Kho Tus Mob Hlwb Hlwb Mob Hlwb Mob Hlwb Hwm Li Cas (CML)?

Zoo Siab

• Yuav kho tus mob CML li cas?
• Hom phiaj kho tshuaj
• Imatinib (Gleevec)
• Dasatinib (Sprycel)
• Nilotinib (Tasigna)
• Bosutinib (Bosulif)
• Ponatinib (Iclusig)
• Sai cov theem kev kho mob
• Qia cell hloov
• Kws khomob
• Cov chaw kuaj mob
• Cov tsev kho mob zoo tshaj plaws rau kev kho mob CML
• Daws cov kev mob tshwm sim
• Cov lus qhia rau kev nyob zoo thaum kho CML
• Txhawb nqa thaum kho
• Cov tshuaj kho homeopathic
• Outlook

Yuav kho tus mob CML li cas?

Mob myeloid ua mob ntshav siab ntev (CML) yog ib hom mob cancer uas cuam tshuam rau cov hlwb pob txha. Nws pib hauv cov qe ntshav uas muaj cov ntshav, nrog rau cov qog ntshav mob hlwb nce qeeb zuj zus lub sijhawm. Cov kab mob hlwb tsis tuag thaum lawv yuav tsum thiab maj mam faib tawm cov hlwb ua kom lub cev noj qab nyob zoo.

CML yog yuav tshwm sim los ntawm kev hloov caj ces uas ua rau cov cell ntshav tsim cov protein tyrosine kinase ntau dhau. Cov protein no yog qhov uas pub rau cov kabmob kheesxaws nce thiab loj hlob tuaj.

Muaj ntau hom kev kho mob sib txawv rau CML. Cov kev kho no yog tsom mus rau kev rhuav tshem cov qe ntshav uas muaj kev hloov caj ces. Thaum cov kabmob no tshem tawm tau zoo, tus kabmob tuaj yeem kho mus rau hauv kev daws dua tshiab.

Hom phiaj kho tshuaj

Thawj kauj ruam ntawm kev kho yog feem ntau chav kawm ntawm cov tshuaj hu ua tyrosine kinase inhibitors (TKIs). Cov no yog qhov ua tau zoo ntawm kev tswj hwm CML thaum nws nyob rau theem ntev, uas yog thaum muaj pes tsawg tus mob qog ntshav mob ntshav hauv ntshav lossis pob txha pob txha tsawg.

TKI ua haujlwm los ntawm kev thaiv qhov kev ua haujlwm ntawm tyrosine kinase thiab txwv tsis pub kev loj hlob ntawm cov qog nqaij hlav cancer tshiab. Cov tshuaj no tuaj yeem noj ntawm qhov ncauj hauv tsev.

TKIs tau dhau los ua cov qauv kev kho mob rau CML, thiab muaj ob peb muaj. Txawm li cas los xij, tsis yog txhua tus neeg teb rau kev kho mob nrog TKIs. Qee tus neeg txawm tias tiv taus. Hauv cov rooj plaub no, kev pom zoo siv tshuaj lossis kho lwm yam txawv.

Cov neeg uas tau kho nrog TKI feem ntau yuav tau coj lawv mus ib txhis. Thaum kho TKI tuaj yeem ua rau kom muaj kev zam txim, nws tsis yog tsis tshem tawm CML tag nrho.

Imatinib (Gleevec)

Gleevec yog thawj TKI ntaus lub lag luam. Coob tus neeg uas muaj CML teb rau Gleevec sai sai. Cov kev mob tshwm sim feem ntau yog me me thiab yuav muaj xws li:

• xeev siab thiab ntuav
• zawv plab
• nkees
• kua buildup, tshwj xeeb hauv lub ntsej muag, plab thiab ceg
• txha thiab cov leeg mob
• daim tawv nqaij ua pob
• tsawg cov ntshav suav

Dasatinib (Sprycel)

Dasatinib tuaj yeem siv ua kev kho mob thawj zaug, lossis thaum Gleevec tsis ua haujlwm lossis tsis tuaj yeem thev tsis taus. Sprycel muaj cov kev mob tshwm sim zoo ib yam li Gleevec.

