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Quick Take: Cardiovascular Safety of Celecoxib
Daim Duab: Quick Take: Cardiovascular Safety of Celecoxib

Zoo Siab

Cov neeg uas noj cov tshuaj tsis-mob hlwb (NSAIDs) (uas tsis yog tshuaj aspirin) xws li celecoxib yuav muaj kev pheej hmoo siab ua mob plawv lossis mob stroke ntau dua li cov neeg uas tsis noj cov tshuaj no. Cov xwm txheej no yuav tshwm sim yam tsis muaj kev ceeb toom thiab tuaj yeem ua rau tuag taus. Qhov kev pheej hmoo no tej zaum yuav siab dua rau cov neeg uas siv NSAIDs ntev. Tsis txhob noj tshuaj NSAID xws li celecoxib yog tias koj nyuam qhuav tau mob plawv, tshwj tsis yog koj tus kws kho mob hais kom ua. Qhia rau koj tus kws kho mob yog tias koj lossis ib tus neeg hauv koj tsev neeg tau muaj lossis muaj mob plawv, mob plawv lossis hlab ntsha tawg, yog tias koj haus luam yeeb, thiab yog tias koj tau lossis muaj dua ntais roj, ntshav siab lossis ntshav qab zib. Nrhiav kev pab kho mob maj nrawm yog tias koj muaj cov tsos mob li no: mob hauv siab, txog siav, tsis muaj zog ntawm ib qho lossis ib sab ntawm lub cev, lossis hais lus tsis meej.

Yog tias koj yuav ua mob rau txoj hlab ntshav hla kev hla pob txha (CABG; ib hom kev phais plawv), koj yuav tsum tsis txhob noj mob celecoxib ua ntej lossis txoj cai tom qab phais mob.


NSAIDs xws li celecoxib yuav ua rau mob txhab, los ntshav, lossis muaj qhov txhab ntawm plab lossis hnyuv. Cov teeb meem no tuaj yeem txhim kho tau txhua lub sijhawm thaum kho, yuav tshwm sim yam tsis muaj kev tshwm sim ua ntej, thiab yuav ua rau tuag taus. Txoj kev pheej hmoo yuav muaj ntau dua rau cov neeg uas siv tshuaj NSAIDs ntev, tus neeg laus dua hnub nyoog, muaj kev noj qab haus huv tsis zoo, lossis haus dej cawv ntau thaum noj celecoxib. Qhia rau koj tus kws kho mob yog tias koj haus dej cawv ntau los yog koj noj cov tshuaj hauv qab no: tshuaj anticoagulants ('ntshav nyias') xws li warfarin (Coumadin, Jantoven); tshuaj aspirin; lwm cov NSAIDs xws li ibuprofen (Advil, Motrin) lossis naproxen (Aleve, Naprosyn); qhov ncauj steroids xws li dexamethasone, methylprednisolone (Medrol), thiab prednisone (Rayos); xaiv serotonin reuptake inhibitors (SSRIs) xws li citalopram (Celexa), fluoxetine (Prozac, Sarafem, hauv Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), thiab sertraline (Zoloft); los yog serotonin norepinephrine reuptake inhibitors (SNRIs) xws li desvenlafaxine (Pristiq), duloxetine (Cymbalta), thiab venlafaxine (Effexor XR). Thiab qhia koj tus kws kho mob yog tias koj tau muaj lossis muaj kev mob lossis mob ntshav ntau ntau hauv koj lub plab lossis plab hnyuv lossis lwm yam kev ntshaus. Yog tias koj muaj cov tsos mob li hais hauv qab no, tsum tsis txhob noj celecoxib thiab hu rau koj tus kws kho mob: mob plab, kub siab, ntuav tej yam uas ua rau ntshav lossis zoo li thaj chaw kas fes, cov ntshav hauv cov quav, lossis cov quav tawv dub.


Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav soj ntsuam koj cov tsos mob kom zoo thiab tej zaum yuav xaj qee yam kev kuaj xyuas koj lub cev qhov lus teb rau celecoxib. Nco ntsoov qhia koj tus kws kho mob seb koj lub siab xav li cas kom koj tus kws kho mob tuaj yeem sau ntawv noj tshuaj rau koj los kho koj tus mob nrog qhov kev pheej hmoo tsawg tshaj plaws ntawm kev phiv.

Koj tus kws kho mob lossis kws muag tshuaj yuav muab daim ntawv qhia txog cov neeg mob rau koj (Phau Ntawv Qhia Tshuaj Kho Mob) thaum koj pib kho nrog celecoxib thiab txhua zaus koj rov ntim tshuaj rau koj. Nyeem cov ntaub ntawv kom zoo thiab nug koj tus kws kho mob lossis kws muag tshuaj yog tias koj muaj lus nug. Koj kuj tuaj yeem mus saib tau Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) lub vev xaib (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) lossis cov chaw tsim tshuaj paus lub vev xaib kom tau txais Kev Qhia Tshuaj.

