Darunavir

Zoo Siab

• Ua ntej noj cov darunavir,
• Darunavir yuav ua rau muaj kev mob tshwm sim. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no, tsum tsis txhob noj darunavir thiab hu rau koj tus kws kho mob tam sim ntawd lossis tau txais kev kho mob kub ceev:

Darunavir yog siv nrog ritonavir (Norvir) thiab lwm yam tshuaj los kho tib neeg cov tshuaj tiv thaiv tus kabmob HIV (HIV) rau cov neeg laus thiab menyuam hnub nyoog 3 xyoos thiab laus dua. Darunavir nyob hauv chav kawm ntawm cov tshuaj hu ua protease inhibitors. Nws ua haujlwm los ntawm kev txo qis hauv cov HIV hauv cov ntshav. Txawm hais tias darunavir tsis kho HIV, nws yuav txo koj txoj hmoo los ntawm kev tiv thaiv kab mob (AIDS) thiab mob ntsig txog HIV xws li kis mob hnyav lossis mob qog ntshav. Siv cov tshuaj no nrog rau kev xyaum pw ua ke kom nyab xeeb thiab hloov ua lwm yam hauv lub neej yuav txo qhov kev pheej hmoo kis tus mob HIV mus rau lwm tus neeg.

Darunavir los ua ib ntsiav tshuaj thiab qhov ncauj ncua (ua kua) los noj ntawm qhov ncauj. Nws feem ntau yog noj nrog zaub mov thiab nrog ritonavir ib zaug lossis ob zaug ib hnub. Siv darunavir nyob ib ncig ntawm tib lub sijhawm (s) txhua txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj darunavir raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Tsis txhob noj tshuaj darunavir yam tsis muaj ritonavir.

Nqos cov ntsiav tshuaj kom tag nrho nrog haus xws li dej lossis mis nyuj. Tsis txhob zom cov ntsiav tshuaj.

Muab co tshem tawm kom raug cai ua ntej txhua zaug siv sib tov cov tshuaj kom ncaj. Siv lub koob txhaj tshuaj noj ntawm qhov ncauj uas tuaj nrog cov tshuaj kom thim txoj kev raug ncua ntawm lub raj mis. Koj tuaj yeem nqos tus ncua kev kawm ncaj qha los ntawm rab koob txhaj tshuaj. Ntxuav cov koob txhaj tshuaj nrog dej thiab cia nws qhuav kom huv si tom qab siv.

Darunavir tswj hwm HIV tab sis nws tsis kho nws. Txuas ntxiv noj cov darunavir txawm tias koj xis nyob. Tsis txhob tsum noj darunavir tsis tas tham nrog koj tus kws kho mob. Yog tias koj tsum tsis noj darunavir los yog ncua tshuaj, koj tus mob yuav nyuaj los kho. Thaum koj cov lus muab ntawm darunavir pib khiav qis, tau ntau los ntawm koj tus kws kho mob lossis kws muag tshuaj.

Nug koj tus kws muag tshuaj lossis tus kws kho mob txog cov ntawv luam ntawm cov ntaub ntawv tsim tawm rau tus neeg mob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj cov darunavir,

• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau darunavir, ritonavir, tshuaj sulfa, lwm yam tshuaj, lossis lwm yam tshuaj hauv darunavir ntsiav tshuaj lossis ncua kev kawm. Nug koj tus kws muag tshuaj kom tau cov npe ntawm cov khoom xyaw lossis yog koj tsis paub meej tias cov tshuaj koj noj tshuaj tsis haum yog tshuaj sulfa.
• qhia rau koj tus kws kho mob yog tias koj noj ib qho tshuaj hauv qab no: alfuzosin (Uroxatral); cisapride (Propulsid) (tsis muaj nyob hauv Asmeskas); dronedarone (Multaq); elbasvir / grazoprevir (Zepatier); ergot-hom tshuaj xws li dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, hauv Cafergot, hauv Migergot), thiab methylergonovine (Methergine); lomitapide (Juxtapid); lovastatin (Mevacor, hauv Tus Kws Pab Qhia); lurasidone (Latuda), midazolam (muab los ntawm qhov ncauj); pimozide (Orap); ranolazine (Ranexa); phom phom (Rifadin, Rimactane, hauv Rifamate, hauv Rifater); sildenafil (tsuas yog Revatio hom siv rau mob ntsws); simvastatin (Zocor, hauv Vytorin); St. John lub wort; lossis triazolam (Halcion). Koj tus kws kho mob yuav qhia koj kom tsis txhob noj tshuaj darunavir. Tsis tas li, yog tias koj muaj mob raum lossis mob siab thiab tab tom noj tshuaj colchicine (Colcrys, Mitigare, hauv Col-Probenecid), koj tus kws kho mob yuav qhia koj kom tsis txhob noj darunavir.
• qhia rau koj tus kws kho mob thiab kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob sau tseg thiab cov tshuaj uas tsis yog kws kho mob, cov vitamins, thiab cov khoom noj zoo uas koj noj lossis npaj yuav noj. Nco ntsoov hais txog ib qho ntawm cov hauv qab no: anticoagulants ('ntshav thinners') xws li apixaban (Eliquis), rivaroxaban (Xarelto), thiab warfarin (Coumadin, Jantoven); antifungals xws li itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), thiab voriconazole (Vfend); artemether / lumefantrine (Coartem); beta blockers xws li carvedilol (Coreg), metoprolol (Lopressor, Toprol XL, hauv Dutoprol, hauv Lopressor HCT), thiab timolol (Betimol, Istalol, hauv Combigan, hauv Cosopt, lwm tus); betamethasone; boceprevir (tsis muaj nyob hauv Tebchaws Meskas; Victrelis); bosentan (Tracleer); budesonide (Entocort, Pulmicort, Uceris, lwm tus); buprenorphine (Belbuca, Buprenex, Butrans, hauv Suboxone, lwm tus); buprenorphine / naloxone (Bunavail, Suboxone, Zubsolv); buspirone; calcium-channel blockers xws li amlodipine (Norvasc, hauv Caduet), diltiazem (Cardizem CD, Cartia, XT, Diltzac, lwm tus), felodipine (Plendil), nicardipine (Cardene), nifedipine (Adalat CC, Afebitab CR, Procardia), thiab verapamil (Calan, Covera, Verelan, hauv Tarka); qee yam tshuaj tua kab mob xws li dasatinib (Sprycel), nilotinib (Tasigna), vinblastine, thiab vincristine (Marqibo Cov Khoom Siv); cov tshuaj ua kom ntshav qab zib (statins) xws li atorvastatin (Lipitor, hauv Caduet), pravastatin (Pravachol), thiab rosuvastatin (Crestor); ciclesonide (Alvesco); clarithromycin (Biaxin, hauv Prevpac); qee cov tshuaj rau kev nyuaj siab xws li amitriptyline, desipramine (Norpramin), imipramine, nortriptyline, paroxetine (Brisdelle, Paxil, Pexeva), sertraline (Zoloft), thiab trazodone; dexamethasone; diazepam (Diastat, Valium); estazolam; fentanyl (Abstral, Duragesic, Subsys); fluticasone (Flonase, Flovent, hauv Advair); qee cov tshuaj rau kab mob siab hom C (HCV) xws li glecaprevir / pibrentasvir (Mavyret) thiab simeprevir (tsis muaj nyob rau U.S.; Olysio); lwm cov tshuaj rau tus kab mob HIV suav nrog indinavir (Crixivan), lopinavir / ritonavir (Kaletra), maraviroc (Selzentry), thiab saquinavir (Invirase); tshuaj tiv thaiv cev xeeb tub (estrogen) (tshuaj txwv tsis pub muaj menyuam, tshuaj pleev ib ce, ib ncig, pleev, lossis txhaj); cov tshuaj rau lub plawv dhia tsis xwm yeem xws li amiodarone (Nexterone, Pacerone), bepridil (tsis muaj nyob hauv Asmeskas), digoxin (Lanoxin), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), thiab quinidine (hauv Nuedes) ); qee yam tshuaj rau qaug dab peg xws li carbamazepine (Carbatrol, Equetro, Tegretol, lwm tus), clonazepam (Klonopin), phenobarbital, thiab phenytoin (Dilantin, Phenytek); qee cov