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Brian Druker (OHSU) Part 1: Imatinib (Gleevec): A Targeted Cancer Therapy
Daim Duab: Brian Druker (OHSU) Part 1: Imatinib (Gleevec): A Targeted Cancer Therapy

Zoo Siab

Imatinib yog siv los kho qee hom ntshav mob (mob cancer uas pib hauv cov qe ntshav dawb) thiab lwm yam mob qog nqaij hlav thiab cov ntshav tsis zoo. Imatinib tseem tseem siv los kho qee yam mob caj dab mob pob qog (GIST; ib hom mob qog uas loj hlob nyob hauv phab ntsa ntawm cov khoom noj zom thiab tuaj yeem kis mus rau lwm qhov ntawm lub cev). Imatinib tseem tseem siv los kho dermatofibrosarcoma protuberans (cov qog uas ua rau txheej txheem sab saum toj ntawm daim tawv) thaum lub qog tsis tuaj yeem tshem tawm phais, tau kis mus rau lwm qhov ntawm lub cev, lossis tau rov qab los tom qab kev phais mob. Imatinib yog nyob hauv chav kawm ntawm cov tshuaj hu ua kinase inhibitors. Nws ua haujlwm los ntawm kev thaiv qhov kev txiav txim ntawm cov protein tsis txaus ntseeg uas ua teeb liab rau cov cell mob qog hlav. Qhov no yuav pab kom tsis txhob kis mob hlwb.

Imatinib los ua ib ntsiav tshuaj noj ntawm qhov ncauj. Nws feem ntau yog noj nrog zaub mov thiab ib khob dej loj loj ib zaug lossis ob zaug ib hnub. Noj imatinib nyob ib ncig ntawm tib lub sijhawm (s) txhua txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj imatinib raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.


Nqos cov ntsiav tshuaj tag nrho; tsis txhob zom lossis tsuj. Yog tias koj kov lossis nkag ncaj qha nrog lub ntsiav tshuaj zuaj, ntxuav thaj tsam kom huv.

Yog tias koj tsis tuaj yeem nqos cov ntsiav tshuaj imatinib, koj tuaj yeem tso tag nrho cov ntsiav tshuaj uas koj xav tau rau ib qho rau hauv ib khob dej lossis kua txiv. Siv 50 millilitres (me me tsawg dua 2 ooj) ntawm cov kua rau ib qho 100-mg ntsiav tshuaj thiab 200 millilitres (me me tsawg dua 7 ooj) ntawm cov kua rau ib qho ntsiav tshuaj 400-mg. Do nrog rab diav kom txog thaum cov ntsiav tshuaj tawg tag thiab haus qhov sib tov tam sim ntawd.

Yog tias koj tus kws kho mob tau hais kom koj noj 800 mg ntawm imatinib, koj yuav tsum noj 2 ntawm 400-mg ntsiav tshuaj. Tsis txhob noj 8 ntawm 100-mg ntsiav tshuaj. Cov ntsiav tshuaj tha xim muaj cov hlau, thiab koj yuav tau txais ntau hlau yog tias koj noj 8 ntawm 100-mg ntsiav tshuaj.

Koj tus kws kho mob tuaj yeem nce lossis txo qis koj cov koob tshuaj imatinib thaum kho koj. Qhov no nws nyob ntawm seb cov tshuaj uas ua hauj lwm zoo rau koj thiab kev phiv los sis koj muaj. Tham nrog koj tus kws kho mob txog saib koj xav li cas thaum kho koj tus mob. Noj cov tshuaj imatinib ntxiv txawm hais tias koj xis neej. Tsis txhob tsum noj imatinib yam tsis tham nrog koj tus kws kho mob.


Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj imatinib,

  • qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau imatinib, lwm yam tshuaj noj, lossis lwm yam tshuaj hauv cov ntsiav tshuaj imatinib. Nug koj tus kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
  • qhia rau koj tus kws kho mob thiab tus kws muag tshuaj tias yam tshuaj twg thiab cov ntawv yuav tshuaj, cov vitamins, thiab cov khoom noj muaj txiaj ntsig koj noj lossis npaj yuav noj.Nco ntsoov hais txog ib yam ntawm cov hauv qab no: acetaminophen (Tylenol), alprazolam (Xanax), amlodipine (Norvasc, hauv Caduet, Lotrel, Tribenzor, lwm tus), atazanavir (Reyataz), atorvastatin (Lipitor, hauv Caduet), carbamazepine (Carbatrol, Equetro, Tegretol, lwm tus), clarithromycin (Biaxin, hauv Prevpac), cyclosporine (Gengraf, Neoral, Sandimmune), dexamethasone, ergotamine (Ergomar, hauv Migergot, Cafergot), erythromycin (EES, Eryc, Eryip, lwm tus), est , fentanyl (Duragesic, Subsys, Fentora, lwm tus), fosphenytoin (Cerebyx), indinavir (Crixivan), hlau, lossis hlau muaj cov tshuaj, isradipine, itraconazole (Onmel, Sporanox), ketoconazole, lovastatin (Altoprev), metoprolol (Lopress) XL, hauv Dutoprol), nefazodone, nelfinavir (Viracept), nicardipine (Cardene), nifedipine (Adalat CC, Procardia, lwm tus), nimodipine (Nymalize), nisoldipine (Sular), oxcarbazepine (Oxtellar XR, Trileptal), pheny Dilantin, Phenytek), pimozide (Orap), primidone (Mysoline), qui nidine (hauv Nuedexta), rifabutin (Mycobutin), rifampin (rifadin, rimactane, hauv Rifamate, Rifater), ritonavir (Norvir, hauv Kaletra, Technivie, Viekira), saquinavir (Fortovase, Invirase), simvastatin (Zocor,) sirolimus (Rapamune), tacrolimus (Astagraf XL, Envarsus XR, Prograf), telithromycin, triazolam (Halcion), voriconazole (Vfend), thiab warfarin (Coumadin, Jantoven). Ntau lwm yam tshuaj kuj tseem tuaj yeem cuam tshuam nrog imatinib, yog li nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj siv, txawm tias tsis tshwm nyob hauv daim ntawv no. Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
  • qhia koj tus kws kho mob tias yam tshuaj ntsuab koj noj, tshwj xeeb tshaj yog St. John wort.
  • qhia rau koj tus kws kho mob yog tias koj tau lossis muaj lub siab mob ntsws, ntsws, qog, mob raum, lossis mob siab.
  • qhia rau koj tus kws kho mob yog tias koj cev xeeb tub los yog npaj yuav cev xeeb tub. Koj yuav tsum tau coj mus kuaj cev xeeb tub ua ntej pib kev kho mob, Koj yuav tsum tsis txhob cev xeeb tub thaum koj tab tom noj tshuaj imatinib thiab rau 14 hnub tom qab koj zaum kawg. Tham nrog koj tus kws kho mob txog cov hau kev tswj kev xeeb menyuam uas koj tuaj yeem siv thaum kho koj. Yog tias koj cev xeeb tub thaum noj cov tshuaj imatinib, hu rau koj tus kws kho mob. Imatinib tuaj yeem tsim kev puas tsuaj rau tus menyuam hauv plab.
  • qhia rau koj tus kws kho mob yog tias koj pub mis niam rau menyuam. Koj yuav tsum tsis txhob pub niam mis thaum koj tab tom noj imatinib thiab rau ib hlis tom qab koj cov tshuaj zaum kawg.
  • yog tias koj muaj kev phais, suav nrog kev phais hniav, qhia tus kws kho mob lossis kws kho hniav tias koj tab tom noj imatinib.
  • koj yuav tsum paub tias imatinib tuaj yeem ua rau koj tsaus muag, tsaus muag, lossis ua kom pom kev plooj plooj. Tsis txhob tsav tsheb los sis siv lub tshuab ua haujlwm kom txog thaum koj paub tias cov tshuaj no cuam tshuam rau koj li cas.

Tsis txhob noj txiv kab ntxwv qaub lossis haus cov txiv kab ntxwv kua txiv thaum noj cov tshuaj no.


Noj cov koob tshuaj uas ploj lawm sai li sai tau thaum koj nco qab nws. Txawm li cas los xij, yog tias nws yuav luag txog rau koob tshuaj txuas ntxiv, hla cov koob tshuaj uas tsis nco qab noj thiab txuas ntxiv koj lub sijhawm noj tshuaj kom tsis tu ncua. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Imatinib tuaj yeem ua phiv. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

  • zawv plab
  • xeev siab
  • ntuav
  • hloov pauv txoj kev uas saj tau
  • qhov ncauj tawm los sis o hauv qhov ncauj
  • tsis qab los noj mov
  • poob phaus
  • Lub siab ua haujlwm lossis kem plab
  • qhov ncauj qhuav
  • mob taub hau
  • mob pob qij txha los yog mob
  • mob pob txha
  • mob leeg, ntswj, lossis mob mob
  • tingling, hlawv. lossis prickling txoj kev xav ntawm daim tawv nqaij
  • teeb meem tsis tsaug zog los yog pw tsaug zog
  • hws
  • teary qhov muag
  • qhov muag daj
  • yaug
  • daim tawv nqaij qhuav
  • ua pob
  • khaus
  • ntsia thawv hloov
  • plaub hau poob

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog koj muaj cov tsos mob no hu rau koj tus kws kho mob:

  • o ncig lub qhov muag
  • o ntawm tes, taw, pob taws, lossis ceg qis
  • nce ceeb thawj sai
  • txog siav
  • lub plawv dhia nrawm, tsis xwm yeem, lossis sib dhia
  • hnoos tau paj yeeb lossis ntshav tawm
  • nce tso zis, tshwj xeeb tshaj yog thaum tsaus ntuj
  • mob hauv siab
  • tev tawv, ua hlwv, lossis tawv
  • daj ntawm daim tawv nqaij lossis qhov muag
  • ntshav hauv cov quav
  • doog ntshav los ntshav tsis txawv
  • cov tsos mob khaub thuas zoo li mob khaub thuas, mob qa, kub cev, ua daus no, thiab lwm yam cim ntawm kev kis
  • nkees dhau heev lawm lossis tsis muaj zog
  • mob plab los yog tsam plab

Imatinib tuaj yeem txo qis kev loj hlob hauv menyuam yaus. Koj tus menyuam tus kws kho mob yuav saib xyuas nws kev loj hlob kom zoo. Tham nrog koj tus menyuam tus kws kho mob txog cov kev pheej hmoo ntawm kev muab tshuaj imatinib rau koj tus menyuam.

Imatinib tuaj yeem ua rau muaj kev phiv ntxiv. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Cov tsos mob ntawm kev noj haus ntau heev yuav suav nrog cov hauv qab no:

  • xeev siab
  • ntuav
  • zawv plab
  • ua pob
  • o tuaj
  • nkees heev
  • mob pob ntseg los yog txha nqaj qaum
  • mob plab
  • mob taub hau
  • tsis qab los noj mov

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj qee yam kev kuaj sim kuaj xyuas koj lub cev cov lus teb rau imatinib.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

  • Gleevec®
Kawg Kho - 03/15/2020

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