Nexium vs. Prilosec: Ob Txoj Kev Kho Mob GERD

Zoo Siab

• Vim li cas PPIs ua haujlwm
• Vim li cas lawv thiaj tau kho
• Qhov sib txawv
• Txij nkawm
• Tus nqi ntawm nyem
• Sab sij huam
• Ceeb toom thiab kev sib txuam
• Yam pheej hmoo
• Cov tshuaj sib cuam tshuam
• Cov nqa mus

Peb suav nrog cov khoom uas peb xav tias tseem ceeb rau peb cov nyeem. Yog tias koj yuav los ntawm cov txuas hauv nplooj ntawv no, peb yuav khwv tau nyiaj me me. Ntawm no yog peb cov txheej txheem.

Nkag siab txog koj cov kev xaiv

Lub siab ua haujlwm dhau los nyuaj txaus. Ua kev txiav txim siab ntawm koj cov kev xaiv tshuaj kho mob rau txoj hlab zis tsis ua mob (GERD) tuaj yeem ua rau nws nyuaj dua.

Ob ntawm cov tshuaj tiv thaiv feem ntau cov tshuaj tiv thaiv proton twj tso kua mis (PPIs) yog omeprazole (Prilosec) thiab esomeprazole (Nexium). Tam sim no muaj ob qho tib si tshuaj yuav tom khw muag tshuaj (OTC).

Saib kom ze rau ob qho tib si seb cov tshuaj uas cov tshuaj tuaj yeem pab tau ib qho rau lwm txoj kev.

Vim li cas PPIs ua haujlwm

Proton twj yog cov enzymes pom hauv parietal hlwb ntawm koj lub plab. Lawv ua hydrochloric acid, lub ntsiab tseem ceeb ntawm lub plab acid.

Koj lub cev xav tau cov plab ua rau kev zom zaub mov. Txawm li cas los xij, thaum cov leeg nqaij ntawm koj lub plab thiab txoj hlab nqos mov tsis kaw kom zoo, cov kua qaub no tuaj yeem ua rau koj txoj hlab pas. Qhov no ua rau cov kev xav hauv koj lub hauv siab thiab caj pas cuam tshuam nrog GERD.

Nws kuj tseem tuaj yeem ua rau:

• hawb pob
• kev hnoos
• mob ntsws o

PPIs txo cov kua qaub uas tsim los ntawm cov twj tso kua mis. Lawv ua hauj lwm zoo tshaj plaws thaum koj coj lawv ib teev mus rau 30 feeb ua ntej noj mov. Koj yuav tsum tau coj lawv mus li ob peb hnub ua ntej lawv pib ua tiav.

Cov tshuaj PPI tau siv txij li xyoo 1981. Lawv tau suav hais tias yog cov tshuaj zoo tshaj plaws rau txo cov plab kua qaub.

Vim li cas lawv thiaj tau kho

PPI zoo li Nexium thiab Prilosec yog siv los kho kev mob ntsig txog tus mob plab, nrog rau:

• GERD
• Kev mob siab
• txoj hlab pas, uas yog mob o los sis yaig ntawm txoj hlab pas
• mob plab thiab duodenal rwj, uas tshwm sim los ntawm Helicobacter pylori (H. pylori) mob kas cees los yog tshuaj siv tshuaj tiv thaiv mob (NSAIDs)
• Zollinger-Ellison syndrome, nws yog ib yam kabmob uas cov hlav ua cov qog kua qaub ntau dhau

Qhov sib txawv

Omeprazole (Prilosec) thiab esomeprazole (Nexium) yog cov tshuaj zoo sib xws. Txawm li cas los xij, muaj qhov sib txawv me me hauv lawv cov tshuaj pleev ib ce.

Prilosec muaj ob lub isomers ntawm cov tshuaj omeprazole, thaum Nexium tsuas muaj ib isomer.

Isomer yog ib lo lus rau lwg me uas suav cov tshuaj lom ib yam, tab sis tau sib tov hauv qhov sib txawv.Yog li, koj tuaj yeem hais tias omeprazole thiab esomeprazole yog ua los ntawm tib lub tuam tsev, tab sis muab tso ua ke sib txawv.

Txawm hais tias qhov sib txawv hauv isomers yuav zoo li me, lawv tuaj yeem ua rau muaj qhov sib txawv hauv cov tshuaj ua haujlwm li cas.

Piv txwv, isomer uas nyob hauv Nexium yog kev ua haujlwm qeeb dua li Prilosec hauv koj lub cev. Qhov no txhais tau hais tias cov qib tshuaj muaj ntau dua nyob hauv koj cov hlab ntshav, thiab cov esomeprazole yuav txo cov kua qaub rau lub sijhawm ntev dua.

Nws kuj tseem tuaj yeem ua haujlwm me ntsis sai dua los kho koj cov tsos mob piv rau omeprazole. Esomeprazole kuj tseem sib cais sib txawv los ntawm koj lub siab, yog li nws yuav ua rau muaj kev sib txuam tshuaj tsawg dua li omeprazole.