tshuaj uas ua kom lub cev tiv thaiv tsis muaj zog xws li cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), thiab tacrolimus (Astagraf XL, Prograf); tshuaj txiav yeeb (Dolophine, Methadose); methylprednisolone; mometasone (Asmanex); omeprazole (Prilosec); cov pa tsoosone (Xtampza); qee yam phosphodiesterase inhibitors (PDE-5 inhibitors) siv rau erectile kawg xws li avanafil (Stendra), sildenafil (Viagra), tadalafil (Cialis), thiab vardenafil (Levitra, Staxyn); perphenazine; prednisone (Rayos); quetiapine (Seroquel); rifabutin (Mycobutin); rab phom loj (Priftin); risperidone (Risperdal); salmeterol (Serevent, hauv Advair); tadalafil (Adcirca); thioridazine; ticagrelor (Brilinta); tramadol (Conzip); triamcinolone (Nasacort); thiab zolpidem (Ambien, Edluar, Intermezzo). Ntau lwm yam tshuaj kuj tseem tuaj yeem cuam tshuam nrog darunavir, yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv, txawm tias tsis tshwm nyob hauv daim ntawv no. Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
• yog tias koj noj didanosine (Videx), noj nws 1 teev ua ntej lossis 2 teev tom qab koj noj darunavir.
• qhia rau koj tus kws kho mob yog tias koj tau lossis tau muaj ntshav qab zib lossis ntshav qab zib siab; hemophilia (ntshav tsis meej hauv ntshav tsis tuaj yeem ntshav txaus); kab mob siab (o rau lub siab tshwm sim los ntawm tus kab mob), mob ntsws (mob uas ua rau mob caj dab daim siab), lossis lwm yam kab mob siab; lossis ib qho kev kis mob uas tsis ploj mus lossis uas los thiab ploj mus xws li cytomegalovirus (CMV; tus kab mob kis uas ua rau cov tsos mob rau cov neeg mob lub cev tsis muaj zog tiv thaiv kab mob), mycobacterium avium complex disease (MAC; cov kab mob uas yog cov mob uas ua rau mob hnyav hauv cov neeg mob AIDS), mob ntsws, lossis mob ntsws (TB; hom mob ntsws).
• qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Yog tias koj cev xeeb tub thaum noj cov tshuaj darunavir, hu rau koj tus kws kho mob. Tsis txhob noj mis yog tias koj kis nrog HIV lossis noj tshuaj darunavir.
• koj yuav tsum paub tias darunavir tuaj yeem txo qhov kev muaj txiaj ntsig ntawm kev tiv thaiv hormonal (tshuaj txwv, tshuaj pleev ib ce, ib puag ncig, txhaj tshuaj lossis siv tshuaj pleev ib ce). Tham nrog koj tus kws kho mob txog kev tswj tsis pub muaj menyuam hauv tsev menyuam xws li cov txheej txheem thaiv teeb meem (khoom siv uas txwv cov phev los nkag rau hauv tsev menyuam xws li siv hnab looj lossis hnab looj qau) tiv thaiv kev xeeb tub thaum koj noj tshuaj. Nug koj tus kws kho mob los pab koj xaiv hom kev tswj tsis pub muaj menyuam uas yuav ua haujlwm rau koj.
• koj yuav tsum paub tias koj lub cev rog tuaj yeem nce lossis txav mus rau thaj chaw ntawm koj lub cev xws li koj lub mis, lub nraub qaum, caj dab, hauv siab thiab lub plab. Kev poob rog los ntawm txhais ceg, caj npab, thiab ntsej muag kuj tuaj yeem tshwm sim.
• koj yuav tsum paub tias koj tuaj yeem ntsib hyperglycemia (nce hauv koj cov piam thaj hauv ntshav) thaum koj tseem noj cov tshuaj no, txawm tias koj tsis tau muaj ntshav qab zib. Qhia rau koj tus kws kho mob tam sim ntawd yog tias koj muaj cov tsos mob hauv qab no thaum koj noj darunavir: nqhis dej heev, tso zis heev, tshaib plab heev, plooj tsis pom kev, lossis tsis muaj zog. Nws yog ib qho tseem ceeb heev uas yuav tau hu rau koj tus kws kho mob sai li sai tau uas koj muaj cov tsos mob no, vim tias cov ntshav qab zib uas tsis tau kho nws tuaj yeem ua rau mob hnyav hu ua ketoacidosis. Ketoacidosis tuaj yeem dhau los ua neeg muaj sia nyob yog tias tsis kho thaum ntxov. Cov tsos mob ntawm ketoacidosis suav nrog: qhov ncauj qhuav, xeev siab thiab ntuav, ua pa luv, ua pa uas hnov ​​tsw thiab tsis nco qab.
• koj yuav tsum paub tias thaum koj tab tom noj tshuaj los kho kab mob HIV, koj lub cev tiv thaiv kab mob yuav muaj zog thiab pib tawm tsam lwm yam kev mob uas twb muaj hauv koj lub cev lawm. Qhov no tuaj yeem ua rau koj tsim cov tsos mob ntawm cov mob ntawd. Yog tias koj muaj cov tsos mob tshiab lossis mob hnyav dua txhua lub sijhawm thaum lub sijhawm kho nrog darunavir, nco ntsoov qhia koj tus kws kho mob.

