Denosumab Txhaj Tshuaj

Zoo Siab

• Kev Siv Tshuaj Denosumab (Prolia) yog siv
• Kev Siv Tshuaj Denosumab (Xgeva) yog siv cov tshuaj Denosumab yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua RANK ligand inhibitors. Nws ua haujlwm tiv thaiv kom tsis txhob muaj pob txha los ntawm kev thaiv qee cov receptor hauv lub cev kom txo cov pob txha tsis zoo. Nws ua haujlwm los kho GCTB los ntawm kev thaiv qee tus receptor hauv cov qog ntshav uas ua rau cov qog loj hlob qeeb. Nws ua haujlwm los kho cov calcium uas ntau ntau los ntawm kev txo cov pob txha tawg vim qhov tawg ntawm cov pob txha tso cov calcium.
• Ua ntej tau txais kev txhaj tshuaj denosumab,
• Kev txhaj tshuaj Denosumab tuaj yeem ua rau muaj kev phiv tshuaj. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no, hu rau koj tus kws kho mob sai lossis tau txais kev kho mob kub ceev:

Kev Siv Tshuaj Denosumab (Prolia) yog siv

• los kho cov txha txha caj (mob uas tus pob txha yuag thiab tsis muaj zog thiab tawg yooj yim) rau cov poj niam uas muaj hnub lawm ('' hloov lub neej; '' xaus rau poj niam coj khaub ncaws) uas muaj kev pheej hmoo ntau rau pob txha (pob txha tawg) lossis yog leej twg tsis tuaj yeem noj lossis tsis teb rau lwm txoj kev kho mob rau pob txha.
• los kho tus txiv neej uas muaj kev pheej hmoo ntau rau pob txha tawg (pob txha tawg) lossis tus uas tsis tuaj yeem noj lossis tsis teb rau lwm txoj kev kho mob rau pob txha txha.
• kho osteoporosis uas tshwm sim los ntawm cov tshuaj corticosteroid hauv cov txiv neej thiab poj niam uas yuav tau noj tshuaj corticosteroid tsawg kawg 6 lub hlis thiab muaj kev pheej hmoo ntau rau pob txha lov lossis leej twg tsis tuaj yeem noj lossis tsis teb rau lwm txoj kev kho mob rau pob txha txha.
• los kho cov pob txha ploj hauv cov txiv neej uas tau raug kho mob qog nqaij hlav cancer nrog qee cov tshuaj uas ua rau pob txha ploj,
• txhawm rau kho pob txha txhawm rau cov poj niam muaj mob cancer mis uas tau txais qee yam tshuaj uas ua rau lawv muaj feem ua rau txha lov.

Kev Siv Tshuaj Denosumab (Xgeva) yog siv cov tshuaj Denosumab yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua RANK ligand inhibitors. Nws ua haujlwm tiv thaiv kom tsis txhob muaj pob txha los ntawm kev thaiv qee cov receptor hauv lub cev kom txo cov pob txha tsis zoo. Nws ua haujlwm los kho GCTB los ntawm kev thaiv qee tus receptor hauv cov qog ntshav uas ua rau cov qog loj hlob qeeb. Nws ua haujlwm los kho cov calcium uas ntau ntau los ntawm kev txo cov pob txha tawg vim qhov tawg ntawm cov pob txha tso cov calcium.

• txhawm rau txo kev pheej hmoo ntawm pob txha tawg rau cov neeg uas muaj ntau yam mob myeloma (mob qog nqaij hlav uas pib hauv cov ntshav ntshav thiab ua rau pob txha puas), thiab cov neeg uas muaj qee yam mob qog ntshav uas tau pib hauv lwm qhov ntawm lub cev tab sis tau kis mus rau cov pob txha.
• rau cov neeg laus thiab qee tus menyuam yaus los kho mob qog nqaij hlav loj hauv pob txha (GCTB; ib hom mob pob txha) uas tsis tuaj yeem kho nrog kev phais mob.
• los kho cov tshuaj calcium siab ntau uas tshwm sim los ntawm mob qog ntshav hauv cov neeg uas tsis teb rau lwm cov tshuaj.

