Polymyositis - neeg laus

Polymyositis thiab dermatomyositis yog yam mob tsis tshua muaj kab mob. (Qhov xwm txheej hu ua dermatomyositis thaum nws cuam tshuam nrog daim tawv.) Cov kabmob no ua rau cov leeg tsis muaj zog, o, mob thiab nqaij mos. Lawv yog ib feem ntawm pawg neeg loj dua ntawm cov kabmob hu ua myopathies.

Polymyositis cuam tshuam rau cov leeg pob txha. Nws tseem muaj lub npe hu ua idiopathic inflammatory myopathy. Tsis paub meej tias vim li cas, tab sis nws yuav cuam tshuam nrog lub cev tiv thaiv kabmob lossis kabmob sib kis.

Polymyositis tuaj yeem cuam tshuam cov neeg ntawm txhua lub hnub nyoog. Feem ntau nws yog cov muaj rau cov laus muaj hnub nyoog 50 txog 60 xyoo, thiab rau cov menyuam hlob dua. Nws cuam tshuam rau cov poj niam ob zaug ntau npaum li txiv neej. Nws muaj ntau nyob rau hauv Asmeskas Neeg Asmeskas dua li cov neeg tawv dawb.

Polymyositis yog ib hom kab mob muaj sia. Qhov no txhais tau tias nws cuam tshuam rau tag nrho lub cev. Mob ua kom tsis muaj zog thiab lub siab tawv tuaj yeem yog qhov qhia ntawm polymyositis. Cov pob xoo yog cov cim ntawm ib yam kev mob, dermatomyositis.

Cov tsos mob tshwm sim suav nrog:

• Lub leeg tsis muaj zog hauv lub xub pwg thiab lub duav. Qhov no tuaj yeem ua rau nws nyuaj los tsa caj npab hla lub taub hau, sawv ntawm qhov chaw zaum, lossis nce ntaiv.
• Nyuaj nqos nyuaj.
• Mob leeg.
• Teeb meem nrog lub suab (los ntawm caj pas tsis muaj zog).
• Ua tsis taus pa.

Koj kuj tseem yuav muaj:

• Nkees
• Ua npaws
• Mob tej pob txha
• Tsis qab los noj mov
• Thaum sawv ntxov txhav
• Lub cev yuag
• Cov tawv nqaij ua pob khaus raws ntiv tes, rov qab rau ntawm daim tawv muag, lossis ntawm ntsej muag

Kev ntsuam xyuas yuav muaj xws li:

• Cov tshuaj tiv thaiv kab mob thiab kev kuaj ntshav
• CPK
• Ntshiab aldolase
• Electromyography
• MRI ntawm cov leeg
• Nqaij xyoob
• Myoglobin hauv cov zis
• ECG
• Xoo hluav taws xob xoo thiab CT scan ntawm lub hauv siab
• Pulmonary muaj nuj nqi xeem
• Txoj hlab nqos mov kawm
• Myositis tshwj xeeb thiab mob cuam tshuam autoantibodies

Cov neeg muaj tus mob no tseem yuav tsum tau ua tib zoo saib kom pom muaj cov cim mob cancer.

Kev kho tseem ceeb yog kev siv tshuaj corticosteroid. Cov koob tshuaj ntawm cov tshuaj yog maj mam kaw tawm raws li cov leeg ua kom muaj zog. Qhov no yuav siv sijhawm li 4 txog 6 lub lim tiam. Koj yuav nyob rau qhov qis tshuaj ntawm corticosteroid tshuaj tom qab ntawd.

Cov tshuaj noj rau tshuaj tiv thaiv kab mob hauv lub cev tej zaum yuav raug siv los hloov corticosteroids. Cov tshuaj no suav nrog azathioprine, methotrexate lossis mycophenolate.

Rau cov kab mob uas tseem muaj sia nyob txawm hais tias corticosteroids, kev muaj mob gamma globulin tau sim nrog kev sib xyaw. Kev siv tshuaj lom neeg kuj tseem siv tau. Rituximab zoo nkaus li yog qhov muaj kev cia siab tshaj plaws. Nws yog ib qho tseem ceeb uas yuav tau txiav txim txog lwm yam mob hauv cov neeg uas tsis teb rau kev kho. Kev rov qab kuaj dua ntawm cov leeg nqaij yuav tsum tau ua qhov kev kuaj mob no.

