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Hnub Kev Tsim: 16 Lub Cuaj Hli Ntuj 2021
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Cannabidiol (CBD) and Health | Pharmacology
Daim Duab: Cannabidiol (CBD) and Health | Pharmacology

Zoo Siab

Cannabidiol yog tshuaj lom neeg hauv Cannabis sativa tsob nroj, tseem hu ua tshuaj maj los yog hemp. Tshaj 80 tshuaj, paub tias yog cannabinoids, tau txheeb pom hauv Cannabis sativa cog. Thaum delta-9-tetrahydrocannabinol (THC) yog cov khoom xyaw tseem ceeb hauv tshuaj maj, cannabidiol tseem tau txais los ntawm hemp, uas tsuas yog muaj tsawg heev ntawm THC.

Kev hla ntawm 2018 Kev Ua Liaj Ua Teb ua rau nws ua kev cai muag cov hemp thiab hemp cov khoom lag luam hauv Teb Chaws Asmeskas. Tab sis qhov ntawd tsis txhais tau tias txhua cov khoom siv hemp-cannabidiol yog kev cai lij choj. Vim tias cannabidiol tau kawm ua cov tshuaj tshiab, nws tsis tuaj yeem txwv tsis raug cai hauv cov zaub mov lossis zaub mov noj. Tsis tas li, cannabidiol tsis tuaj yeem suav nrog cov khoom lag luam muag nrog cov nqi kho mob. Cannabidiol tuaj yeem suav nrog hauv cov khoom lag luam "kom hniav zoo nkauj" thiab tsuas yog tias nws muaj tsawg dua 0.3% THC. Tab sis tseem muaj cov khoom lag luam sau npe hais tias yog cov khoom noj muaj txiaj ntsig ntawm khw muag zaub uas muaj cannabidiol. Tus nqi ntawm cannabidiol muaj nyob rau hauv cov khoom lag luam tsis yog ib txwm tau hais tawm kom raug rau ntawm daim ntawv lo khoom.

Cannabidiol feem ntau siv rau qaug dab peg (mob vwm). Nws kuj tseem siv rau kev ntxhov siab, mob, mob nqaij pob txha hu ua dystonia, Parkinson tus kab mob, Crohn kab mob, thiab ntau yam mob, tab sis tsis muaj cov pov thawj tshawb pom zoo los pab txhawb cov kev siv no.

Cov Tshuaj Kho Kom Zoo Database cov txiaj ntsig raws li cov pov thawj tshawb fawb tau raws li cov teev hauv qab no: Siv tau zoo, Yuav muaj txiaj ntsig zoo, Muaj txiaj ntsig zoo, Muaj txiaj ntsig zoo, tsis muaj txiaj ntsig zoo, tsis muaj txiaj ntsig, tsis muaj txiaj ntsig, thiab tsis muaj pov thawj txaus rau tus nqi.

Cov hauj lwm zoo rau CANNABIDIOL (CBD) muaj raws li nram no:


Yuav zoo rau ...

  • Kev chua leeg mob (mob qaug dab peg)Cov. Cov tshuaj tshwj xeeb cannabidiol (Epidiolex, GW Tshuaj) tau pom tias yuav txo tau qaug dab peg rau cov neeg laus thiab menyuam yaus uas muaj ntau yam mob uas cuam tshuam nrog qaug dab peg. Cov khoom no yog cov tshuaj kho mob rau kev kho mob qaug dab peg los ntawm Dravet syndrome, Lennox-Gastaut syndrome, lossis tuberous sclerosis complex. Nws kuj tau pom tias yuav txo tau qaug dab peg hauv cov neeg muaj Sturge-Weber syndrome, febrile-cuam tshuam nrog kev kis mob vwm (HLUB), thiab cov kev mob caj dab tshwj xeeb uas ua rau mob puas hlwb. Tab sis nws tsis pom zoo rau kev kho rau lwm yam mob chua leeg no. Cov khoom no feem ntau raug coj los ua ke nrog cov tshuaj tua kab mob sib kis. Qee cov khoom siv cannabidiol uas tau tsim hauv ib chav kuaj tseem tab tom kawm txog kev mob vwm. Tab sis kev tshawb fawb muaj tsawg, thiab tsis muaj ib qho ntawm cov khoom no tau pom zoo raws li cov tshuaj noj.

Cov pov thawj tsis txaus ntseeg kom ntsuas kev ua haujlwm rau ...

