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Ribociclib plus endocrine therapy boosts survival of HR+/HER2- breast cancer
Daim Duab: Ribociclib plus endocrine therapy boosts survival of HR+/HER2- breast cancer

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Ribociclib yog siv ua ke nrog lwm cov tshuaj los kho qee yam ntawm cov tshuaj hormone receptor – positive (nyob ntawm cov tshuaj hormones xws li cov tshuaj estrogen loj hlob) nce qog noj ntshav mis lossis cov uas tau kis mus rau lwm qhov hauv lub cev hauv cov poj niam uas tsis tau muaj lub cev ntas (hloov lub neej; xaus ntawm kev coj khaub ncaws txhua hli) thiab cov uas ze lossis cov uas twb tau lawm lawm. Ribociclib kuj tseem siv nrog kev ua kom zoo tag nrho (Faslodex) los kho qee yam ntawm cov tshuaj hormone receptor – positive cancer mis los yog kis mus rau lwm qhov ntawm lub cev ua kev kho mob thawj zaug lossis hauv cov neeg uas tsis tau kho zoo nrog lwm cov kev kho mob rau cov poj niam uas twb tau lawm lawm. Ribociclib yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua kinase inhibitors. Nws ua haujlwm los ntawm kev thaiv qhov kev txiav txim ntawm cov protein tsis txaus uas ua rau muaj hlwb hlav hlav. Qhov no yuav pab kom qeeb los yog txwv tsis pub kis mob hlwb.

Ribociclib los ua ib ntsiav tshuaj noj ntawm qhov ncauj. Nws feem ntau tau noj nrog lossis tsis noj zaub mov ib zaug nyob rau yav sawv ntxov rau thawj 21 hnub ntawm 28-hnub voj voog. Siv ribociclib nyob ib ncig ntawm tib lub sijhawm txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj ribociclib raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.


Nqos cov ntsiav tshuaj tag nrho; tsis txhob sib faib, zom, lossis tsoo lawv. Tsis txhob noj cov ntsiav tshuaj uas tawg lossis tsoo.

Yog tias koj ntuav tom qab noj ribociclib, tsis txhob noj tshuaj ntxiv. Ua koj cov tshuaj noj tas li.

Koj tus kws kho mob tuaj yeem txo koj cov koob tshuaj ribociclib lossis tas mus li lossis tsum ib ntus lossis kho koj tus mob. Qhov no nws nyob ntawm seb cov tshuaj ua hauj lwm zoo npaum li cas rau koj thiab kev phiv uas koj ntsib. Nco ntsoov qhia koj tus kws kho mob seb koj xav li cas thaum kho koj mob ribociclib.

Nug koj tus kws muag tshuaj lossis tus kws kho mob txog cov ntawv luam ntawm cov ntaub ntawv tsim tawm rau tus neeg mob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj ribociclib,

  • qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau ribociclib, lwm yam tshuaj noj, lossis ib qho twg hauv cov ntsiav tshuaj ribociclib. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
  • qhia rau koj tus kws kho mob thiab kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob thiab cov tshuaj uas tsis yog kws kho mob sau, tshuaj vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txhua yam ntawm cov hauv qab no: amiodarone (Nexterone, Pacerone); qee yam tshuaj tua kab mob xws li clarithromycin (Biaxin, hauv Prevpac), erythromycin (E.E.S., Ery-tab, Eryped), thiab moxifloxacin (Avelox); qee cov tshuaj tua kabmob xws li itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), thiab voriconazole (Vfend); bepridil (tsis muaj nyob hauv Tebchaws Meskas); boceprevir (Victrelis, tsis muaj nyob hauv Asmeskas); chloroquine (Aralen); conivaptan; cyclosporine (Gengraf, Neoral, Sandimmune); dihydroergotamine (D.H.E. 45, Migranal); disopyramide (Norpace); ergotamine (Ergomar, hauv Cafergot, hauv Migergot); everolimus (Afinitor, Zortress); fentanyl (Abstral, Actiq, Fentora, Onsolis); halofantrine (Halfan; tsis muaj nyob hauv Asmeskas); haloperidol (Haldol); qee cov tshuaj rau tib neeg cov tshuaj tiv thaiv kab mob (HIV) xws li efavirenz (Sustiva, hauv Atripla), indinavir (Crixivan), lopinavir (hauv Kaletra), nelfinavir (Viracept), ritonavir (Norvir, hauv Kaletra), thiab saquinavir (Invirase); qee cov tshuaj rau qaug dab peg xws li carbamazepine (Carbatrol, Equetro, Teril, lwm tus) thiab phenytoin (Dilantin, Phenytek); tshuaj txiav yeeb (Dolophine, Methadose); nefazodone; ondansetron (tso ntshav dej); pimozide (Orap); procainamide; quinidine (hauv Nuedexta); phom phom (Rimactane, Rifadin, hauv Rifamate, hauv Rifater); sirolimus (Rapamune); sotalol (Betapace, Sotylize); tacrolimus (Envarsus XR, Prograf), thiab tamoxifen (Soltamox). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.Ntau lwm yam tshuaj kuj tseem tuaj yeem cuam tshuam nrog ribociclib, yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv, txawm tias tsis tshwm nyob hauv daim ntawv no.
  • qhia koj tus kws kho mob tias yam tshuaj ntsuab koj noj, tshwj xeeb tshaj yog St. John's Wort.
  • qhia rau koj tus kws kho mob yog tias koj tau mob plawv sai sai no; lossis tau lossis muaj lub siab qeeb qeeb dua; lub sijhawm QT ntu ntev (qhov teeb meem tsis tshua muaj lub siab uas yuav ua rau lub plawv dhia tsis xwm yeem, tsaus muag, lossis cia li tuag tam sim ntawd); theem qis ntawm potassium, calcium, phosphorus, lossis magnesium nyob hauv koj cov ntshav; lub plawv dhia; lossis lub siab, raum, lossis mob plawv.
  • qhia rau koj tus kws kho mob yog tias koj cev xeeb tub los yog npaj yuav cev xeeb tub. Koj yuav tsum tau coj mus kuaj cev xeeb tub ua ntej koj pib kho. Siv ib txoj hauv kev tiv thaiv kev tswj tsis pub muaj menyuam kom tiv thaiv kev xeeb tub lub sijhawm thaum kho koj thiab rau 3 lub lis piam tom qab koj cov tshuaj kawg. Tham nrog koj tus kws kho mob txog kev tiv thaiv kev xeeb tub uas yuav ua haujlwm rau koj. Yog tias koj xeeb tub thaum noj cov tshuaj ribociclib, hu rau koj tus kws kho mob tam sim ntawd. Ribociclib tuaj yeem tsim kev puas tsuaj rau tus me nyuam hauv plab.
  • qhia rau koj tus kws kho mob yog tias koj pub mis niam lossis npaj yuav pub mis. Koj yuav tsum tsis txhob pub niam mis thaum noj ribociclib thiab tsawg kawg 3 lub lis piam tom qab koj cov tshuaj zaum kawg.
  • koj yuav tsum paub tias cov tshuaj no tuaj yeem txo qis kev muaj menyuam hauv cov txiv neej. Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev mob ribociclib.
  • yog tias koj muaj kev phais, suav nrog kev phais hniav, qhia tus kws kho mob lossis kws kho hniav tias koj noj ribociclib.

Tsis txhob noj txiv kab ntxwv qaub lossis haus txiv kab ntxwv qaub thaum noj cov tshuaj no.


Hla lub tshuaj uas tsis nco qab noj thiab txuas ntxiv koj lub sijhawm noj tshuaj. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Ribociclib yuav ua rau muaj kev phiv tshuaj. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

  • zawv plab
  • cem quav
  • mob plab
  • mob taub hau
  • plaub hau poob
  • rov qab mob
  • khaus
  • qhov ncauj tawm
  • o ntawm tes, taw, pob taws, lossis ceg qis
  • teeb meem tsis tsaug zog los yog pw tsaug zog

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob no, hu rau koj tus kws kho mob:

  • kub taub hau, mob caj pas, ua daus no, los yog lwm yam cim ntawm tus kab mob
  • ua pob
  • blistering lossis tev ntawm daim tawv nqaij
  • mob los yog nqaij to ntawm daim di ncauj, qhov muag, lossis qhov ncauj
  • lub plawv dhia ceev ceev, tsis meej, los yog sib tsoo
  • ua pa nyuaj lossis txog siav; hnoos nrog lossis tsis muaj hnoos qeev; lossis mob hauv siab
  • kiv taub hau
  • tsaus muag
  • daj ntawm daim tawv nqaij lossis qhov muag
  • tsaus nti los sis xim av (tso zis-xim) zis
  • nkees nkees
  • tsis qab los noj mov
  • mob mob sab saud hauv plab
  • xeev siab
  • ntuav
  • los ntshav lossis doog ntshav yooj yim dua li ib txwm

Ribociclib yuav ua rau muaj kev phiv lwm yam ntxiv. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.


Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev kuaj sim ua ntej thiab thaum kho koj lub cev kom kuaj xyuas koj lub cev cov lus teb rau ribociclib. Koj tus kws kho mob kuj tuaj yeem xaj hluav taws xob (ECG; ntsuas ntsuas qhov ntsuas hluav taws xob hauv plawv) ua ntej thiab thaum kho koj.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

  • Kisqali®
  • Kisqali® Femera® (raws li cov khoom sib txuas ua ke muaj cov Letrazole thiab Ribociclib)
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