib nrab ntau hnub migraine hnub tom qab kho lossis tsawg dua. Ntawm cov neeg uas tau txais Ajovy txhua peb lub hlis, nyob ib ncig ntawm 37 feem pua ​​muaj cov qhab nia zoo sib xws.

Cov nqi

Aimovig thiab Ajovy yog ob lub npe tshuaj noj tshuaj pab. Nws tsis muaj cov ntawv sau npe ib txwm siv ntawm ib qho tshuaj twg. Cov tshuaj muaj npe lag luam feem ntau raug nqi dua cov ntawv sau ntau dua.

Raws li kev kwv yees los ntawm GoodRx.com, Aimovig thiab Ajovy raug nqi ib yam li tus nqi. Tus nqi tiag uas koj yuav them rau ib qho tshuaj twg yog nyob ntawm koj qhov kev fajseeb khomob, koj qhov chaw nyob, thiab lub tsev muag tshuaj uas koj siv. Koj tus nqi rau Aimovig kuj yuav yog nyob ntawm koj cov koob tshuaj.

Aimovig vs Botox

Aimovig muaj cov monoclonal antibody hu ua erenumab. Ib qho tshuaj tiv thaiv monoclonal yog ib hom tshuaj tsim nyob hauv chav kuaj. Cov tshuaj no yog tsim los ntawm cov tshuaj tiv thaiv kab mob hauv lub cev. Aimovig ua haujlwm tiv thaiv kev mob taub hau los ntawm kev thaiv cov haujlwm ntawm cov protein tshwj xeeb uas tuaj yeem ua rau lawv.

Botox muaj cov tshuaj onabotulinumtoxinA. Cov tshuaj no zwm rau hauv ib chav kawm ntawm cov tshuaj hu ua neurotoxins. Botox ua haujlwm los txhawm rau txhawm rau txhawm rau cov leeg nqaij uas nws tau txhaj rau. Cov nyhuv no tiv thaiv qhov taw qhia mob hauv cov leeg mob los ntawm kev ua haujlwm.Nws tau xav tias qhov txheej txheem no pab tiv thaiv kev mob taub hau ua ntej lawv pib.

Kev Siv

Aimovig tau txais kev pom zoo los ntawm FDA los tiv thaiv kev mob taub hau lossis mob tob hau mob taub hau rau cov neeg laus.

Botox yog FDA pom zoo kom tiv thaiv mob tob hau mob taub hau rau cov neeg laus. Botox kuj tseem pom zoo kom kho ob peb lwm yam mob, xws li:

• ncauj tsev menyuam dystonia (mob caj dab sib heev)
• daim tawv muag daj sib deev
• qhov muag tsis pom tseeb
• leeg txha caj
• tawm hws ntau dhau

Cov ntawv thiab cov thawj coj

Aimovig ua li uas ib leeg ib zaug xwb prefilled autoinjector. Nws tau muab raws li kev txhaj tshuaj hauv qab koj cov tawv nqaij (subcutaneous) uas koj tuaj yeem muab koj tus kheej hauv tsev. Nws tau muab rau ntawm koob tshuaj 70 mg lossis 140 mg rau ib hlis.

Aimovig tuaj yeem raug txhaj nyob hauv qee qhov ntawm lub cev. Cov no yog:

• koj lub plab
• sab xub ntiag ntawm koj tus ncej puab
• sab nraub qaum koj sab caj npab

Botox tsuas yog muab rau hauv kws kho mob lub chaw ua haujlwm. Nws tau txhaj cov koob txhaj tshuaj rau hauv cov leeg nqaij (intramuscular), feem ntau txhua 12 asthiv. Cov chaw ib txwm siv rau kev txhaj tshuaj suav nrog:

• koj lub hauv pliaj
• sab nraub qaum koj lub caj dab thiab xwb pwg
• saum toj thiab ze koj lub pob ntseg
• ze rau koj cov plaub hau tom qab ntawm koj lub caj dab

Koj tus kws kho mob feem ntau yuav muab 31 koob tshuaj rau koj nyob rau txhua zaus uas koj mus ntsib lawv.

Phiv thiab txaus ntshai

Aimovig thiab Botox yog ob leeg siv los tiv thaiv kev mob taub hau, tab sis lawv ua haujlwm sib txawv. Yog li ntawd, lawv muaj qee qhov tshwm sim zoo sib xws thiab qee qhov sib txawv.

Ntau cov kev mob tshwm sim

Cov npe no muaj cov piv txwv ntawm cov kev mob tshwm sim loj uas tuaj yeem tshwm sim nrog Aimovig, nrog Botox, lossis nrog ob qho tshuaj (thaum noj ib leeg).

• Yuav tshwm sim nrog Aimovig:
• cem quav
• mob leeg
• cov leeg pob txha mus los
• rov qab mob
• kis mob sab saud (xws li mob khaub thuas lossis mob hauv cov hlab ntshav)
• Muaj peev xwm tshwm sim nrog Botox:
• mob taub hau lossis loj zuj zus tuaj
• tawv muag droop
• lub ntsej muag cov leeg tuag tes tuag taw
• caj dab mob
• leeg khov kho
• leeg mob thiab tsis muaj zog
• Yuav tshwm sim nrog ob leeg Aimovig thiab Botox:
• qhov chaw txhaj tshuaj tiv thaiv
• cov tsos mob khaub thuas zoo li

Cov kev mob tshwm sim hnyav heev

Cov npe no muaj cov piv txwv ntawm cov kev mob tshwm sim loj uas tuaj yeem tshwm sim nrog Aimovig, nrog Botox, lossis nrog ob qho tshuaj (thaum noj ib leeg).

• Yuav tshwm sim nrog Aimovig:
• ob peb yam kev phiv loj heev
• Muaj peev xwm tshwm sim nrog Botox:
• kis tuag tes tuag taw rau cov leeg ze ze *
• muaj teeb meem nqos thiab ua pa
• loj kis kab mob
• Yuav tshwm sim nrog ob leeg Aimovig thiab Botox:
• kev fab tshuaj hnyav heev

* Botox muaj lub thawv ceeb toom los ntawm FDA rau kev kis mob tuag tes tuag taw rau cov leeg ze ze tom qab txhaj tshuaj. Lub thawv ceeb toom yog qhov kev ceeb toom zoo tshaj plaws ntawm FDA tau hais. Nws ceeb toom cov kws kho mob thiab cov neeg mob txog tshuaj phiv uas tuaj yeem tsim kev puas tsuaj.

Txij nkawm

Tib qho xwm txheej uas ob leeg Aimovig thiab Botox siv los tiv thaiv yog mob tob hau mob taub hau heev.