  • Ib hom mob hnyuv mob (Kab mob Crohn)Cov. Kev tshawb nrhiav thaum ntxov qhia tias kev noj cannabidiol tsis txo qis kev muaj mob ntawm cov neeg laus nrog Crohn.
  • Mob ntshav qab zibCov. Kev tshawb nrhiav thaum ntxov qhia tias kev noj cannabidiol tsis txhim kho cov ntshav qabzib tswj cov neeg laus uas muaj ntshav qab zib hom 2.
  • Ib qhov kev tsis sib haum xeeb ntawm cov nqaij mob plab (dystonia)Cov. Nws tsis meej yog tias cannabidiol muaj txiaj ntsig rau dystonia.
  • Ib qho mob muaj mob uas tau muaj los ntawm kev kawm tsis taus (kab mob-X syndrome)Cov. Kev tshawb nrhiav thaum ntxov qhia tias kev thov cannabidiol gel tuaj yeem txo qhov kev ntxhov siab thiab txhim kho tus cwj pwm hauv cov menyuam yaus uas muaj tus kab mob X yooj yim.
  • Ib qho mob uas cov ntshav hloov mus rau hauv lub cev (txhom-mob tiv thaiv tus kab mob lossis GVHD)Cov. Graft-tiv tiag-tus kab mob rau lub cev yog qhov teeb meem uas tuaj yeem tshwm sim tom qab hloov hlwb pob txha. Cov kev tshawb fawb thaum ntxov tau pom tias noj cannabidiol txhua hnub pib 7 hnub ua ntej hloov pob txha thiab txuas ntxiv rau 30 hnub tom qab hloov tau tuaj yeem txuas lub sijhawm uas nws siv rau ib tus neeg los tsim GVHD
  • Cov kab mob hauv lub hlwb uas muaj feem cuam tshuam rau kev txav, kev xav thiab kev xav (Kab mob Huntington)Cov. Kev tshawb nrhiav thaum ntxov qhia tias kev noj cannabidiol txhua hnub tsis txhim kho cov tsos mob ntawm tus kab mob Huntington.
  • Ntau yam sclerosis (MS)Cov. Kev tshawb nrhiav thaum ntxov qhia tias kev siv cannabidiol cov tshuaj tsuag nyob hauv tus nplaig yuav txhim kho qhov mob thiab mob nruj hauv cov neeg nrog MS.
  • Thau tawm ntawm yeeb dawb, morphine, thiab lwm yam tshuaj opioidCov. Kev tshawb nrhiav thaum ntxov qhia tias kev noj cannabidiol rau 3 hnub yuav txo qis kev nqhis thiab kev ntxhov siab rau cov neeg uas muaj kev siv yeeb dawb (heroin).
  • Kab mob ParkinsonCov. Kev tshawb nrhiav thaum ntxov qhia tias cannabidiol yuav txo qis kev ntxhov siab thiab mob hlwb hauv cov neeg uas muaj tus kab mob Parkinson.
  • SchizophreniaCov. Cov kev tshawb fawb thaum ntxov qhia tias kev noj cannabidiol txhim kho cov tsos mob thiab kev muaj txiaj ntsig hauv cov neeg muaj tus mob schizophrenia.
  • Txiav kev haus luam yeebCov. Cov kev tshawb pom thaum ntxov qhia tias kev nqus tau cov pa cannabidiol nrog lub tshuaj nqus pa rau ib lub lim tiam yuav txo qis cov neeg haus luam yeeb uas cov neeg haus luam yeeb sim txiav luam yeeb.
  • Ib hom kev ntxhov siab uas khij los ntawm kev ntshai nyob hauv qee qhov lossis txhua qhov chaw muaj kev sib raug zoo (kev txhawj xeeb ntawm tib neeg)Cov. Kev tshawb nrhiav thaum ntxov qhia tias cannabidiol tuaj yeem txhim kho kev ntxhov siab hauv cov neeg muaj kev tsis zoo no. Tab sis nws tsis meej yog tias nws yuav pab txo kev ntxhov siab thaum hais lus hauv zej zog.
  • Ib pawg ntawm cov kev mob uas cuam tshuam rau lub puab tsaig ua ke thiab cov leeg (temporomandibular ntshawv siab lossis TMD)Cov. Kev tshawb nrhiav ntxov pom tias kev thov cov roj uas muaj cannabidiol rau ntawm daim tawv nqaij tuaj yeem txo qhov mob hauv cov neeg mob TMD.
  • Kev puas ntsoog hauv txhais tes thiab txhais taw (mob leeg hlwb).
  • Muaj kev puas siab puas ntsws bipolar.
  • Insomnia.
  • Lwm yam mob.
Cov ntaub ntawv pov thawj ntxiv xav tau txhawm rau ntsuas qhov ua tau zoo ntawm cannabidiol rau cov kev siv no.

