Tezacaftor thiab Ivacaftor

Zoo Siab

• Ua ntej noj tezacaftor thiab ivacaftor,
• Tezacaftor thiab ivacaftor tuaj yeem ua rau phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob no, tsum tsis txhob noj tezacaftor thiab ivacaftor thiab hu rau koj tus kws kho mob tam sim ntawd:

Kev sib xyaw ntawm tezacaftor thiab ivacaftor yog siv nrog rau ivacaftor los kho qee yam mob cystic fibrosis (mob inborn uas ua rau muaj teeb meem nrog kev ua pa, plab zom mov, thiab rov ua dua tshiab) hauv cov laus thiab cov menyuam hnub nyoog 6 xyoo thiab laus dua. Tezacaftor thiab ivacaftor yuav tsum tau siv rau cov tib neeg muaj qee yam kev tu caj ces xwb. Koj tus kws kho mob yuav kom kuaj ntshav los pab txiav txim seb cov tshuaj no puas zoo rau koj. Tezacaftor nyob hauv chav kawm ntawm cov tshuaj hu ua cystic fibrosis transmembrane conductance regulator (CFTR) correctors. Ivacaftor yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. Ob yam tshuaj no ua haujlwm los ntawm kev txhim kho kev ua haujlwm ntawm protein nyob rau hauv lub cev kom txo qis tsim cov qog ua kua rau hauv lub ntsws thiab txhim kho lwm yam cystic fibrosis cov tsos mob.

Kev sib xyaw ntawm tezacaftor thiab ivacaftor thiab ivacaftor tuaj ua cov ntsiav tshuaj los noj ntawm qhov ncauj. Cov tshuaj no los hauv ib pob nrog 4 lub lim tiam ntawm kev muab tshuaj. Txhua koob tshuaj txhua hnub muaj ntau hom ntsiav tshuaj: ib ntsiav tshuaj yog kev sib xyaw ntawm tezacaftor thiab ivacaftor thiab lwm lub ntsiav tshuaj yog ivacaftor. Siv tezacaftor thiab ivacaftor (1 ntsiav tshuaj daj) txhua tag kis sawv ntxov nrog cov khoom noj muaj roj thiab ivacaftor (1 ntsiav tshuaj xiav) txhua txhua hmo nrog rau cov khoom noj muaj roj, 12 teev sib nrug. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj cov tshuaj no raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Nqos cov ntsiav tshuaj tag nrho; tsis txhob sib faib, zom, lossis tsoo lawv.

Noj ua ke ntawm tezacaftor thiab ivacaftor thiab ivacaftor nrog cov khoom noj muaj roj xws li qe, butter, txiv ntoo, txiv laum huab xeeb, cheese pizza, thiab tag nrho cov khoom noj mis nyuj (xws li mis nyuj, cheese, thiab yogurt). Tham nrog koj tus kws kho mob txog lwm cov zaub mov muaj roj los noj nrog cov tshuaj no.

Kev sib xyaw ntawm tezacaftor thiab ivacaftor nrog rau ivacaftor ua haujlwm los tswj cystic fibrosis, tab sis lawv tsis kho nws. Txuas ntxiv noj cov tshuaj no txawm hais tias koj twb xis neej. Tsis txhob tsum tsis txhob noj cov tshuaj no yam tsis tau tham nrog koj tus kws kho mob.

Nug koj tus kws muag tshuaj lossis tus kws kho mob txog cov ntawv luam ntawm cov ntaub ntawv tsim tawm rau tus neeg mob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj tezacaftor thiab ivacaftor,

