Natalizumab Txhaj Tshuaj

Zoo Siab

• Natalizumab yog siv los tiv thaiv kev mob tshwm sim thiab qeeb ntawm kev tsis taus ntawm cov neeg laus uas tau rov ua ntau hom mob sclerosis (MS; kab mob uas cov hlab ntsha tsis ua haujlwm zoo thiab cov neeg yuav muaj kev qaug zog, qaug zog, tsis tuaj yeem ua kom muaj leeg mob, thiab teeb meem nrog lub zeem muag, hais lus, thiab zais zis tswj), suav nrog:
• Ua ntej tau txais natalizumab txhaj tshuaj,
• Natalizumab tuaj yeem ua phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob li hais los no lossis cov uas tau hais hauv nqe lus YUAV UA LI CAS LOS TSEEM CEEB, hu rau koj tus kws kho mob tam sis lossis tau txais kev kho mob kub ceev:

Tau txais natalizumab txhaj tshuaj tuaj yeem ua rau muaj kev pheej hmoo ntau ntxiv uas koj yuav tsim kho ntau yam mob hlwb (PML; ib qho kev kis mob tsis tshua muaj mob ntawm lub hlwb uas tsis tuaj yeem kho, tiv thaiv lossis kho thiab uas feem ntau ua rau tuag lossis mob xiam oob khab loj). Qhov muaj feem uas koj yuav tsim PML lub sijhawm koj kho natalizumab yog siab dua yog tias koj muaj ib lossis ntau yam ntawm cov teeb meem phom sij nram no.

• Koj tau txais ntau yam tshuaj natalizumab, tshwj xeeb yog tias koj tau txais kev kho mob ntev tshaj 2 xyoos.
• Koj tau raug coj mus kho cov tshuaj uas ua rau lub cev tsis muaj zog, suav nrog azathioprine (Azasan, Imuran), cyclophosphamide, methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), mitoxantrone, thiab mycophenolate mofetil (CellCept).
• Kev kuaj ntshav qhia tau hais tias koj tau kis tus kab mob John Cunningham (JCV; tus kab mob uas ntau tus neeg kis rau thaum menyuam yaus uas feem ntau ua rau tsis muaj tsos mob tab sis tuaj yeem ua rau PML rau cov neeg tsis muaj zog tiv thaiv kab mob).

Tej zaum koj tus kws kho mob yuav xaj kuaj ntshav ua ntej lossis thaum kho koj nrog txhaj tshuaj natalizumab kom pom tias koj tau kis JCV. Yog tias kev kuaj pom tias koj tau kis JCV, koj thiab koj tus kws kho mob yuav txiav txim siab tias koj yuav tsum tsis txhob txhaj tshuaj natalizumab, tshwj xeeb yog tias koj tseem muaj ib lossis ob qho ntawm lwm qhov kev pheej hmoo muaj nyob rau saud. Yog tias qhov kev kuaj tsis pom tias koj tau JCV, koj tus kws kho mob yuav rov qab kuaj dua ib zaug thaum koj kho nrog natalizumab txhaj. Koj yuav tsum tsis txhob ntsuam xyuas yog tias koj tau hloov ntshav plasma (kev kho mob hauv qhov ua kua ntawm cov ntshav tawm ntawm lub cev thiab hloov nrog lwm cov kua) thaum 2 lub lis piam dhau los vim tias cov ntawv kuaj yuav tsis raug.

