Riociguat

Zoo Siab

• Ua ntej noj riociguat,
• Riociguat tuaj yeem ua phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas tau nyob hauv ntu TSHWJ XEEB, hu rau koj tus kws kho mob tam sis lossis tau txais kev kho mob kub ceev:

Tsis txhob noj tshuaj riociguat yog tias koj xeeb tub lossis npaj yuav muaj menyuam. Riociguat tuaj yeem tsim kev puas tsuaj rau tus me nyuam hauv plab. Yog tias koj tau sib deev thiab muaj peev xwm cev xeeb tub, koj yuav tsum tsis txhob pib noj riociguat mus txog thaum kuaj pom tias koj tsis tau xeeb tub. Koj yuav tsum siv txoj hauv kev tswj hwm kev cia siab thaum lub sij hawm kho thiab rau ib hlis tom qab nres riociguat. Tsis txhob lam tau lam ua. Tham nrog koj tus kws kho mob txog kev tiv thaiv kev xeeb tub uas siv tau zoo thiab yuav ua haujlwm rau koj. Hu rau koj tus kws kho mob tam sim ntawd yog tias koj tsis coj khaub ncaws los yog xav tias koj tuaj yeem cev xeeb tub thaum koj tab tom noj tshuaj riociguat.

Yog tias koj yog niam txiv lossis tus saib xyuas ntawm tus poj niam uas tseem tsis tau mus txog thaum tiav nkauj tiav nraug, xyuas koj tus menyuam tsis tu ncua seb nws puas muaj tus cim ntawm nkauj tiav nraug (lub mis, pub plaub hau) thiab qhia rau nws tus kws kho mob paub txog kev hloov pauv. Koj tus menyuam yuav muaj peev xwm ua tiav nkauj tiav nraug ua ntej muaj hnub coj khaub ncaws.

Vim tias txoj kev pheej hmoo ntawm kev yug menyuam tsis muaj mob, riociguat tsuas yog muaj los ntawm txoj kev txwv tshwj xeeb txoj kev faib khoom. Ib qhov kev pab cuam hu ua Adempas Kev Ntsuam Xyuas Kev Phom Sij thiab Kev Tshawb Nrhiav (REMS) tau tsim los rau txhua tus neeg mob poj niam kom paub tseeb tias lawv raug kuaj mob cev xeeb tub txhua lub hlis thaum kho mob thiab rau 1 hlis tom qab nres riociguat.Female cov neeg mob tuaj yeem tau txais riociguat tsuas yog tias lawv tau rau npe nrog Adempas REMS Program. Thaum lub sij hawm cuv npe koj yuav xaiv ib lub tsev muag tshuaj uas muaj ntawv pov thawj tshwj xeeb uas yuav thauj koj cov tshuaj rau koj. Nug koj tus kws kho mob yog tias koj muaj lus nug txog yuav ua li cas koj yuav tau txais koj cov tshuaj.

Koj tus kws kho mob lossis kws muag tshuaj yuav muab daim ntawv qhia txog cov neeg mob rau koj (Kev Siv Tshuaj) thaum koj pib kho mob riociguat thiab txhua zaus koj rov ntim tshuaj rau koj. Nyeem cov ntaub ntawv kom zoo thiab nug koj tus kws kho mob lossis kws muag tshuaj yog tias koj muaj lus nug. Koj kuj tuaj yeem mus saib zaub mov thiab Tshuaj (FDA) lub vev xaib (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kom tau Phau Ntawv Qhia Tshuaj.

Tham nrog koj tus kws kho mob txog cov kev pheej hmoo ntawm kev siv tshuaj riociguat.

Riociguat yog siv los kho mob ntsws ntsig (PAH; ntshav siab hauv cov hlab ntsha uas nqa ntshav mus rau lub ntsws). Riociguat tseem tseem siv coj los kho tus mob ntsig tsis muaj ntshav siab (pulmonary hypermonary hypertension) (CTEPH; ntshav siab hauv lub ntsws cov hlab ntsha los ntawm cov ntshav txhaws lossis ntshav khov) hauv cov neeg laus uas tsis tuaj yeem phais lossis cov neeg uas raug phais mob uas tseem muaj ntshav siab hauv lub ntsws. siab theem tom qab phais tas. Riociguat tuaj yeem txhim kho qhov muaj peev xwm ua kom tawm dag zog hauv cov neeg muaj PAH thiab CTEPH thiab tuaj yeem ua rau qeeb qeeb ntawm cov tsos mob tshwm sim hauv cov neeg muaj PAH. Riociguat nyob hauv chav kawm ntawm cov tshuaj hu ua soluble guanylate cyclase (sGC) stimulants. Nws ua haujlwm los ntawm kev ua kom cov hlab ntshav hauv lub ntsws ua kom cov ntshav ntws tau yooj yim.

Riociguat los ua ib ntsiav tshuaj noj ntawm qhov ncauj. Nws feem ntau yog noj nrog lossis tsis muaj zaub mov 3 zaug hauv ib hnub. Siv riociguat nyob ib ncig ntawm tib lub sijhawm (s) txhua txhua hnub thiab qhov chaw koj cov koob tshuaj li 6 txog 8 teev sib nrug. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj riociguat raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Yog tias koj tsis tuaj yeem nqos lub ntsiav tshuaj tag nrho, koj tuaj yeem tsoo lub ntsiav tshuaj thiab muab cov ntsiab lus sib xyaw nrog dej me me lossis zaub mov muag xws li txiv applesauce. Txhos qhov sib tov tom qab koj muab sib xyaw.

