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Mechanism of Action -- Glimepiride | Dr. Shantanu. R. Joshi | 2019
Daim Duab: Mechanism of Action -- Glimepiride | Dr. Shantanu. R. Joshi | 2019

Zoo Siab

Glimepiride siv nrog rau kev noj haus thiab kev tawm dag zog, thiab qee zaum nrog lwm cov tshuaj, los kho ntshav qab zib hom 2 (mob uas lub cev tsis siv insulin ib txwm thiab, yog li ntawd, tsis tuaj yeem tswj cov piam thaj hauv ntshav). Glimepiride txo qis cov ntshav qab zib los ntawm kev ua rau tus txiav ua tiav insulin (ib yam khoom uas xav tau los rhuav tshem piam thaj hauv lub cev) thiab pab lub cev siv cov insulin zoo. Cov tshuaj no tsuas yog pab txo cov ntshav qab zib hauv cov neeg uas lawv lub cev tsim cov tshuaj insulin lawm xwb. Glimepiride tsis yog siv los kho ntshav qab zib hom 1 (mob uas lub cev tsis tsim cov tshuaj insulin thiab, yog li ntawd, tsis tuaj yeem tswj cov piam thaj hauv ntshav) lossis ntshav qab zib ketoacidosis (mob hnyav uas yuav tshwm sim yog tias ntshav qab zib tsis kho )).

Sij hawm dhau mus, cov neeg muaj ntshav qab zib thiab ntshav qab zib yuav tsim teeb meem loj lossis txaus ntshai rau lub neej, nrog rau kev mob plawv, mob hlab ntsha tawg, raum teeb meem, puas hlab ntshav, thiab teeb meem qhov muag. Noj tshuaj, hloov kev ua neej (xws li kev noj haus, kev tawm dag zog, txiav kev haus luam yeeb), thiab kev tshuaj xyuas koj cov piam thaj hauv ntshav tas li yuav pab tswj koj cov ntshav qab zib thiab txhim kho koj kev noj qab haus huv. Qhov kev kho no tseem yuav ua rau koj muaj feem yuav muaj mob plawv, mob stroke, lossis lwm yam mob ntsig txog ntshav qab zib xws li lub raum tsis ua hauj lwm, mob hlab hlwb (loog, ceg txias lossis txhais taw; txo qis kev sib deev hauv txiv neej thiab poj niam), teeb meem qhov muag, suav nrog kev hloov pauv los sis tsis pom kev, lossis pos hniav mob. Koj tus kws kho mob thiab lwm tus kws saib xyuas kev noj qab haus huv yuav tham nrog koj txog txoj kev zoo tshaj plaws los tswj koj cov ntshav qab zib.


Glimepiride los ua ib ntsiav tshuaj noj ntawm qhov ncauj. Nws feem ntau noj ib hnub ib zaug nrog pluas tshais lossis thawj cov zaub mov tseem ceeb ntawm lub hnub. Txhawm rau kom koj nco qab noj glimepiride, coj nws ncig ntawm tib lub sijhawm txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj glimepiride raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Koj tus kws kho mob tej zaum yuav pib rau koj ntawm qhov tsawg kawg ntawm glimepiride thiab maj mam nce koj cov koob tshuaj yog tias xav tau. Tom qab koj tau noj glimepiride rau qee lub sijhawm, glimepiride yuav tswj tsis tau koj cov ntshav qab zib kom zoo li nws tau ua thaum pib kho koj. Koj tus kws kho mob tuaj yeem hloov kho qhov muab tshuaj rau koj raws li qhov xav tau kom cov tshuaj yuav ua haujlwm zoo tshaj rau koj. Nco ntsoov qhia koj tus kws kho mob seb koj nyob zoo li cas thiab yog tias koj cov txiaj ntsig ntsuas ntshav qab zib tau siab dua lossis qis dua li ib txwm muaj thaum lub sijhawm koj kho.


Glimepiride pab tswj cov ntshav qab zib tab sis tsis kho ntshav qab zib. Txuas ntxiv noj glimepiride txawm hais tias koj xis neej. Tsis txhob tsum noj glimepiride yam tsis tham nrog koj tus kws kho mob.