Muaj lwm yam xwm txheej uas kuj tseem tuaj yeem ua rau muaj qhov pheej hmoo ntxiv uas koj yuav tsim PML. Qhia rau koj tus kws kho mob yog tias koj tau lossis tau muaj PML, hloov khoom nruab nrog cev, lossis lwm yam mob uas cuam tshuam rau koj lub cev tiv thaiv kab mob xws li tib neeg cov tshuaj tiv thaiv kab mob HIV (HIV), tau txais kev txhaj tshuaj tiv thaiv kab mob (AIDS), ntshav muaj ntshav (mob qog ntshav uas ua rau cov ntshav muaj ntshav ntau dhau tsim thiab tso tawm rau hauv cov hlab ntshav), lossis mob qog nqaij hlav (mob qog nqaij hlav hauv lub nruab nrog cev tiv thaiv kab mob). Kuj qhia koj tus kws kho mob yog tias koj noj lossis koj tau puas tau noj lwm yam tshuaj uas cuam tshuam rau lub cev tiv thaiv kab mob xws li adalimumab (Humira); cyclosporine (Gengraf, Neoral, Sandimmune); etanercept (Enbrel); glatiramer (Copaxone, Glatopa); infliximab (Remicade); interferon beta (Avonex, Betaseron, Rebif); tshuaj rau mob cancer; mercaptopurine (Purinethol, Purixan); qhov ncauj steroids xws li dexamethasone, methylprednisolone (Depo-medrol, Medrol, Solu-medrol), prednisolone (Prelone), thiab prednisone (Rayos); sirolimus (Rapamune); thiab tacrolimus (Astagraf, Envarsus XR, Prograf). Koj tus kws kho mob yuav qhia koj tias koj yuav tsum tsis txhob txhaj tshuaj natalizumab.

Ib qho kev pab hu ua TOUCH tau teeb tsa los pab tswj cov kev pheej hmoo ntawm kev kho natalizumab. Koj tsuas tuaj yeem tau txais kev noj tshuaj natalizumab yog tias koj tau sau npe nrog TOUCH program, yog tias natalizumab raug kho rau koj los ntawm tus kws kho mob uas tau sau npe nrog txoj haujlwm, thiab yog tias koj tau txais cov tshuaj nyob hauv lub chaw kho mob uas tau sau npe nrog txoj haujlwm. Koj tus kws kho mob yuav qhia koj ntxiv txog txoj haujlwm, yuav kom koj kos npe rau daim ntawv cuv npe nkag, thiab yuav teb koj cov lus nug uas koj muaj txog txoj haujlwm thiab kev kho koj nrog txhaj tshuaj natalizumab.

Ua ib feem ntawm TOUCH program, koj tus kws kho mob lossis tus neeg saib xyuas mob yuav muab ib Daim Ntawv Qhia Tshuaj Kho Mob rau koj ua ntej koj pib kho nrog kev txhaj tshuaj natalizumab thiab ua ntej koj tau txais txhua qhov kev mob ntshav. Nyeem cov ntaub ntawv no kom zoo zoo txhua zaus koj tau txais nws thiab nug koj tus kws kho mob lossis tus nais maum yog tias koj muaj lus nug. Koj kuj tuaj yeem mus saib tau Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) lub vev xaib (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) lossis cov chaw tsim tshuaj paus lub vev xaib kom tau txais Kev Qhia Tshuaj.

Kuj tseem yog ib feem ntawm TOUCH program, koj tus kws kho mob yuav tsum ntsib koj txhua 3 lub hlis thaum pib kho koj thiab tom qab ntawd tsawg kawg txhua 6 lub hlis los txiav txim siab seb koj puas yuav tsum tau siv natalizumab ntxiv mus. Koj kuj tseem yuav tsum tau teb qee cov lus nug ua ntej koj tau txais txhua txoj kev lis ntshav kom paub tseeb tias natalizumab tseem zoo rau koj.

Hu rau koj tus kws kho mob tam sim ntawd yog tias koj muaj ib qho teeb meem tshiab lossis mob hnyav ntxiv thaum kho koj tus kheej, thiab rau 6 lub hlis tom qab koj qhov tshuaj kawg. Nco ntsoov hu tuaj rau koj tus kws kho mob yog tias koj pom muaj cov tsos mob hauv qab no: kev tsis muaj zog ntawm ib sab ntawm lub cev uas lub sijhawm ua tsis zoo; clumsiness ntawm caj npab los yog txhais ceg; cov kev hloov hauv koj txoj kev xav, kev nco, taug kev, tshuav nyiaj li cas, hais lus, pom kev, lossis lub zog uas kav mus ob peb hnub; mob taub hau; qaug dab peg; tsis meej pem; lossis tus kheej hloov.

