Nilotinib

Zoo Siab

• Ua ntej noj nilotinib,
• Nilotinib yuav ua rau muaj kev phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas teev rau hauv seem ceeb toom ceeb toom, hu rau koj tus kws kho mob tam sim ntawd:

Nilotinib tuaj yeem ua rau QT lub sijhawm (lub siab ua haujlwm tsis haum lub siab uas tuaj yeem ua rau tsaus muag, tsis nco qab, qaug dab peg lossis tuag sai). Qhia rau koj tus kws kho mob yog tias koj lossis ib tus neeg hauv koj tsev neeg muaj lossis muaj tus kab mob QT ntev mus ntev (qhov mob tau los ntawm tus neeg yuav muaj QT ntev dua) lossis koj tau lossis tau muaj tsawg dua cov potassium lossis magnesium hauv koj cov ntshav. , kev txhim kho lub plawv dhia tsis xwm yeem, lossis mob siab rau daim siab. Qhia koj tus kws kho mob thiab kws tshuaj yog tias koj noj tshuaj amiodarone (Nexterone, Pacerone); antifungals xws li ketoconazole, itraconazole (Onmel, Sporanox), lossis voriconazole (Vfend); chloroquine (Plaquenil); clarithromycin (Biaxin, hauv Prevpac); disopyramide (Norpace); erythromycin (E.E.S., Eryc, PCE); qee cov tshuaj rau tib neeg cov tshuaj tiv thaiv kab mob (HIV) lossis tau txais tshuaj tiv thaiv kab mob (AIDS) xws li atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, hauv Kaletra), thiab saquinavir (Invirase); haloperidol (Haldol); tshuaj txiav yeeb (Dolophine, Methadose); moxifloxacin (Avelox); nefazodone; pimozide (Orap); procainamide; quinidine (hauv Nuedexta); sotalol (Betapace, Betapace AF, lwm tus); telithromycin (Ketek); thiab thioridazine. Yog tias koj muaj cov tsos mob nram qab no, tsum tsis noj nilotinib thiab hu rau koj tus kws kho mob tam sim ntawd: nrawm, nrawm, lossis lub plawv dhia tsis xwm yeem; tsaus muag; tsis nco qab; lossis qaug dab peg.

Tsis txhob noj zaub mov kom tsawg 2 teev ua ntej noj nilotinib thiab rau 1 teev tom qab noj cov tshuaj no.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev kuaj, xws li kuaj ntshav thiab electrocardiograms (EKGs, kev ntsuas uas sau cov hluav taws xob kev ua haujlwm ntawm lub plawv) ua ntej thiab thaum kho koj kom ntseeg tau tias nws muaj kev nyab xeeb rau koj noj nilotinib.

Koj tus kws kho mob lossis kws muag tshuaj yuav muab daim ntawv qhia txog cov neeg mob rau koj (phau Qhia Siv Tshuaj) thaum koj pib kho nilotinib thiab txhua zaus koj rov ntim tshuaj rau koj. Nyeem cov ntaub ntawv kom zoo thiab nug koj tus kws kho mob lossis kws muag tshuaj yog tias koj muaj lus nug. Koj kuj tuaj yeem mus saib tau Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) lub vev xaib (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) lossis cov chaw tsim tshuaj paus lub vev xaib kom tau txais Kev Qhia Tshuaj.

Tham nrog koj tus kws kho mob txog cov kev pheej hmoo noj nilotinib.

Nilotinib raug siv los kho qee yam mob myeloid leukemia (CML; ib hom mob qog noj ntshav dawb) uas tsis ntev los no pom tias muaj tus mob no rau cov neeg laus thiab cov menyuam hnub nyoog 1 xyoos thiab laus dua. Nws kuj tseem siv los kho qee hom mob CML uas lawv tsis tuaj yeem kho tus mob nrog imatinib (Gleevec) lossis cov neeg laus uas tsis tuaj yeem siv tshuaj imatinib. Nilotinib tseem tseem siv coj los kho qee yam mob ntawm CML rau cov menyuam yaus hnub nyoog 1 xyoos lossis laus dua uas tus kab mob no tsis tuaj yeem kho nrog lwm tus mob tyrosine kinase inhibitor tshuaj. Nilotinib nyob hauv chav kawm ntawm cov tshuaj hu ua kinase inhibitors. Nws ua haujlwm los ntawm kev thaiv qhov kev txiav txim ntawm cov protein tsis txaus ntseeg uas ua teeb liab rau cov cell mob qog hlav. Qhov no yuav pab kom nres lossis qeeb qeeb kis mob hlwb.

