Deferasirox

Zoo Siab

• Txhawm rau nqa cov tshuaj deferasirox rau kev ncua (Exjade), ua raws li cov theem hauv qab no:
• Ua ntej noj deferasirox,
• Deferasirox yuav ua rau muaj kev mob tshwm sim. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:
• Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas tau hais hauv ntu CEEB TOOM TSEEM CEEB, hu rau koj tus kws kho mob tam sim ntawd:
• Cov tsos mob ntawm kev noj haus ntau heev yuav suav nrog cov hauv qab no:

Deferasirox tuaj yeem ua rau mob hnyav lossis phom sij rau lub raum. Txoj kev pheej hmoo uas koj yuav ua mob raum yuav muaj ntau dua yog tias koj muaj ntau yam mob, lossis mob hnyav heev vim yog mob ntshav. Qhia rau koj tus kws kho mob yog tias koj tau lossis muaj dua li mob raum. Koj tus kws kho mob yuav qhia koj kom tsis txhob noj cov tshuaj deferasirox. Yog tias koj pom muaj cov tsos mob hauv qab no, hu rau koj tus kws kho mob tam sim ntawd: tso zis tsawg dua, o nrawm, pob taws, lossis ko taw, nkees dhau heev, ua pa ceev thiab tsis meej pem. Rau cov menyuam yaus noj cov tshuaj no, muaj kev pheej hmoo ntau ntxiv tias koj yuav muaj teeb meem lub raum yog tias koj mob thaum siv cov tshuaj tiv thaiv deferasirox thiab pib zawv plab, ntuav, kub cev lossis haus dej haus ib txwm. Hu rau koj tus kws kho mob tam sim ntawd yog tias koj muaj cov tsos mob no.

Deferasirox tuaj yeem ua rau lub siab ua rau mob hnyav lossis tuag tau rau lub siab. Txoj kev pheej hmoo uas koj yuav muaj lub siab ua puas yog ntau dua yog tias koj muaj hnub nyoog laus dua 55 xyoos, lossis yog tias koj muaj lwm yam mob loj. Qhia rau koj tus kws kho mob yog tias koj tau lossis muaj kab mob siab dua. Yog tias koj muaj qee cov tsos mob hauv qab no, hu rau koj tus kws kho mob tam sim ntawd: ua kom tawv nqaij lossis ob lub qhov muag, zoo li mob khaub thuas, tsis muaj zog, tsis qab los noj mov, mob rau sab xis sab xis ntawm lub plab, lossis txawv doog lossis los ntshav.

Deferasirox kuj tseem tuaj yeem ua rau mob hnyav lossis kom tuag taus uas yog los ntshav hauv plab lossis hnyuv. Txoj kev pheej hmoo uas koj yuav los ntshav hnyav hauv plab lossis plab hnyuv yuav muaj ntau dua yog tias koj laus, lossis mob hnyav los ntawm ntshav. Qhia rau koj tus kws kho mob yog tias koj tau lossis tau muaj ntshav qes qis tsawg (ib hom ntshav uas xav tau los tswj kev los ntshav), lossis yog koj noj ib qho tshuaj twg hauv qab no: anticoagulants (ntshav nyias) xws li warfarin (Coumadin , Jantoven); cov tshuaj aspirin lossis lwm cov tshuaj tiv thaiv tsis siv tshuaj (NSAIDs) xws li ibuprofen (Advil, Motrin, lwm tus) thiab naproxen (Aleve, Naprosyn, lwm tus); qee cov tshuaj kom ntxiv dag zog rau cov pob txha suav nrog alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), thiab zoledronic acid (Reclast, Zometa); lossis steroids xws li dexamethasone, methylprednisolone (A-methapred, Depo-medrol, Medrol, Solu-medrol), lossis prednisone (Rayos). Yog tias koj muaj cov tsos mob li hais hauv qab no, hu rau koj tus kws kho mob tam sim ntawd: kub lub plab, ntuav uas liab liab lossis zoo li thaj chaw kas fes, ntshav liab nyob rau hauv cov quav, lossis cov quav tawv dub.