Yog tias koj txoj kev kho mob natalizumab txhaj tshuaj tso tseg vim tias koj muaj PML, koj tuaj yeem tsim lwm yam mob hu ua kev tiv thaiv kab mob tiv thaiv mob (IRIS; o thiab mob ntxiv rau cov tsos mob uas yuav tshwm sim vim lub cev tiv thaiv pib ua haujlwm dua tom qab qee yam tshuaj uas cuam tshuam rau nws tau pib lossis nres), tshwj xeeb yog tias koj tau txais kev kho mob kom tshem tawm natalizumab ntawm koj cov ntshav sai dua. Koj tus kws kho mob yuav saib xyuas koj kom zoo rau cov cim IRIS thiab yuav kho cov tsos mob no yog tias lawv tshwm sim.

Qhia rau txhua tus kws kho mob uas kho koj tias koj tau txais kev txhaj tshuaj natalizumab.

Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev txhaj tshuaj natalizumab.

Natalizumab yog siv los tiv thaiv kev mob tshwm sim thiab qeeb ntawm kev tsis taus ntawm cov neeg laus uas tau rov ua ntau hom mob sclerosis (MS; kab mob uas cov hlab ntsha tsis ua haujlwm zoo thiab cov neeg yuav muaj kev qaug zog, qaug zog, tsis tuaj yeem ua kom muaj leeg mob, thiab teeb meem nrog lub zeem muag, hais lus, thiab zais zis tswj), suav nrog:

• cov kws khomob raug cais tawm (CIS; thawj qhov kev mob tshwm sim tsawg kawg 24 teev),
• huam mob rov huam tuaj (hom mob uas cov tsos mob tshwm sim ib lub sijhawm),
• yam kab mob ua mob hnyav zaum ob (tom qab ntawm cov kab mob nrog cov tsos mob tsis tu ncua.)

Natalizumab tseem tseem siv coj los kho thiab tiv thaiv kev mob tshwm sim hauv cov neeg laus uas muaj Crohn's mob (mob uas lub cev ua rau lub plab zom mov, ua rau mob, raws plab, yuag, thiab kub taub hau) uas tsis tau txais kev pab los ntawm lwm qhov cov tshuaj lossis cov uas tsis tuaj yeem siv lwm yam tshuaj. Natalizumab nyob hauv chav kawm ntawm cov tshuaj hu ua monoclonal antibodies. Nws ua haujlwm los ntawm kev tso tseg qee lub hlwb ntawm lub cev tsis ua haujlwm kom mus txog rau lub hlwb thiab tus txha caj qaum lossis lub plab thiab lub plab thiab ua rau kev puas tsuaj.

Natalizumab los ua cov tshuaj tov kua (kua) yuav tsum tau tov thiab maj mam txhaj mus rau hauv cov hlab ntshav los ntawm kws kho mob lossis kws saib xyuas neeg mob. Nws feem ntau yog muab ib zaug nyob rau txhua 4 lub lis piam hauv ib qho chaw sau npe. Nws yuav siv li 1 teev rau koj kom koj tau txais koj cov koob tshuaj ntawm natalizumab tag nrho.

Natalizumab tuaj yeem ua rau muaj kev tsis haum tshuaj loj uas yuav tshwm sim ntau tshaj li 2 teev tom qab pib mob ntshav tiam sis yuav tshwm sim thaum twg los tau thaum kho koj. Koj yuav tsum tau nyob hauv lub tsev kho mob rau 1 teev tom qab koj Txoj kev lis ntshav tiav. Tus kws kho mob lossis tus nais maum yuav saib xyuas koj lub sijhawm no seb koj puas muaj qhov tsis haum tshuaj loj. Qhia rau koj tus kws kho mob lossis kws saib xyuas neeg mob yog tias koj pom muaj cov tsos mob txawv txawv xws li khaus, tawm pob, khaus, ua pa nyuaj lossis ua pa, kub ib ce, kiv taub hau, mob hauv siab, plhaws, nkees, lossis ua daus no, tshwj xeeb yog tias lawv tshwm sim li 2 teev tom qab pib. ntawm koj Txoj kev lis ntshav.

Yog tias koj tau txais natalizumab txhaj tshuaj los kho tus kab mob Crohn, koj tus mob yuav tsum zoo tuaj ntawm thawj ob peb hlis tom qab koj tau txais kev kho mob. Qhia rau koj tus kws kho mob yog tias koj cov tsos mob tsis tau zoo dua tom qab 12 lub lim tiam ntawm kev kho mob. Koj tus kws kho mob tuaj yeem tsis kho koj nrog txhaj tshuaj natalizumab.