Cannabidiol muaj cov txiaj ntsig rau lub hlwb. Qhov tseeb yog vim li cas rau cov teebmeem no tsis paub meej. Txawm li cas los xij, cannabidiol zoo li tiv thaiv kev puas tsuaj ntawm tshuaj hauv lub hlwb uas cuam tshuam rau qhov mob, lub siab lub ntsws thiab lub hlwb kev ua haujlwm. Tiv thaiv kev puas ntsoog ntawm cov tshuaj no thiab nce ntau ntau hauv cov ntshav zoo li txo cov tsos mob psychotic cuam tshuam nrog cov mob xws li mob schizophrenia. Cannabidiol tseem tuaj yeem thaiv qee qhov kev puas siab ntsws ntawm delta-9-tetrahydrocannabinol (THC). Tsis tas li ntawd, cannabidiol zoo li txo qhov mob thiab ntxhov siab.

Thaum noj ntawm qhov ncauj: Cannabidiol yog POSSIBLY KEV CAI thaum noj ntawm qhov ncauj los yog txau rau hauv qab nplaig kom tsim nyog. Cannabidiol hauv koob tshuaj txog 300 mg txhua hnub tau noj ntawm qhov ncauj kom nyab xeeb txog 6 lub hlis. Kev txhaj tshuaj ntau dua ntawm 1200-1500 mg txhua hnub tau noj ntawm qhov ncauj zoo txog 4 lub lis piam. Cov tshuaj cannabidiol (Epidiolex) raug pom zoo kom noj ntawm qhov ncauj hauv kwv yees li 25 mg / kg txhua hnub. Cannabidiol tshuaj txau uas tau thov nyob hauv tus nplaig tau siv nyob rau hauv lub koob tshuaj ntawm 2.5 mg rau txog li 2 lub lis piam.

Qee qhov qhia txog kev cuam tshuam ntawm cannabidiol suav nrog lub qhov ncauj qhuav, tsis muaj ntshav siab, lub teeb taws lub taub hau, thiab tsaug zog. Cov tsos mob ntawm kev mob siab kuj tseem tau tshaj tawm hauv qee tus neeg mob, tab sis qhov no tsis tshua muaj.

Thaum ua ntawv thov rau daim tawv: Tsis muaj cov ntaub ntawv txaus ntseeg txaus kom paub tias cannabidiol muaj kev nyab xeeb lossis qhov cuam tshuam yuav tshwm sim li cas.

Cov kev ceev faj & cov lus ceeb toom:

Cev xeeb tub thiab pub niam mis: Cannabidiol yog YAM TSIS TAU KEV PAB DAWB siv yog tias koj xeeb tub los yog pub niam mis. Cov tshuaj cannabidiol tuaj yeem nkag nrog lwm cov khoom sib xyaw uas tuaj yeem tsim kev puas tsuaj rau tus menyuam lossis menyuam mos. Nyob rau sab muaj kev nyab xeeb thiab zam kev siv.

Cov menyuam: Ib daim ntawv yuav tshuaj cannabidiol (Epidiolex) yog POSSIBLY KEV CAI thaum noj ntawm qhov ncauj hauv koob tshuaj txog 25 mg / kg txhua hnub. Cov khoom no tau pom zoo rau siv rau hauv qee tus menyuam hnub nyoog 1 xyoos thiab laus dua.

Mob siab: Cov neeg muaj kab mob siab yuav tau siv koob tshuaj cannabidiol qis dua piv rau cov neeg mob noj qab nyob zoo.

Kab mob Parkinson: Qee qhov kev tshawb pom thaum ntxov qhia tias kev noj cov cannabidiol ntau dua yuav ua rau cov leeg muaj zog thiab tshee tshee muaj qee tus neeg muaj tus mob Parkinson.