Cov txheej txheem ntawm kev kho mob pom zoo kom Aimovig ua qhov kev xaiv rau cov neeg uas tsis tuaj yeem txo lawv tus naj npawb hnub so txaus nrog rau lwm cov tshuaj. Nws kuj tseem raug pom zoo rau cov neeg uas tsis tuaj yeem siv lwm cov tshuaj vim tias muaj kev phiv lossis cuam tshuam nrog tshuaj.

Botox tau pom zoo los ntawm American Academy of Neurology yog ib txoj kev xaiv rau kev kho mob rau cov neeg muaj kev mob taub hau heev.

Qhov ua tau zoo ntawm cov tshuaj tsis tau raug muab piv rau hauv kev tshawb nrhiav. Txawm li cas los xij, hauv kev tshawb fawb cais, Aimovig thiab Botox ob leeg ua tiav cov txiaj ntsig zoo hauv kev tiv thaiv mob tob hau mob taub hau.

• Hauv kev tshawb fawb txog Aimovig, kwv yees li 40 feem pua ​​ntawm cov neeg muaj mob migraine uas tau txais 70 mg lossis 140 mg muaj ib nrab ntau hnub migraine lossis tsawg dua tom qab peb lub hlis.
• Hauv kev tshawb fawb soj ntsuam ntawm cov neeg muaj kev mob taub hau ntau, Botox txo cov hnub mob taub hau txog 9.2 hnub nyob rau nruab nrab ib hlis, dhau 24 lub lis piam. Hauv lwm qhov kev tshawb fawb, kwv yees li 47 feem pua ​​ntawm cov neeg txo qis lawv cov hnub mob taub hau tsawg kawg ib nrab.

Cov nqi

Aimovig thiab Botox yog ob hom tshuaj uas nrov npe. Tam sim no tsis muaj cov ntawv sau rau ib qho ntawm cov tshuaj.

Raws li kev kwv yees los ntawm GoodRx.com, Botox feem ntau tsis tshua kim dua li Aimovig. Tus nqi tiag uas koj yuav them rau ib qho tshuaj twg yog nyob ntawm koj qhov koob tshuaj, kev tuav pov hwm, koj qhov chaw nyob, thiab lub tsev muag tshuaj uas koj siv.

Aimovig vs Emgality

Aimovig muaj cov monoclonal antibody hu ua erenumab. Emgality muaj cov monoclonal antibody hu ua galcanezumab. Ib qho tshuaj tiv thaiv monoclonal yog ib hom tshuaj tsim nyob hauv chav kuaj. Cov tshuaj no yog tsim los ntawm cov tshuaj tiv thaiv kab mob hauv lub cev. Lawv ua haujlwm los ntawm kev thaiv cov kev ua ntawm cov protein tshwj xeeb hauv koj lub cev.

Aimovig thiab Emgality ob leeg thaiv cov kev ua haujlwm ntawm cov protein hauv koj lub cev hu ua calcitonin gene-ntsig txog peptide (CGRP). CGRP ua rau mob o thiab txhaws pa (nthuav dav hlab ntsha) hauv lub hlwb, uas tuaj yeem ua rau mob tob hau mob taub hau. Los ntawm kev thaiv cov haujlwm ntawm CGRP, cov tshuaj no pab ua kom tsis txhob muaj nqaij thiab mob ntsws. Qhov no yuav pab tiv thaiv mob taub hau.

Kev Siv

Aimovig thiab Emgality yog ob leeg FDA-pom zoo tiv thaiv kev mob taub hau rau cov neeg laus.

Cov ntawv thiab cov thawj coj

Aimovig yog khoom hauv ib koob tshuaj prefilled autoinjector. Emgality yog txhaj rau hauv ib koob tshuaj prefilled koob tshuaj thiab ib zaug-muab xaum. Ob qho tshuaj noj yog muab raws li kev txhaj tshuaj hauv qab (qhov kev txhaj tshuaj hauv qab daim tawv). Koj tuaj yeem muab tshuaj rau koj tus kheej hauv tsev ib hlis ib zaug.

Ob qho tshuaj yuav tuaj yeem raug hno hauv qab daim tawv nqaij ntawm qee qhov chaw hauv koj lub cev. Cov no yog:

• koj lub plab
• sab xub ntiag ntawm koj tus ncej puab
• sab nraub qaum koj sab caj npab

Emgality tseem tuaj yeem raug hno hauv qab daim tawv nqaij ntawm koj lub pob tw.

Aimovig raug tshuaj yog 70-mg lossis 140-mg ib hlis ib zaug. Emgality tau raug muab txhaj raws li 120-mg txhaj ib hlis ib zaug.

Phiv thiab txaus ntshai

Aimovig thiab Emgality yog cov tshuaj zoo sib xws uas ua rau qee qhov zoo ib yam thiab muaj kev phiv loj heev. Hauv qab no yog cov piv txwv ntawm cov kev mob tshwm sim no.

Ntau cov kev mob tshwm sim

Cov npe no muaj cov piv txwv ntawm cov kev mob tshwm sim uas yuav tshwm sim nrog Aimovig, nrog Emgality, lossis nrog ob qho tshuaj (thaum noj ib leeg).

• Yuav tshwm sim nrog Aimovig:
• cem quav
• mob leeg
• cov leeg pob txha mus los
• cov tsos mob khaub thuas zoo li
• Yuav tshwm sim nrog Emgality:
• mob caj pas
• Yuav tshwm sim nrog ob Aimovig thiab Emgality:
• qhov chaw txhaj tshuaj tiv thaiv
• rov qab mob
• sab sauv ntawm txoj hlab ua pa (xws li mob khaub thuas lossis mob hauv qhov ntswg)

Cov kev mob tshwm sim hnyav heev

Cov kev txhaum fab hnyav yog ib qho kev phiv tsis tshua muaj rau ob leeg Aimovig thiab Emgality. (Yog xav paub ntxiv, saib "Kev tsis haum tshuaj" raws li "Aimovig phiv" saum toj).

Kev siv tshuaj tiv thaiv

Hauv kev sim tshuaj rau txhua cov tshuaj, muaj tsawg tus tib neeg muaj kev tiv thaiv tsis haum rau Aimovig thiab Emgality. Nrog rau kev sib tw no, lub cev tiv thaiv kab mob tau tsim cov tshuaj tiv thaiv kev tawm tsam cov tshuaj.

