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Itraconazole - Mechanism, side effects, precautions & uses
Daim Duab: Itraconazole - Mechanism, side effects, precautions & uses

Zoo Siab

Itraconazole tuaj yeem ua rau lub plawv tsis ua haujlwm (mob uas lub siab tsis tuaj yeem nqus ntshav txaus hauv lub cev). Qhia rau koj tus kws kho mob yog tias koj tau ua tiav lossis muaj lub siab tsis ua haujlwm lawm. Koj tus kws kho mob yuav qhia koj kom tsis txhob noj itraconazole. Kuj qhia koj tus kws kho mob yog tias koj muaj lossis tau muaj lub plawv nres dua; lub plawv dhia tsis xwm yeem; lossis lwm hom mob plawv, ntsws, mob siab lossis mob raum. Yog tias koj muaj cov tsos mob nram qab no, tsum tsis noj tshuaj itraconazole thiab hu rau koj tus kws kho mob tam sim ntawd: txog siav; hnoos tau dawb lossis daj phlegm; tsis muaj zog; kev nkees ntau dhau; lub plawv dhia ceev; o ntawm cov taw, pob taws, lossis ceg; sawv thaum tsaus ntuj; thiab cia li nce ceeb thawj.

Tsis txhob noj tshuaj cisapride (Propulsid) (tsis muaj nyob hauv Asmeskas), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), eplerenone (Inspra), ergot-yam tshuaj xws li dihydroergotamine (DHE, Migranal), ergotamine ( Ergomar, hauv Cafergot, hauv Migergot), methylergometrine (Methergine); felodipine (Plendil), irinotecan (Camptosar), ivabradine (Corlanor), levomethadyl acetate (Orlaam) (tsis muaj nyob hauv Asmeskas), lovastatin (Altoprev, hauv Advicor), lurasidone (Latuda), Methadone (Dolophine, Methadose), midazolam ( noj ntawm qhov ncauj), nisoldipine (Sular), pimozide (Orap), quinidine (hauv Nuedexta), ranolazine (Ranexa), simvastatin (Zocor, hauv Simcor, hauv Vytorin), ticagrelor (Brilinta), thiab triazolam (Halcion) thaum noj nws. thiab rau 2 lub lis piam tom qab. Qhia rau koj tus kws kho mob yog tias koj muaj mob raum lossis mob siab thiab tau noj qee yam tshuaj hauv qab no: colchicine (Colcrys, Mitigare), fesoterodine (Toviaz), solifenacin (Vesicare), lossis telithromycin (Ketek). Noj cov tshuaj no nrog itraconazole tuaj yeem ua rau muaj mob plawv heev nrog rau QT lub sijhawm (lub plawv dhia tsis xwm yeem uas tuaj yeem ua rau tsaus muag, tsis nco qab, qaug dab peg lossis tuag tam sim ntawd).


Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev noj tshuaj itraconazole.

Itraconazole tsiav tshuaj yog siv los kho cov kab mob fungal hauv lub ntsws uas tuaj yeem kis thoob plaws lub cev. Itraconazole capsules kuj tseem siv los kho mob fungal ntawm cov rau tes. Itraconazole ntsiav tshuaj thiab tshuaj ntsiav yog siv los kho cov kab mob fungal ntawm cov ntiv taw. Itraconazole qhov ncauj tov (ua kua) yog siv los kho cov poov xab mob ntawm lub qhov ncauj thiab lub caj pas lossis txoj hlab pas (txoj hlab uas txuas lub caj pas mus rau lub plab). Itraconazole nyob hauv chav kawm ntawm tus kabmob hu ua triazoles. Nws ua haujlwm los ntawm kev ua kom qeeb ntawm kev loj hlob ntawm cov fungi uas ua rau kis kab mob.

Itraconazole los ua cov tshuaj ntsiav, ntsiav tshuaj, thiab tov (ua kua) los noj ntawm qhov ncauj. Yog tias koj noj tshuaj itraconazole los kho cov kab mob fungal hauv lub ntsws, lub tsiav tshuaj feem ntau noj thaum lossis tom qab ib pluas noj tag ib lossis ob zaug hauv ib hnub rau tsawg kawg 3 lub hlis. Txawm li cas los xij, yog tias koj noj tshuaj itraconazole los kho kab mob loj nyob rau hauv lub ntsws, lub tsiav tshuaj yuav noj nrog ib pluas peb zaug ib hnub rau thawj 3 hnub ntawm kev kho mob thiab tom qab ntawd noj ib zaug lossis ob zaug ib hnub nrog ib pluas noj tsawg kawg 3 hli. Yog tias koj noj tshuaj itraconazole los kho cov kab mob fungal ntawm cov ntiv taw (suav nrog lossis tsis muaj rau tes), cov tshuaj ntsiav lossis cov ntsiav tshuaj feem ntau noj ib hnub ib zaug nrog tag nrho cov zaub mov rau 12 lub lis piam. Yog tias koj noj tshuaj itraconazole los kho cov kab mob fungal ntawm cov rau tes tsuas yog, cov tsiav tshuaj feem ntau noj ob zaug ib hnub nrog ib pluas mov rau 1 lub lis piam, hla mus rau 3 lub lis piam, thiab tom qab ntawd noj ob zaug ib hnub nrog ib pluas mov rau ib asthiv. Itraconazole qhov ncauj hais daws feem ntau yog noj ntawm plab tas ib zaug lossis ob zaug ib hnub rau 1 txog 4 lub lim tiam lossis ntev dua. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj itraconazole raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.