Ntsawv
Ceev faj nrog txoj kev sib xyaw ua ke no.
Brivaracetam (Briviact)
Brivaracetam tau hloov pauv thiab tawg los ntawm lub cev. Cannabidiol yuav txo qis sai li cas lub cev zom tawm ntawm brivaracetam. Qhov no yuav nce qib ntawm brivaracetam hauv lub cev.
Carbamazepine (Tegretol)
Carbamazepine raug hloov pauv thiab raug rhuav tshem los ntawm lub cev. Cannabidiol tuaj yeem txo qis sai sai lub cev zom cov carbamazepine. Qhov no yuav nce qib kev noj cov carbamazepine hauv lub cev thiab ua rau muaj kev phiv ntau ntxiv.
Clobazam (Onfi)
Clobazam tau hloov pauv thiab kho lub siab. Cannabidiol yuav txo qis sai sai ua rau daim siab tawg clobazam. Qhov no tuaj yeem ua rau muaj kev cuam tshuam thiab phiv ntawm clobazam.
Eslicarbazepine (Aptiom)
Eslicarbazepine yog hloov pauv thiab tawg ntawm lub cev. Cannabidiol tuaj yeem txo qis lub cev sai sai eslicarbazepine. Qhov no yuav nce qib eslicarbazepine hauv lub cev los ntawm qhov me me.
Everolimus (Zostress)
Everolimus hloov pauv thiab cais los ntawm lub cev. Cannabidiol tuaj yeem txo qis sai sai vim lub cev zom zaws everolimus. Qhov no yuav ua kom nce qib everolimus hauv lub cev.
Lithium
Kev noj tshuaj ntau dua ntawm cannabidiol tuaj yeem nce qib ntau ntawm lithium. Qhov no tuaj yeem ua rau kom muaj kev pheej hmoo ntawm lithium lom.
Cov tshuaj pauv hloov los ntawm lub siab (Cytochrome P450 1A1 (CYP1A1) substrates)
Qee yam tshuaj kho mob pauv hloov thiab cais tawm lub siab. Cannabidiol yuav txo qis sai sai li cas lub siab tawg tawm qee cov tshuaj. Hauv txoj kev xav, kev siv cannabidiol nrog rau qee cov tshuaj uas ua rau lub siab tawg tuaj yeem ua rau muaj kev cuam tshuam thiab phiv los ntawm qee cov tshuaj. Ua ntej siv cov cannabidiol, nrog koj tus kws kho mob tham yog tias koj noj ib yam tshuaj uas hloov pauv lub siab.

Qee cov tshuaj uas hloov los ntawm daim siab yog chlorzoxazone (Lorzone) thiab theophylline (Theo-Dur, lwm tus).
Cov tshuaj pauv hloov los ntawm lub siab (Cytochrome P450 1A2 (CYP1A2) substrates)
Qee yam tshuaj kho mob pauv hloov thiab cais tawm lub siab. Cannabidiol yuav txo qis sai sai li cas lub siab tawg tawm qee cov tshuaj. Hauv txoj kev xav, kev siv cannabidiol nrog rau qee cov tshuaj uas ua rau lub siab tawg tuaj yeem ua rau muaj kev cuam tshuam thiab phiv los ntawm qee cov tshuaj. Ua ntej siv cov cannabidiol, nrog koj tus kws kho mob tham yog tias koj noj ib yam tshuaj uas hloov pauv lub siab.

Qee cov tshuaj pauv hloov los ntawm daim siab muaj xws li amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, lwm tus), verapamil (Calan, Isoptin, lwm tus), thiab lwm yam.
Cov tshuaj pauv hloov los ntawm lub siab (Cytochrome P450 1B1 (CYP1B1) substrates)
Qee yam tshuaj kho mob pauv hloov thiab cais tawm lub siab. Cannabidiol yuav txo qis sai sai li cas lub siab tawg tawm qee cov tshuaj. Hauv txoj kev xav, kev siv cannabidiol nrog rau qee cov tshuaj uas ua rau lub siab tawg tuaj yeem ua rau muaj kev cuam tshuam thiab phiv los ntawm qee cov tshuaj. Ua ntej siv cov cannabidiol, nrog koj tus kws kho mob tham yog tias koj noj ib yam tshuaj uas hloov pauv lub siab.

Qee cov tshuaj pauv hloov los ntawm daim siab muaj xws li theophylline (Theo-Dur, lwm tus), omeprazole (Prilosec, Omesec), clozapine (Clozaril, FazaClo), progesterone (Prometrium, lwm tus), lansoprazole (Prevacid), flutamide (Eulexin), oxaliplatin (Eloxatin) ), erlotinib (Tarceva), thiab khoom qab zib.
Cov tshuaj pauv hloov los ntawm lub siab (Cytochrome P450 2A6 (CYP2A6) substrates)
Qee yam tshuaj kho mob pauv hloov thiab cais tawm lub siab. Cannabidiol yuav txo qis sai sai li cas lub siab tawg tawm qee cov tshuaj. Hauv txoj kev xav, kev siv cannabidiol nrog rau qee cov tshuaj uas ua rau lub siab tawg tuaj yeem ua rau muaj kev cuam tshuam thiab phiv los ntawm qee cov tshuaj. Ua ntej siv cov cannabidiol, nrog koj tus kws kho mob tham yog tias koj noj ib yam tshuaj uas hloov pauv lub siab.