Txij nkawm

Qee qhov kev tshawb fawb qhia tau hais tias qhov sib txawv ntawm omeprazole thiab esomeprazole tuaj yeem muaj qee qhov zoo rau cov neeg uas muaj qee yam mob.

Ib qho kev tshawb fawb laus dua los ntawm 2002 pom tias esomeprazole muab kev tswj hwm zoo dua ntawm GERD dua omeprazole ntawm tib lub koob tshuaj.

Raws li kev tshawb pom tom qab xyoo 2009, esomeprazole muab kev pab sai dua omeprazole hauv thawj lub lim tiam ntawm kev siv. Tom qab ib asthiv, kev mob tshwm sim tau zoo sib xws.

Txawm li cas los xij, hauv tsab xov xwm 2007 hauv Asmeskas Tsev Neeg Kws Kho Mob, cov kws kho mob tau nug txog cov no thiab lwm cov kev tshawb fawb txog PPIs. Lawv suav cov kev txhawj xeeb xws li:

• qhov sib txawv ntawm cov nyiaj ntawm cov khoom xyaw nquag muab rau hauv cov kev tshawb fawb
• qhov loj me ntawm kev tshawb fawb
• cov chaw kho mob siv los ntsuas cov hauj lwm zoo

Cov kws sau ntawv tau tshawb 41 cov kev tshawb fawb txog qhov ua tau zoo ntawm PPIs. Lawv xaus lus tias muaj qhov sib txawv me me ntawm qhov ua tau zoo ntawm PPIs.

Yog li, thaum muaj qee cov ntaub ntawv qhia tias esomeprazole ua hauj lwm zoo dua ntawm kev txo cov tsos mob, cov kws tshaj lij pom zoo tias PPIs muaj qhov cuam tshuam zoo ib yam.

American College of Gastroenterology hais tias tsis muaj qhov sib txawv ntawm qhov sib txawv PPI ua haujlwm li cas rau kev kho mob GERD.

Tus nqi ntawm nyem

Qhov txawv loj tshaj ntawm Prilosec thiab Nexium yog tus nqi thaum tshuaj xyuas.

Mus txog Lub Peb Hlis 2014, Nexium tsuas yog muaj los ntawm cov tshuaj muaj nqi thiab tus nqi tseem ceeb. Nexium tam sim no muaj cov tshuaj yuav khoom (OTC) cov khoom lag luam uas muaj nqi nrog kev sib tw nrog Prilosec OTC. Txawm li cas los xij, cov tshuaj omeprazole feem ntau yuav tsis tshua kim dua Prilosec OTC.

Ib txwm, cov tuam txhab tuav pov hwm tsis them rau OTC cov khoom. Txawm li cas los xij, kev lag luam PPI tau ua rau ntau tus neeg los kho lawv cov kev pab them nqi ntawm Prilosec OTC thiab Nexium OTC. Yog tias koj qhov kev pov hwm tseem tsis them rau OTC PPIs, daim ntawv yuav tshuaj rau omeprazole lossis esomeprazole feem ntau yuav yog qhov zoo tshaj rau koj xaiv.

Qee zaum Nexium hu ua "kuv ib yam nkaus" vim tias nws zoo ib yam li Prilosec, ib qho tshuaj uas twb muaj lawm. Qee cov neeg xav tias “kuv thiab” tshuaj yog tib txoj kev rau cov tuam txhab muag nyiaj kom tau nyiaj los ntawm kev luam cov tshuaj uas twb muaj lawm. Tab sis lwm tus neeg tau sib cav hais tias "kuv ib yam nkaus" cov tshuaj yuav txo tus nqi tshuaj, vim tias lawv txhawb kev sib tw ntawm cov tuam txhab muag tshuaj.

Ua haujlwm nrog koj tus kws kho mob lossis kws muag tshuaj los txiav txim siab uas PPI yog qhov zoo tshaj rau koj. Ntxiv nrog rau tus nqi, xav txog tej yam xws li:

• phiv
• lwm yam mob
• lwm yam tshuaj uas koj tau noj

Sab sij huam

Cov neeg feem coob tsis muaj kev phiv los ntawm PPIs. Tau yooj yim, cov neeg yuav muaj kev:

• zawv plab
• xeev siab
• ntuav
• mob taub hau

Cov kev mob tshwm sim no tej zaum yuav muaj feem nrog esomeprazole dua li omeprazole.

Nws tseem ntseeg tias ob qho ntawm cov PPI yuav ua rau muaj kev pheej hmoo:

• tus txha caj qaum thiab pob tes ua pob txha nyob hauv tus poj niam tom qab yug me nyuam, tshwj xeeb tshaj yog tias cov tshuaj no noj rau ib xyoos lossis ntau dua lossis ntau dua ntawm kev txhaj tshuaj
• cov kab mob ua paug ntawm txoj hnyuv, tshwj xeeb tshaj yog tom tsev kho mob
• mob ntsws o
• kev noj zaub mov tsis txaus, suav nrog vitamin B-12 thiab magnesium tsis muaj zog

Ib qhov txuas rau kev pheej hmoo dementia tau tshaj tawm hauv xyoo 2016, tab sis kev tshawb pom loj dua nyob rau xyoo 2017 txiav txim siab tias tsis muaj kev pheej hmoo dementia los ntawm kev siv PPI.

