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What you need to know about Mayzent® (siponimod)
Daim Duab: What you need to know about Mayzent® (siponimod)

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Siponimod yog siv los tiv thaiv kev mob tshwm sim thiab ua rau qeeb qeeb ntawm kev tsis taus ntawm cov neeg laus uas muaj cov ntawv rov huam dua (cov kab mob uas qhov tsos mob pheej dhau ib ntus) ntawm ntau yam sclerosis (MS; tus kab mob uas cov leeg tsis ua haujlwm zoo. thiab tib neeg yuav ntsib kev qaug zog, loog, poob ntawm cov leeg nqaij, thiab teeb meem nrog lub zeem muag, hais lus, thiab zais zis). Siponimod nyob hauv chav kawm ntawm cov tshuaj hu ua sphingosine l-phosphate receptor modulators. Nws ua haujlwm los ntawm kev txo qis qhov kev txiav txim ntawm cov qe ntshav tsis muaj zog uas yuav ua rau lub paj hlwb tsis zoo.

Siponimod los ua ib ntsiav tshuaj los noj ntawm qhov ncauj. Nws feem ntau yog noj ib zaug ib hnub nrog lossis tsis muaj zaub mov. Noj siponimod nyob ib ncig ntawm tib lub sijhawm txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj siponimod raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Koj tus kws kho mob tej zaum yuav pib koj noj tsawg kawg ntawm siponimod thiab maj mam nce koj cov koob rau thawj 4 lossis 5 hnub,


Siponimod tuaj yeem ua rau lub plawv dhia qeeb, tshwj xeeb tshaj yog thawj 6 teev tom qab koj noj thawj zaug. Koj yuav tau txais ib qho electrocardiogram (ECG; ntsuas uas sau cov hluav taws xob kev ua haujlwm ntawm lub siab) ua ntej koj noj koj thawj koob thiab dua 6 teev tom qab koj noj tshuaj. Koj yuav noj koj thawj koob tshuaj siponimod hauv koj tus kws kho mob lub chaw haujlwm lossis lwm lub tsev kho mob. Koj yuav tsum tau nyob hauv lub tsev kho mob tsawg kawg 6 teev tom qab koj noj tshuaj kom koj tuaj yeem tshuaj xyuas. Koj yuav tsum tau nyob hauv tsev kho mob ntev dua 6 teev los yog ib hmos yog tias koj muaj qee yam kev mob lossis noj qee yam tshuaj uas ua rau muaj kev pheej hmoo tias koj lub plawv dhia yuav qeeb lossis yog tias koj lub plawv dhia qeeb dua qhov xav tau lossis tseem qeeb tom qab thawj 6 cov sij hawm. Koj kuj yuav tsum nyob hauv tsev kho mob tsawg kawg 6 teev tom qab koj noj tshuaj thib ob yog tias lub plawv dhia qeeb dhau lawm thaum koj noj thawj koob. Qhia rau koj tus kws kho mob yog tias koj muaj kiv taub hau, nkees, mob hauv siab, lossis plawv dhia qeeb los yog qoj ib ce txhua lub sijhawm thaum kho koj.


Siponimod tuaj yeem pab tswj ntau tus sclerosis tab sis yuav tsis kho nws. Tsis txhob tsum noj siponimod yam tsis tham nrog koj tus kws kho mob. Yog tias koj tsis noj siponimod rau 1 hnub lossis ntev dua thaum thawj 4 lossis 5 hnub ntawm kev kho lossis 4 hnub lossis ntev dua tom qab thawj lub limtiam ntawm kev kho mob, nrog koj tus kws kho mob tham ua ntej koj pib noj dua. Koj yuav hnov ​​lub plawv dhia qeeb dua thaum koj pib noj siponimod dua, yog li koj yuav tsum tau rov pib noj tshuaj dua nyob rau hauv qis dua hauv koj tus kws kho mob lub chaw ua haujlwm thiab maj mam nce cov tshuaj ntau dua li 4 lossis 5 hnub.

Koj tus kws kho mob lossis kws muag tshuaj yuav muab daim ntawv qhia txog cov neeg mob rau koj (phau Qhia Siv Tshuaj) thaum koj pib kho nrog siponimod thiab txhua zaus koj rov ntim tshuaj. Nyeem cov ntaub ntawv kom zoo thiab nug koj tus kws kho mob lossis kws muag tshuaj yog tias koj muaj lus nug. Koj kuj tuaj yeem mus saib tau Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) lub vev xaib (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) lossis cov chaw tsim tshuaj paus lub vev xaib kom tau txais Kev Qhia Tshuaj.


Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj siponimod,

  • qhia rau koj tus kws kho mob thiab kws muag tshuaj yog tias koj muaj kev fab tshuaj rau siponimod lwm yam tshuaj, lossis ib yam ntawm cov tshuaj hauv siponimod ntsiav tshuaj. Nug koj tus kws muag tshuaj lossis tshawb xyuas Phau Ntawv Qhia Tshuaj Kho Mob rau cov npe ntawm cov khoom siv.
  • qhia rau koj tus kws kho mob thiab kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob thiab cov tshuaj uas tsis yog kws kho mob sau, tshuaj vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txhua yam ntawm cov hauv qab no: alemtuzumab (Campath, Lemtrada); amiodarone (Nexterone, Pacerone); beta-blockers xws li atenolol (Tenormin, hauv Tenoretic), carteolol, labetalol (Trandate), metoprolol (Lopressor, Toprol-XL, hauv Dutoprol, hauv Lopressor HCT), nadolol (Corgard, hauv Corzide), nebivolol (Bystolic, hauv Byvalson) ), propranolol (Inderal LA, Innopran XL), thiab timolol; carbamazepine (Carbatrol, Equetro, Tegretol, lwm tus); digoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, lwm tus); efavirenz (Sustiva, hauv Atripla, hauv Symfi); fluconazole (Diflucan); ivabradine (Corlanor); modafinil (Provigil); procainamide; quinidine (hauv Nuedexta); rifampin (Rifadin, Rimactane, hauv Rifamate, lwm tus); sotalol (Betapace, Tshais, Sotylize); thiab verapamil (Calan, Verelan, hauv Tarka). Kuj qhia koj tus kws kho mob yog tias koj tau noj ib qho tshuaj hauv qab no, lossis yog koj tau noj lawv yav dhau los: corticosteroids xws li dexamethasone, methylprednisolone (Medrol), thiab prednisone (Rayos); tshuaj rau mob cancer; thiab cov tshuaj noj kom tsis muaj zog lossis tswj lub cev tsis muaj zog xws li glatiramer acetate (Copaxone, Glatopa) thiab interferon beta (Betaseron, Extavia, Plegridy). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv. Ntau lwm cov tshuaj yuav tuaj yeem cuam tshuam nrog siponimod, yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv, txawm tias tsis tshwm nyob hauv daim ntawv no.
  • qhia rau koj tus kws kho mob yog tias koj muaj lossis muaj qee yam ntawm cov xwm txheej no nyob rau lub hlis tas los: mob plawv, mob caj pas (mob hauv siab), mob stroke lossis mini mob stroke, lossis lub plawv dhia. Kuj qhia koj tus kws kho mob yog tias koj muaj lub plawv tsis xwm yeem. Koj tus kws kho mob yuav hais kom koj tsis txhob noj siponimod.
  • qhia rau koj tus kws kho mob yog tias koj tau tsaus muag, muaj mob plawv nres, mob hlab ntsha tawg, lossis mob stroke luv; Yog tias koj tam sim no kub taub hau lossis lwm yam cim ntawm kev kis mob lossis yog tias koj muaj kev kis mob uas tuaj thiab mus lossis qhov ntawd tsis ploj; thiab yog tias koj tau ua lossis tau muaj ntshav qab zib ib zaug li; pw tsaug zog apnea (mob uas koj maj mam ua pa ntau zaus thaum hmo ntuj) lossis lwm yam teeb meem ua pa; ntshav siab; uveitis (mob rau sab hauv qhov muag) lossis lwm yam teeb meem qhov muag; lub plawv dhia qeeb; daim tawv nqaij mob cancer, lossis mob plawv lossis kab mob siab. Thiab qhia koj tus kws kho mob yog tias koj nyuam qhuav tau txais tshuaj tiv thaiv.
  • qhia koj tus kws kho mob yog tias koj cev xeeb tub los yog npaj yuav cev xeeb tub, lossis pub mis niam. Koj yuav tsum siv kev tswj tsis pub muaj menyuam kom tiv thaiv kev xeeb tub thaum koj kho thiab tsawg kawg 10 hnub tom qab koj tau txais koob tshuaj zaum kawg. Yog tias koj cev xeeb tub thaum noj siponimod lossis tsis pub dhau 10 hnub tom qab koj txhaj tshuaj zaum kawg, hu rau koj tus kws kho mob.
  • tsis muaj kev txhaj tshuaj li 1 lub lis piam ua ntej koj pib kho nrog siponimod, thaum kho koj, lossis rau 1 hlis tom qab koj noj zaum kawg tsis tas tham nrog koj tus kws kho mob. Tham nrog koj tus kws kho mob txog kev txhaj tshuaj uas koj yuav tsum tau txais ua ntej pib kho koj nrog siponimod.
  • qhia rau koj tus kws kho mob yog tias koj tsis tau mob qoob dua thiab tsis tau txais kev txhaj tshuaj tiv thaiv mob qhua qaib. Koj tus kws kho mob yuav hais kom kuaj ntshav seb koj puas tau kis mob qoob. Tej zaum koj yuav tsum tau txais tshuaj tiv thaiv mob qoob thiab tom qab ntawd tos 1 lub hlis ua ntej koj pib kho nrog siponimod.