Tshuaj tua kab mob yog cov protein nyob hauv koj lub cev tiv thaiv kab mob tawm tsam lwm yam tshuaj hauv koj lub cev. Koj lub cev tuaj yeem ua cov tshuaj tiv thaiv rau ib qho tshuaj txawv teb chaws, suav nrog cov tshuaj tiv thaiv monoclonal xws li Aimovig thiab Emgality.

Yog tias koj lub cev tsim cov tshuaj tiv thaiv rau ib qho ntawm cov tshuaj no, nws muaj peev xwm tias cov tshuaj yuav tsis ua haujlwm ntxiv txhawm rau tiv thaiv kev mob taub hau rau koj.

Hauv kev tshawb fawb soj ntsuam ntawm Aimovig, ntau dua 6 feem pua ​​ntawm cov neeg siv cov tshuaj tsim cov tshuaj tiv thaiv rau nws. Thiab hauv kev tshawb fawb soj ntsuam ntawm Emgality, yuav luag 5 feem pua ​​ntawm tib neeg tsim cov tshuaj tiv thaiv kom ua rau Emgality.

Vim tias Aimovig thiab Emgality tau pom zoo rau xyoo 2018, nws tseem ntxov dhau los paub txog pes tsawg tus neeg yuav muaj kev tiv thaiv zoo li no. Nws tseem ntxov dhau los paub txog seb nws yuav cuam tshuam li cas rau tib neeg siv cov tshuaj no rau yav tom ntej.

Txij nkawm

Aimovig thiab Emgality tsis tau muab piv rau hauv cov kev tshawb fawb, tab sis ob qho tib si zoo rau kev tiv thaiv kev mob taub hau.

Cov txheej txheem kev kho mob pom zoo kom Aimovig thiab Emgality yog kev xaiv rau cov neeg muaj mob vwm lossis mob taub hau ntev uas:

• tsis tuaj yeem noj lwm yam tshuaj vim tias muaj kev phiv lossis cuam tshuam txog kev siv yeeb tshuaj
• tsis tuaj yeem txo lawv tus naj npawb ntawm cov hnub migraine zoo txaus nrog lwm cov tshuaj

Kev mob taub hau ntu

Kev tshawb fawb sib txawv ntawm Aimovig thiab Emgality pom tau hais tias ob qho tshuaj muaj txiaj ntsig zoo rau kev tiv thaiv mob taub hau mob taub hau:

• Hauv kev tshawb fawb soj ntsuam ntawm Aimovig, txog li 50 feem pua ​​ntawm cov neeg uas mob taub hau uas tau txais 140 mg ntawm cov tshuaj txo lawv cov hnub migraine tsawg kawg yog ib nrab dhau rau lub hlis. Txog 40 feem pua ​​ntawm cov neeg uas tau txais 70 mg pom cov txiaj ntsig zoo sib xws.
• Hauv Emgality qhov kev tshawb fawb soj ntsuam ntawm cov neeg muaj kev mob taub hau, ib ncig ntawm 60 feem pua ​​ntawm cov neeg txo lawv tus naj npawb hnub migraine tsawg kawg ib nrab dhau rau lub hlis ntawm kev kho mob Emgality. Mus txog rau 16 feem pua ​​yog yuaj yuaj tom qab li rau lub hlis ntawm kev kho mob.

Mob taub hau ntev

Kev tshawb fawb sib txawv ntawm Aimovig thiab Emgality pom tau hais tias ob qho tshuaj muaj txiaj ntsig zoo rau kev tiv thaiv kev mob taub hau ntev:

• Hauv kev tshawb nrhiav peb lub hlis dhau los ntawm cov neeg muaj kev mob taub hau ntev, kwv yees li 40 feem pua ​​ntawm cov neeg uas tau noj 70 mg lossis 140 mg ntawm Aimovig muaj ib nrab ntau hnub so lossis tsawg dua nrog kev kho mob.
• Hauv kev tshawb nrhiav peb lub hlis dhau los ntawm cov neeg muaj kev mob taub hau ntau, yuav luag 30 feem pua ​​ntawm cov neeg uas tau noj Emgality rau peb lub hlis muaj ib nrab ntawm ntau hnub migraine lossis tsawg dua nrog kev kho mob.

Cov nqi

Aimovig thiab Emgality yog ob hom tshuaj uas nrov npe. Tam sim no tsis muaj cov ntawv sau rau ib qho ntawm cov tshuaj. Cov tshuaj muaj npe lag luam feem ntau raug nqi ntau dua li cov generics.

Raws li kev kwv yees los ntawm GoodRx.com, Aimovig thiab Emgality tus nqi yuav luag ntau tus nqi. Tus nqi tiag uas koj yuav them rau ib qho tshuaj twg yog nyob ntawm koj qhov koob tshuaj, kev tuav pov hwm, koj qhov chaw nyob, thiab lub tsev muag tshuaj uas koj siv.

Aimovig vs Topamax

Aimovig muaj cov monoclonal antibody hu ua erenumab. Ib qho tshuaj monoclonal yog ib hom tshuaj tsim los ntawm cov tshuaj tiv thaiv kab mob hauv lub cev. Cov tshuaj ntawm hom no yog tsim hauv ib chav kuaj tshuaj. Aimovig pab tiv thaiv kev mob taub hau los ntawm kev txwv cov haujlwm ntawm cov protein tshwj xeeb uas ua rau lawv.

Topamax muaj cov tshuaj topiramate, yog ib hom tshuaj uas tseem siv los kho mob qaug dab peg. Nws tsis to taub yuav ua li cas Topamax ua haujlwm los tiv thaiv mob taub hau. Nws tau xav tias cov tshuaj txo qis cov hlab ntsha hauv lub hlwb uas ua rau mob tob hau mob taub hau.

Kev Siv

Ob leeg Aimovig thiab Topamax yog FDA pom zoo los tiv thaiv mob taub hau. Aimovig raug pom zoo rau kev siv rau cov neeg laus, thaum Topamax pom zoo rau siv rau cov laus thiab menyuam hnub nyoog 12 thiab tshaj saud.

Cov Topamax kuj tseem pom zoo kom kho mob vwm.

Cov ntawv thiab cov thawj coj

Aimovig ua li nyob rau hauv ib leeg-prefilled autoinjector. Nws tau raug muab los ntawm kev txhaj tshuaj hauv qab koj cov tawv nqaij (subcutaneous) uas koj muab rau koj tus kheej hauv tsev ib hlis ib zaug. Qhov kev txhaj tshuaj ib txwm yog 70 mg, tab sis qee cov neeg yuav tau txais txiaj ntsig los ntawm 140-mg koob tshuaj.