Celecoxib yog siv los daws qhov mob, mob siab, o thiab mob tawv nqaij los ntawm osteoarthritis (mob caj dab los ntawm kev puas tsuaj rau sab hauv ntawm cov qij txha), mob caj dab mob rwj (mob caj dab los ntawm kev o ntawm cov leeg), thiab ankylosing spondylitis (mob caj dab tias feem ntau cuam tshuam tus txha nraub qaum). Celecoxib tseem tseem siv coj los kho tus neeg mob caj dab mob rwj mob (hom mob caj dab uas cuam tshuam rau cov menyuam yaus) hauv cov menyuam hnub nyoog 2 xyoos thiab laus dua. Celecoxib kuj tseem siv los kho lub cev ntas thiab ua kom mob lwm yam mob luv nrog rau mob los ntawm kev raug mob, phais thiab lwm cov txheej txheem kho mob lossis kho hniav, lossis cov kev mob uas yuav siv sijhawm ntev. Celecoxib nyob hauv chav kawm ntawm NSAIDs hu ua COX-2 inhibitors. Nws ua haujlwm los ntawm kev nres lub cev ntawm kev tsim cov khoom uas ua rau mob thiab o.


Celecoxib los ua tshuaj ntsiav los noj ntawm qhov ncauj. Celecoxib tsiav tshuaj feem ntau noj ib zaug lossis ob zaug ib hnub. Yog tias koj noj 200 mg celecoxib tsiav tshuaj ib zaug, koj tuaj yeem noj cov tshuaj nrog lossis tsis noj mov.Yog tias koj noj ntau tshaj 200 mg ntawm celecoxib tsiav tshuaj ib zaug, koj yuav tsum noj tshuaj nrog zaub mov. Nug koj tus kws kho mob lossis kws muag tshuaj yog tias koj tsis paub meej tias koj yuav tsum noj koj cov tshuaj nrog zaub mov. Txhawm rau pab koj nco qab noj celecoxib tsiav tshuaj, noj nws ib puag ncig lub sijhawm (s) txhua hnub.

Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj celecoxib raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Yog tias koj tsis tuaj yeem nqos cov tshuaj ntsiav lossis yog tias koj muab cov tshuaj no rau menyuam yaus, koj tuaj yeem qhib cov tshuaj ntsiav thiab nphoo cov ntsiab lus me me rau me nyuam diav los yog txias. Koj tuaj yeem npaj cov dej sib xyaw ua ntej thiab khaws nws txog li 6 teev hauv lub tub yees. Thaum koj npaj txhij yuav noj koj cov tshuaj, nqos tag nrho cov sib xyaw kom haum. Tom qab ntawd haus dej kom ntxuav qhov sib tov thiab nco ntsoov tias koj tau nqos tag nrho nws.

Celecoxib kuj tseem siv qee zaum nrog kev phais mob thiab lwm yam kev kho mob kom txo cov polyps (kev loj hlob tsis zoo) hauv txoj hnyuv (plab hnyuv loj) thiab lub qhov quav hauv cov neeg mob nrog adenomatous polyposis (mob uas ntau pua lossis ntau txhiab polyps ua rau hauv txoj hnyuv thiab mob cancer tej zaum yuav pib). Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev siv cov tshuaj no rau koj tus mob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj celecoxib,

  • qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau celecoxib, tshuaj aspirin lossis lwm yam tshuaj NSAIDs xws li ibuprofen (Advil, Motrin) thiab naproxen (Aleve, Naprosyn), tshuaj sulfa, lwm yam tshuaj noj, lossis ib yam ntawm cov khoom xyaw tsis haum hauv celecoxib tsiav tshuaj. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom siv tsis ua haujlwm.
  • qhia rau koj tus kws kho mob thiab kws muag tshuaj uas siv tshuaj thiab cov tshuaj uas tsis yog kws kho mob, cov vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txog cov tshuaj teev tseg rau hauv seem tseem ceeb ceeb toom thiab ib qho twg ntawm cov hauv qab no: angiotensin-hloov enzyme (ACE) inhibitors xws li benazepril (Lotensin, hauv Lotrel), captopril, enalapril (Epaned, Vasotec, hauv Vaseretic), fosinopril, lisinopril (Qbrelis, hauv Zestoretic), moexipril (Univasc), perindopril (Aceon, hauv Prestalia), quinapril (Accupril, hauv Quinaretic), ramipril (Altace), thiab trandolapril (hauv Tarka); angiotensin receptor blockers xws li candesartan (Atacand, hauv Atacand HCT), eprosartan, irbesartan (Avapro, hauv Avalide), losartan (Cozaar, hauv Hyzaar), olmesartan (Benicar, hauv Azor, hauv Benicar HCT, hauv Tribenzor), telmisartan ( , hauv Micardis HCT, hauv Twynsta), thiab valsartan (Dioavan, hauv Entresto, hauv Exforge HCT); atomoxetine (Strattera); beta blockers xws li atenolol (Tenormin, hauv Tenoretic), labetalol (Trandate), metoprolol (Kapspargo Sprinkle, Lopressor, Toprol XL, hauv Dutoprol), nadolol (Corgard, hauv Corzide), thiab propranolol (Hemangeol, Inderal, Innopran); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); diuretics ('dej tshuaj'); fluconazole (Diflucan); lithium (Lithobid); methotrexate (Otrexup, Rasuvo, Reditrex, Trexall); thiab pemtrexed (Alimta, Pemfexy). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv. Ntau lwm yam tshuaj kuj tseem tuaj yeem cuam tshuam nrog celecoxib, yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv, txawm tias tsis tshwm nyob hauv daim ntawv no.
  • qhia rau koj tus kws kho mob yog tias koj tau lossis muaj dua li cov kev mob uas tau hais tseg hauv seem ceeb toom lossis mob hawb pob, tshwj xeeb yog tias koj nquag txhaws lossis los ntswg lossis polyps qhov ntswg (o rau lub qhov ntswg ntawm qhov ntswg); o ntawm tes, caj npab, ko taw, pob taws, lossis ceg qis; lub plawv dhia; lossis mob rau daim siab lossis lub raum.
  • qhia rau koj tus kws kho mob yog tias koj cev xeeb tub, npaj ua cev xeeb tub; lossis tab tom pub niam mis. Celecoxib tuaj yeem tsim kev puas tsuaj rau tus menyuam hauv plab thiab tsim teeb meem nrog kev xa menyuam yog tias nws yuav nyob ib ncig 20 lub lis piam lossis tom qab ntawd thaum cev xeeb tub. Tsis txhob noj celecoxib puag ncig lossis tom qab 20 lub limtiam uas cev xeeb tub, tshwj tsis yog koj tus kws khomob hais kom koj ua. Yog tias koj cev xeeb tub thaum noj celecoxib, hu rau koj tus kws kho mob.
  • yog tias koj muaj kev phais, suav nrog kev phais hniav, qhia tus kws kho mob lossis kws kho hniav tias koj noj celecoxib.

