Anti-glomerular qab daus membrane kab mob

Anti-glomerular qab daus membrane kab mob (anti-GBM kab mob) yog ib qho kev tsis txaus ntseeg uas tuaj yeem cuam tshuam sai ntawm lub raum tsis ua haujlwm thiab mob ntsws.

Qee hom mob tsuas yog mob ntsws lossis raum. Anti-GBM tus kab mob siv los hu ua Goodpasture syndrome.

Anti-GBM tus kab mob yog autoimmune tsis meej. Nws tshwm sim thaum lub nruab zog tiv thaiv kab mob hauv lub cev tsis raug lawm thiab rhuav tshem cov ntaub so ntswg lub cev noj qab haus huv. Cov neeg muaj tus mob no tau tsim cov tshuaj uas tua cov protein hu ua collagen hauv cov hnab huab cua nyob hauv lub ntsws thiab cov chaw lim (glomeruli) ntawm lub raum.

Cov tshuaj no hu ua tshuaj thaiv kab mob antiglomerular hauv qab daus. Glomerular hauv qab daim nyias nyias yog ib feem ntawm lub raum uas pab lim cov dej khib nyiab thiab cov kua dej ntxiv los ntawm cov ntshav. Antiglomerular hauv qab daus membrane cov tshuaj tiv thaiv yog cov tshuaj tiv thaiv cov kab mob no. Lawv tuaj yeem ua rau lub qab daus daim nyias nyias, tuaj yeem ua rau lub raum puas tsuaj.

Qee zaum, qhov kev cuam tshuam no tshwm sim los ntawm kev ua pa ntawm lub ntsws lossis los ntawm kev ua pa hauv cov roj av hydrocarbon. Hauv cov xwm txheej zoo li no, lub cev tiv thaiv kab mob tuaj yeem ua rau cov khoom nruab nrog lossis cov nqaij mos vim nws ua yuam kev rau cov kab mob no lossis tshuaj lom neeg txawv teb chaws.

Lub cev tsis muaj zog cov lus teb ua rau cov ntshav hauv lub hnab ntawm lub ntsws thiab cov ntshav tawm ntawm lub raum lub raum.

Cov tsos mob yuav tshwm sim qeeb heev rau ntau lub hlis lossis ntau xyoo, tab sis feem ntau lawv huam sai heev ntawm hnub mus rau lis piam.

Tsis qab los noj mov, nkees thiab qaug zog yog cov tsos mob tshwm sim thaum ntxov.

Cov mob cov ntsws yuav muaj:

• Kev hnoos ntshav
• Qhuav hnoos
• Ua tsis taus pa

Raum thiab lwm cov tsos mob muaj xws li:

• Ntshav cov zis
• Hlawv kho mob thaum tso zis
• Xeev siab thiab ntuav
• Tawv nqaij daj
• O o (edema) nyob rau hauv txhua qhov chaw ntawm lub cev, tshwj xeeb tshaj yog nyob hauv ceg

Txoj kev kuaj mob lub cev yuav qhia pom cov ntshav siab thiab kua dej dhau mus. Tus kws kho mob yuav hnov ​​suab tsis zoo li lub siab thiab lub ntsws thaum mloog lub hauv siab nrog lub stethoscope.

Cov txiaj ntsig urinalysis feem ntau yog qhov txawv txav, thiab qhia cov ntshav thiab protein nyob hauv cov zis. Yuav pom cov ntshav liab uas tsis zoo.