Topamax los ua ib lub qhov ncauj tshuaj ntsiav lossis qhov ncauj ntsiav tshuaj. Kev noj tshuaj li ib txwm yog 50 mg noj ob zaug ib hnub. Ua raws li koj tus kws kho mob pom zoo, koj tuaj yeem pib noj tshuaj qis dua thiab nce ntxiv rau kev siv ntau dua li ob peb hlis.

Phiv thiab txaus ntshai

Aimovig thiab Topamax ua haujlwm nyob rau hauv kev sib txawv ntawm lub cev thiab yog li ntawd muaj cov kev phiv sib txawv. Qee qhov tshwm sim thiab mob loj ntawm ob qho tshuaj muaj nyob hauv qab no. Cov npe hauv qab no tsis suav tag nrho cov kev mob tshwm sim.

Ntau cov kev mob tshwm sim

Cov npe no muaj cov piv txwv ntawm cov kev mob tshwm sim loj uas tuaj yeem tshwm sim nrog Aimovig, nrog rau Topamax, lossis nrog ob qho tshuaj (thaum noj ib leeg).

• Yuav tshwm sim nrog Aimovig:
• qhov chaw txhaj tshuaj tiv thaiv
• rov qab mob
• cem quav
• mob leeg
• mob leeg pob txha
• cov tsos mob khaub thuas zoo li
• Yuav tshwm sim nrog Topamax:
• mob caj pas
• nkees
• paresthesia (kev hnov ​​ntawm “koob thiab koob”)
• xeev siab
• zawv plab
• poob phaus
• tsis qab los noj mov
• teeb meem kev xav tsis tau
• Yuav tshwm sim nrog ob Aimovig thiab Topamax:
• voos ua pa (xws li mob khaub thuas, lossis mob ntsws)

Cov kev mob tshwm sim hnyav heev

Cov npe no muaj cov piv txwv ntawm cov kev mob tshwm sim loj uas tuaj yeem tshwm sim nrog Aimovig, nrog rau Topamax, lossis nrog ob qho tshuaj (thaum noj ib leeg).

• Yuav tshwm sim nrog Aimovig:
• ob peb yam kev phiv loj heev
• Yuav tshwm sim nrog Topamax:
• cov teeb meem tsis pom kev, nrog rau kev mob txha caj dab
• kev tawm hws tsawg (ua tsis tau los tswj lub cev kub)
• metabolic acidosis
• yus tua yus xav thiab ua
• xav teeb meem xws li tsis meej pem thiab nco txog teeb meem
• kev nyuaj siab
• encephalopathy (mob hlwb)
• raum pob zeb
• ntau chua leeg thaum cov tshuaj nres dheev (thaum siv tshuaj rau qaug dab peg)
• Yuav tshwm sim nrog ob Aimovig thiab Topamax:
• kev fab tshuaj hnyav heev

Txij nkawm

Lub hom phiaj nkaus xwb ob leeg Aimovig thiab Topamax yog FDA-pom zoo rau yog kev tiv thaiv kev mob taub hau.

Cov txheej txheem kev kho mob pom zoo kom Aimovig ua ib txoj hauv kev xaiv rau kev tiv thaiv kev mob taub hau lossis mob taub hau ntev hauv cov neeg uas:

• tsis tuaj yeem noj lwm yam tshuaj vim tias muaj kev phiv lossis cuam tshuam txog kev siv yeeb tshuaj
• tsis tuaj yeem txo lawv tus naj npawb ntawm mob taub hau ib hlis ib zaug txaus nrog lwm cov tshuaj

Cov txheej txheem kev kho mob pom zoo kom Topiramate ua ib qho kev xaiv rau kev tiv thaiv mob taub hau mob taub hau.

Cov kev tshawb fawb soj ntsuam tsis tau ncaj qha piv rau qhov ua tau zoo ntawm ob qho tshuaj no rau kev tiv thaiv mob taub hau. Tab sis cov tshuaj muaj tau kawm nyias.

Kev mob taub hau ntu

Kev tshawb fawb sib txawv ntawm Aimovig thiab Topamax pom tias ob yam tshuaj ua tau zoo hauv kev tiv thaiv mob taub hau mob taub hau:

• Hauv Aimovig cov kev tshawb fawb soj ntsuam, nce txog 50 feem pua ​​ntawm cov neeg muaj mob pob qij txha uas tau txais 140 mg txiav lawv cov hnub migraine tsawg kawg yog ib nrab dhau rau lub hlis ntawm kev kho mob. Txog 40 feem pua ​​ntawm cov neeg uas tau txais 70 mg pom cov txiaj ntsig zoo sib xws.
• Hauv kev tshawb fawb soj ntsuam ntawm cov neeg muaj mob pob qij txha uas noj Topamax, cov muaj hnub nyoog 12 xyoos thiab laus dua muaj txog ob leeg tsawg dua kev mob taub hau mob txhua lub hlis. Cov menyuam yaus hnub nyoog 12 txog 17 nrog mob qog mob taub hau muaj peb zaug kev mob taub hau tsawg dua txhua lub hlis.

Mob taub hau ntev

Kev tshawb fawb sib txawv ntawm cov tshuaj pom tias Aimovig thiab Topamax muaj txiaj ntsig zoo rau kev tiv thaiv mob tob hau mob taub hau:

• Hauv kev tshawb nrhiav 3 lub hlis ntawm Aimovig, kwv yees li 40 feem pua ​​ntawm cov neeg muaj mob tob hau mob taub hau uas tau txais 70 mg lossis 140 mg muaj ib nrab ntau hnub so lossis qis dua tom qab kho tas.
• Hauv kev tshawb nrhiav uas tau saib cov txiaj ntsig ntawm ntau qhov kev sim tshuaj pom pom tias hauv cov neeg muaj kev mob taub hau heev, Topamax tau txo tus neeg mob taub hau lossis mob taub hau ntau npaum li tsib txog rau cuaj lub hlis.

Cov nqi

Aimovig thiab Topamax yog ob lub npe tshuaj noj tshuaj pab. Cov tshuaj muaj npe lag luam feem ntau raug nqi ntau dua cov tshuaj tsis nrov npe. Aimovig tsis muaj nyob rau hauv daim ntawv foos, tab sis Topamax los ua cov qauv hu ua cov tshuaj topiramate.

Raws li kev kwv yees los ntawm GoodRx.com, Topamax yuav raug nqi ntau dua lossis tsawg dua Aimovig, nyob ntawm koj cov koob tshuaj. Thiab topiramate, daim faus ntawm Topamax, yuav raug nqi tsawg dua li Topamax lossis Aimovig.