Koj tus kws kho mob yuav pib koj ntawm qhov qis ntawm riociguat thiab maj mam nce koj cov koob tshuaj, tsis pub ntau tshaj ib zaug txhua 2 lub lis piam. Koj tus kws kho mob tuaj yeem txo koj cov koob tshuaj yog tias koj muaj kev mob tshwm sim.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj riociguat,

• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau riociguat, lwm yam tshuaj noj, lossis lwm yam tshuaj hauv riociguat ntsiav tshuaj. Nug koj tus kws muag tshuaj lossis tshawb xyuas Phau Ntawv Qhia Tshuaj Kho Mob rau cov npe ntawm cov khoom siv.
• qhia rau koj tus kws kho mob yog tias koj noj lossis tsis ntev los no tau noj ib qho nitrate xws li isosorbide dinitrate (Isordil, hauv BiDil), isosorbide mononitrate (Monoket), lossis nitroglycerin (Nitro-Dur, Nitromist, Nitrostat, Minitran, Rectiv, lwm tus) ,; phosphodiesterase inhibitors (PDE-5) xws li avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), lossis vardenafil (Levitra, Staxyn); lossis yog tias koj noj cov tshuaj dipyridamole (Persantine, hauv Aggrenox), lossis theophylline (Theo-24, Theochron, Theolair, lwm tus). Koj tus kws kho mob yuav qhia koj kom tsis txhob noj tshuaj riociguat yog tias koj noj cov tshuaj no ib lossis ntau dua ntawm cov tshuaj no. Tsis txhob noj riociguat hauv 24 teev ua ntej lossis tom qab noj sildenafil lossis hauv 24 teev ua ntej lossis 48 teev tom qab noj tadalafil.
• qhia rau koj tus kws kho mob thiab kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob thiab cov tshuaj uas tsis yog kws kho mob sau, tshuaj vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txog ib qho ntawm cov hauv qab no: qee yam antifungals xws li itraconazole (Onmel, Sporanox) thiab ketoconazole (Extina, Nizoral, Xolegel); HIV protease inhibitors suav nrog ritonavir (Norvir, hauv Kaletra); qee yam tshuaj rau qaug dab peg xws li carbamazepine (Epitol, Equetro, Tegretol, lwm tus), phenobarbital, thiab phenytoin (Dilantin, Phenytek); thiab tshuaj kho ntshav siab. Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
• yog tias koj noj tshuaj antacids uas muaj aluminium hydroxide lossis magnesium hydroxide (Maalox, Mylanta, Tums, lwm tus), coj lawv 1 teev ua ntej lossis 1 teev tom qab noj riociguat.
• qhia koj tus kws kho mob tias yam tshuaj ntsuab koj noj, tshwj xeeb tshaj yog St. John wort.
• qhia rau koj tus kws kho mob yog tias koj mob qog nqaij ntshav txhaws mob ntsws (idiopathic interstitial pneumonia) (PH-IIP; mob ntsws). Koj tus kws kho mob yuav qhia koj kom tsis txhob noj tshuaj riociguat.
• qhia koj tus kws kho mob yog tias koj tam sim no haus luam yeeb lossis pib txiav lossis haus luam yeeb thaum kho. Kuj qhia koj tus kws kho mob yog tias koj nyuam qhuav mob zawv plab, ntuav lossis tawm hws ntau ntau uas tuaj yeem ua rau lub cev qhuav dej (poob ntawm lub cev dej ntau); ib qho kev los ntshav los ntawm koj lub ntsws; yog tias koj muaj tus txheej txheem los txwv koj kom tsis txhob hnoos los ntshav; yog tias koj muaj ntshav qis, mob ntsws ntsig (veno-occlusive disease) (thaiv cov hlab ntsha hauv lub ntsws); lossis mob plawv, raum, lossis kab mob siab.
• qhia rau koj tus kws kho mob yog tias koj pub mis niam rau menyuam. Tsis txhob noj mis thaum koj tab tom noj riociguat.
• koj yuav tsum paub tias riociguat tuaj yeem ua rau kiv taub hau thiab pom tob tob. Tsis txhob tsav tsheb los sis siv lub tshuab ua haujlwm kom txog thaum koj paub tias cov tshuaj no cuam tshuam rau koj li cas.

Tshwj tsis yog koj tus kws kho mob hais rau koj lwm yam, txuas ntxiv koj li kev noj haus zoo.

Hla lub tshuaj uas tsis nco qab noj thiab txuas ntxiv koj lub sijhawm noj tshuaj. Yog tias koj tsis tuaj noj tshuaj riociguat ntau dua 3 hnub, hu rau koj tus kws kho mob. Koj tus kws kho mob yuav xav rov pib noj koj cov tshuaj kom tsawg dua.

Riociguat tuaj yeem ua phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• mob taub hau
• cem quav
• Kev mob siab
• mob plab
• xeev siab
• ntuav
• zawv plab
• o koj ob txhais tes o, txhais taw, ko taw, thiab pob taws

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas tau nyob hauv ntu TSHWJ XEEB, hu rau koj tus kws kho mob tam sis lossis tau txais kev kho mob kub ceev:

• hnoos tau hnoos qeev, ntshav hnoos qeev lossis ntshav
• tsaus muag
• mob hauv siab
• txog siav

Riociguat tuaj yeem ua lwm cov kev mob tshwm sim. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Khaws tag nrho cov kev teem caij ntsib nrog koj tus kws kho mob. Koj tus kws kho mob yuav tshuaj xyuas koj cov ntshav siab tsis tu ncua thaum koj kho mob nrog riociguat.

Tsis txhob cia lwm tus noj koj cov tshuaj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

• Pheej Los Noj^®