Nqos itraconazole tsiav tshuaj tag nrho; tsis txhob qhib, chew, lossis zuaj lawv.

Koj tus kws kho mob yuav hais kom koj noj itraconazole tsiav tshuaj nrog haus kafes yog tias koj muaj qee yam mob lossis noj ib qho tshuaj hauv qab no: cimetidine; famotidine (Pepcid); nizatidine (Axid); proton-twj tso kua mis inhibitors xws li esomeprazole (Nexium, hauv Vimovo), lansoprazole (Prevacid, hauv Prevpac), omeprazole (Prilosec, hauv Zegerid), pantoprazole (Protonix), rabeprazole (AcipHex), lossis ranitidine (Zantac). Ua raws li cov lus qhia no kom zoo.

Yuav kom siv cov tshuaj itraconazole ntawm qhov ncauj rau kev kho mob ntawm lub qhov ncauj lossis caj pas, sib txuas 10 mauj (li 2 diav) ntawm cov tshuaj hauv koj lub qhov ncauj rau ob peb feeb thiab nqos. Rov ua dua yog tias tsim nyog los noj koj cov tshuaj tag nrho.

Itraconazole tsiav tshuaj thiab tshuaj tov hauv qhov ncauj tau nqus mus rau hauv lub cev sib txawv thiab ua haujlwm los kho cov mob sib txawv. Tsis hloov cov tshuaj ntsiav rau cov kua los yog cov kua rau cov tsiav tshuaj. Nco ntsoov tias koj tus kws muag tshuaj muab cov tshuaj itraconazole uas koj tus kws kho mob xaj.


Yog tias koj tab tom noj itraconazole los kho tus kab mob ntsia hlau, koj cov rau tes yuav tsis pom kev noj qab haus huv dua kom txog thaum muaj cov ntsia hlau tshiab. Nws tuaj yeem siv li 6 lub hlis los ua tus ntiv tes tshiab thiab nce mus rau 12 lub hlis kom loj tuaj tshiab tuaj tshiab, yog li koj yuav tsum tsis txhob cia siab tias yuav pom kev txhim kho thaum kho lossis ob peb hlis tom qab ntawd. Txuas ntxiv noj cov itraconazole txawm hais tias koj tsis pom muaj kev txhim kho.

Noj cov tshuaj itraconazole ntxiv kom txog thaum koj tus kws kho mob hais kom koj tsum txawm tias koj xis neej. Tsis txhob tsum tsis txhob noj itraconazole yam tsis tham nrog koj tus kws kho mob. Yog tias koj tsum tsis noj itraconazole sai sai no, koj tus mob yuav rov qab los tom qab ib ntus.

Nug koj tus kws muag tshuaj lossis tus kws kho mob txog cov ntawv luam ntawm cov ntaub ntawv tsim tawm rau tus neeg mob.

Itraconazole qee zaum kuj yog siv los kho lwm yam kab mob fungal thiab tiv thaiv cov kab mob fungal hauv cov neeg uas muaj tus kab mob tib neeg tiv thaiv kab mob HIV (HIV) lossis tau txais tshuaj tiv thaiv kab mob (AIDS). Tham nrog koj tus kws kho mob txog cov kev pheej hmoo uas yuav siv cov tshuaj no rau koj tus mob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj itraconazole,