Qee cov tshuaj pauv hloov los ntawm daim siab muaj xws li nicotine, chlormethiazole (Heminevrin), coumarin, methoxyflurane (Penthrox), halothane (Fluothane), valproic acid (Depacon), disulfiram (Antabuse), thiab lwm yam.
Cov tshuaj pauv hloov los ntawm lub siab (Cytochrome P450 2B6 (CYP2B6) substrates)
Qee yam tshuaj kho mob pauv hloov thiab cais tawm lub siab. Cannabidiol yuav txo qis sai sai li cas lub siab tawg tawm qee cov tshuaj. Hauv txoj kev xav, kev siv cannabidiol nrog rau qee cov tshuaj uas ua rau lub siab tawg tuaj yeem ua rau muaj kev cuam tshuam thiab phiv los ntawm qee cov tshuaj. Ua ntej siv cov cannabidiol, nrog koj tus kws kho mob tham yog tias koj noj ib yam tshuaj uas hloov pauv lub siab.

Qee cov tshuaj pauv hloov los ntawm daim siab yog ketamine (Ketalar), phenobarbital, orphenadrine (Norflex), secobarbital (Seconal), thiab dexamethasone (Decadron).
Cov tshuaj pauv hloov los ntawm lub siab (Cytochrome P450 2C19 (CYP2C19) substrates)
Qee yam tshuaj kho mob pauv hloov thiab cais tawm lub siab. Cannabidiol yuav txo qis sai sai li cas lub siab tawg tawm qee cov tshuaj. Hauv txoj kev xav, kev siv cannabidiol nrog rau qee cov tshuaj uas ua rau lub siab tawg tuaj yeem ua rau muaj kev cuam tshuam thiab phiv los ntawm qee cov tshuaj. Ua ntej siv cov cannabidiol, nrog koj tus kws kho mob tham yog tias koj noj ib yam tshuaj uas hloov pauv lub siab.

Qee cov tshuaj uas hloov los ntawm lub siab muaj cov tshuaj tiv thaiv proton twj tso kua mis suav nrog omeprazole (Prilosec), lansoprazole (Prevacid), thiab pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); thiab lwm tus.
Cov tshuaj pauv hloov los ntawm lub siab (Cytochrome P450 2C8 (CYP2C8) substrates)
Qee yam tshuaj kho mob pauv hloov thiab cais tawm lub siab. Cannabidiol yuav txo qis sai sai li cas lub siab tawg tawm qee cov tshuaj. Hauv txoj kev xav, kev siv cannabidiol nrog rau qee cov tshuaj uas ua rau lub siab tawg tuaj yeem ua rau muaj kev cuam tshuam thiab phiv los ntawm qee cov tshuaj. Ua ntej siv cov cannabidiol, nrog koj tus kws kho mob tham yog tias koj noj ib yam tshuaj uas hloov pauv lub siab.
Qee cov tshuaj pauv hloov los ntawm daim siab muaj xws li amiodarone (Cordarone), carbamazepine (Tegretol), chloroquine (Aralen), diclofenac (Voltaren), paclitaxel (Taxol), repaglinide (Prandin) thiab lwm yam.
Cov tshuaj pauv hloov los ntawm lub siab (Cytochrome P450 2C9 (CYP2C9) substrates)
Qee yam tshuaj kho mob pauv hloov thiab cais tawm lub siab. Cannabidiol yuav txo qis sai sai li cas lub siab tawg tawm qee cov tshuaj. Hauv txoj kev xav, kev siv cannabidiol nrog rau qee cov tshuaj uas ua rau lub siab tawg tuaj yeem ua rau muaj kev cuam tshuam thiab phiv los ntawm qee cov tshuaj. Ua ntej siv cov cannabidiol, nrog koj tus kws kho mob tham yog tias koj noj ib yam tshuaj uas hloov pauv lub siab.

Qee cov tshuaj pauv hloov los ntawm lub siab muaj xws li tshuaj tiv thaiv nonsteroidal (NSAIDs) xws li diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), piroxicam (Feldene), thiab celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); thiab lwm tus.
Cov tshuaj pauv hloov los ntawm lub siab (Cytochrome P450 2D6 (CYP2D6) substrates)
Qee yam tshuaj kho mob pauv hloov thiab cais tawm lub siab. Cannabidiol yuav txo qis sai sai li cas lub siab tawg tawm qee cov tshuaj. Hauv txoj kev xav, kev siv cannabidiol nrog rau qee cov tshuaj uas ua rau lub siab tawg tuaj yeem ua rau muaj kev cuam tshuam thiab phiv los ntawm qee cov tshuaj. Ua ntej siv cov cannabidiol, nrog koj tus kws kho mob tham yog tias koj noj ib yam tshuaj uas hloov pauv lub siab.

