Mixed Tawv nqaij Mob

Zoo Siab

• Dab tsi yog qhov sib xyaw ua mob nqaij?
• Cov tsos mob zoo li cas?
• Dab tsi ua rau nws?
• Puas muaj kev pheej hmoo?
• Nws kuaj tau li cas?
• Yuav kho nws li cas?
• Qhov tshwm sim yog dab tsi?

Dab tsi yog qhov sib xyaw ua mob nqaij?

Mixed connective tissue disease (MCTD) yog qhov tsis zoo autoimmune tsis zoo. Qee lub sijhawm nws hu ua tus kabmob sib kis vim tias ntau qhov ntawm nws cov tsos mob sib kis nrog rau lwm cov kev sib txuas ntawm cov nqaij mob, xws li:

• mauj lupus erythematosus
• scleroderma
• polymyositis

Qee kis mob ntawm MCTD kuj tseem muaj tsos mob nrog mob caj dab.

Tsis muaj kev kho rau tus mob MCTD, tab sis feem ntau nws tuaj yeem tswj tau nrog kev noj tshuaj thiab kev hloov pauv hauv lub neej.

Txij li cov kabmob no tuaj yeem cuam tshuam rau ntau yam kabmob xws li tawv nqaij, leeg, plab zom mov thiab lub ntsws, ntxiv rau koj cov pob qij txha, kev kho mob yog lub hom phiaj los tswj hwm thaj chaw tseem ceeb ntawm kev koom tes.

Cov ntaub ntawv qhia tawm hauv chav kho mob tuaj yeem mob sib khuav mus rau qhov hnyav mus rau mob hnyav, nyob ntawm cov tshuab ua haujlwm.

Cov kab mob ua ntej xws li nonsteroidal anti-inflammatory agents tuaj yeem siv thaum xub thawj, tab sis qee tus neeg mob yuav xav tau kev kho mob ntau ntxiv nrog cov tshuaj tiv thaiv kab mob hydroxychloroquine (Plaquenil) lossis lwm yam kab mob hloov kho kab mob thiab kev siv tshuaj lom.

Raws li National Institutes of Health, 10 xyoo kev muaj sia nyob rau cov neeg nrog MCTD yog kwv yees li 80 feem pua. Qhov ntawd txhais tau hais tias 80 feem pua ​​ntawm cov neeg nrog MCTD tseem muaj sia nyob 10 xyoo tom qab kuaj mob.

Cov tsos mob zoo li cas?

Cov tsos mob ntawm MCTD feem ntau tshwm sim ua ntu zus hauv ntau lub xyoo, tsis yog txhua qhov.

Li ntawm 90 feem pua ​​ntawm cov neeg nrog MCTD muaj Raynaud's qhov tshwm sim. Qhov no yog tus mob uas tau raug muaj hnyav hnyav ntawm tus mob khaub thuas, loog ntiv tes uas ua xiav, dawb, lossis ntshav. Nws qee zaum tshwm sim lub hlis lossis xyoo ua ntej lwm cov tsos mob.

Cov tsos mob ntxiv ntawm MCTD sib txawv ntawm ib tus neeg mus rau lwm tus, tab sis qee qhov feem ntau muaj xws li:

• nkees
• ua npaws
• mob hauv ntau pob qij txha
• ua pob
• o hauv pob qij txha
• leeg tsis muaj zog
• txias txias nrog kev hloov xim ntawm txhais tes thiab hauv taw

Lwm cov tsos mob ua tau muaj xws li:

• mob hauv siab
• mob plab o
• kua qaub reflux
• teeb meem ua tsis taus pa vim tias nce ntshav siab hauv lub ntsws lossis mob ntsws ntawm cov nqaij mos
• ua kom tawv nqaij lossis tawv nqaij tawv
• o ob txhais tes

Dab tsi ua rau nws?

Qhov tseeb ua rau MCTD tseem tsis tau paub. Nws yog ib qho ua rau lub hlwb khiav tsis zoo, lub ntsiab lus nws cuam tshuam txog koj lub cev tiv thaiv tsis tau cov ntaub so ntswg noj qab haus huv.

MCTD tshwm sim thaum koj lub cev tiv thaiv cov kab mob sib txuas uas muab lub moj khaum rau cov kabmob ntawm koj lub cev.

Puas muaj kev pheej hmoo?

Qee tus neeg nrog MCTD muaj keeb kwm tsev neeg ntawm nws, tab sis cov kws tshawb nrhiav tsis tau pom muaj cov keeb caj ces meej.

Raws li Lub Chaw Genetic thiab Rare Cov Ntaub Ntawv Xov Xwm (GARD), cov poj niam muaj peb zaug ntau dua li cov txiv neej los tsim tus mob. Nws tuaj yeem tawm tsam thaum muaj hnub nyoog li cas, tab sis lub hnub nyoog ib txwm muaj thaum pib yog 15 thiab 25 xyoos.

Nws kuaj tau li cas?

MCTD tuaj yeem nyuaj rau kev kuaj mob vim tias nws tuaj yeem ua tau ntau yam kev mob. Tej zaum nws yuav muaj yam ntxwv ntawm scleroderma, lupus, myositis lossis mob rheumatoid mob caj dab lossis kev sib txuas ntawm cov mob no.