Nilotinib los ua tshuaj ntsiav los noj ntawm qhov ncauj. Nws feem ntau yog noj yam tsis muaj zaub mov ob zaug ib hnub. Nilotinib yuav tsum noj ntawm lub plab khoob, tsawg kawg 2 teev ua ntej lossis 1 teev tom qab noj zaub mov ib qho twg. Noj nilotinib nyob ib ncig ntawm tib lub sijhawm txhua hnub. Sim tso koj cov tshuaj li 12 teev sib nrug. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj nilotinib raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Nqos cov tsiav tshuaj tag nrho nrog ib khob dej; tsis txhob sib faib, zom, lossis tsoo lawv. Yog tias koj tsis tuaj yeem nqos cov tshuaj ntsiav tag nrho, sib xyaw cov ntsiab lus ntawm ib lub tshuaj ntsiav hauv ib me nyuam diav ntawm applesauce. Nqos cov khoom sib tov tam sim ntawd (hauv 15 feeb.) Tsis txhob cia cov khoom sib tov rau kev siv yav tom ntej.

Koj tus kws kho mob tuaj yeem txo koj cov tshuaj nilotinib lossis tso tseg kev kho mob nyob ntawm seb cov tshuaj ua haujlwm rau koj npaum li cas thiab yog tias koj muaj kev mob tshwm sim. Txuas ntxiv noj cov nilotinib txawm hais tias koj xis neej. Tsis txhob tsum noj nilotinib yam tsis tau nrog koj tus kws kho mob tham.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj nilotinib,

• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau nilotinib, lwm yam tshuaj, lossis lwm yam tshuaj hauv nilotinib tsiav tshuaj. Nug koj tus kws muag tshuaj lossis tshawb xyuas Phau Ntawv Qhia Tshuaj Kho Mob rau cov npe ntawm cov khoom siv.
• qhia rau koj tus kws kho mob thiab kws muag tshuaj tias lwm yam tshuaj uas tsis yog kws kho mob sau tseg thiab cov tshuaj uas tsis yog kws kho mob, cov vitamins, thiab cov khoom noj zoo uas koj noj lossis npaj yuav noj. Nco ntsoov hais txog cov tshuaj teev tseg rau hauv seem tseem ceeb ceeb toom thiab ib qho twg ntawm cov hauv qab no: qee cov tshuaj angiotensin-receptor blockers xws li irbesartan (Avapro, hauv Avalide) thiab losartan (Cozaar, hauv Hyzaar); anticoagulants ('' ntshav thinners '') xws li warfarin (Coumadin, Jantoven); aripiprazole (Abilify); qee yam benzodiazepines xws li alprazolam (Xanax), diazepam (Valium), midazolam, thiab triazolam (Halcion); buspirone (Buspar); qee qhov calcium channel blockers xws li amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, lwm tus), felodipine, nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipine (Sular), thiab verapamil (Calan, Verelan, lwm tus) ; qee yam tshuaj ua kom ntshav (cholesterol) tsawg (statins) suav nrog atorvastatin (Lipitor), fluvastatin (Lescol XL), lovastatin (Altoprev), thiab simvastatin (Zocor); chlorpheniramine (Chlor-Trimeton, lwm yam tshuaj hnoos thiab mob khaub thuas); dexamethasone; dihydroergotamine (D.H.E. 45, Migranal); ergotamine (hauv Cafergot, hauv Ergomar); fentanyl (Actiq, Duragesic, Subsys); flecainide (Tambocor); qee yam tshuaj siv rau kev ntxhov siab xws li amitriptyline, desipramine (Norpramin); duloxetine (Cymbalta); imipramine (Tofranil); paroxetine (Brisdelle, Paxil, Pexeva); thiab venlafaxine (Effexor); qee cov tshuaj noj rau qhov mob ntshav qab zib xws li glipizide (Glucotrol) thiab tolbutamide; qee cov tshuaj uas ua kom lub cev tiv thaiv tsis muaj zog xws li cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), thiab tacrolimus (Prograf); qee yam tshuaj rau qaug dab peg xws li carbamazepine (Equetro, Tegretol, Teril), phenobarbital, thiab phenytoin (Dilantin, Phenytek); mexiletine; qee yam tshuaj nonsteroidal anti-inflammatory (NSAIDs) xws li celecoxib (Celebrex), diclofenac (Voltaren), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), thiab piroxicam (Feldene); ondansetron (Zofran); propafenone (Rythmol); proton-twj tso kua mis inhibitors xws li esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), thiab rabeprazole (AcipHex); quinine (Qualaquin); rifabutin (Mycobutin); rifampin (Rifadin); rab phom loj (Priftin); risperidone (Risperdal); sildenafil (Viagra, Revatio); tamoxifen; testosterone (Androderm, Androgel, Striant, lwm tus); timolol; torsemide; tramadol (Ultram, hauv Ultracet); trazodone; thiab vincristine. Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv. Ntau lwm yam tshuaj kuj tuaj yeem cuam tshuam nrog nilotinib, yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv, txawm tias tsis tshwm nyob hauv daim ntawv no.
• yog tias koj noj tshuaj antacids uas muaj cov tshuaj magnesium, aluminium (Maalox, Mylanta, Tums, lwm tus), lossis simethicone, noj cov tshuaj antacid 2 teev ua ntej lossis tsawg kawg 2 teev tom qab koj noj nilotinib.
• yog tias koj noj tshuaj rau kem plab, kub siab, lossis mob rau sab hauv xws li cimetidine (Tagamet), famotidine (Pepcid, hauv Duexis), nizatidine (Axid), lossis ranitidine (Zantac), noj nws tsawg kawg 10 teev ua ntej lossis tsawg kawg 2 sij hawm tom qab koj noj nilotinib.
• qhia koj tus kws kho mob tias yam tshuaj ntsuab koj noj, tshwj xeeb tshaj yog St. John wort.
• qhia rau koj tus kws kho mob yog tias koj muaj mob hlab ntsha tawg lossis phais mob txhawm rau tshem tawm tag nrho lub plab (tag nrho txoj hlab ntsws). Thiab, qhia rau koj tus kws kho mob yog tias koj tau lossis puas tau txo qis ntshav ntws mus rau koj ob txhais ceg, txhua yam teeb meem lub plawv, teeb meem los ntshav, mob voos (mob vias), mob caj pas nyob tom qab uas tsim cov tshuaj los pab ua rau lub plab zom mov), lossis ib qho xwm txheej ua rau nws nyuaj rau koj zom cov lactose (mis qab zib) lossis lwm yam piam thaj.
• qhia rau koj tus kws kho mob yog tias koj cev xeeb tub los yog npaj yuav cev xeeb tub. Koj yuav tsum tsis txhob cev xeeb tub thaum koj noj nilotinib. Koj yuav tsum siv kev tswj kom tsis txhob muaj menyuam kom tiv thaiv kev xeeb tub thaum lub sijhawm koj kho nrog nilotinib thiab rau 14 hnub tom qab koj zaum kawg. Tham nrog koj tus kws kho mob txog cov hau kev tswj kev xeeb menyuam uas koj tuaj yeem siv thaum kho koj. Yog tias koj cev xeeb tub thaum noj nilotinib, hu rau koj tus kws kho mob tam sim ntawd. Nilotinib tuaj yeem tsim kev puas tsuaj rau tus menyuam hauv plab.
• qhia rau koj tus kws kho mob yog tias koj pub mis. Koj yuav tsum tsis txhob pub niam mis thaum koj noj nilotinib thiab rau 14 hnub tom qab koj zaum kawg.
• yog tias koj muaj kev phais, suav nrog kev phais hniav, qhia tus kws kho mob lossis kws kho hniav tias koj noj nilotinib.