Coob tus neeg ntsib cov kua qaub ntau dhau thaum lawv nres siv PPIs. Txawm li cas los xij, vim li cas qhov no tshwm sim tsis tau to taub tag nrho.

Txog rau feem ntau cov teeb meem hauv lub plab, nws tau pom zoo kom koj siv cov tshuaj PPI ntev dua plaub mus rau yim lub lim tiam tshwj tsis yog koj tus kws kho mob txiav txim tias yuav siv sijhawm ntev kho dua.

Ntawm qhov kawg ntawm kev pom zoo rau lub sijhawm kho, koj yuav tsum maj mam tawm ntawm cov tshuaj maj mam. Ua haujlwm nrog koj tus kws kho mob txhawm rau ua li ntawd.

Ceeb toom thiab kev sib txuam

Ua ntej yuav noj ib qho tshuaj twg, nrog koj tus kws kho mob tham txog cov kev pheej hmoo thiab kev cuam tshuam nrog tshuaj nrog lawv.

Yam pheej hmoo

• yog ntawm Neeg Esxias, qhov uas koj lub cev yuav siv sijhawm ntev dua los ua cov txheej txheem PPI thiab koj yuav xav tau ntau npaum li cas
• muaj kab mob siab
• muaj tsawg theem magnesium
• cev xeeb tub los yog npaj yuav muaj menyuam
• yog niam mis

Cov tshuaj sib cuam tshuam

Nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj, tshuaj ntsuab thiab cov vitamins koj noj. Prilosec thiab Nexium tuaj yeem cuam tshuam nrog lwm cov tshuaj uas koj yuav tau noj.

Tsoom Fwv Teb Chaws Asmeskas Khoom Noj thiab Tshuaj (FDA) tau ceeb toom tias cov tshuaj hauv Prilosec txo cov txiaj ntsig ntawm cov ntshav thin clopidogrel (Plavix).

Koj yuav tsum tsis txhob noj ob yam tshuaj ua ke. Lwm lub PPI tsis muab tso rau hauv cov lus ceeb toom vim tias lawv tsis tau sim qhov haujlwm no.

Cov tshuaj no yuav tsum tsis txhob noj nrog Nexium lossis Prilosec:

• clopidogrel
• delavirdine
• nelfinavir
• rab phom phom
• rilpivirine
• lus qhuab qhia
• St. John lub wort

Lwm yam tshuaj muaj peev xwm cuam tshuam nrog Nexium lossis Prilosec, tab sis kuj tseem yuav noj nrog qee yam yeeb tshuaj. Qhia rau koj tus kws kho mob yog tias koj noj cov tshuaj no lawv tuaj yeem soj ntsuam koj qhov kev pheej hmoo:

• amphetamine
• aripiprazole
• atazanavir
• bisphosphonates
• bosentan
• carvedilol
• cilostazol
• citalopram
• clozapine
• cyclosporine
• dextroamphetamine
• escitalopram
• antifungal tshuaj
• fosphenytoin
• hlau
• hydroxyone
• mesalamine
• methotrexate
• methylphenidate
• phenytoin
• raltegravir
• saquinavir
• tacrolimus
• warfarin lossis lwm yam tshuaj tua kab mob vitamin K kev tawm tsam
• voriconazole

Cov nqa mus

Feem ntau, koj tuaj yeem xaiv daim phiaj PPI uas tuaj yeem yooj yim thiab cov nqi qis dua. Tab sis nco ntsoov tias PPIs kho tsuas yog cov tsos mob ntawm GERD thiab lwm yam kev cuam tshuam. Lawv tsis kho tus mob thiab tsuas yog qhia luv luv siv tshwj tsis yog koj tus kws kho mob txiav txim lwm yam.

Kev pauv hloov hauv lub neej yuav tsum yog thawj koj thawj kauj ruam hauv kev tswj hwm GERD thiab kub siab. Koj yuav xav sim:

• kev tswj xyuas lub cev hnyav
• Tsis txhob noj mov loj ua ntej koj yuav mus pw
• txiav luam yeeb lossis tsis haus luam yeeb, yog koj siv nws

Ntev zus, ntev ntev GERD tuaj yeem ua rau mob qa ntshav. Txawm hais tias tsawg leej neeg mob GERD muaj mob qog noj ntshav, nws yog ib qho tseem ceeb kom yuav tsum paub txog qhov kev pheej hmoo.

PPIs siv tau maj mam, yog li ntawd lawv yuav tsis yog lo lus teb rau qee zaus kub siab los yog rov thim rov qab.

Lwm txoj kev tuaj yeem muab kev kho rau qee lub sijhawm, xws li:

• chewable calcium carbonate ntsiav tshuaj
• kua xws li txhuas hydroxide thiab magnesium hydroxide (Maalox) los yog txhuas / magnesium / simethicone (Mylanta)
• acid-txo cov tshuaj zoo li famotidine (Pepcid) los yog cimetidine (Tagamet)

Tag nrho cov no muaj OTC tshuaj.