Mifepristone (Korlym)

Zoo Siab

• Ua ntej noj mifepristone,
• Mifepristone yuav ua rau muaj kev phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no, hu rau koj tus kws kho mob sai lossis tau txais kev kho mob kub ceev:

Rau poj niam mob:

Tsis txhob noj mifepristone yog tias koj cev xeeb tub los yog npaj yuav cev xeeb tub. Mifepristone tuaj yeem ua rau xeeb tub. Koj yuav tsum muaj kev kuaj mob tsis zoo thaum cev xeeb tub ua ntej pib kho nrog mifepristone thiab ua ntej pib kev kho mob dua yog tias koj tsum tsis noj ntau dua 14 hnub. Yog tias koj tuaj yeem cev xeeb tub, koj yuav tsum zam kom tsis txhob muaj menyuam hauv plab thaum kho mob nrog mifepristone. Koj yuav tsum siv cov ntawv tswj xeeb tsis pub siv thaum lub sij hawm kho koj thiab tsawg kawg 1 hlis tom qab ua tiav koj txoj kev kho mob. Koj tus kws kho mob yuav qhia koj txog hom kev tswj tsis pub muaj menyuam siv tau. Yog tias koj xav tias koj cev xeeb tub, koj ncua lub sijhawm coj khaub ncaws, lossis koj tau sib deev yam tsis siv kev tswj tsis pub muaj menyuam thaum noj mifepristone lossis hauv 1 hlis tom qab kho koj tus kheej, hu rau koj tus kws kho mob tam sim ntawd

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev kuaj xyuas koj lub cev cov lus teb rau mifepristone.

Koj tus kws kho mob lossis kws muag tshuaj yuav muab daim ntawv qhia txog cov neeg mob rau koj (Phau Ntawv Qhia Tshuaj Kho Mob) thaum koj pib kho mifepristone thiab txhua zaus koj rov ntim tshuaj rau koj. Nyeem cov ntaub ntawv kom zoo thiab nug koj tus kws kho mob lossis kws muag tshuaj yog tias koj muaj lus nug. Koj kuj tuaj yeem mus saib tau Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) lub vev xaib (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) lossis cov chaw tsim tshuaj paus lub vev xaib kom tau txais Kev Qhia Tshuaj.

Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev siv tshuaj mifepristone.

Mifepristone (Korlym) yog siv los kho hyperglycemia (ntshav qab zib ntshav siab) hauv cov neeg muaj qee yam mob Cushing's syndrome uas lub cev ua rau cortisol ntau dhau (ib yam tshuaj hormones) thiab tus uas tau ua tsis tiav los yog tsis tuaj yeem raug phais los kho tus mob no. Mifepristone yog nyob hauv chav kawm ntawm cov tshuaj hu ua cortisol receptor blockers. Nws ua haujlwm los ntawm kev thaiv cov haujlwm ntawm cortisol.

Mifepristone tseem tseem muaj lwm cov khoom lag luam (Mifeprex) uas yog siv ib leeg lossis ua ke nrog lwm cov tshuaj los xaus kev xeeb tub thaum ntxov. Cov monograph no tsuas yog muab cov ntaub ntawv hais txog mifepristone (Korlym) siv los tswj hyperglycemia rau cov neeg uas muaj qee hom mob Cushing's syndrome. Yog tias koj siv mifepristone los txiav tawm kev xeeb tub, nyeem cov ntawv muaj npe ntawm mifepristone (Mifeprex), uas tau sau txog cov khoom no.

Mifepristone los ua ib ntsiav tshuaj noj ntawm qhov ncauj. Nws feem ntau yog noj ib zaug ib hnub nrog ib pluag mov. Siv mifepristone nyob ib ncig ntawm tib lub sijhawm txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj mifepristone raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Nqos cov ntsiav tshuaj tag nrho; tsis txhob sib faib, zom, lossis tsoo lawv. Qhia rau koj tus kws kho mob lossis kws muag tshuaj yog tias koj tsis tuaj yeem nqos cov ntsiav tshuaj tag nrho.

Koj tus kws kho mob yuav pib koj noj tshuaj mifepristone qis dua thiab maj mam nce koj cov koob tshuaj, tsis yog ntau tshaj ib zaug txhua 2 rau 4 lub lis piam. Yog tias koj tsum tsis noj mifepristone, hu rau koj tus kws kho mob. Koj tus kws kho mob yuav tsum pib koj dua ntawm kev noj tshuaj mifepristone qis dua thiab maj mam nce koj cov koob tshuaj.

Mifepristone tuaj yeem tswj hwm koj tus mob tab sis tsis kho nws. Nws yuav siv li 6 lub lis piam lossis ntev dua ua ntej koj xav tias tag nrho cov txiaj ntsig ntawm mifepristone. Noj tshuaj mifepristone txuas ntxiv txawm tias koj tus kheej yuav xis nyob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj mifepristone,