Tus nqi tiag uas koj yuav them rau ib qho ntawm cov tshuaj yuav nyob ntawm koj qhov koob tshuaj, koj qhov kev pov hwm, koj qhov chaw nyob, thiab lub tsev muag tshuaj uas koj siv.

Aimovig thiab cawv

Tsis muaj kev cuam tshuam los ntawm Aimovig thiab cawv.

Tseem, qee tus neeg yuav xav tias cov tshuaj tsis muaj txiaj ntsig yog tias lawv haus cawv thaum noj Aimovig. Qhov no yog vim tias cawv yuav ua rau mob taub hau rau ntau tus neeg. Txawm tias haus cawv me me yuav ua rau mob tob tob rau lawv.

Koj yuav tsum tsis txhob haus cawv uas muaj cawv yog tias koj pom tias cov cawv ua rau mob tob hau lossis mob taub hau heev.

Aimovig kev sib cuam tshuam

Ntau yam tshuaj tuaj yeem cuam tshuam nrog lwm cov tshuaj. Qhov sib txawv tuaj yeem tshwm sim los ntawm kev sib cuam tshuam sib txawv. Piv txwv li, qee qhov kev cuam tshuam muaj peev xwm cuam tshuam nrog kev siv yeeb tshuaj zoo li cas, thaum lwm tus tuaj yeem tsim kev phiv ntau dua.

Aimovig tsis feem ntau muaj kev sib txuam tshuaj. Qhov no yog vim txoj kev Aimovig ua tiav hauv koj lub cev.

Yuav ua li cas Aimovig yog metabolized

Ntau yam tshuaj, tshuaj ntsuab, thiab tshuaj noj yog metabolized (ua tiav) los ntawm cov enzymes hauv koj lub siab. Tab sis monoclonal antibody tshuaj, xws li Aimovig, feem ntau tsis ua nyob rau hauv daim siab. Hloov chaw, cov hom tshuaj no yog ua hauv lwm cov cell hauv koj lub cev.

Vim tias Aimovig tsis tau ua nyob rau hauv daim siab zoo li ntau lwm yam tshuaj, nws feem ntau tsis cuam tshuam nrog lwm cov tshuaj.

Yog tias koj muaj kev txhawj xeeb txog kev sib txuas nrog Aimovig nrog lwm cov tshuaj uas koj yuav tau noj, tham nrog koj tus kws kho mob. Thiab nco ntsoov qhia rau lawv txog txhua yam tshuaj noj, cov tshuaj yuav tom kiab khw, thiab lwm yam tshuaj koj noj. Koj yuav tsum tau qhia rau lawv txog cov tshuaj ntsuab, cov vitamins, thiab cov khoom noj zoo uas koj siv.

Cov lus qhia ntawm yuav ua li cas noj Aimovig

Aimovig yog los raws li kev txhaj tshuaj uas tau muab hauv qab koj cov tawv nqaij (subcutaneous). Koj muab koj tus kheej txhaj rau hauv tsev ib hlis ib zaug. Thawj zaug koj tau txais tshuaj rau Aimovig, koj tus neeg saib xyuas kev noj qab haus huv yuav piav qhia txog kev muab tshuaj rau koj tus kheej li cas.

Aimovig ua li nyob rau hauv ib koob (70 mg) autoinjector. Txhua tus tsav tsheb tsuas muaj ib qho tshuaj xwb thiab tau txhais rau siv ib zaug thiab mam li muab pov tseg. (Yog tias koj tus kws kho mob tau sau 140 mg rau ib hlis, koj yuav tsum siv ob lub kho tsheb hauv ib lub hlis.)

Hauv qab no yog cov lus qhia txog yuav ua li cas siv cov koob txhaj kom tau npaj. Txog lwm yam ntsiab lus, vis dis aus, thiab cov duab ntawm cov lus qhia txhaj tshuaj, saib cov tuam txhab cov vev xaib.

Yuav txhaj li cas

Koj tus kws kho mob yuav sau tshuaj rau 70 mg ib hlis ib zaug lossis 140 mg ib hlis ib zaug. Yog tias koj tau noj tshuaj 70 mg txhua hli, koj yuav muab koj tus kheej txhaj ib zaug. Yog tias koj tau noj tshuaj 140 mg ib hlis ib zaug, koj yuav muab koj tus kheej ob koob tshuaj, ib qho ntxiv tom qab.

Npaj mus txhaj

• Nqa koj Aimovig autoinjector ntawm lub tub yees 30 feeb ua ntej koj npaj ua koj kev txhaj tshuaj. Qhov no yuav ua rau cov tshuaj ua kom sov sov rau chav sov. Tseg lub hau tso rau ntawm tus kws kho mob lub zog kom txog thaum koj npaj siab yuav txhaj tshuaj.
• Tsis txhob sim kom sov siab rau lub autoinjector sai dua los ntawm kev microwaving nws lossis caws dej kub rau nws. Tsis tas li, tsis txhob co tus neeg kho mob. Ua cov haujlwm no tuaj yeem ua rau Aimovig tsis muaj kev nyab xeeb thiab muaj txiaj ntsig zoo.
• Yog tias koj tau poob rau lub autoinjector, tsis txhob siv nws. Cov khoom me me ntawm tus kws tsav tsheb yuav tawg rau sab hauv, txawm tias koj tsis tuaj yeem pom ib qho kev puas tsuaj.
• Thaum koj tseem tos Aimovig tuaj rau chav sov, nrhiav lwm yam khoom siv uas koj xav tau. Cov no suav nrog:
• cawv txiv quav cawv
• cov paj rwb lossis ntaub qhwv nyias
• nplaum cov ntaub qhwv
• pov tseg thawv rau khoom ntse
• Tshawb xyuas tus kws kho mob lub tsheb thiab xyuas kom meej cov tshuaj kom tsis muaj huab. Nws yuav tsum tsis muaj xim rau daj ntseg daj ntau hauv cov xim. Yog tias nws zoo li qhov pom, muaj huab lossis muaj ib qho ntxig ntawm cov kua, tsis txhob siv nws. Yog tias xav tau, hu rau koj tus kws kho mob txog kev txais ib qho tshiab. Tsis tas li, kuaj xyuas lub hnub tas sij hawm ntawm lub ntaus ntawv kom paub tseeb tias cov tshuaj tsis tas sij hawm.
• Tom qab ntxuav koj ob txhais tes nrog xab npum thiab dej, xaiv qhov chaw txhaj tshuaj. Aimovig tuaj yeem raug txhaj tshuaj rau ntawm cov chaw no:
• koj lub plab (tsawg kawg 2 nti ntawm koj lub plab khawm)
• sab xub ntiag ntawm koj tus ncej (yam tsawg kawg 2 ntiv saum koj lub hauv caug lossis 2 nti hauv qab ntawm koj lub puab tais)
• sab qaum ntawm koj sab caj npab (yog tias muaj lwm tus muab koj txhaj tshuaj)
• Siv dej cawv so kom huv qhov chaw koj npaj yuav txhaj. Tso cov cawv kom huv ua ntej koj txhaj cov tshuaj.
• Tsis txhob txhaj tshuaj Aimovig rau thaj tsam ntawm daim tawv nqaij uas nqaij tawv, tawv, liab, lossis muag.