Kev txhaj tshuaj Denosumab yog los ntawm kev daws teeb meem (ua kua) yuav raug txhaj tshuaj subcutaneously (hauv qab daim tawv) hauv koj sab caj npab, sab sauv, lossis hauv plab. Feem ntau nws tau txhaj tshuaj los ntawm kws kho mob lossis kws saib xyuas mob hauv chaw ua haujlwm lossis chaw kuaj mob. Feem ntau cov tshuaj Denosumab (Prolia) txhaj ib zaug txhua 6 lub hlis. Thaum denosumab txhaj tshuaj (Xgeva) yog siv los txo qis kev pheej hmoo ntawm pob txha tawg los ntawm ntau tus mob myeloma, lossis mob qog nqaij hlav uas tau kis mus rau cov pob txha, feem ntau yog muab ib zaug txhua 4 lub lis piam. Thaum denosumab txhaj tshuaj (Xgeva) yog siv los kho kab mob loj ntawm lub cev ntawm cov pob txha, lossis qib siab calcium los ntawm mob cancer, feem ntau yog muab rau txhua 7 hnub rau thawj peb koob tshuaj (hnub 1, hnub 8, thiab hnub 15) thiab tom qab ntawd ib zaug txhua 4 lub lis piam pib 2 lub lis piam tom qab thawj peb koob.

Koj tus kws kho mob yuav qhia koj kom noj tshuaj ntxiv ntawm calcium thiab vitamin D thaum lub sijhawm koj tau kho nrog denosumab txhaj. Noj cov tshuaj no raws nraim li qhia.

Thaum denosumab txhaj tshuaj (Prolia) yog siv los kho pob txha txha pob txha lossis mob pob txha, koj tus kws kho mob lossis kws muag tshuaj yuav muab daim ntawv qhia cov neeg mob rau koj (Daim Ntawv Qhia Tshuaj) thaum koj pib kho nrog denosumab txhaj tshuaj thiab txhua zaus koj rov ntim tshuaj. Nyeem cov ntaub ntawv kom zoo thiab nug koj tus kws kho mob lossis kws muag tshuaj yog tias koj muaj lus nug. Koj kuj tuaj yeem mus saib tau Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) lub vev xaib (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) lossis cov chaw tsim tshuaj paus lub vev xaib kom tau txais Kev Qhia Tshuaj.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej tau txais kev txhaj tshuaj denosumab,

• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau denosumab (Prolia, Xgeva), lwm yam tshuaj noj, hnab looj, lossis ib qho twg hauv cov tshuaj txhaj denosumab. Nug koj tus kws muag tshuaj lossis tshawb xyuas Phau Ntawv Qhia Tshuaj Kho Mob rau cov npe ntawm cov khoom siv.
• koj yuav tsum paub tias kev txhaj tshuaj denosumab yog muaj nyob hauv cov npe lag luam Prolia thiab Xgeva. Koj yuav tsum tsis txhob txais ntau dua ib qho khoom lag luam muaj denosumab tib lub sijhawm. Nco ntsoov qhia koj tus kws kho mob yog tias koj tau txais kev kho nrog ib qho ntawm cov tshuaj no.
• qhia rau koj tus kws kho mob thiab kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob thiab cov tshuaj uas tsis yog kws kho mob sau, tshuaj vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj.Nco ntsoov hais txog ib qho ntawm cov hauv qab no: angiogenesis inhibitors xws li axitinib (Inlyta), bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), lossis sunitinib (Neutav); bisphosphonates xws li alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), zoledronic acid (Reclast); kev siv tshuaj kho mob cancer; cov tshuaj uas ua rau lub cev tiv thaiv tsis muaj zog xws li azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), sirolimus (Rapamune), thiab tacrolimus (Astagraf XL, Envarsus, Prograf) ; cov tshuaj steroids xws li dexamethasone, methylprednisolone (A-Methapred, Depo-Medrol, Medrol, Solu-Medrol), thiab prednisone (Rayos); lossis cov tshuaj siv kom txo qis koj cov calcium, xws li cinacalcet (Sensipar). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
• qhia rau koj tus kws kho mob yog tias koj tau lossis tsis tau muaj tshuaj calcium qis hauv koj cov ntshav. Koj tus kws kho mob tej zaum yuav kuaj seb cov calcium nyob hauv koj cov ntshav ua ntej koj pib kev kho mob thiab tej zaum yuav qhia koj kom tsis txhob txais qhov kev txhaj tshuaj denosumab yog tias qib qis heev.
• qhia rau koj tus kws kho mob yog tias koj tau txais kev kho mob lim ntshav lossis yog tias koj tau lossis nws tau ua haujlwm rau lub cev tsis muaj ntshav (qhov mob cov ntshav liab tsis nqa oxygen txaus rau txhua qhov ntawm lub cev); mob cancer; ib yam kab mob twg, tshwj xeeb hauv koj lub qhov ncauj; teeb meem nrog koj lub qhov ncauj, hniav, pos hniav, lossis hniav cuav; kev kho hniav los yog qhov ncauj (tshem tawm cov hniav, kev cog hniav); tej yam mob uas ua rau koj cov ntshav txhaws tsis los ntshav; tej yam mob uas ua rau kom lub cev tsis muaj zog tiv thaiv kab mob; phais mob ntawm koj lub qog caj pas lossis parathyroid caj pas (cov qog me me hauv caj dab); phais kom tshem tawm ib feem ntawm koj txoj hnyuv; teeb meem nrog koj lub plab lossis plab hnyuv uas ua rau nws lub cev tsis yooj yim kom nqus tau cov as-ham; polymyalgia rheumatica (kev tsis sib haum uas ua rau mob nqaij thiab leeg tsis muaj zog); mob ntshav qab zib, lossis parathyroid lossis mob raum.
• qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Koj yuav tsum muaj qhov tsis zoo kuaj cev xeeb tub ua ntej pib kho nrog kev txhaj tshuaj denosumab. Koj yuav tsum tsis txhob cev xeeb tub thaum koj tau txais kev txhaj tshuaj denosumab. Koj yuav tsum siv txoj hauv kev tiv thaiv tsis pub muaj menyuam kom tiv thaiv tsis pub muaj menyuam thaum koj tseem tau txais qhov kev txhaj tshuaj denosumab thiab tsawg kawg 5 lub hlis tom qab koj tau txais kev kho zaum kawg. Yog tias koj cev xeeb tub thaum tau txais kev txhaj tshuaj denosumab, lossis tsis pub dhau 5 lub hlis ntawm koj txoj kev kho mob, hu rau koj tus kws kho mob sai. Denosumab tuaj yeem tsim kev puas tsuaj rau tus me nyuam hauv plab.
• koj yuav tsum paub tias kev txhaj tshuaj denosumab tuaj yeem ua rau txha ntawm lub puab tsaig (ONJ, mob hnyav ntawm lub puab tsaig pob txha), tshwj xeeb tshaj yog tias koj tau kho hniav lossis kho hniav thaum koj tau txais cov tshuaj no. Tus kws kho hniav yuav tsum kuaj koj cov hniav thiab ua txhua yam kev kho mob tsim nyog, suav nrog ntxuav lossis kho cov hniav cuav kom tsis txhob mob, ua ntej koj pib txhaj cov tshuaj denosumab. Nco ntsoov txhuam koj cov hniav thiab ntxuav koj lub qhov ncauj kom zoo thaum koj tau txais kev txhaj tshuaj denosumab. Tham nrog koj tus kws kho mob ua ntej muaj kev kho hniav thaum koj tau txais cov tshuaj no.

Tshwj tsis yog koj tus kws kho mob hais rau koj lwm yam, txuas ntxiv koj li kev noj haus zoo.