• qhia rau koj tus kws kho mob yog tias koj muaj kev fab tshuaj rau mifepristone, lwm yam tshuaj noj, lossis lwm yam tshuaj hauv mifepristone ntsiav tshuaj. Nug koj tus kws muag tshuaj lossis tshawb xyuas cov ntaub ntawv ntawm tus neeg mob rau cov npe ntawm cov khoom sib xyaw.
• qhia rau koj tus kws kho mob yog tias koj noj cov tshuaj hauv qab no lossis tau noj hauv ob lub lis piam dhau los: corticosteroids xws li betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, Dexpak, Dexasone, lwm tus) , fludrocortisone (Floriner), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, lwm tus), prednisolone (Prelone, lwm tus), prednisone (Deltasone, Meticorten, Sterapred, lwm tus), thiab triamcinolone (Aristocort), Azm; cov tshuaj noj uas tiv thaiv lub cev tiv thaiv kab mob xws li cyclosporine (Neoral, Sandimmune), sirolimus (Rapamune), thiab tacrolimus (Prograf); dihydroergotamine (D.H.E. 45, Migranal); ergotamine (Ergomar, hauv Cafergot, hauv Migergot); fentanyl (Duragesic); lovastatin (Mevacor); pimozide (Orap); quinidine (Quinidex); thiab simvastatin (Zocor). Koj tus kws kho mob yuav qhia koj kom tsis txhob noj mifepristone yog tias koj noj ib lossis ntau hom tshuaj no.
• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj tias lwm yam tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob, cov vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis tau noj hauv ob lub lis piam dhau los no yog dabtsi. Nco ntsoov hais txog ib qho ntawm cov hauv qab no: anticoagulants ('ntshav cov ntshav') xws li warfarin (Coumadin); cov tshuaj tua kab mob xws li itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), lossis voriconazole (Vfend); cov tshuaj aspirin thiab lwm cov tshuaj tiv thaiv tsis haum (NSAIDs) xws li ibuprofen (Advil, Motrin) thiab naproxen (Aleve, Naprosyn); bupropion (Wellbutrin); ciprofloxacin (Cipro); clarithromycin (Biaxin); conivaptan (Vaprisol); diltiazem (Cardizem); erythromycin (E.E.S., E-Mycin, Erythrocin); fluvastatin (Lescol); tshuaj tiv thaiv cev xeeb tub xws li tshuaj txwv tsis pub muaj menyuam, cog hniav, pleev ib ncig, nplhaib, lossis hno; tshuaj noj rau kab mob siab C xws li boceprevir (Victrelis) thiab telaprevir (Incivek); cov tshuaj rau HIV lossis AIDS xws li amprenavir (Agenerase), atazanavir (Reyataz), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir thiab ritonavir ua ke (Kaletra), nelfinavir (Viracept), rvonav thiab saquinavir (Fortovase, Invirase); tshuaj noj rau qaug dab peg xws li carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin); tshuaj rau tuberculosis xws li rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, hauv Rifamate, hauv Rifater) thiab rifapentine (Priftin); nefazodone (Serzone); repaglinide (Prandin); telithromycin (Ketek); thiab verapamil (Calan, Isoptin, lwm tus). Ntau lwm yam tshuaj kuj tseem tuaj yeem cuam tshuam nrog mifepristone, yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv, txawm tias tsis tshwm nyob hauv daim ntawv no. Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
• qhia koj tus kws kho mob tias yam tshuaj ntsuab koj noj, tshwj xeeb tshaj yog St. John's Wort.
• qhia rau koj tus kws kho mob yog tias koj tau muaj kev hloov khoom nruab nrog lossis koj puas tau lossis muaj tus mob qog ib zaug. Yog tias koj yog tus poj niam thiab tsis tau muaj kev phais los tshem koj lub tsev menyuam, qhia rau koj tus kws kho mob yog tias koj muaj lossis puas tau muaj ntshav tawm ntawm qhov chaw mos ua tsis muaj mob, endometrial hyperplasia (hla ntawm cov leeg ntawm lub tsev menyuam), lossis mob qog nqaij hlav endometrial (mob qog nqaij hlav cancer) koj lub tsev menyuam). Koj tus kws kho mob yuav qhia koj kom tsis txhob noj tshuaj mifepristone.
• qhia rau koj tus kws kho mob yog tias koj tau lossis muaj lub plawv tsis ua haujlwm ntev, QT ncua ntev (qhov teeb meem tsis tshua muaj lub plawv uas yuav ua rau lub plawv dhia tsis xwm yeem, tsaus muag, lossis cia li tuag kiag), muaj cov poov tshuaj tsawg hauv koj cov ntshav, adrenal tsis txaus (mob uas cov qog adrenal tsis tsim cov tshuaj hormones txaus txaus rau lub cev tseem ceeb lub luag haujlwm), kev los ntshav, lossis mob siab, lub raum, lossis mob plawv.
• qhia rau koj tus kws kho mob yog tias koj pub mis.

Tsis txhob noj txiv kab ntxwv qaub lossis haus cov txiv kab ntxwv kua txiv thaum koj tseem noj hom tshuaj no.

Noj cov koob tshuaj uas ploj lawm sai li sai tau thaum koj nco qab nws. Txawm li cas los xij, yog tias nws yuav luag txog rau koob tshuaj txuas ntxiv, hla cov koob tshuaj uas tsis nco qab noj thiab txuas ntxiv koj lub sijhawm noj tshuaj kom tsis tu ncua. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Mifepristone yuav ua rau muaj kev phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• mob taub hau
• ntuav
• qhov ncauj qhuav
• zawv plab
• cem quav
• mob pob qij txha lossis mob leeg
• o ntawm tes, taw, pob taws, lossis ceg qis
• ua pob
• khaus

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no, hu rau koj tus kws kho mob sai lossis tau txais kev kho mob kub ceev:

• xeev siab
• tsis qab los noj mov
• kiv taub hau lossis tsaus ntais
• nkees txawv lossis tsis muaj zog
• poob siab lossis txob taus
• tshee
• hws
• leeg tsis muaj zog, leeg, lossis mob plab
• lub plawv dhia ceev ceev, tsis meej, los yog sib tsoo
• Qhov xav tias yuav los ntshav lossis los ntshav
• txog siav

Mifepristone yuav ua rau muaj kev phiv ntxiv. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Ua ntej muaj kev sim ntsuas, qhia rau koj tus kws kho mob thiab cov neeg ua haujlwm hauv chav kuaj pom tias koj noj mifepristone.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

• Korlym^®