Sprycel kuj tseem pom tias yuav ua rau muaj kev pheej hmoo ntawm cov hlab ntsws txhaws (PAH). PAH yog ib qho xwm txheej txaus ntshai heev uas tshwm sim thaum ntshav siab dhau los ntawm cov hlab ntsha ntawm lub ntsws.

Lwm qhov kev cuam tshuam loj heev ntawm Sprycel yog ib qho kev pheej hmoo ntawm pleural effusion. Qhov no yog thaum cov kua tsim tawm puag ncig lub ntsws. Sprycel tsis pom zoo rau cov neeg muaj teeb meem plawv lossis mob ntsws.

Nilotinib (Tasigna)

Zoo li Gleevec thiab Sprycel, Nilotinib (Tasigna) tseem tuaj yeem ua thawj kab kev kho mob. Ib qho ntxiv, nws tuaj yeem siv yog tias lwm cov tshuaj tsis muaj txiaj ntsig lossis kev phiv loj heev.

Tasigna muaj cov kev mob tshwm sim ib yam li lwm cov TKI, nrog rau qee qhov kev phom sij loj tshaj uas cov kws kho mob yuav tsum saib xyuas. Cov no suav nrog:

• tuaj yeem mob caj dab
• teeb meem mob siab
• electrolyte teeb meem
• hemorrhage (los ntshav)
• ib qho mob hnyav thiab yuav ua rau lub siab tuag uas hu ua kev ua haujlwm QT ntev

Bosutinib (Bosulif)

Thaum qee lub sijhawm Bosutinib (Bosulif) tuaj yeem siv los ua kev kho mob thawj zaug rau CML, feem ntau yog siv rau cov neeg uas twb sim lwm cov TKI.

Ntxiv rau cov kev phiv uas zoo rau lwm cov TKIs, Bosulif kuj tseem tuaj yeem ua rau daim siab puas, mob raum, lossis mob plawv. Txawm li cas los xij, cov hom kev mob tshwm sim no muaj tsawg.

Ponatinib (Iclusig)

Ponatinib (Iclusig) tsuas yog tib cov tshuaj uas raug hloov pauv hloov tshwj xeeb. Vim tias qhov tshwm sim muaj cov kev mob tshwm sim loj heev, nws tsuas yog tsim nyog rau cov neeg uas muaj kev hloov tus kheej no lossis cov uas tau sim tag nrho lwm cov TKI tsis muaj kev vam meej.

Iclusig nce ntawm cov ntshav txhaws feem uas tuaj yeem ua rau lub plawv nres lossis hlab ntsha tawg thiab kuj tseem tuaj yeem ua rau lub plawv tsis ua haujlwm. Lwm yam kev phiv tshuaj suav nrog daim siab ua mob rau daim siab thiab mob caj pas.

Sai cov theem kev kho mob

Hauv theem nrawm ntawm CML, cov qog nqaij hlav cancer pib tsim sai sai. Vim tias tam sim no, cov neeg nyob rau theem no yuav tsis tshua muaj peev xwm teb tau qee yam kev kho mob.

Zoo li hauv theem ntev, ib qho kev kho mob thawj zaug rau kev kho kom ceev nrawm CML yog siv TKIs. Yog tias ib tus neeg twb tau noj Gleevec, lawv cov koob tshuaj yuav raug nce ntxiv. Nws kuj tseem muaj peev xwm tias lawv yuav hloov mus rau TKI tshiab dua.

Lwm txoj hauv kev muaj peev xwm kho tau ceev nrawm rau suav nrog kev hloov kho lub qia hauv pob qog lossis kev muab tshuaj kho mob. Cov no tuaj yeem pom zoo tshwj xeeb rau cov neeg uas kho nrog TKIs tsis tau ua haujlwm.