Siv lub tsheb tsav tsheb

1. Rub lub hau dawb ncaj ncaj rau ntawm nws tus kheej. Ua qhov no tsis pub ntau tshaj tsib feeb ua ntej koj yuav siv lub cuab yeej.
2. Ncab los yog txaws thaj chaw ntawm cov tawv nqaij uas koj npaj kom txhaj tshuaj. Tsim thaj chaw ruaj khov ntawm daim tawv nqaij ntev li 2 ntiv tes dav rau koj qhov kev txhaj tshuaj.
3. Tso lub chaw kho mob rau koj cov tawv nqaij ntawm 90-degree lub kaum ntse ntse. Kev ntseeg khov kho nias rau ntawm koj cov tawv nqaij kom deb npaum li nws yuav ploj mus.
4. Nias lub khawm pib xim liab nyob rau sab saum toj ntawm tus kws kho tsheb kom txog thaum koj hnov ​​qhov chaw nyem.
5. Tso lub khawm pib ntshav tab sis txuas ntxiv tuav tus ntaiv cia rau hauv koj cov tawv nqaij kom txog thaum lub qhov rais ntawm tus kws kho tsheb tig daj. Koj kuj tuaj yeem hnov ​​lossis hnov ​​ib qho “nyem.” Qhov no yuav siv sijhawm ntev li 15 feeb. Nws yog ib qho tseem ceeb uas ua cov kauj ruam no kom ntseeg tau tias koj tau txais tag nrho cov tshuaj.
6. Tshem tawm cov autoinjector tawm ntawm koj cov tawv nqaij thiab pov tseg rau hauv koj lub thawv ntim khoom pov tseg.
7. Yog tias muaj ntshav ntawm qhov chaw txhaj tshuaj, nias lub paj rwb lossis ntaub nyias nyias mus rau ntawm daim tawv nqaij, tab sis tsis txhob txhuam. Siv daim ntaub nplaum qhwv tawm yog tias xav tau.
8. Yog tias koj cov tshuaj yog 140 mg rau ib hlis, rov ua cov kauj ruam no nrog tus kws kho tsheb ob. Tsis txhob siv cov khoom siv xws li qhov kev txhaj tshuaj thawj zaug.

Sijhawm

Aimovig yuav tsum noj ib hlis ib zaug. Nws tuaj yeem siv tau thaum twg los tau nruab hnub.

Yog tias koj tsis nco qab noj ib zaug, noj Aimovig sai li sai tau thaum koj nco qab. Cov koob tshuaj ntxiv no yuav tsum yog ib hlis tom qab koj noj qhov tshuaj ntawd. Siv cov cuab yeej ceeb toom tshuaj tuaj yeem pab koj kom nco ntsoov noj Aimovig raws sij hawm.

Noj Aimovig nrog zaub mov noj

Aimovig tuaj yeem noj nrog lossis tsis muaj zaub mov noj.

Cia

Aimovig yuav tsum khaws cia hauv tub yees. Nws tuaj yeem nqa tawm hauv lub tub yees tab sis yuav tsum siv li ntawm xya hnub. Tsis txhob muab tso rau hauv lub tub yees thaum nws tau hle tawm thiab coj mus rau chav kub.

Don’t fog Aimovig. Kuj, khaws nws hauv nws cov pob qub los tiv thaiv nws ntawm lub teeb.

Aimovig ua haujlwm licas

Aimovig yog ib qho tshuaj hu ua monoclonal antibody. Qhov hom tshuaj no yog tsim hauv ib lub chaw kuaj ntshav los ntawm cov tshuaj tiv thaiv kab mob hauv lub cev. Aimovig ua haujlwm los ntawm kev tso tseg cov haujlwm ntawm cov protein nyob hauv koj lub cev hu ua calcitonin gene-ntsig txog peptide (CGRP). CGRP tuaj yeem ua rau mob voos thiab vasodilation (nthuav dav ntawm cov hlab ntsha) hauv koj lub hlwb.

Tus mob thiab vasodilation nqa tuaj ntawm CGRP yog qhov ua rau mob taub hau mob taub hau. Qhov tseeb, thaum kev mob taub hau mob taub hau pib pib tshwm sim, tib neeg muaj ntau dua ntawm CGRP nyob rau hauv lawv cov hlab ntsha. Aimovig pab tiv thaiv kev mob taub hau los ntawm kev txwv tsis pub muaj kev ua ub no ntawm CGRP.

Thaum feem ntau cov tshuaj ua haujlwm los ntawm kev cuam tshuam ntau yam tshuaj hauv koj lub cev, cov tshuaj tiv thaiv monoclonal xws li Aimovig ua haujlwm ntawm tsuas yog ib qho protein hauv lub cev. Vim tias qhov no, Aimovig tuaj yeem ua rau muaj kev sib txuam tshuaj tsawg dua thiab cov kev mob tshwm sim. Qhov no tuaj yeem ua cov kev xaiv zoo rau cov neeg uas tsis tuaj yeem siv lwm cov tshuaj vim muaj kev phiv lossis cuam tshuam.

Aimovig kuj tseem yog txoj kev kho mob zoo rau cov neeg uas tsis tau pom dua lwm cov tshuaj uas tuaj yeem txo lawv hnub migraine txaus.

Yuav siv sijhawm ntev npaum li cas ua haujlwm?

Tom qab koj pib noj Aimovig, nws yuav siv li ob peb lub lis piam kom pom kev txhim kho hauv koj lub taub hau mob taub hau. Aimovig tuaj yeem siv tag nrho cov txiaj ntsig tom qab ob peb lub hlis.

Coob tus neeg uas tau siv Aimovig thaum kuaj mob muaj tsawg hnub mob qog tsawg dua hauv ib hlis txij li pib siv tshuaj. Tib neeg kuj muaj hnub mob migraine tsawg dua tom qab txuas ntxiv kev kho mob mus ntau lub hlis.