  • qhia rau koj tus kws kho mob thiab kws muag tshuaj yog tias koj ua xua nrog itraconazole; lwm cov tshuaj tua kab mob xws li fluconazole (Diflucan), ketoconazole (Nizoral), lossis voriconazole (Vfend); lwm cov tshuaj noj, lossis ib qho twg ntawm cov khoom xyaw hauv itraconazole cov khoom lag luam. Yog tias koj noj tshuaj itraconazole ntawm qhov ncauj, qhia rau koj tus kws kho mob yog tias koj muaj kev fab tshuaj rau saccharin los yog tshuaj sulfa. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
  • qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj noj cov tshuaj hauv qab no lossis coj lawv hauv 2 lub lis piam tas los ua ntej pib kho nrog itraconazole: carbamazepine (Epitol, Tegretol, Teril, lwm tus); efavirenz (Sustiva, hauv Atripla); isoniazid (Laniazid, hauv Rifamate, hauv Rifater); rifabutin (Mycobutin); rifampicin; nevirapine (Viramune); phenobarbital; thiab phenytoin (Dilantin, Phenytek).
  • qhia rau koj tus kws kho mob lossis kws muag tshuaj yog tias koj noj cov tshuaj nram qab no: aliskiren (Tekturna, hauv Amturnide, Tekamlo, thiab Tekturna HCT), apixaban (Eliquis), axitinib (Inlyta), colchicine (Colcrys, Mitigare), dabrafemob (Taflinar), darifenac (Enablex), dasatinib (Sprycel), everolimus (Afinitor, Zortress), ibrutinib (Imbruvica), nilotinib (Tasigna), rivaroxaban (Xarelto), salmeterol (Serevent), sildenafil (tsuas yog Revatio lub npe siv rau kev mob ntsws), simeprevir ), sunitinib (Sutent), tamsulosin (Flomax, hauv Jalyn), temsirolimus (Torisel), trabectedin (Yondelis), thiab vardenafil (Staxyn, Levitra). Koj tus kws kho mob yuav qhia koj kom tsis txhob noj cov tshuaj no thaum lub sijhawm kho thiab 2 lub lis piam tom qab koj siv tshuaj kho itraconazole.
  • qhia rau koj tus kws kho mob thiab tus kws muag tshuaj tias lwm yam tshuaj thiab cov tshuaj uas tsis yog kws kho mob sau npe, vitamins, khoom noj khoom haus zoo thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj dab tsi. Nco ntsoov hais txog cov tshuaj teev tseg rau hauv seem tseem ceeb ceeb toom thiab ib qho ntawm cov lus hauv qab no: cov tshuaj tua kab mob xws li ciprofloxacin (Cipro), clarithromycin (Biaxin, hauv PrevPac), erythromycin (EES Ery-Tab, lwm tus), thiab telithromycin (Ketek) ; anticoagulant ('' ntshav thinner '') xws li warfarin (Coumadin, Jantoven); alprazolam (Xanax); aprepitant (Hloov Kho); aripiprazole (Abilify); atorvastatin (Lipitor, hauv Caduet, hauv Liptruzet); bortezomib (Velcade); bosentan (Tracleer); budesonide (Entocort EC, Pulmicort, Uceris); buprenorphine (Buprenex, Butrans, hauv Bunavail; lwm tus); buspirone; ciclesonide (Alvesco, Omnaris, Zetonna); cilostazol (Pletal); cinacalcet (Sensipar); cyclosporine (Gengraf, Neoral, Sandimmune); Dabigatran (Pradaxa); dexamethasone; diazepam (Valium); digoxin (Lanoxin); docetaxel (Docefrez, Taxotere); eletriptan (Txom Nyem); erlotinib (Tarceva); fentanyl (Actiq, Duragesic, Fentora, Subsys, lwm tus); fesoterodine (Toviaz); fluticasone (Flovent, hauv Advair); gefitinib (Iressa); haloperidol (Haldol); HIV protease inhibitors suav nrog indinavir (Crixivan), darunavir (Prezista) noj nrog ritonavir, fosamprenavir (Lexiva) noj nrog ritonavir, thiab saquinavir (Invirase); imatinib (Gleevac); ixabepilone (Ixempra Pob Khoom); lapatinib (Tykerb); maraviroc (Selzentry); meloxicam (Mobic); methylprednisolone (Medrol); nadolol (Corgard, hauv Corzide); oxygenbutynin (Ditropan XL, Oxytrol); oxygencodone (Oxaydo, Oxycontin, hauv Percodan; lwm tus); ponatinib (Iclusig); praziquantel (Biltricide); quetiapine (Seroquel); ramelteon (Rozerem); repaglinide (Prandin, hauv Prandimet); riociguat (Adempas); risperidone (Risperdal); saxagliptin (Kombiglyze XR, Onglyza); sirolimus (Rapamune); solifenacin (Vesicare); tacrolimus (Astagraf, Prograf); tadalafil (Adcirca, Cialis); tolterodine (Detrol); vardenafil (Levitra, Staxyn); verapamil (Calan, Covera, Verelan PM, hauv Tarka), vinblastine, vincristine (Marqibo Cov Khoom), thiab vinorelbine (Navelbine). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv. Ntau lwm yam tshuaj yuav tuaj yeem cuam tshuam nrog itraconazole, yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv, txawm tias cov tshuaj tsis tshwm hauv cov npe no.
  • yog tias koj noj tshuaj antacid, noj nws 1 teev ua ntej lossis 2 teev tom qab koj siv tshuaj itraconazole.
  • qhia rau koj tus kws kho mob yog tias koj tau lossis muaj cov teeb meem tau hais tseg hauv ntu CEEB TOOM TSEEM CEEB,, cystic fibrosis (ib qho mob hauv lub cev uas ua rau muaj teeb meem ua pa, plab zom mov thiab rov tsim dua tshiab), ib qho xwm txheej twg uas txo cov kua qaub hauv koj lub plab, lossis HIV.
  • qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Koj yuav tsum tsis txhob noj itraconazole los kho tus ntsia thawv pwm yog tias koj cev xeeb tub lossis tuaj yeem cev xeeb tub. Koj tuaj yeem pib noj itraconazole los kho tus ntsia thawv pwm tsuas yog hnub thib ob lossis thib peb ntawm lub sijhawm coj khaub ncaws thaum koj paub meej tias koj tsis tau xeeb tub. Koj yuav tsum siv kev tswj tsis pub muaj menyuam thaum lub sijhawm kho thiab 2 hlis tom qab. Yog tias koj cev xeeb tub thaum noj itraconazole los kho ib qho mob twg, hu rau koj tus kws kho mob.
  • koj yuav tsum paub tias itraconazole tuaj yeem ua rau koj tsaus muag lossis ua qhov muag plooj lossis pom lub zeem muag. Tsis txhob tsav tsheb los sis siv lub tshuab ua haujlwm kom txog thaum koj paub tias cov tshuaj no cuam tshuam rau koj li cas.