Qia cell hloov

Zuag qhia tag nrho, cov neeg ntawm cov neeg niaj hnub hloov cov qog hloov rau CML vim muaj cov txiaj ntsig ntawm TKIs. Hloov ntshav feem ntau yog pom zoo rau cov neeg uas tsis tau teb rau lwm cov kev kho mob CML lossis muaj qhov ua rau muaj kev pheej hmoo siab ntau ntawm CML.

Hauv cov qog cell hloov, ntau cov tshuaj tua kab mob siv los tua cov kab mob hauv koj cov pob txha pob txha, suav nrog cov qog nqaij hlav cancer. Tom qab ntawd, cov ntshav tsim cov qia los ntawm tus neeg pub khoom, feem ntau yog cov nkauj sib ze lossis cov neeg hauv tsev neeg, tau nkag mus rau hauv koj cov hlab ntshav.

Cov qog hlwb ntshav tshiab no tuaj yeem hloov mus cuag cov qog nqaij hlav cancer uas tau raug tshem tawm los ntawm kev siv tshuaj khomob. Tshaj tag nrho, kev hloov kho qia ntawm tes yog ib hom kev kho mob uas tuaj yeem kho tus mob CML.

Cov qog hloov pauv ntawm lub cev tuaj yeem siv lub cev heev thiab ua rau muaj kev pheej hmoo ntawm kev phiv loj heev. Vim tias qhov no, lawv tsuas yog pom zoo rau cov neeg uas muaj CML uas tseem hluas dua thiab feem ntau noj qab nyob zoo.

Kws khomob

Kev siv tshuaj kho mob yog cov qauv kev kho mob rau CML ua ntej TKIs. Nws tseem muaj txiaj ntsig zoo rau qee tus neeg mob uas tsis tau ua zoo nrog TKIs.

Qee zaum, kev kho mob rau tshuaj yuav raug kho nrog rau TKI. Kev siv tshuaj kho mob tuaj yeem siv los tua cov kab mob qog nqaij hlav uas twb muaj lawm, thaum TKI khaws cov qog nqaij hlav cancer tshiab los ntawm kev tsim.

Qhov kev mob tshwm sim los ntawm kev siv tshuaj kho mob yog nyob ntawm cov tshuaj khomob uas tau noj. Lawv tuaj yeem suav cov khoom xws li:

• nkees
• xeev siab thiab ntuav
• plaub hau poob
• daim tawv nqaij ua pob
• muaj feem kis tau yooj yim dua kom kis tau tus mob
• ntxiv lawm tshob

Cov chaw kuaj mob

Cov chaw soj ntsuam tau tsom mus rau kev kho mob CML tseem tab tom muaj. Lub hom phiaj ntawm cov kev sim no feem ntau txhawm rau txhawm rau ntsuas kev nyab xeeb thiab ua tau zoo ntawm kev kho mob tshiab CML lossis txhim kho thaum muaj kev kho mob CML uas twb muaj lawm.

Koom nrog hauv kev sim tshuaj kho mob tuaj yeem muab rau koj nkag mus rau qhov kev kho tshiab tshiab, kho tshiab tshaj plaws. Txawm li cas los xij, nws tseem ceeb heev uas yuav tsum nco ntsoov tias qhov kev kho mob uas siv hauv kev sim kho mob yuav ua rau tsis zoo li cov qauv CML kho mob.

Yog koj xav koom nrog kev kuaj mob, tham nrog koj tus kws kho mob. Lawv tuaj yeem muab tswv yim rau koj tias kev sim uas koj tuaj yeem tsim nyog rau tau txais nrog rau cov txiaj ntsig sib txawv thiab cov kev pheej hmoo uas cuam tshuam nrog lawv.