Aimovig thiab cev xeeb tub

Tsis tau muaj kev tshawb fawb txaus ua kom paub tias Aimovig muaj kev nyab xeeb rau noj thaum cev xeeb tub. Cov kev tshawb fawb tsiaj tsis qhia txog kev pheej hmoo rau lub cev xeeb tub thaum Aimovig tau muab rau tus poj niam cev xeeb tub. Txawm li cas los xij, kev tshawb nrhiav tsiaj tsis txhua lub sijhawm kwv yees tias cov tshuaj yuav muaj kev nyab xeeb rau tib neeg.

Yog tias koj cev xeeb tub los yog txiav txim siab cev xeeb tub, tham nrog koj tus kws kho mob saib seb Aimovig puas zoo rau koj. Koj yuav tsum tau tos kom txog thaum koj tsis cev xeeb tub siv Aimovig.

Aimovig thiab noj mis

Nws tsis paub yog tias Aimovig kis mus rau niam mis. Yog li, nws tsis paub meej yog Aimovig siv tau zoo thaum pub niam mis.

Yog tias koj tab tom txiav txim siab kho nrog Aimovig thaum koj tab tom pub mis rau koj tus menyuam, tham nrog koj tus kws kho mob txog cov txiaj ntsig thiab kev pheej hmoo. Koj yuav tsum tau tsum tsis txhob pub mis niam yog tias koj pib noj Aimovig.

Cov lus nug uas nquag muaj txog Aimovig

Nov yog cov lus teb rau qee cov lus nug nquag txog Aimovig.

Siv ceev xwmphem Aimovig ua rau rho tawm?

Tsis muaj cov ntawv tshaj tawm ntawm kev thim tawm tom qab txiav tawm Aimovig. Txawm li cas los xij, Aimovig tsuas yog nyuam qhuav pom zoo los ntawm FDA, xyoo 2018. Cov neeg tau siv thiab tso tseg Aimovig kev kho mob tseem muaj tsawg.

Aimovig puas yog roj ntsha?

Yog lawm. Aimovig yog cov tshuaj monoclonal antibody, uas yog hom kev lom tsiaj. Kev siv roj ntsha yog ib qho yeeb tshuaj uas tau tsim los ntawm cov khoom siv roj ntsha, tsis yog siv tshuaj.

Vim tias lawv cuam tshuam nrog lub hlwb tsis muaj zog tiv thaiv lub cev thiab cov protein ntau, biologics xws li Aimovig yog xav tias muaj cov kev mob tshwm sim tsawg dua piv rau cov tshuaj uas cuam tshuam rau ntau qhov ntawm lub cev, xws li lwm cov tshuaj migraine ua.

Koj puas tuaj yeem siv Aimovig kho qhov mob tob hau?

Tsis yog. Aimovig tsuas yog siv los tiv thaiv kev mob taub hau ua ntej nws pib. Nws yuav tsis zoo rau kho qhov mob taub hau uas twb tau pib lawm.

Puas yog Aimovig kho mob tob hau?

Tsis yog, Aimovig yuav tsis kho tus mob migraine. Tam sim no tsis muaj tshuaj los kho hom mob taub hau.

Aimovig txawv li cas ntawm lwm cov tshuaj migraine?

Aimovig txawv ntawm ntau lwm cov tshuaj migraine vim tias nws yog thawj zaug pom zoo FDA pom zoo noj tshwj xeeb ua rau kev tiv thaiv mob tob hau. Aimovig yog ib feem ntawm cov chav kawm tshiab hauv cov tshuaj hu ua calcitonin gene-ntsig txog peptide (CGRP) antagonists.

Feem ntau lwm yam tshuaj siv los tiv thaiv mob taub hau tau raug tsim los rau lwm cov laj thawj, xws li kev kho mob chua leeg, ntshav siab, lossis kev nyuaj siab. Ntau yam ntawm cov tshuaj no siv sab-daim ntawv lo los tiv thaiv mob taub hau mob taub hau.

Ua txhua hli txhaj tshuaj tseem ua rau Aimovig txawv ntawm ntau lwm cov tshuaj tiv thaiv kev mob taub hau. Feem ntau ntawm lwm cov tshuaj tuaj tshuaj ntsiav lossis tshuaj noj. Botox yog lwm txoj kev xaiv tshuaj uas los ua kev txhaj tshuaj. Txawm li cas los xij, nws yuav tsum tau muab nyob hauv kws kho mob lub chaw haujlwm ib zaug hauv peb lub hlis ib zaug. Koj tuaj yeem muab tshuaj pleev rau koj tus kheej ntawm Aimovig tom tsev.

Thiab tsis zoo li feem ntau lwm cov tshuaj tiv thaiv kev mob taub hau, Aimovig yog ib qho tshuaj monoclonal. Nov yog hom tshuaj uas tau tsim hauv chav kuaj ntshav. Nws tau tsim los ntawm cov kab mob tiv thaiv kab mob.

Cov tshuaj tua kabmob Monoclonal tau tawg rau hauv ntau ntau lub hlwb hauv lub cev. Lwm yam tshuaj tiv thaiv kev mob taub hau tau muab cais tawm los ntawm lub siab. Vim tias qhov sib txawv no, cov tshuaj tiv thaiv monoclonal xws li Aimovig muaj feem cuam tshuam tshuaj tsawg dua lwm cov tshuaj siv los tiv thaiv mob taub hau.

Yog tias kuv noj Aimovig, kuv puas tuaj yeem tsum tsis noj kuv cov tshuaj tiv thaiv lwm tus ntxiv?

Tejzaum nws. Txhua tus neeg lub cev yuav teb rau Aimovig txawv. Yog tias Aimovig txo qis ntau tus mob taub hau uas koj muaj, koj tuaj yeem tso tseg tsis noj lwm yam tshuaj tiv thaiv. Tab sis thaum koj pib kho mob, koj tus kws kho mob yuav pom zoo kom koj pib noj Aimovig nrog rau lwm cov tshuaj tiv thaiv.

Tom qab koj tau siv Aimovig li ntawm ob mus rau peb hlis, koj tus kws kho mob yuav tham nrog koj seb cov tshuaj ua haujlwm zoo rau koj npaum li cas. Koj thiab koj tus kws kho mob tuaj yeem sib tham txog kev txiav lwm cov tshuaj tiv thaiv koj noj lossis txo koj cov tshuaj noj ntau npaum li cas.

Aimovig overdose

Kev txhaj tshuaj ntau ntawm Aimovig tuaj yeem ua rau koj muaj feem ntau nrog kev txhaj tshuaj nyob rau thaj chaw. Yog tias koj muaj kev fab tshuaj lossis hypersensitive rau Aimovig lossis rau latex (ib qho khoom xyaw hauv Aimovig lub ntim), koj yuav muaj kev pheej hmoo rau qhov kev txhaum loj dua.