Tham nrog koj tus kws kho mob txog kev haus kua txiv kab ntxwv qaub thaum noj cov tshuaj no.

Noj cov koob tshuaj uas ploj lawm sai li sai tau thaum koj nco qab nws. Txawm li cas los xij, yog tias nws yuav luag txog rau koob tshuaj txuas ntxiv, hla cov koob tshuaj uas tsis nco qab noj thiab txuas ntxiv koj lub sijhawm noj tshuaj kom tsis tu ncua. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Itraconazole yuav ua rau muaj kev mob tshwm sim. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

  • zawv plab
  • cem quav
  • roj lossis tsam plab
  • Kev mob siab
  • tsis kaj siab saj
  • mob voos lossis ntshav tawm ntawm cov pos hniav
  • mob taub hau
  • kiv taub hau
  • hws
  • mob leeg los yog tsis muaj zog
  • mob tej pob txha
  • txo qis kev sib deev muaj siab lossis muaj peev xwm
  • kev tshee
  • kev nyuaj siab
  • los ntswg thiab lwm yam mob khaub thuas
  • ua npaws
  • plaub hau poob

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob no, hu rau koj tus kws kho mob:

  • qhov muag plooj lossis ob lub zeem muag
  • coov hauv pob ntseg
  • Lub cev tsis tuaj yeem tswj kev tso zis lossis tso zis ntau dua li ib txwm muaj

Yog koj muaj cov tsos mob li hais los no lossis cov uas teev rau hauv seem ceeb toom ceeb toom, tsum tsis txhob noj itraconazole thiab hu rau koj tus kws kho mob tam sim ntawd lossis tau txais kev kho mob kub ceev:

  • nkees dhau heev lawm
  • tsis qab los noj mov
  • xeev siab
  • mob plab
  • ntuav
  • daj ntawm daim tawv nqaij lossis qhov muag
  • tsaus zis
  • daj ntseg quav
  • cov kev xav ntawm loog, tingling, pricking, hlawv, lossis hma ntawm daim tawv nqaij
  • hnov lus
  • nce rhiab heev rau lub teeb
  • cov tawv nqaij mob hnyav
  • hnov lus
  • ua pob
  • khaus
  • khaus
  • o ntawm lub ntsej muag, lub caj pas, tus nplaig, daim di ncauj, qhov muag, tes, pob taws, lossis ceg qis
  • txhaws qa
  • ua pa nyuaj lossis nqos

Ib qho ntawm cov khoom xyaw hauv itraconazole qhov ncauj daws teeb meem ua rau mob qog ntshav hauv qee hom tsiaj kuaj. Kuj tsis paub meej tias cov neeg uas siv cov tshuaj iraconazole puas muaj kev pheej hmoo ntawm kev mob qog noj ntshav. Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev noj tshuaj itraconazole.

Itraconazole yuav ua rau muaj lwm cov kev mob tshwm sim. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws hauv chav sov thiab deb ntawm qhov kub tshaj, teeb thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev kuaj sim kuaj xyuas koj cov lus teb rau itraconazole.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj. Yog tias koj tseem muaj cov tsos mob ntawm tus mob tom qab koj ua tiav tawm cov mob itraconazole, hu rau koj tus kws kho mob.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

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Kawg Kho - 11/15/2017

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