Yog tias koj tsis tau teem caij mus txhaj cov tshuaj denosumab, koj yuav tsum hu rau koj tus kws kho mob kom sai li sai tau. Cov koob tshuaj tsis nco qab yuav tsum tau muab sai li sai tau nws tuaj yeem rov teem sijhawm dua. Thaum denosumab txhaj tshuaj (Prolia) yog siv rau kev mob pob txha lossis mob pob txha, tom qab koj tau txais koob tshuaj tsis nco qab lawm, koj kev txhaj tshuaj ntxiv yuav tsum teem sijhawm 6 lub hlis txij hnub koj tau txhaj tshuaj zaum kawg.

Kev txhaj tshuaj Denosumab tuaj yeem ua rau muaj kev phiv tshuaj. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• daim tawv liab, qhuav, lossis khaus
• ua pa los yog ua zig tawv nqaij rau ntawm daim tawv nqaij
• tev tawv nqaij
• rov qab mob
• mob hauv koj txhais tes
• o caj npab lossis txhais ceg o
• leeg mob lossis mob pob qij txha
• xeev siab
• zawv plab
• cem quav
• mob plab
• mob taub hau

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no, hu rau koj tus kws kho mob sai lossis tau txais kev kho mob kub ceev:

• cov leeg txhav txhav, pob tw, tu-sauv los yog txhaw
• loog lossis ntxais hauv koj cov ntiv tes, ntiv taw, lossis ib ncig ntawm koj lub qhov ncauj
• ua xua, tawm pob, khaus, ua pa nyuaj lossis nqos, o ntawm lub ntsej muag, ob lub qhov muag, caj pas, nplaig lossis daim di ncauj,
• ua npaws lossis ua daus no
• liab, leeg, o lossis sov ntawm thaj chaw ntawm daim tawv nqaij
• kub taub hau, hnoos, txog siav
• pob ntseg ua pob ntseg lossis mob pob ntseg heev
• heev los yog maj mam tso zis, mob zoo thaum koj tso zis
• mob plab heev
• qhov mob lossis o ntawm cov pos hniav, xoob ntawm cov hniav, loog lossis qhov hnyav hauv lub puab tsaig, kev kho tsis zoo ntawm lub puab tsaig
• ntshav txawv lossis doog ntshav
• xeev siab, ntuav, mob taub hau, thiab tsis tau ras txog tom qab cheem denosumab thiab mus txog 1 xyoo tom qab

Kev txhaj tshuaj Denosumab tuaj yeem ua rau muaj kev pheej hmoo ntau ntxiv tias koj yuav ua rau koj cov pob txha ncej puab koj yuav hnov ​​mob hauv koj lub duav, puab tais, lossis ncej puab li ob peb lub lis piam lossis hli ua ntej cov pob txha (pob) tawg, thiab koj yuav pom tias ib lossis ob qho tib si koj cov ceg ncej puab tau tawg txawm tias koj tsis tau poob lossis tau ntsib lwm yam kev poob plig. Nws yog qhov txawv rau cov pob txha ncej puab txhawm rau tawg rau hauv cov neeg muaj kev noj qab haus huv, tab sis cov neeg uas muaj pob txha pob yuav tawg tus pob txha no txawm tias lawv tsis tau txais kev txhaj tshuaj denosumab Kev txhaj tshuaj Denosumab tseem tuaj yeem ua rau cov pob txha tawg kom zoo sai thiab ua rau cov pob txha loj tuaj thiab tiv thaiv cov hniav los ntawm kev tuaj rau hauv menyuam yaus. Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev txhaj tshuaj denosumab.

Kev txhaj tshuaj Denosumab tuaj yeem ua lwm cov kev phiv lwm yam. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum tau txais cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Tsis txhob co cov khoom txhaj denosumab. Khaws nws rau hauv tub yees thiab tiv thaiv nws los ntawm lub teeb. Tsis khov. Kev txhaj tshuaj Denosumab tuaj yeem khaws cia hauv chav tsev ntev txog 14 hnub.

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev kuaj mob kom ntseeg tau tias koj tau txais qhov kev txhaj tshuaj denosumab thiab xyuas koj lub cev cov lus teb rau kev txhaj tshuaj denosumab.

Tsis txhob cia lwm tus siv koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

• Prolia^®
• Xgeva^®