Cov kev ntsuam xyuas hauv qab no kuj tseem yuav ua tau:

• Antiglomerular qab daus membrane kuaj
• Arterial ntshav roj
• BUN
• Kev ntsuas hluav taws xob xoo
• Creatinine (ntshiab)
• Lub ntsws me
• Raum raum

Lub hom phiaj tseem ceeb yog kom tshem tawm cov teeb meem tshuaj tiv thaiv cov ntshav. Kev kho mob yuav suav nrog:

• Plasmapheresis, uas tshem tawm cov tshuaj phom sij kom pab txo tus mob hauv ob lub raum thiab lub ntsws.
• Cov tshuaj Corticosteroid (xws li prednisone) thiab lwm yam tshuaj, uas txwv los yog nyob ntsiag to hauv lub cev.
• Cov tshuaj noj xws li angiotensin-hloov enzyme (ACE) inhibitors thiab angiotensin receptor blockers (ARBs), uas pab tswj ntshav siab.
• Kev lim ntshav, uas yuav ua tau yog tias lub raum tsis tuaj yeem kho mob ntxiv lawm.
• Lub raum hloov raum, uas yuav ua tau thaum koj lub raum tsis ua haujlwm lawm.

Luag yuav qhia rau koj kom koj tsis txhob noj ntsev thiab kua dej ntau kom tswj kev o tuaj. Muaj qee kis, pom zoo kom noj cov protein tsawg-txog qib nrab yuav tsum noj.

Cov peev txheej no tuaj yeem muab cov ntaub ntawv ntau ntxiv rau kev tiv thaiv tus kabmob GBM:

• Koom lub koom haum ntshav qab zib thiab lub plab thiab lub raum muaj cov kab mob - www.niddk.nih.gov/health-information/kidney-disease/glomerular-diseases/anti-gbm-goodpastures-disease
• Pob Txha National Kidney - www.kidney.org/atoz/content/goodpasture
• Koom haum Lub Tebchaws rau Cov Tsis Txaus Ntseeg - rarediseases.org/rare-diseases/goodpasture-syndrome

Kev kuaj pom thaum ntxov tseem ceeb heev. Qhov tsis pom yuav zoo dua yog tias lub raum twb mob loj heev thaum kev kho mob pib. Lub ntsws mob ua tau ntev npaum li cas txog ntawm qhov mob nyhav.

Coob leej ntau tus neeg yuav tsum raug lim ntshav los yog lub raum hloov ntshav.

Yog tsis kho, tus mob no tuaj yeem ua rau qee yam hauv qab no:

• Mob raum
• Mob raum-theem kab mob
• Lub ntsws tsis ua haujlwm
• Kev loj hlob sai ntawm glomerulonephritis
• Mob ntsws los ntshav hnyav (mob ntsws los ntshav)

Hu mus teem sijhawm nrog koj tus kws khomob yog tias koj tso zis tsawg dua, lossis koj muaj lwm yam tsos mob tiv thaiv tus kabmob GBM.

Tsis txhob hnia cov kua nplaum lossis cov roj siphon nrog koj lub qhov ncauj, uas ua rau lub ntsws ua kom muaj cov kuab tshuaj hydrocarbon thiab tuaj yeem ua rau tus mob.

Cov Tshuaj Kho Mob Goodpasture; Kev loj hlob sai ntawm glomerulonephritis nrog mob ntsws ntsig; Mob ntsws ntsws raum; Glomerulonephritis - mob ntsws ntsig

• Raum muab ntshav
• Glomerulus thiab nephron

Collard HR, King TE, Schwarz MI. Alveolar hemorrhage thiab tsis tshua muaj kab mob infiltrative. Hauv: Broaddus VC, Mason RJ, Ernst JD, li al, eds. Murray thiab Nadel Cov Ntawv Phau Ntawv Qhia Txog Cov PaCov. 6 tus ed. Philadelphia, PA: Elsevier Saunders; 2016: chap 67.

Phelps RG, Turner AN. Anti-glomerular hauv qab daus membrane kab mob thiab Kab mob Goodpasture. Hauv: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Cov Chaw Kho Mob Tshaj LojCov. 6 tus ed. Philadelphia, PA: Elsevier; 2019: chap 24.

Radhakrishnan J, Appel GB, D'Agati VD. Kab mob glomerular SecondaryCov. Hauv: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner thiab Rector's RaumCov. 11th ed. Philadelphia, PA: Elsevier; 2020: chap 32.