Txhawm rau kuaj mob, koj tus kws kho mob yuav kuaj koj lub cev. Lawv kuj yuav nug koj kom paub cov keeb kwm tseeb ntawm koj cov tsos mob. Yog tias ua tau, khaws cov ntaub ntawv qhia txog koj cov tsos mob, sau cia thaum lawv tshwm sim thiab lawv yuav kav ntev li cas. Cov ntaub ntawv no yuav pab tau rau koj tus kws kho mob.

Yog tias koj tus kws kho mob lees paub txog cov kab mob kuaj mob ntawm MCTD, xws li o ncig ntawm cov pob qij txha, tawm pob, los yog pov thawj ntawm cov neeg mob khaub thuas, lawv tuaj yeem xaj kuaj ntshav mus kuaj qee yam tshuaj tiv thaiv cuam tshuam nrog MCTD, xws li tshuaj tiv thaiv RNP, thiab tseem muaj ntawm inflammatory cim.

Lawv kuj tuaj yeem xaj kom kuaj xyuas seb puas muaj cov tshuaj tiv thaiv ua kom ze rau lwm cov kab mob autoimmune kom paub tseeb tias muaj tseeb thiab / lossis paub meej tias tus mob sib kis.

Yuav kho nws li cas?

Cov tshuaj noj tuaj yeem pab tswj hwm tus mob tshwm sim ntawm MCTD. Qee tus neeg tsuas xav kho lawv tus kab mob thaum nws nplaim taws xwb, tab sis lwm tus yuav tsum kho mob ntev.

Cov tshuaj siv los kho MCTD suav nrog:

• Nonsteroidal anti-inflammatory tshuaj (NSAIDs). Kev siv tshuaj NSAIDs ntau, xws li ibuprofen (Advil, Motrin) thiab naproxen (Aleve), tuaj yeem kho cov leeg mob thiab mob.
• Corticosteroids. Cov tshuaj steroid, xws li prednisone, tuaj yeem kho qhov mob thiab pab ua kom koj lub cev tiv thaiv kab mob ntawm cov ntaub so ntswg uas muaj kev noj qab haus huv. Vim tias lawv tuaj yeem ua rau ntau cov kev mob tshwm sim, xws li mob ntshav siab, tawm tswv yim, hloov mus rau hauv lub siab, thiab nce phaus, lawv feem ntau tsuas yog siv lub sijhawm luv luv kom tsis txhob muaj kev pheej hmoo ntev.
• Cov tshuaj antimalarial. Hydroxychloroquine (Plaquenil) tuaj yeem pab mentsis MCTD thiab tej zaum yuav pab tiv thaiv kom txhob huam.
• Cov calcium calcium blockers. Cov tshuaj noj xws li nifedipine (Procardia) thiab amlodipine (Norvasc) pab tswj hwm tus mob Raynaud.
• Kev txhaj tshuaj tiv thaiv kab mob. Cov mob MCTD hnyav yuav xav tau kev kho mob mus ntev nrog cov tshuaj txhaj tiv thaiv kab mob, uas yog cov tshuaj uas tswj koj lub cev tsis muaj zog. Cov qauv piv txwv suav nrog azathioprine (Imuran, Azasan) thiab mycophenolate mofetil (CellCept). Cov tshuaj no tuaj yeem txwv thaum cev xeeb tub vim muaj feem ua rau menyuam hauv plab tsis zoo lossis ua rau muaj tshuaj lom.
• Pulmonary tawg cov tshuaj. Kev mob ntsws pulmonary yog qhov ua rau ploj tuag ntawm cov neeg mob MCTD. Cov kws kho mob tuaj yeem sau tshuaj xws li bosentan (Tracleer) lossis sildenafil (Revatio, Viagra) txhawm rau pab tiv thaiv kev mob ntshav siab los ntawm kev tsis zoo.

Ntxiv nrog rau kev siv tshuaj, ntau txoj kev ua neej pauv hloov kuj tseem tuaj yeem pab:

• Qhov tshwm sim yog dab tsi?

  Txawm hais tias nws ua ntau cov tsos mob tshwm sim, MCTD tuaj yeem nthuav tawm raws li thiab tseem nyob rau me ntsis mus rau mob sib khuav.

  Txawm li cas los xij, qee tus neeg mob tuaj yeem txhim kho thiab nthuav dav cov kab mob loj uas cuam tshuam nrog cov kabmob loj xws li lub ntsws.

  Feem ntau cov kab mob sib txuas ntawm cov nqaij yog suav tias yog kab mob multisystem thiab yuav tsum tau saib xws li. Saib xyuas cov plab hnyuv siab raum yog qhov tseem ceeb rau kev tswj hwm kev kho mob.

  Nyob rau hauv rooj plaub ntawm MCTD, kev tshuaj xyuas tsis tu ncua ntawm cov kab ke yuav tsum muaj cov tsos mob thiab cov paib ntsig txog:

  • XIB
  • polymyositis
  • scleroderma

  Vim tias MCTD tuaj yeem muaj cov yam ntxwv ntawm cov kabmob no, cov kabmob loj xws li lub ntsws, lub siab, lub raum, thiab lub hlwb tuaj yeem koom tes.

  Tham nrog koj tus kws kho mob txog kev tsim kho kav ntev thiab phiaj xwm kev tswj hwm uas ua haujlwm zoo tshaj rau koj cov tsos mob.

  Xa mus rau kws kho mob rheumatology tshwj xeeb tej zaum yuav pab tau vim tias qhov cuam tshuam loj ntawm cov kab mob no.