Khaws tag nrho cov kev teem caij mus ntsib koj tus kws kho mob thiab chav kuaj mob. Koj tus kws kho mob yuav xaj kuaj sim ua ntej thiab thaum kho koj tus mob kom paub tseeb tias nws zoo rau koj noj deferasirox thiab saib koj puas tsim cov kev mob tshwm sim loj heev.

Deferasirox yog siv los kho cov neeg laus thiab menyuam yaus hnub nyoog 2 xyoos thiab laus dua uas muaj cov hlau ntau hauv lawv lub cev vim lawv tau txais ntau cov ntshav. Nws kuj tseem siv coj los kho cov laus thiab menyuam yaus hnub nyoog 10 xyoo thiab laus dua uas muaj cov hlau ntau hauv lawv lub cev vim muaj kev mob caj ces hu ua non-transfusion-dependent thalassemia (NTDT). Deferasirox yog nyob rau hauv chav kawm ntawm cov tshuaj noj hu ua hlau chelators. Nws ua hauj lwm los ntawm kev txuas rau hlau hauv lub cev kom nws thiaj li tawm (tshem tawm hauv lub cev) hauv cov quav.

Deferasirox los ua ib ntsiav tshuaj, granules, thiab ntsiav tshuaj rau ncua kev kawm (ib ntsiav tshuaj kom yaj ua kua) mus noj ntawm qhov ncauj. Nws yuav tsum noj rau ntawm lub plab khoob ib hnub ib zaug, tsawg kawg 30 feeb ua ntej noj mov, Cov ntsiav tshuaj thiab cov hmoov nplej tseem tuaj yeem noj nrog lub teeb noj mov xws li cov tseem nplej Askiv muffin nrog jelly thiab skim mis, lossis nqaij qaib ntxhw me me tag nrho cov mov ci. Noj deferasirox nyob ib ncig ntawm tib lub sijhawm txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj noj kom zoo, thiab nug koj tus kws kho mob lossis kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj deferasirox raws nraim li qhia. Tsis txhob noj ntau dua lossis tsawg dua lossis siv ntau dua li uas koj tus kws khomob tau qhia.

Cov khoom siv sib txawv ntawm cov khoom sib txawv txawv tuaj ntawm lub cev sib txawv thiab tsis tuaj yeem hloov kho rau lwm tus. Yog tias koj xav hloov los ntawm ib qho khoom lag luam deferasirox mus rau lwm tus, koj tus kws kho mob yuav xav kho koj qhov tshuaj. Txhua zaus koj tau txais koj cov tshuaj, tshuaj xyuas kom paub tseeb tias koj tau txais cov khoom lag luam deferasirox uas yog tshuaj rau koj. Nug koj tus kws muag tshuaj yog tias koj tsis paub meej tias koj tau txais tshuaj zoo.

Nqos ntsiav tshuaj deferasirox Nqaij (Jadenu) nrog dej lossis lwm yam kua. Yog tias koj muaj teeb meem nqos lub ntsiav tshuaj, koj tuaj yeem tsoo lub ntsiav tshuaj thiab sib tov nrog cov khoom noj muag muag zoo li kua mis nyeem qaub los yog txiv tsawb ua ntej noj. Txawm li cas los xij, tsis txhob zuaj lub 90 mg ntsiav tshuaj (Jadenu) siv kev txhuam cov khoom lag luam uas muaj cov npoo jagged.

Txhawm rau noj deferasirox granules (Jadenu), nphoo cov kua me rau ntawm cov zaub mov muag xws li kua mis nyeem qaub lossis txiv applesauce ua ntej noj.