• qhia rau koj tus kws kho mob thiab kws muag tshuaj yog tias koj muaj kev fab tshuaj rau tezacaftor, ivacaftor, lwm yam tshuaj noj, lossis lwm yam tshuaj hauv tezacaftor thiab ivacaftor thiab ivacaftor ntsiav tshuaj. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob thiab cov ntawv yuav tshuaj, cov vitamins, khoom noj khoom haus muaj txiaj ntsig zoo, koj noj lossis npaj yuav noj. Nco ntsoov hais txog ib qho ntawm cov hauv qab no: qee yam tshuaj tua kab mob xws li clarithromycin (Biaxin, hauv PrevPac), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), thiab telithromycin (Ketek); qee yam antifungals xws li fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), thiab voriconazole (Vfend); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); everolimus (Afinitor, Zortress); qee cov tshuaj rau qaug dab peg xws li carbamazepine (Carbatrol, Epitol, Tegretol, lwm tus), phenobarbital, thiab phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); rifampin (Rifadin, hauv Rifamate, hauv Rifater, Rimactane); sirolimus (Rapamune); lossis tacrolimus (Astagraf, Prograf). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv. Ntau lwm yam tshuaj kuj tseem tuaj yeem cuam tshuam nrog tezacaftor thiab ivacaftor, yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv, txawm tias cov uas tsis tshwm hauv cov npe no.
• qhia koj tus kws kho mob tias yam tshuaj ntsuab koj noj, tshwj xeeb tshaj yog St. John wort. Koj tus kws kho mob yuav qhia koj kom tsis txhob coj St. John lub wort thaum noj ua ke ntawm tezacaftor thiab ivacaftor nrog rau ivacaftor.
• qhia rau koj tus kws kho mob yog tias koj tau lossis tau muaj mob raum lossis mob siab.
• qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Yog tias koj cev xeeb tub thaum noj tshuaj tezacaftor thiab ivacaftor ua ke nrog ivacaftor, hu rau koj tus kws kho mob.
• koj yuav tsum paub tias cov tshuaj no tuaj yeem ua rau koj tsaug zog. Tsis txhob tsav tsheb los sis siv lub tshuab ua haujlwm kom txog thaum koj paub tias cov tshuaj no cuam tshuam rau koj li cas.

Tsis txhob noj txiv kab ntxwv qaub lossis txiv kab ntxwv Seville lossis haus kua txiv txiv kab ntxwv thaum noj cov tshuaj no.

Yog tias koj nco qab cov koob tsis nco qab ntawm ib ntsiav tshuaj tsis dhau 6 teev ntawm lub sijhawm uas koj tau teem caij mus noj, noj cov tshuaj uas ploj lawm tam sim ntawd nrog ib qho khoom noj muaj rog. Txawm li cas los xij, yog tias ntau dua 6 teev tau dhau mus txij li lub sijhawm teem sijhawm los noj cov ntsiav tshuaj twg, hla cov koob tshuaj uas tsis nco qab noj thiab txuas ntxiv rau koj cov sijhawm noj tshuaj tas li. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Tezacaftor thiab ivacaftor tuaj yeem ua rau phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• mob taub hau
• ntswg ntswg
• kiv taub hau

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob no, tsum tsis txhob noj tezacaftor thiab ivacaftor thiab hu rau koj tus kws kho mob tam sim ntawd:

• daj ntawm daim tawv nqaij lossis qhov muag
• tsis qab los noj mov
• xeev siab
• ntuav
• daj ntseg quav
• mob plab
• tsaus zis

Tezacaftor thiab ivacaftor tuaj yeem ua rau mob cataracts (txhaws xaj ntawm lub qhov muag uas yuav ua teeb meem tsis pom kev) hauv cov menyuam yaus thiab cov hluas. Cov menyuam yaus thiab tub ntxhais hluas siv cov tshuaj tezacaftor thiab ivacaftor yuav tsum mus ntsib kws kho qhov muag ua ntej thiab thaum kho lawv. Tham nrog koj tus menyuam tus kws khomob txog cov kev pheej hmoo ntawm kev muab tezacaftor thiab ivacaftor rau koj tus menyuam.

Tezacaftor thiab ivacaftor tuaj yeem ua rau lwm cov kev mob tshwm sim. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj kuaj qhov muag (rau menyuam yaus thiab tub ntxhais hluas) thiab qee qhov kev kuaj sim ua ntej thiab thaum kho koj qhov kuaj xyuas koj lub cev teb rau tezacaftor thiab ivacaftor.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

• Symdeko^®