Cov tshuaj no qee zaum sau tseg rau lwm qhov kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj glimepiride,

  • qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau glimepiride, lwm yam tshuaj, lossis ib qho twg hauv glimepiride. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
  • qhia rau koj tus kws kho mob thiab kws muag tshuaj uas siv tshuaj thiab cov tshuaj uas tsis yog kws kho mob, cov vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txog anticoagulants ('ntshav cov ntshav') xws li warfarin (Coumadin); cov tshuaj aspirin thiab lwm cov tshuaj tiv thaiv tsis haum (NSAIDs) xws li ibuprofen (Advil, Motrin) thiab naproxen (Aleve, Naprosyn); beta blockers xws li atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), thiab propranolol (Inderal); chloramphenicol; clarithromycin (Biaxin); disopyramide (Norpace); diuretics ('dej tshuaj'); fluconazole (Diflucan); fluoxetine (Prozac, Sarafem); kev hloov kho tshuaj thiab tshuaj tiv thaiv hormonal tshuaj (tshuaj txwv, thaj ua rau thaj, ib ncig, kev cog hniav, thiab kev txhaj tshuaj); tshuaj insulin lossis lwm yam tshuaj los kho ntshav qab zib lossis ntshav qab zib; isoniazid (INH); MAO inhibitors xws li isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), thiab tranylcypromine (Parnate); tshuaj rau mob hawb pob thiab mob khaub thuas; tshuaj rau kev mob hlwb thiab xeev siab; miconazole (Monistat); niacin; qhov ncauj steroids xws li dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), thiab prednisone (Deltasone); phenytoin (Dilantin); probenecid (Benemid); tshuaj tua kab mob quinolone thiab fluoroquinolone xws li cinoxacin (Cinobac), ciprofloxacin (Cipro), enoxacin (Penetrex), gatifloxacin (Tequin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxinin (moxifloxin), moxifloxacin (norox) ), ofloxacin (Floxin), sparfloxacin (Zagam), trovafloxacin thiab alatrofloxacin ua ke (Trovan); rifampin (Rifadin); salicylate mob mob xws li choline magnesium trisalicylate, choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan's, lwm tus), thiab salsalate (Argesic, Disalcid, Salgesic); cov tshuaj tua kab mob sulfa xws li co-trimoxazole (Bactrim, Septra); sulfasalazine (Azulfidine); thiab cov tshuaj kho cov thyroid. Tsis tas li ntawd nco ntsoov qhia koj tus kws kho mob lossis kws muag tshuaj yog tias koj tsum tsis noj tshuaj thaum noj glimepiride. Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
  • qhia rau koj tus kws kho mob yog tias koj muaj lossis tsis tau muaj G6PD tsis txaus (ib qho mob uas tau muaj los ua rau cov ntshav liab los sis ntshav liab tsawg); yog tias koj muaj cov tshuaj hormone cuam tshuam nrog adrenal, pituitary, lossis thyroid caj pas; lossis yog tias koj muaj mob plawv, raum, lossis mob siab.
  • qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Yog tias koj cev xeeb tub thaum noj cov tshuaj glimepiride, hu rau koj tus kws kho mob.
  • tham nrog koj tus kws kho mob txog cov kev pheej hmoo thiab cov txiaj ntsig ntawm kev noj tshuaj glimepiride yog tias koj muaj hnub nyoog 65 xyoos lossis laus dua. Cov neeg laus dua yuav tsum tsis txhob noj tshuaj glimepiride vim tias nws tsis zoo lossis muaj txiaj ntsig zoo li lwm yam tshuaj uas tuaj yeem siv los kho cov mob qub.
  • yog tias koj muaj kev phais, suav nrog kev phais hniav, qhia tus kws kho mob lossis kws kho hniav tias koj noj glimepiride.
  • nug koj tus kws kho mob txog kev haus cawv zoo thaum koj siv tshuaj glimepiride. Cawv yuav ua rau muaj kev phiv los ntawm glimepiride mob heev dua. Kev haus dej haus cawv thaum noj glimepiride tseem yuav ua rau cov tsos mob xws li dej ntws yaug (liab ntsej muag), mob taub hau, xeev siab, ntuav, mob hauv siab, tsis muaj zog, tsis pom kev, ua tsis tau pa, tawm hws, txhawm chim, ua tsis taus pa, thiab ntxhov siab.
  • npaj ua kom tsis txhob muaj qhov phom sij lossis tsis haum rau lub hnub ci thiab hnav khaub ncaws tiv thaiv, tsom iav, thiab tshuaj pleev thaiv hnub. Glimepiride tuaj yeem ua rau koj cov tawv nqaij tiv tshav ntuj.
  • nug koj tus kws kho mob seb yuav ua li cas yog tias koj mob, kis kab mob lossis ua npaws, muaj kev ntxhov siab txawv txawv, lossis raug mob. Cov mob no tuaj yeem cuam tshuam koj cov ntshav qab zib thiab cov ntshav glimepiride uas koj xav tau.