Natalizumab tuaj yeem pab tswj koj cov tsos mob tab sis yuav tsis kho koj tus mob. Nco ntsoov txhua lub sijhawm teem tseg kom tau txhaj tshuaj natalizumab txawm tias koj xis neej.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej tau txais natalizumab txhaj tshuaj,

• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau natalizumab, lwm yam tshuaj, lossis lwm yam tshuaj hauv natalizumab txhaj. Nug koj tus kws kho mob lossis kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
• qhia rau koj tus kws kho mob thiab kws muag tshuaj uas siv tshuaj thiab cov tshuaj uas tsis yog kws kho mob, cov vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj noj Nco ntsoov hais txog cov tshuaj teev tseg rau ntawm ntu CEEB TOOM TSEEM CEEB. Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
• qhia rau koj tus kws kho mob yog tias koj tau txais kev txhaj tshuaj natalizumab ua ntej thiab yog tias koj muaj lossis koj tau muaj ib yam kev mob uas tau hais tseg rau hauv seem tseem ceeb. Ua ntej koj tau txhaj txhua lub sijhawm ntawm natalizumab, qhia rau koj tus kws kho mob yog tias koj mob kub taub hau lossis ib hom kev kis mob, suav nrog kev kis mob uas mob mus ntev ntev xws li mob yoov (muaj pob xua uas tuaj yeem tshwm sim los ntawm lub sijhawm rau cov neeg uas muaj mob qhua maj los yav dhau los).
• qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Yog tias koj xeeb tub thaum koj tau txais kev txhaj tshuaj natalizumab, hu rau koj tus kws kho mob.
• tsis muaj kev txhaj tshuaj yam tsis tau tham nrog koj tus kws kho mob.

Tshwj tsis yog koj tus kws kho mob hais rau koj lwm yam, txuas ntxiv koj li kev noj haus zoo.

Yog tias koj plam tsis tau teem caij kom tau txais qhov mob natalizumab, hu rau koj tus kws kho mob sai li sai tau.

Natalizumab tuaj yeem ua phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• mob taub hau
• nkees heev
• tsaug zog
• mob pob qij txha los yog o
• mob mob ntawm caj npab lossis txhais ceg
• rov qab mob
• o ntawm caj npab, tes, taw, pob taws, lossis ceg qis
• mob leeg
• mob plab
• zawv plab
• Kev mob siab
• cem quav
• roj
• qhov hnyav los poob
• kev nyuaj siab
• tsaus ntuj tawm hws
• mob, tsis meej, los yog ncua kev coj khaub ncaws (ntu)
• o, liab, kub, lossis khaus ntawm lub paum
• paug paum dawb
• nyuaj tswj kev tso zis
• mob hniav
• qhov ncauj tawm
• ua pob
• daim tawv nqaij qhuav
• khaus

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob li hais los no lossis cov uas tau hais hauv nqe lus YUAV UA LI CAS LOS TSEEM CEEB, hu rau koj tus kws kho mob tam sis lossis tau txais kev kho mob kub ceev:

• mob caj pas, kub taub hau, hnoos, ua daus no, mob khaub thuas xws li cov tsos mob, mob plab, raws plab, tso zis heev lossis nquag, cia li tso zis tam sim, lossis lwm yam cim ntawm tus kabmob
• yuas tawv nqaij lossis qhov muag, xeev siab, ntuav, nkees heev, tsis qab los, tso zis tsaus nti, mob plab sab saud
• pom kev hloov, qhov muag liab, lossis hnov ​​mob
• ntshav txawv lossis doog ntshav
• me me, puag ncig, xim liab los yog xim paj yeeb-xim me ntsis ntawm daim tawv nqaij
• hnyav ntshav tawm los ntshav

Natalizumab txhaj tshuaj tuaj yeem ua lwm cov phiv. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum tau txais cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj qee qhov kev kuaj sim kuaj xyuas koj lub cev cov lus teb rau kev txhaj tshuaj natalizumab.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

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