Qee cov tshuaj pauv hloov los ntawm daim siab muaj xws li amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine ), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), thiab lwm yam.
Cov tshuaj pauv hloov los ntawm lub siab (Cytochrome P450 3A4 (CYP3A4) substrates)
Qee yam tshuaj kho mob pauv hloov thiab cais tawm lub siab. Cannabidiol yuav txo qis sai sai li cas lub siab tawg tawm qee cov tshuaj. Hauv txoj kev xav, kev siv cannabidiol nrog rau qee cov tshuaj uas ua rau lub siab tawg tuaj yeem ua rau muaj kev cuam tshuam thiab phiv los ntawm qee cov tshuaj. Ua ntej siv cov cannabidiol, nrog koj tus kws kho mob tham yog tias koj noj ib yam tshuaj uas hloov pauv lub siab.

Qee cov tshuaj pauv hloov los ntawm daim siab muaj xws li alprazolam (Xanax), amlodipine (Norvasc), clarithromycin (Biaxin), cyclosporine (Sandimmune), erythromycin, lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenia (Halcion), verapamil (Calan, Isoptin) thiab lwm yam.
Cov tshuaj pauv hloov los ntawm lub siab (Cytochrome P450 3A5 (CYP3A5) substrates)
Qee yam tshuaj kho mob pauv hloov thiab cais tawm lub siab. Cannabidiol yuav txo qis sai sai li cas lub siab tawg tawm qee cov tshuaj. Hauv txoj kev xav, kev siv cannabidiol nrog rau qee cov tshuaj uas ua rau lub siab tawg tuaj yeem ua rau muaj kev cuam tshuam thiab phiv los ntawm qee cov tshuaj. Ua ntej siv cov cannabidiol, nrog koj tus kws kho mob tham yog tias koj noj ib yam tshuaj uas hloov pauv lub siab.

Qee cov tshuaj pauv hloov los ntawm daim siab muaj xws li testosterone, progesterone (Endometrin, Prometrium), nifedipine (Adalat CC, Procardia XL), cyclosporine (Sandimmune), thiab lwm yam.
Cov tshuaj pauv hloov los ntawm lub siab (Cov tshuaj Glucuronidated)
Qee yam tshuaj kho mob pauv hloov thiab cais tawm lub siab. Cannabidiol yuav txo qis sai sai li cas lub siab tawg tawm qee cov tshuaj. Kev noj cannabidiol nrog rau qee cov tshuaj noj uas lub siab ua rau lub siab tuaj yeem ua rau muaj kev cuam tshuam thiab phiv los ntawm cov tshuaj no.
Qee cov tshuaj uas hloov pauv los ntawm daim siab muaj xws li acetaminophen (Tylenol, lwm tus) thiab oxazepam (Serax), haloperidol (Haldol), lamotrigine (Lamictal), morphine (MS Txuas, Roxanol), zidovudine (AZT, Retrovir), thiab lwm yam.
Cov tshuaj uas txo qis ntawm lwm cov tshuaj los ntawm lub siab (Cytochrome P450 2C19 (CYP2C19) inhibitors)
Cannabidiol tau tawg ua lub siab. Qee yam tshuaj noj tuaj yeem txo qis sai sai rau daim siab ua rau cannabidiol sai sai. Kev noj cannabidiol nrog rau cov tshuaj no yuav ua rau muaj kev cuam tshuam thiab phiv los ntawm cannabidiol.
Qee cov tshuaj uas yuav ua rau txo qis hauv cannabidiol hauv lub siab suav nrog cimetidine (Tagamet), fluvoxamine (Luvox), omeprazole (Prilosec); ticlopidine (Ticlid), topiramate (Topamax), thiab lwm yam.
Cov tshuaj uas txo qis ntawm lwm cov tshuaj hauv lub siab (Cytochrome P450 3A4 (CYP3A4) inhibitors)
Cannabidiol tau tawg ua lub siab. Qee yam tshuaj noj tuaj yeem txo qis sai sai rau daim siab ua rau cannabidiol sai sai. Kev noj cannabidiol nrog rau cov tshuaj no yuav ua rau muaj kev cuam tshuam thiab phiv los ntawm cannabidiol.
Qee cov tshuaj uas yuav txo qis sai ua rau daim siab ua rau cannabidiol suav nrog amiodarone (Cordarone), clarithromycin (Biaxin), diltiazem (Cardizem), erythromycin (E-mycin, Erythrocin), indinavir (Crixivan), ritonavir (Norvir), saquinav (Norvir) , Invirase), thiab lwm yam.
Cov tshuaj uas ua rau ntxiv dag zog rau lwm cov tshuaj los ntawm lub siab (Cytochrome P450 3A4 (CYP3A4) inducers)
Cannabidiol tau tawg ua lub siab. Qee cov tshuaj yuav ua rau nce siab sai sai ua rau daim siab ua rau cannabidiol. Kev noj cannabidiol nrog rau cov tshuaj no yuav txo qis kev cuam tshuam ntawm cannabidiol.
Qee yam tshuaj no suav nrog carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), thiab lwm yam.
Cov tshuaj uas ua rau ntxiv dag zog rau lwm cov tshuaj los ntawm lub siab (Cytochrome P450 2C19 (CYP2C19) inducers)
Cannabidiol tau tawg ua lub siab. Qee cov tshuaj yuav ua rau nce siab sai sai ua rau daim siab ua rau cannabidiol sai. Kev noj cannabidiol nrog rau cov tshuaj no yuav txo qis kev cuam tshuam ntawm cannabidiol.
Qee cov tshuaj uas yuav ua rau nce tuaj yeem ua rau cannabidiol hauv lub siab muaj xws li carbamazepine (Tegretol), prednisone (Deltasone), thiab rifampin (Rifadin, Rimactane).
Tshuaj txiav yeeb (Dolophine)
Tshuaj txiav yeeb ua rau lub siab. Cannabidiol yuav txo qis sai sai ua rau daim siab ua rau qaug tshuaj txiav yeeb. Kev noj cannabidiol nrog rau tshuaj txiav yeeb yuav ua rau muaj kev cuam tshuam ntxiv thiab phiv tshuaj txiav yeeb.
Rufinamide (Banzel)
Rufinamide yog hloov pauv thiab tawg ntawm lub cev. Cannabidiol tuaj yeem txo qis sai sai lub cev tawg sai rufinamide. Qhov no tuaj yeem nce qib ntawm rufinamide hauv lub cev los ntawm qhov me me.
Cov tshuaj tsis haum (CNS depressants)
Cannabidiol yuav ua rau kev tsaug zog thiab tsaug zog. Cov tshuaj uas ua rau tsaug zog hu ua sedatives. Kev noj cannabidiol nrog rau cov tshuaj loog yuav ua rau tsaug zog ntau dhau.