Tshwj tsis yog koj tus kws kho mob hais rau koj lwm yam, txuas ntxiv koj li kev noj haus zoo.

Yog tias koj noj celecoxib, noj qhov koob uas ploj lawm sai li sai tau thaum koj nco qab nws. Txawm li cas los xij, yog tias nws yuav luag txog rau koob tshuaj txuas ntxiv, hla cov koob tshuaj uas tsis nco qab noj thiab txuas ntxiv koj lub sijhawm noj tshuaj kom tsis tu ncua. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Celecoxib yuav ua rau muaj kev phiv tshuaj. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

  • roj lossis tsam plab
  • mob caj pas
  • cov tsos mob khaub thuas
  • cem quav
  • kiv taub hau
  • mob plab

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob hauv qab no lossis cov uas tau hais hauv ntu CEEB TOOM TSEEM CEEB, hu rau koj tus kws kho mob tam sim ntawd. Tsis txhob noj ib qho ntxiv celecoxib kom txog rau thaum koj nrog koj tus kws kho mob tham.

  • piav tsis hnyav ntxiv
  • txog siav siav lossis ua pa nyuaj
  • o ntawm lub plab, taw, pob taws, lossis ceg qis
  • zawv plab
  • xeev siab
  • nkees dhau heev lawm
  • ntshav txawv lossis doog ntshav
  • khaus
  • tsis muaj lub zog
  • tsis qab los noj mov
  • mob hauv sab saud hauv plab
  • daj ntawm daim tawv nqaij lossis qhov muag
  • cov tsos mob khaub thuas zoo li
  • hlwv
  • ua npaws
  • ua pob
  • khaus
  • o ntawm lub ntsej muag, caj pas, tus nplaig, daim di ncauj, qhov muag, lossis tes
  • txhaws qa
  • teeb meem nqos lossis ua pa
  • daj ntseg tawv nqaij
  • lub plawv dhia ceev
  • pos huab, tshem tawm, lossis tso zis ntshav
  • rov qab mob
  • nyuaj los yog mob tso zis
  • nquag tso zis heev, tshwj xeeb tshaj yog thaum tsaus ntuj

Celecoxib tuaj yeem ua lwm yam phiv. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum koj tseem noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Cov tsos mob ntawm kev haus ntau tshaj yuav suav nrog:

  • tsis muaj lub zog
  • tsaug zog
  • xeev siab
  • ntuav
  • mob plab
  • ntuav cov khoom uas muaj ntshav lossis zoo li thaj chaw kas fes
  • los ntshav lossis dub, quav ua quav
  • tsis nco qab
  • khaus
  • ua pob
  • o ntawm lub qhov muag, ntsej muag, nplaig, daim di ncauj, caj pas, caj npab, tes, taw, pob taws, lossis ceg qis
  • ua pa nyuaj lossis nqos

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Koj cov ntshav siab yuav tsum kuaj xyuas tsis tu ncua thaum koj kho.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

  • Celebrex®
  • Elyxyb®
  • Txwm suav® (muaj Amlodipine, Celecoxib)

Cov khoom muaj npe khoom no tsis nyob rau ntawm kev ua lag luam. Muaj lwm cov kev xaiv uas siv tau.

Kawg Kho - 03/15/2021

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