Yog tias tus mob cuam tshuam nrog cov qog, nws tuaj yeem kho yog tias cov qog tshem tawm.

Kev teb rau kev kho mob mas nws txawv, raws cov teeb meem tshwm sim. Muaj ntau li 1 ntawm 5 tus neeg yuav tuag li ntawm 5 xyoos ntawm kev tsim tus mob.

Coob tus neeg, tshwj xeeb yog menyuam yaus, rov zoo los ntawm tus mob thiab tsis xav tau kev kho mob tsis tu ncua. Rau feem ntau cov neeg laus, txawm li cas los xij, cov tshuaj tiv thaiv txhaj tshuaj tiv thaiv yuav tsum tau los tswj tus kab mob.

Qhov tsis pom kev rau cov neeg muaj kab mob ntsws nrog cov tshuaj tiv thaiv MDA-5 tsis zoo txawm hais tias tam sim no kev kho mob.

Hauv cov laus, kev tuag tshwm sim los ntawm:

• Khoom noj khoom haus tsis muaj zog
• Mob ntsws o
• Kev ua pa tsis ua haujlwm
• Mob hnyav, mob lub sijhawm ntev ua kom cov leeg tsis muaj zog

Cov ua rau muaj ploj tuag yog mob cancer thiab mob ntsws.

Teeb meem yuav suav nrog:

• Cov tshuaj calcium tso rau hauv cov leeg nqaij, tshwj xeeb tshaj yog nyob hauv cov menyuam muaj tus mob
• Mob Cancer
• Kab mob hauv lub plawv, mob ntsws, lossis mob plab

Hu koj tus kws kho mob yog tias koj muaj cov tsos mob ntawm qhov tsis zoo no. Nrhiav kev kho mob maj nrawm yog tias koj muaj txog siav thiab ua tsis taus pa.

• Sab nqaij tawv ntawm xub ntiag

Aggarwal R, Rider LG, Ruperto N, li al. 2016 American College of Rheumatology / European League tawm tsam Rheumatism Cov Qauv rau tsawg tshaj plaws, Nruab Nrab, thiab Chaw Kho Mob Loj hauv Kev Kho Kab Mob Hauv Cov Neeg Dermatomyositis thiab Polymyositis: Kev Tshuaj Ntsuam Xyuas Myositis Thoob Ntiaj Teb thiab Kev Ntsuam Xyuas Pab Pawg / Kab Mob Rheumatology Thoob Ntiaj Teb Kev Tshawb Nrhiav Kev Koom Tes Ua Haujlwm. Mob Pob Txha RheumatolCov. 2017; 69 (5): 898-910. PMID: 28382787 www.ncbi.nlm.nih.gov/pubmed/28382787.

Dalakas MC. Cov leeg mob. N Engl J MedCov. Xyoo 2015; 373 (4): 393-394. PMID: 26200989 www.ncbi.nlm.nih.gov/pubmed/26200989.

Greenberg SA. Cov mob myopathies. Hauv: Goldman L, Schafer AI, eds. Goldman-Cecil TshuajCov. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: tshooj 269.

Nagaraju K, Gladue HS, Lundberg IE.Cov mob o ntawm cov leeg nqaij thiab lwm yam mob myopathies. Hauv: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelley thiab Firestein Cov Ntawv Phau Ntawv ntawm RheumatologyCov. 10 tus ed. Philadelphia, PA: Elsevier; 2017: chap 85.

Yoshida N, Okamoto M, Kaieda S, li al. Koom xwm ntawm anti-aminoacyl-hloov RNA synthetase antibody thiab anti-melanoma sib txawv-txuam cov noob 5 tiv thaiv nrog kev kho cov lus teb ntawm polymyositis / dermatomyositis-txuam interstitial mob ntsws. Teb Tshawb PomCov. 2017; 55 (1): 24-32. PMID: 28012490 www.ncbi.nlm.nih.gov/pubmed/28012490.