Acromegaly

Acromegaly yog qhov xwm txheej uas muaj ntau dhau lawm kev loj hlob hormone (GH) hauv lub cev.

Acromegaly yog qhov tsis tshua muaj tshwm sim. Nws tshwm sim thaum lub caj pas pituitary ua rau ntau dhau kev loj hlob hormone. Lub caj pas pituitary yog lub caj pas endocrine me txuas rau hauv qab ntawm lub paj hlwb. Nws tswj, tsim, thiab tso tawm ntau cov tshuaj hormones, suav nrog kev loj hlob hormone.

Feem ntau tsis mob (non-mob) lub qog ua rau lub caj pas pituitary tso tawm ntau lawm ntau lawm. Muaj qee zaus, cov qog nqaij hlav pituitary tuaj yeem tau txais los ntawm caj ces.

Hauv cov menyuam yaus, ntau dhau GH ua rau gigantism tsis yog acromegaly.

Cov tsos mob ntawm acromegaly yuav muaj xws li hauv qab no:

• Lub cev ntxhiab tsw
• Cov ntshav hauv cov quav
• Tus mob carpal
• Txo cov leeg tsis muaj zog (tsis muaj zog)
• Txo qhov pom kev lub qhov muag
• Qaug zog yooj yim
• Tshaj qhov siab (thaum GH ntau lawm pib thaum yau)
• Dhau hws
• Mob taub hau
• Kev mob plawv, uas tuaj yeem ua rau tsaus muag
• Khuam
• Puab tsaig mob
• Mob tej pob txha, txwv txoj leeg sib koom tes, o ntawm thaj chaw ib ncig
• Cov pob txha loj ntawm lub ntsej muag, lub puab tsaig loj thiab tus nplaig, cov hniav dav dav
• Loj taw (hloov hauv khau loj), ob txhais tes loj loj (pauv nplhaib los yog hnab looj tes loj)
• Cov qog loj hauv daim tawv nqaij (cov qog sebaceous) ua rau cov tawv nqaij oily, cov tawv nqaij ua rau tuab, daim tawv nqaij (loj tuaj)
• Pw tsaug zog apnea
• Dav ntiv tes lossis ntiv taw, nrog o, liab thiab mob

Lwm tus tsos mob uas yuav tshwm sim nrog tus kab mob no:

• Nyuv polyps
• Kev noj hau ntau heev hauv poj niam (hirsutism)
• Ntshav siab
• Mob ntshav qab zib Hom 2
• Lub qog ua kom loj tuaj
• Qhov hnyav nce

Tus kws kho mob yuav kuaj ib ce thiab nug txog koj cov tsos mob.

Cov kev ntsuam xyuas hauv qab no yuav raug yuam kom paub meej tias kuaj mob acromegaly thiab kuaj xyuas cov teeb meem:

• Ntshav qabzib
• Kev loj hlob qog thiab ntsuas kev loj hlob hormone tawm kev ntsuas
• Insulin-zoo li qhov kev loj hlob zoo 1 (IGF-1)
• Prolactin
• Spine xoo hluav taws xob
• MRI ntawm lub paj hlwb, suav nrog lub caj pas pituitary
• Echocardiogram
• Kev kuaj mob hnyuv
• Pw tsaug zog kawm

Lwm qhov kev ntsuam xyuas yuav raug yuam kom kuaj seb lub puas ntawm lub caj pas ua haujlwm ua haujlwm zoo li qub.

Kev phais kom tshem tawm cov qog pituitary uas ua rau tus mob no feem ntau kho qhov txawv txav GH. Qee zaum, lub qog loj dhau lawm yuav raug tshem tawm kom meej thiab acromegaly tsis tau kho. Hauv qhov no, tshuaj thiab hluav taws xob (duab hluav taws xob) yuav siv los kho acromegaly.

Qee tus neeg mob qog uas nyuab dhau hwv los ntawm kev phais mob raug kho nrog cov tshuaj tsis yog phais. Cov tshuaj no tuaj yeem thaiv kev tsim GH los ntawm lub caj pas pituitary lossis tiv thaiv qhov kev ua ntawm GH hauv lwm qhov ntawm lub cev.

Tom qab kho, koj yuav tsum tau mus ntsib koj tus kws kho mob tsis tu ncua kom paub tseeb tias lub caj pas pituitary ua haujlwm zoo li qub thiab tias acromegaly tsis rov qab los. Cov kev ntsuam xyuas ib xyoos ib zaug raug pom zoo.

Cov peev txheej no yuav qhia ntxiv txog acromegaly:

• Koom lub koom haum ntshav qab zib thiab lub plab thiab lub raum muaj cov kab mob - www.niddk.nih.gov/health-information/endocrine-diseases/acromegaly
• Koom haum Lub Tebchaws rau Cov Tsis Txaus Ntseeg - rarediseases.org/rare-diseases/acromegaly

Kev phais mob Pituitary tau ua tiav rau feem ntau ntawm cov neeg, nyob ntawm qhov loj ntawm cov qog thiab cov kev paub dhau los ntawm cov leeg hlwb nrog cov qog pituitary.

Yog tias tsis kho, cov tsos mob yuav mob heev ntxiv. Cov mob xws li ntshav siab, ntshav qab zib, thiab mob plawv tuaj yeem ua.

Hu rau koj tus kws khomob yog:

• Koj muaj tsos mob acromegaly
• Koj cov tsos mob tsis zoo nrog kev kho

Tiv thaiv tsis tau Acromegaly. Ntxov kho thaum ntxov yuav tiv thaiv tus kab mob tsis txhob loj hlob tuaj thiab pab zam kev nyuaj.

Somatotroph adenoma; Kev loj hlob hormone tshaj; Kev loj hlob hormone secreting pituitary adenoma; Pituitary loj heev (thaum tseem yau)

• Cov qog endocrine

Katznelson L, Txoj Cai ER Jr, Melmed S, li al. Acromegaly: ib qho ntawm endocrine zej zog soj ntsuam kev coj ua. J Clin Endocrinol MetabCov. Xyoo 2014; 99 (11): 3933-3951. PMID: 25356808 www.ncbi.nlm.nih.gov/pubmed/25356808.

Klein I. Endocrine mob thiab kab mob plawv. Hauv: Mann DL, Zipes DP, Libby P, Bonow RO, Braunwald E, eds. Braunwald's Plawv Lub Plawv: Phau Ntawv Qhia Txog Cov Tshuaj Mob plawv. 10 tus ed. Philadelphia, PA: Elsevier Saunders; Xyoo 2015: chap 81.

Melmed S. Acromegaly. Hauv: Jameson JL, De Groot LJ, de Kretser DM, li al, eds. Endocrinology: Cov Neeg Loj thiab PediatricCov. 7 tus ed. Philadelphia, PA: Elsevier Saunders; 2016: chap 12.