Nco ntsoov ua raws li tag nrho cov kev tawm dag zog thiab kev noj haus pom zoo ua los ntawm koj tus kws kho mob lossis tus kws qhia noj zaub mov. Nws yog ib qho tseem ceeb kom noj zaub mov zoo, tawm dag zog kom tsis tu ncua, thiab poob ceeb thawj yog tsim nyog.


Ua ntej koj pib noj cov tshuaj glimepiride, nug koj tus kws kho mob tias koj yuav tsum ua li cas yog tias koj tsis nco qab noj qhov tshuaj. Sau cov lus qhia no sab hauv kom koj tuaj yeem xa lawv tom qab.

Raws li txoj cai dav dav, noj cov koob tshuaj uas ploj lawm sai li sai tau thaum koj nco qab nws. Yog tias nws yuav luag txog rau kev noj tshuaj ntxiv, hla cov tshuaj tsis nco qab thiab txuas ntxiv rau koj lub sijhawm noj tshuaj kom tsis tu ncua.Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Cov tshuaj no tuaj yeem hloov pauv hauv koj cov piam thaj hauv ntshav. Koj yuav tsum paub cov tsos mob uas muaj ntshav qab zib thiab ntshav qab zib thiab yuav ua li cas yog tias koj muaj cov tsos mob no.

Glimepiride tuaj yeem ua rau phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

  • kiv taub hau
  • xeev siab

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob no, hu rau koj tus kws kho mob:

  • daj ntawm daim tawv nqaij lossis qhov muag
  • lub teeb xim ua kom nruj
  • tsaus zis
  • mob hauv sab saud hauv plab
  • doog ntshav los ntshav tsis txawv
  • zawv plab
  • ua npaws
  • mob caj pas

Glimepiride tuaj yeem ua rau lwm cov kev mob tshwm sim. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Hauv ib txoj kev tshawb nrhiav, cov neeg uas tau noj tshuaj zoo ib yam li glimepiride los kho lawv cov ntshav qab zib tau ntxim yuav muaj mob plawv ntau dua li cov neeg uas tau raug kho los ntawm insulin thiab kev hloov pauv zaub mov. Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev noj tshuaj glimepiride.

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Cov tsos mob ntawm overdose tej zaum yuav muaj xws li hypoglycemia cov tsos mob raws li nram qab no:

  • qaug dab peg
  • tsis nco qab

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj qhov kev yoo ntshav cov piam thaj hauv ntshav thiab glycosylated hemoglobin (HbA1c) yuav tsum raug kuaj xyuas tsis tu ncua los txiav txim koj cov lus teb rau glimepiride. Koj tus kws kho mob tuaj yeem xaj lwm yam kev kuaj ntshav kuaj xyuas koj cov lus teb rau glimepiride. Koj tus kws kho mob tseem yuav qhia koj txog kev kuaj xyuas koj cov lus teb rau cov tshuaj no li cas los ntawm kev ntsuas koj cov piam thaj hauv ntshav hauv tsev. Ua raws li cov lus qhia no kom zoo.

Koj yuav tsum hnav txoj hlua tes uas muaj ntshav qab zib kom paub tseeb tias koj tau txais kev kho mob tau zoo thaum muaj xwm txheej ceev.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

  • Amaryl®
  • Avandaryl® (muaj cov tshuaj Glimepiride, Rosiglitazone)
  • Duetact® (uas muaj cov tshuaj Glimepiride, Pioglitazone)
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