Tshuav cov tsos mob

Cov tsos mob ntawm kev noj haus ntau dhau muaj xws li:

• mob hnyav, khaus, lossis liab ntawm thaj chaw ze ntawm kev txhaj tshuaj
• yaug
• khaus
• angioedema (o hauv qab tawv nqaij)
• o ntawm tus nplaig, caj pas, lossis qhov ncauj
• teeb meem ua pa

Dab tsi yog qhov ua txhaum cai dhau

Yog koj xav tias koj tau noj ntau dhau ntawm cov tshuaj no, hu rau koj tus kws kho mob lossis nrhiav kev qhia los ntawm American Association of Poison Control Center ntawm 800-222-1222 lossis hauv lawv cov twj online. Tab sis yog tias koj cov tsos mob hnyav, hu 911 lossis mus rau chav kho mob ze tshaj plaws tam sim ntawd.

Aimovig cov lus ceeb toom

Ua ntej noj Aimovig, nrog koj tus kws kho mob tham txog koj li kev noj qab haus huv keeb kwm. Aimovig tej zaum yuav tsis zoo rau koj yog tias koj muaj qee yam mob. Cov no suav nrog:

• Cov xua yas ua xua. Aimovig autoinjector muaj ib hom roj hmab uas zoo ib yam li latex. Qhov no tuaj yeem ua rau muaj kev fab tshuaj rau cov tib neeg ua xua rau latex. Yog tias koj muaj keeb kwm muaj kev tsis haum cov khoom lag luam uas muaj cov tshuaj latex, Aimovig yuav tsis yog qhov tshuaj zoo rau koj.

Aimovig tas sijhawm thiab cia khoom

Thaum Aimovig raug faib tawm los ntawm lub tsev muag tshuaj, tus kws muag tshuaj yuav ntxiv hnub tas sij hawm rau cov ntawv sau ntawm lub raj mis. Hnub no ib txwm muaj ib xyoos suav txij hnub pib muab tshuaj rau.

Lub hom phiaj ntawm cov hnub tas sij hawm no yog kom tau txais txiaj ntsig zoo ntawm kev noj tshuaj nyob rau lub sijhawm no. Txoj cai tam sim no ntawm Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) yog kom tsis txhob siv cov tshuaj uas tas sij hawm.

Kev noj tshuaj ntev npaum li cas tuaj yeem nyob ntawm ntau yam, nrog rau seb yuav khaws cia cov tshuaj thiab cia.

Aimovig prefilled autoinjector yuav tsum muab cia rau hauv tub yees. Nws tuaj yeem khaws cia sab nraud ntawm lub tub yees ntev txog xya hnub. Tsis txhob tso rov qab rau hauv lub tub yees thaum nws tau mus txog chav sov.

Tsis txhob co los yog khov rau Aimovig tus tsav tsheb. Thiab khaws cov autoinjector hauv cov ntawv ntim khoom qub los tiv thaiv nws los ntawm lub teeb.

Yog tias koj tsis tau siv cov tshuaj uas dhau lub caij nyoog tas sijhawm, tham nrog koj tus kws muag tshuaj txog seb koj puas tseem tuaj yeem siv ntxiv.

Cov ntaub ntawv tshaj lij rau Aimovig

Cov ntaub ntawv hauv qab no yog muab rau cov kws kho mob thiab lwm tus kws kho mob.

Mechanism ntawm kev ua

Aimovig (erenumab) yog tib neeg monoclonal antibody uas khi rau calcitonin gene-ntsig txog peptide (CGRP) receptor thiab tiv thaiv CGRP lig los ntawm kev ua kom cov receptor.

Pharmacokinetics thiab cov metabolism

Aimovig siv tshuaj txhua lub hlis thiab nce mus txog qhov ntau-tom qab uas muaj 3 koob. Qhov siab tshaj plaws tau nce txog hauv rau hnub. Kev mob Metabolism tsis tshwm sim ntawm cytochrome P450 txoj hauv kev.

Kev khi rau CGRP yog qhov siv tau thiab tsav kev tshem tawm ntawm qhov chaw qis ntau. Thaum muaj kev sib luag ntau dua, Aimovig yog tshem tawm los ntawm cov kab mob tsis muaj qhov tshwj xeeb proteolytic. Cov raum lossis cov hlab ntsws tsis muaj zog tsis xav tias yuav cuam tshuam cov khoom pharmacokinetic.

Cov Yuav Tsum Tau Ua

Tsis muaj contraindications rau siv Aimovig.

Cia

Aimovig prefilled autoinjector yuav tsum muab cia rau hauv tub yees ntawm qhov kub ntawm 36⁰F thiab 46⁰F (2⁰C thiab 8⁰C). Nws yuav raug tshem tawm hauv lub tub yees thiab khaws cia hauv chav tsev qhov kub (txog 77⁰F, lossis 25⁰C) rau 7 hnub.

Khaws Aimovig hauv cov ntawv ntim thawj los tiv thaiv nws ntawm lub teeb. Tsis txhob muab nws tso rau hauv lub tub yees txias thaum nws tau txias mus rau chav sov. Tsis txhob ua kom khov los yog co tawm Aimovig tus tsav tsheb.

Tsis lees paub: Cov Xov Xwm Kho Mob Niaj Hnub no tau ua txhua yam kom paub tseeb tias txhua yam ntaub ntawv yog qhov tseeb, raug, thiab dhau-hnub. Txawm li cas los xij, cov kab lus no yuav tsum tsis txhob siv los hloov chaw rau qhov kev paub thiab kev paub ntawm tus neeg muaj ntawv tso cai kho mob. Koj yuav tsum tau sab laj nrog koj tus kws kho mob lossis lwm tus kws saib xyuas kev noj qab haus huv ua ntej noj tshuaj. Cov ntaub ntawv tshuaj muaj nyob ntawm no yuav raug hloov thiab tsis yog npaj rau txhua txoj kev siv, cov lus qhia, kev ceev faj, ceeb toom, kev cuam tshuam nrog tshuaj, kev fab tshuaj, lossis muaj kev cuam tshuam tsis zoo. Qhov tsis muaj lus ceeb toom lossis lwm cov ntaub ntawv rau kev muab tshuaj tsis qhia tias kev sib txuam tshuaj lossis tshuaj muaj kev nyab xeeb, siv tau, lossis tsim nyog rau txhua tus neeg mob lossis txhua qhov siv tshwj xeeb.