Tham nrog koj tus kws kho mob txog kev noj txiv kab ntxwv qaub thiab haus kua txiv thaum lub sijhawm noj cov tshuaj no.

Yog tias koj noj tshuaj darunavir ib zaug ib hnub thiab koj ncua sijhawm tsawg dua 12 teev, noj cov koob tshuaj uas ploj lawm sai li sai tau thaum koj nco qab nws thiab tom qab ntawd noj cov tshuaj ntxiv raws sijhawm. Txawm li cas los xij, yog tias koj tsis nco qab ntau dua 12 teev, hla lub koob tshuaj uas tsis nco qab noj thiab txuas ntxiv koj lub sijhawm noj tshuaj. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Yog tias koj noj tshuaj darunavir ib hnub ob zaug thiab koj tsis nco qab noj ntau dua li 6 teev, noj koob tshuaj uas ploj sai li uas koj nco qab nws thiab tom qab ntawd noj ib zaug ntxiv thaum lub sijhawm teem tseg. Txawm li cas los xij, yog tias koj tsis nco qab ntau dua li 6 teev, hla lub koob tshuaj uas tsis nco qab noj thiab txuas ntxiv koj lub sijhawm noj tshuaj. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Darunavir yuav ua rau muaj kev mob tshwm sim. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• mob taub hau
• zawv plab
• ntuav
• mob plab
• cem quav

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no, tsum tsis txhob noj darunavir thiab hu rau koj tus kws kho mob tam sim ntawd lossis tau txais kev kho mob kub ceev:

• ua pob
• tev lossis tawv nqaij ntawm daim tawv nqaij
• qhov ncauj tawm
• liab, o, khaus, los yog qhov muag daj
• leeg los sis mob ib ce
• ua npaws
• o, mob, liab, lossis lwm yam cim ntawm tus kab mob
• xeev siab
• nkees heev
• tsis qab los noj mov
• mob hauv sab saud hauv plab
• daj ntawm daim tawv nqaij lossis qhov muag
• daj ntseg los yog tsaus tso quav

Darunavir yuav ua rau muaj lwm cov kev mob tshwm sim. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev kuaj mob kom ntseeg tau tias koj noj darunavir thiab kuaj xyuas koj lub cev cov lus teb rau darunavir.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

• Prezista^®
• Prezcobix^® (muaj cov Darunavir, Cobicistat)

• TMC-114