Yog tias koj xav tau tswv yim txog kev sim siab tam sim no, muaj qee yam kev pab rau koj. Lub National Cancer Institute tswj tuav tam sim no NCI-txhawb CML cov kev sim. Ib qho ntxiv, ClinicalTrials.gov yog cov ncauj lus tawm los ntawm cov chaw tshawb pom muaj los ntawm tsoomfwv thiab cov kws kho mob.

Cov tsev kho mob zoo tshaj plaws rau kev kho mob CML

Tom qab kuaj mob qog noj ntshav, koj yuav xav nrhiav lub tsev kho mob uas muaj cov kws tshwj xeeb tau tsom mus rau kev kho mob CML. Muaj ob peb txoj hauv kev uas koj tuaj yeem mus hais txog qhov no:

• Hais rau xa mus kom. Koj tus thawj kws kho mob tuaj yeem qhia koj txog cov tsev kho mob zoo tshaj plaws ntawm koj thaj chaw kom kho CML.
• Siv Txoj Haujlwm ntawm Cov Tsev Kho Mob Kas Fes Tsev Kho Mob. Tswj los ntawm American College of Surgeons, cov cuab yeej no tso cai rau koj los sib piv cov chaw kho mob txawv hauv koj thaj chaw.
• Tshawb xyuas lub chaw National Cancer Institute-xaiv cov chaw. Cov no tuaj yeem suav nrog cov chaw zov me nyuam uas muab cov kev kho mob qog nqaij hlav yooj yim rau cov kws tshaj lij, kev saib xyuas txhua yam. Koj tuaj yeem tshawb nrhiav cov npe npe rau lawv.

Daws cov kev mob tshwm sim

Qee qhov kev mob tshwm sim uas ib txwm muaj rau ntau yam kev kho mob CML suav nrog yam xws li:

• nkees
• ib ce thiab hauj sim
• xeev siab thiab ntuav
• tsawg cov ntshav suav

Nkees yuav dhau thiab ntws. Qee hnub koj yuav muaj lub zog ntau, thiab lwm hnub koj yuav nkees heev. Kev qoj ib ce feem ntau tuaj yeem siv los tawm tsam kev qaug zog. Tham nrog koj tus kws kho mob txog hom kev tawm dag zog twg tuaj yeem tsim nyog rau koj.

Koj tus kws kho mob tseem yuav ua haujlwm nrog koj los tsim phiaj xwm los pab tswj kev mob. Qhov no tuaj yeem suav cov khoom xws li noj tshuaj pab, ntsib nrog tus kws paub mob, lossis siv cov kev kho kom zoo ib yam li zaws lossis acupuncture.

Cov tshuaj yuav pab txo cov tsos mob zoo li xeev ntuav thiab ntuav. Txuas ntxiv, koj tuaj yeem xaiv kom tsis txhob noj zaub mov lossis dej haus uas ua rau cov tsos mob no hnyav dua.

Kev noj ntshav kom tsawg tuaj yeem ua rau koj muaj kev cuam tshuam rau ntau yam mob xws li lub cev tsis muaj ntshav, ua kom ntshav qis, lossis nqis nrog kab mob. Saib xyuas cov xwm txheej no nws yog ib qho tseem ceeb heev uas koj tuaj yeem paub lawv cov tsos mob thiab nrhiav kev kho kom raws sijhawm.

Cov lus qhia rau kev nyob zoo thaum kho CML

Ua raws li cov lus qhia ntxiv hauv qab no los pab ua kom muaj kev noj qab haus huv zoo li qub thaum tab tom kho mob CML:

• Txuas ntxiv ntawm lub cev ua si.
• Noj zaub mov kom zoo rau lub cev, tsom mus rau cov txiv hmab txiv ntoo thiab zaub tshiab.
• Txwv txiav cov cawv uas koj haus cawv ntau.
• Ntxuav koj ob txhais tes kom tsis tu ncua thiab ntxuav kom huv qhov chaw kov kom tsis txhob kis kab mob.
• Sim txiav luam yeeb.
• Noj tag nrho cov tshuaj raws li qhia.
• Qhia rau pab neeg tu koj paub yog tias koj muaj cov tsos mob tshiab lossis qhov hnyav zuj zus.