Tsis txhob noj txiv kab ntxwv qaub, haus kua txiv kab ntxwv qaub, lossis noj lwm yam ntxiv uas muaj cov txiv kab ntxwv qaub thaum koj noj cov tshuaj no.

Hla lub tshuaj uas tsis nco qab noj thiab txuas ntxiv koj lub sijhawm noj tshuaj. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Nilotinib yuav ua rau muaj kev phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• ua pob
• khaus
• xeev siab
• ntuav
• zawv plab
• cem quav
• Kev mob siab
• roj
• tsis qab los noj mov
• mob taub hau
• kiv taub hau
• nkees nkees
• teeb meem tsis tsaug zog los yog pw tsaug zog
• tsaus ntuj tawm hws
• mob leeg
• sab nraub qaum, pob txha, pob qij, tes, lossis mob leeg
• plaub hau poob
• tawv nqaij qhuav lossis liab pliv
• loog loog, hlawv, lossis kov hauv tes lossis taw

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas teev rau hauv seem ceeb toom ceeb toom, hu rau koj tus kws kho mob tam sim ntawd:

• ntshav txawv lossis doog ntshav
• ntshav hauv zis
• los ntshav lossis dub, quav ua quav
• mob taub hau sai sai, tsis meej pem, lossis pauv qhov muag pom kev
• nkees txawv lossis tsis muaj zog
• mob hauv siab lossis tsis xis nyob
• teeb meem taug kev los yog hais lus
• loog
• hloov ceg tawv xim
• kev hnov ​​mob lossis txias txias hauv cov ceg
• mob plab nrog xeev ntuav thiab ntuav
• kub taub hau, ua daus no, mob caj pas, hnoos txuas ntxiv thiab txhaws ntswg, lossis lwm yam cim ntawm tus kab mob
• daj ntseg tawv nqaij
• txog siav
• hnyav
• o ntawm tes, pob taws, ko taw, lossis ntsej muag
• mob los yog tsis xis nyob sab xis lub plab
• daj ntawm daim tawv nqaij thiab qhov muag
• tsaus zis
• tso zis tsawg dua li ib txwm

Nilotinib yuav ua rau me nyuam yaus loj hlob qeeb dua. Koj tus menyuam tus kws kho mob yuav saib xyuas koj tus menyuam txoj kev loj hlob kom zoo thaum koj tus menyuam noj nilotinib. Tham nrog koj tus menyuam tus kws khomob txog cov kev pheej hmoo ntawm kev muab cov tshuaj no rau koj tus menyuam.

Nilotinib tuaj yeem ua lwm cov kev mob tshwm sim. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Cov tsos mob ntawm kev haus ntau tshaj yuav suav nrog:

• kub taub hau, mob caj pas, ua daus no, los yog lwm yam cim ntawm tus kab mob
• ntuav
• tsaug zog

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

• Tasigna^®