Qee cov tshuaj loog suav nrog benzodiazepines, pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), thiopental (Pentothal), fentanyl (Duragesic, Sublimaze), morphine, propofol (Diprivan), thiab lwm yam.
Sirolimus (Rapamune)
Sirolimus hloov pauv thiab txhawm rau lub cev. Cannabidiol tuaj yeem txo qis sai sai lub cev zom ua sirolimus. Qhov no yuav nce qib sirolimus hauv lub cev.
Stiripentol (Daws Kev)
Stiripentol hloov pauv thiab zom los ntawm lub cev. Cannabidiol tuaj yeem txo qis sai sai lub cev zom kom sib xyaw stiripentol. Qhov no yuav nce qib theem siab ntawm stiripentol hauv lub cev thiab ua rau muaj kev phiv ntau ntxiv.
Tacrolimus (Prograf)
Tacrolimus hloov pauv thiab cais los ntawm lub cev. Cannabidiol tuaj yeem txo qis lub cev sai sai tacrolimus. Qhov no yuav nce qib tacrolimus hauv lub cev.
Topiramate (Tompamax)
Topiramate hloov pauv thiab cais tawm ntawm lub cev. Cannabidiol tuaj yeem txo qis sai sai lub cev zom tawm ntawm cov tshuaj topiramate. Qhov no tuaj yeem nce qib ntawm topiramate hauv lub cev los ntawm qhov me me.
Siv txiaj ntsig
Valproic acid tuaj yeem ua rau daim siab raug mob. Noj cannabidiol nrog valproic acid yuav ua rau muaj kev pheej hmoo mob siab. Cannabidiol thiab / lossis valproic acid yuav tsum tau tsum, lossis cov koob tshuaj yuav tsum raug txo kom tsawg.
Warfarin
Cannabidiol tuaj yeem nce qib ntawm warfarin, uas tuaj yeem ua rau muaj kev pheej hmoo los ntshav. Cannabidiol thiab / lossis warfarin xav kom nres, lossis cov koob yuav tsum raug txo kom tsawg.
Zonisamide
Zonisamide raug hloov pauv thiab piam rau ntawm lub cev. Cannabidiol tuaj yeem txo qis sai sai lub cev zom zonisamide sai sai. Qhov no tej zaum yuav nce qib ntawm zonisamide hauv lub cev los ntawm qhov me me.
Tshuaj ntsuab thiab tshuaj ntxiv nrog sedative zog
Cannabidiol tuaj yeem ua rau tsaug zog lossis tsaug zog. Siv nws nrog rau lwm yam tshuaj ntsuab thiab tshuaj muaj txiaj ntsig zoo ib yam yuav ua rau ntau tsaug zog. Qee yam ntawm cov tshuaj ntsuab thiab tshuaj ntxiv muaj xws li calamus, California poppy, catnip, hops, Jamaican dogwood, kava, L-tryptophan, melatonin, sage, SAMe, St. John's wort, sassafras, skullcap, thiab lwm yam.
Cawv (Ethanol)
Kev noj cov cannabidiol nrog haus cawv kom ntau ntxiv cannabidiol uas nqus los ntawm lub cev. Qhov no yuav ua rau muaj kev cuam tshuam thiab phiv los ntawm cannabidiol.
Cov rog thiab cov khoom noj muaj roj
Kev noj cannabidiol nrog cov pluas noj uas muaj rog lossis tsawg kawg muaj qee cov rog, ua rau cannabidiol ntau dua uas nqus los ntawm lub cev. Qhov no yuav ua rau muaj kev cuam tshuam thiab phiv los ntawm cannabidiol.
Mis
Kev noj cannabidiol nrog rau mis nyuj nce tus naj npawb ntawm cannabidiol uas nqus los ntawm lub cev. Qhov no yuav ua rau muaj kev cuam tshuam thiab phiv los ntawm cannabidiol.
Cov koob tshuaj nram no tau kawm hauv kev tshawb fawb:

COV LAUS

BY MOUTH:
  • Rau qaug dab peg: Ib qho tshuaj noj cannabidiol tshuaj (Epidiolex) tau siv lawm. Qhov pom zoo kom pib koob rau Lennox-Gastaut syndrome thiab Dravet syndrome yog 2.5 mg / kg ob zaug ib hnub (5 mg / kg / hnub). Tom qab ib lub lis piam tuaj yeem nce ntxiv rau 5 mg / kg ob zaug ib hnub (10 mg / kg / hnub). Yog tias tus neeg tsis teb rau cov koob tshuaj no, qhov kev pom zoo tshaj plaws yog 10 mg / kg ob zaug ib hnub (20 mg / kg / hnub). Qhov pom zoo kom pib siv rau kev txhaj tshuaj rau cov hlab ntsws txhaws yog 2.5 mg / kg ob zaug ib hnub (5 mg / kg / hnub). Qhov no tuaj yeem nce ntxiv nyob rau ntawm cov kev sib txuas txhua lub limtiam yog tias tsim nyog, nce mus txog ntau kawg yog 12.5 mg / kg ob zaug ib hnub (25 mg / kg / hnub). Tsis muaj qhov tseeb ua pov thawj tau qhia tias cov khoom noj tsis tau tshuaj lom cannabidiol muaj txiaj ntsig zoo rau kev mob vwm.
TUS ME NYUAM

BY MOUTH:
  • Rau qaug dab peg: Ib qho tshuaj noj cannabidiol tshuaj (Epidiolex) tau siv lawm. Qhov pom zoo kom pib koob rau Lennox-Gastaut syndrome thiab Dravet syndrome yog 2.5 mg / kg ob zaug ib hnub (5 mg / kg / hnub). Tom qab ib lub lis piam tuaj yeem nce ntxiv rau 5 mg / kg ob zaug ib hnub (10 mg / kg / hnub). Yog tias tus neeg tsis teb rau cov koob tshuaj no, qhov kev pom zoo ntau tshaj yog 10 mg / kg ob zaug ib hnub (20 mg / kg / hnub). Qhov pom zoo kom pib siv rau kev txhaj tshuaj rau cov hlab ntsws txhaws yog 2.5 mg / kg ob zaug ib hnub (5 mg / kg / hnub). Qhov no tuaj yeem nce ntxiv nyob rau ntawm cov kev sib txuas txhua lub limtiam yog tias tsim nyog, nce txog 12.5 mg / kg ob zaug ib hnub (25 mg / kg / hnub). Tsis muaj qhov tseeb ua pov thawj tau qhia tias cov khoom noj tsis tau tshuaj lom cannabidiol muaj txiaj ntsig zoo rau kev mob vwm.
2 - [(1R, 6R) -3-Methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl] -5-pentylbenzene-1,3-diol, CBD.

Xav paub ntau ntxiv txog yuav sau li cas cov lus tau sau, thov saib cov Cov Tshuaj Kho Kom Zoo Database kev qhia txujci.


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