Txhawm rau nqa cov tshuaj deferasirox rau kev ncua (Exjade), ua raws li cov theem hauv qab no:

1. Ib txwm yaj lub ntsiav tshuaj rau kev ncua hauv cov kua ua ntej koj yuav tsum noj. Tsis txhob zom los yog nqos cov ntsiav tshuaj rau kev ncua tag nrho.
2. Yog tias koj noj tsawg dua 1000 mg ntawm deferasirox, sau rau ib nrab khob (li 3.5 oz / 100 mL) nrog dej, kua txiv, lossis kua txiv kab ntxwv. Yog tias koj noj ntau tshaj 1000 mg ntawm deferasirox, sau lub khob (li 7 oz / 200 mL) nrog dej, kua txiv, lossis kua txiv kab ntxwv. Yog tias koj tsis paub tseeb ntau npaum li cas deferasirox koj yuav noj, nug koj tus kws kho mob lossis kws muag tshuaj.
3. Tso cov naj npawb ntawm cov ntsiav tshuaj uas koj tus kws kho mob tau hais kom koj noj rau hauv lub khob.
4. Do cov kua li 3 feeb kom yaj cov ntsiav tshuaj kom tag.Qhov sib xyaw kom tuab uas koj do.
5. Haus cov kua txiv kom sai.
6. Ntxiv me me ntawm kua rau lub khob khoob thiab do. Zuaj lub khob kom yaj lub khob rau cov tshuaj uas tseem nyob rau hauv lub khob los yog ntawm cov dej haus.
7. Haus cov kua tas.

Koj tus kws kho mob tuaj yeem hloov kho koj li koob tshuaj deferasirox tsis pub ntau tshaj ib zaug txhua 3 rau 6 hlis, nyob ntawm kev soj ntsuam koj lub chaw kuaj ntsuas.

Deferasirox tshem tawm cov hlau ntxiv los ntawm koj lub cev maj mam dhau sijhawm. Kav tsij noj deferasirox txawm hais tias koj tus kheej yuav xis nyob. Tsis txhob tsum noj deferasirox yam tsis tau tham nrog koj tus kws kho mob.

Cov tshuaj no tuaj yeem tsim tawm rau lwm txoj kev siv; nug koj tus kws kho mob lossis kws muag tshuaj kom paub ntaub ntawv ntau ntxiv.

Ua ntej noj deferasirox,

• qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj muaj kev fab tshuaj rau deferasirox, lwm yam tshuaj, los yog ib qho twg hauv cov khoom hauv deferasirox ntsiav tshuaj, granules, lossis ntsiav tshuaj rau ncua kev kawm. Nug koj tus kws kho mob lossis kws muag tshuaj rau cov npe ntawm cov khoom xyaw.
• qhia rau koj tus kws kho mob thiab kws muag tshuaj uas siv tshuaj thiab cov tshuaj uas tsis yog kws kho mob, cov vitamins, khoom noj khoom haus zoo, thiab tshuaj ntsuab koj tau noj lossis npaj yuav noj. Nco ntsoov hais txog cov tshuaj teev tseg rau hauv seem tseem ceeb ceeb toom thiab ib qho twg ntawm cov hauv qab no: alosetron (Lotronex), aprepitant (Cinvanti, Emend), budesonide (Entocort, Pulmicort, Uceris, hauv Symbicort), buspirone, cholestyramine (Prevalite), colesevelam (Welchol), colestipol (Colestid), conivaptan (Vaprisol), cyclosporine (Gengraf, Neoral, Sandimmune), darifenacin (Enablex), darunavir (Prezista, hauv Prezcobix), dasatinib (Sprycel), dihydroergaramine (DHE 45, Migoned) (Multaq), duloxetine (Cymbalta), eletriptan (Relpax), eplerenone (Inspra), ergotamine (Ergomar, hauv Cafergot, Migergot), everolimus (Afinitor, Zortress), felodipine, fentanyl (Actiq, Duragesic, Subsentes) (Arnuity Ellipta, Flovent, hauv Breo Ellipta, Advair), tshuaj tiv thaiv hormonal (tshuaj txwv, thaj ua rau thaj, lossis ib ce), indinavir (Crixivan), lopinavir (hauv Kaletra), lovastatin (Altoprev), lurasidone (Latuda), maraviroc (Selzentry), midazolam, nisoldipine (Sular), paclitax el. , hauv Rifamate, hauv Rifater), ritonavir (Norvir, hauv Kaletra, Technivie, Viekira Pak), saquinavir (Invirase), sildenafil (Revatio, Viagra), simvastatin (Flolopid, Zocor, hauv Vytorin), siroliumus (Rapamune), Astagraf, Envarsus, Prograf), theophylline (Theo-24), ticagrelor (Brilinta), tipranavir (Aptivus), tizanidine (Zanaflex), triazolam (Halcion), tolvaptan (Samsca), thiab vardenafil (Levitra, Staxyn). Koj tus kws kho mob tej zaum yuav tau hloov qhov tshuaj ntawm koj cov tshuaj lossis saib xyuas koj kom zoo rau kev phiv.
• yog tias koj noj cov tshuaj txhuas uas muaj antacids xws li Amphojel, Alternagel, Gaviscon, Maalox, lossis Mylanta, noj lawv 2 teev ua ntej lossis tom qab deferasirox.
• qhia koj tus kws kho mob seb cov khoom lag luam cuav koj noj, tshwj xeeb yog melatonin, lossis khoom noj muaj caffeine.
• qhia rau koj tus kws kho mob yog tias koj muaj myelodysplastic syndrome (qhov teeb meem loj nrog cov pob txha pob txha uas muaj kev pheej hmoo siab yuav mob qog nqaij hlav cancer), lossis mob cancer. Koj tus kws kho mob yuav qhia koj kom tsis txhob noj cov tshuaj deferasirox.
• qhia koj tus kws kho mob yog tias koj cev xeeb tub, npaj yuav cev xeeb tub, lossis pub mis niam. Yog tias koj cev xeeb tub thaum noj cov tshuaj deferasirox, hu rau koj tus kws kho mob.