Tshwj tsis yog koj tus kws kho mob hais rau koj lwm yam, txuas ntxiv koj li kev noj haus zoo.

Noj cov koob tshuaj uas ploj lawm sai li sai tau thaum koj nco qab nws. Txawm li cas los xij, yog tias nws yuav luag txog rau koob tshuaj txuas ntxiv, hla cov koob tshuaj uas tsis nco qab lawm thiab hu rau koj tus kws kho mob ua ntej koj yuav siv tshuaj ntxiv. Tej zaum koj yuav tsum tau saib xyuas koj li koj rov pib noj tshuaj ntawm qhov tshuaj tsawg dua thiab vim tias cov tshuaj ntau zuj zus dhau 4 lossis 5 hnub. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Siponimod tuaj yeem tshwm sim phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

  • tsis muaj zog
  • mob mob ntawm caj npab, ceg, tes, lossis taw
  • zawv plab
  • mob taub hau

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob no, hu rau koj tus kws kho mob:

  • lub plawv dhia qeeb
  • mob caj pas, mob ib ce, kub ib ce, ua daus no, hnoos, thiab lwm yam cim ntawm tus mob thiab thaum kho thiab ntev mus txog 1 hlis tom qab kho koj
  • mob taub hau, caj dab txhav, kub taub hau, rhiab heev rau lub teeb, xeev siab, lossis feeb meej lub sijhawm kho thiab mus txog 1 hlis tom qab koj tau kho mob
  • mob taub hau heev, tsis meej pem, pauv qhov muag pom kev, lossis qaug dab peg
  • qhov muag plooj, ntxoov ntxoo, lossis qhov muag dig thaum nruab nrab ntawm koj lub zeem muag; rhiab rwg mus rau lub teeb; xim txawv txawv rau koj lub zeem muag lossis lwm yam teeb meem tsis pom kev
  • kev ua kom tsis muaj zog ntawm ib sab ntawm lub cev lossis tsis paub qhov tseeb ntawm caj npab lossis ceg uas cuam tshuam nrog kev ua haujlwm ntev mus; cov kev hloov hauv koj txoj kev xav, kev nco, lossis kev tshuav; rov quav niab lossis tus yam ntxwv hloov; lossis poob ntawm lub zog
  • tshiab lossis ua tsis taus pa txog siav
  • xeev siab, ntuav, tsis qab los noj mov, mob plab, yuag tawv nqaij lossis qhov muag, lossis tso zis dub

Siponimod tuaj yeem ua rau muaj kev pheej hmoo mob qog nqaij hlav cancer ntau dua. Tham nrog koj tus kws kho mob txog kev pheej hmoo ntawm kev noj cov tshuaj no.

Cov kev mob tshwm sim sai sai ntawm MS cov tsos mob thiab kev ua tsis zoo ntawm kev tsis taus yuav tshwm sim tom qab koj tsum tsis noj siponimod. Qhia rau koj tus kws kho mob yog tias koj cov tsos mob MS mob heev tom qab koj tso tseg siponimod.

Siponimod tuaj yeem ua rau lwm cov kev mob tshwm sim. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Muab cov ntim tsis tau ntim ntawm cov tshuaj no tso rau hauv tub yees. Qhib ua cov hlwv ntim thiab cov fwj yuav khaws cia ntawm chav sov thiab kom deb ntawm kev ua kom sov thiab noo noo (tsis nyob hauv chav dej) rau qee lub sijhawm. Cov hlwv ntsej muag yuav khaws cia nyob hauv chav tsev ntev txog li 1 asthiv tom qab siv thawj zaug. Cov fwj qhib tau muab khaws cia hauv chav sov txog li 1 hlis tom qab siv thawj zaug.

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Cov tsos mob ntawm kev noj haus ntau heev yuav suav nrog cov hauv qab no:

  • ua plawv dhia qeeb lossis qog tsis txaus

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev kuaj ntshav kuaj, kuaj qhov muag, thiab yuav soj ntsuam koj cov ntshav siab ua ntej thiab lub sijhawm kho koj kom paub tseeb tias nws muaj kev nyab xeeb rau koj pib noj lossis txuas ntxiv noj siponimod.

Ua ntej muaj kev sim ntsuas, qhia rau koj tus kws kho mob thiab cov neeg ua haujlwm kuaj pom tias koj noj siponimod.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

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