Txhawb nqa thaum kho

Nws yog qhov ib txwm muaj qhov paub txog ntau yam thaum koj tab tom kho mob CML. Ntxiv nrog daws qhov tshwm sim ntawm lub cev ntawm kev kho, koj kuj yuav qee zaum muaj kev ntxhov siab, ntxhov siab, lossis tu siab.

Qhib thiab ncaj ncees nrog cov neeg koj hlub hais txog qhov koj xav zoo li cas. Nco ntsoov tias lawv yuav tau nrhiav kev txhawb nqa koj, yog li qhia rau lawv paub tias lawv tuaj yeem pab tau li cas. Qhov no tuaj yeem suav cov haujlwm xws li khiav cov haujlwm khiav haujlwm, pab nyob ib puag ncig lub tsev, lossis txawm tias tsuas yog qev pob ntseg mloog xwb.

Qee zaum, hais lus nrog tus kws paub txog kev mob hlwb txog koj cov kev xav kuj yuav pab tau. Yog tias qhov no yog qee yam uas koj xav tau, koj tus kws kho mob tuaj yeem pab xa koj mus rau cov kws pab tswv yim lossis tus kws kho mob.

Ib qho ntxiv, qhia koj cov kev paub rau lwm tus uas tau hla dhau ib yam zoo sib xws kuj tuaj yeem muaj txiaj ntsig zoo. Nco ntsoov nug txog cov pab txhawb mob qog nqaij hlav hauv koj thaj chaw.

Cov tshuaj kho homeopathic

Tshuaj ntxiv thiab lwm yam tshuaj (CAM) suav nrog kev tsis ua raws li kev noj qab haus huv, xws li homeopathy, uas tau siv los hloov lossis nrog cov kev kho mob sib xws.

Tam sim no tsis muaj cov tshuaj CAM uas tau muab pov thawj los kho CML ncaj qha

Txawm li cas los xij, koj yuav pom tias qee hom CAM pab koj daws nrog cov tsos mob CML lossis tshuaj phiv xws li qaug zog lossis mob qhov mob. Qee cov qauv no suav nrog qee yam xws li:

• zaws
• yoga
• tshuaj pleev ib ce
• kev xav

Nco ntsoov nrog koj tus kws kho mob tham uantej pib txhua hom haujlwm CAM. Nws muaj peev xwm ua tau rau qee hom CAM kev kho mob tuaj yeem ua rau koj txoj kev kho mob CML tsis zoo.

Outlook

Kev kho thib ib-kab rau CML yog TKIs. Txawm hais tias cov tshuaj no muaj ntau qhov kev mob tshwm sim, qee qhov nws tuaj yeem mob hnyav, lawv feem ntau muaj txiaj ntsig zoo los kho CML.

Qhov tseeb, 5- thiab 10-xyoo kev muaj sia nyob rau CML txij li thaum TKIs raug qhia ua ntej. Txawm hais tias muaj coob leej neeg mus rau kev zam txim thaum nyob rau TKIs, feem ntau lawv yuav tsum tau noj ntxiv mus kom tag lawv lub neej.

Tsis yog txhua kis ntawm CML teb rau kev kho mob nrog TKIs. Qee tus neeg yuav muaj peev xwm tiv taus lawv, hos lwm cov neeg yuav muaj kev txhoj puab heev lossis cov kabmob muaj feem ntau. Hauv cov xwm txheej no, kev siv tshuaj kho mob lossis qia hlwb qia tuaj yeem pom zoo.

Nws yog ib qho tseem ceeb nrog koj tus kws kho mob tham ua ntej pib kev kho mob CML tshiab. Lawv tuaj yeem muab tswv yim rau koj txog hom kev mob tshwm sim uas koj tuaj yeem ntsib nrog cov hauv kev uas yuav pab koj tiv nrog lawv.