Tshwj tsis yog koj tus kws kho mob hais rau koj lwm yam, txuas ntxiv koj li kev noj haus zoo.

Noj cov koob tshuaj uas ploj lawm hauv ib hnub, tsawg kawg 2 teev tom qab koj cov pluas mov kawg thiab 30 feeb ua ntej noj mov. Txawm li cas los xij, yog tias nws yuav luag txog sijhawm rau kev txhaj tshuaj ntxiv lossis yog tias koj yuav tsis tuaj yeem noj cov tshuaj tiv thaiv deferasirox ntawm lub plab khoob, hla lub koob tshuaj uas tsis pom zoo thiab txuas ntxiv rau koj lub sijhawm noj tshuaj kom ntau. Tsis txhob noj tshuaj rau ob zaug kom ua rau qhov ploj lawm ib zaug.

Deferasirox yuav ua rau muaj kev mob tshwm sim. Qhia rau koj tus kws kho mob yog tias ib qho ntawm cov tsos mob no hnyav lossis tsis ploj mus:

• mob plab
• xeev siab
• ntuav
• zawv plab

Qee qhov kev mob tshwm sim tuaj yeem loj heev. Yog tias koj muaj cov tsos mob no lossis cov uas tau hais hauv ntu CEEB TOOM TSEEM CEEB, hu rau koj tus kws kho mob tam sim ntawd:

• hnov lus
• teeb meem tsis pom kev
• xoo pob khaus, ua xua, nti lossis ua paug ntawm daim tawv nqaij, ua npaws, o cov qog ntshav
• ua pa nyuaj lossis nqos; o ntawm lub ntsej muag, caj pas, tus nplaig, daim di ncauj, lossis qhov muag; txhaws qa
• doog ntshav los ntshav tsis txawv

Deferasirox tuaj yeem ua lwm cov kev mob tshwm sim. Hu rau koj tus kws kho mob yog tias koj muaj teeb meem txawv txawv thaum noj cov tshuaj no.

Yog tias koj muaj kev mob tshwm sim loj, koj lossis koj tus kws kho mob tuaj yeem xa ntawv ceeb toom rau Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) lossis hauv xov tooj ( 1-800-332-1088).

Khaws cov tshuaj no rau hauv lub khob uas nws nkag los, kaw kom nruj, thiab ncav tsis cuag ntawm cov menyuam. Khaws nws ntawm chav sov thiab deb ntawm qhov kub thiab noo noo (tsis nyob hauv chav dej).

Nws yog ib qho tseem ceeb kom tsis txhob muaj txhua yam tshuaj rau qhov tsis pom thiab ncav cuag ntawm cov menyuam yaus ntau li ntau ntim (xws li tshuaj ntsiav tshuaj txhua lub limtiam thiab cov tshuaj rau qhov muag, tshuaj pleev, pleev xim, thiab nqus tshuaj) tsis tiv thaiv menyuam yaus thiab cov menyuam yaus tuaj yeem qhib lawv tau yooj yim. Txhawm rau tiv thaiv cov menyuam yaus me los ntawm kev lom, ib txwm kaw lub kaus mom kev nyab xeeb thiab muab cov tshuaj tso rau qhov chaw nyab xeeb - ib qho chaw nyob thiab deb thiab tawm ntawm lawv pom thiab ncav cuag. http://www.upandaway.org

Cov tshuaj tsis siv tshuaj yuav tsum tau muab pov tseg hauv txoj kev tshwj xeeb kom ntseeg tau tias cov tsiaj, menyuam yaus, thiab lwm tus neeg tsis tuaj yeem haus lawv. Txawm li cas los xij, koj yuav tsum tsis txhob yaug cov tshuaj no hauv lub qhov viv. Hloov chaw, txoj hauv kev zoo tshaj plaws hauv kev muab koj cov tshuaj tshem tawm yog los ntawm kev siv tshuaj rov qab. Tham nrog koj tus kws muag tshuaj lossis tiv tauj koj lub chaw khaws khib nyiab / chaw khaws khoom ubno hauv ib cheeb tsam kom paub txog cov haujlwm thim rov qab hauv koj lub zej zog. Saib ntawm FDA's Kev Nyab Xeeb Kev Nyab Xeeb Kev Siv Tshuaj lub vev xaib (http://goo.gl/c4Rm4p) kom paub cov ntaub ntawv ntau ntxiv yog tias koj tsis muaj kev nkag mus saib rov qab.

Yog hais tias noj ntau dhau, hu rau kem tus xov tooj kev pab tswj kev lom ntawm 1-800-222-1222. Cov ntaub ntawv tseem muaj nyob online ntawm https://www.poisonhelp.org/help. Yog tus neeg raug tsim txom, tsaus muag, ua tsis taus pa, lossis sawv tsis taus, hu rau 911 tus neeg pab thaum muaj xwm ceev.

Cov tsos mob ntawm kev noj haus ntau heev yuav suav nrog cov hauv qab no:

• daj ntawm daim tawv nqaij lossis qhov muag
• mob hauv sab saud hauv plab
• doog ntshav los ntshav tsis txawv
• tsis muaj lub zog
• tsis qab los noj mov
• cov tsos mob khaub thuas zoo li
• zawv plab
• xeev siab
• ntuav
• tsis tso zis tsawg
• o ntawm cov ceg lossis pob taws

Khaws tag nrho cov kev teem caij ntsib nrog koj tus kws kho mob. Koj yuav tsum tau kuaj pob ntseg thiab qhov muag kuaj ua ntej pib deferasirox thiab ib xyoos ib zaug thaum noj cov tshuaj no.

Tsis txhob cia lwm tus noj koj cov tshuaj. Nug koj tus kws muag tshuaj cov lus nug uas koj muaj txog kev rov ntxiv tshuaj rau koj.

Nws yog ib qho tseem ceeb rau koj kom koj muaj ib daim ntawv sau tag nrho cov tshuaj noj thiab cov tshuaj uas tsis yog kws kho mob sau ntawv (tsis yuav khoom) uas koj tab tom noj, nrog rau txhua yam khoom xws li cov vitamins, minerals, lossis lwm yam tshuaj noj rau lub cev. Koj yuav tsum nqa cov ntawv no nrog koj txhua zaus koj mus ntsib kws kho mob lossis yog tias koj tuaj nyob hauv tsev kho mob. Nws tseem yog cov ntaub ntawv tseem ceeb los nqa nrog koj thaum muaj xwm txheej ceev.

• Exjade^®
• Jadenu^®