Thrombotic Thrombocytopenic Purpura: Nws Yog Dab Tsi, Ua rau thiab Kho

Zoo Siab

• Ua rau ntawm PTT
• Cov cim tseem ceeb thiab cov tsos mob
• Yuav kuaj li cas
• Kev Kho Mob PTT

Thrombotic thrombocytopenic purpura, lossis PTT, yog ib qho mob uas tsis tshua pom tab sis ua rau neeg tuag taus uas yog tus yam ntxwv ua kom muaj ntshav me me hauv cov hlab ntshav thiab muaj ntau rau cov neeg muaj hnub nyoog 20 txog 40 xyoo.

Hauv PTT muaj qhov cim tseg ntawm cov ntshav platelets, ntxiv rau qhov ua npaws thiab, feem ntau, mob puas hlwb vim qhov hloov ntawm cov ntshav ntws mus rau lub hlwb vim txhaws.

Kev kuaj mob ntawm PTT yog tsim los ntawm hematologist lossis kws kho mob raws li cov tsos mob thiab tshwm sim los ntawm kev ua tiav cov ntshav thiab cov ntshav pleev thiab cov kev kho mob yuav tsum tau pib sai sai, vim tias tus kab mob yog cov neeg tuag txog li 95% thaum tsis kho.

Ua rau ntawm PTT

Thrombotic thrombocytopenic purpura feem ntau yog los ntawm qhov tsis muaj peev xwm lossis kev hloov caj ces ntawm kev enzyme, ADAMTS 13, uas yog lub luag haujlwm ua cov molecules ntawm von Willebrand qhov ua tau me dua, thiab nyiam lawv txoj haujlwm. Lub ntsiab lus ntawm von Willebrand tshwm sim hauv platelets thiab yog lub luag haujlwm txhawb kev platelet adhesion mus rau endothelium, txo qis thiab txwv tsis txhob los ntshav.

Yog li, thaum tsis muaj ADAMTS 13 enzyme, lub ntsiab lus von Willebrand molecules tseem loj thiab cov txheej txheem ntshav tsis tuaj yeem mob thiab muaj feem ntau ntawm txoj kev txhaws.

Yog li, PTT tej zaum yuav muaj cov kab mob muaj keeb, uas sib haum rau ADAMTS 13 tsis txaus, lossis yuav kis tau, uas yog cov uas ua rau cov platelets txo qis, xws li kev siv cov tshuaj tiv thaiv kab mob los yog tshuaj kho mob lossis tshuaj tiv thaiv kab mob, kev kis kab mob, kev noj zaub mov tsis zoo lossis Piv txwv cov kab mob autoimmune, piv txwv.

Cov cim tseem ceeb thiab cov tsos mob

Feem ntau PTT qhia cov tsos mob tsis tseem ceeb, txawm li cas los xij nws yog ib qho muaj rau cov neeg mob uas xav tias PTT muaj yam tsawg kawg 3 yam ntawm cov yam ntxwv hauv qab no:

1. Ntaus cim thrombocythemia;
2. Hemolytic anemia, txij li thaum thrombi tsim txaus nyiam lysis ntawm cov qe ntshav liab;
3. Ua npaws;
4. Mob ntsws nqaj hlau, uas tuaj yeem tshwm sim hauv ntau lub nruab nrog cev;
5. Mob plab heev vim tias hnyuv ischemia;
6. Kev puas tsuaj raum;
7. Neurological ua rau lub cev tsis muaj zog, uas tuaj yeem pom los ntawm mob taub hau, tsis meej pem rau lub cev, tsaug zog thiab tseem rov xeev qhuav.

Nws kuj tseem muaj rau cov neeg mob uas xav tias PTT muaj cov tsos mob ntawm thrombocytopenia, xws li cov tsos ntawm daim tawv nqaij lossis xim tawv nqaij rau daim tawv nqaij, cov pos hniav los ntshav los yog los ntawm lub qhov ntswg, ntxiv rau qhov nyuaj tswj tau los ntshav los ntawm cov kiav txhab me. Paub lwm cov tsos mob ntawm thrombocytopenia.

Xws li lub raum thiab cov hlab ntaws ntshav yog qhov teeb meem loj ntawm PTT thiab tshwm sim thaum lub plab me me cuam tshuam txoj kev hla ntawm cov ntshav mus rau ob lub raum thiab lub hlwb, uas tuaj yeem ua rau lub raum tsis ua haujlwm thiab mob stroke, piv txwv. Txhawm rau kom tsis txhob muaj teeb meem, nws yog ib qho tseem ceeb uas sai li sai sai thaum thawj cov tsos mob tshwm sim, ib tug kws kho mob feem ntau lossis hematologist tau sab laj kom kuaj thiab kuaj mob tuaj yeem pib kho.

Yuav kuaj li cas

Kev kuaj mob ntawm thrombotic thrombocytopenic purpura yog ua raws cov tsos mob uas qhia los ntawm tus neeg, ntxiv rau qhov txiaj ntsig ntawm cov ntshav suav, uas qhov kev txo qis ntawm cov ntshav plasmaets, hu ua thrombocytopenia, raug soj ntsuam, ntxiv rau qhov raug soj ntsuam hauv cov ntshav pleev platelet sib sau ua ke, uas yog thaum lub platelets tau daig ua ke, ntxiv rau schizocytes, uas yog cov tawg ntawm cov ntshav liab, vim cov ntshav liab hla mus rau cov hlab ntshav uas thaiv los ntawm cov hlab ntsha me.

Lwm qhov kev ntsuam xyuas kuj tseem yuav raug coj los pab kev kuaj mob ntawm PTT, xws li lub sijhawm los ntshav, uas tau nce ntxiv, thiab qhov tsis tuaj lossis txo qis rau ntawm enamme ADAMTS 13, uas yog ib qho ua rau tsim cov ntshav me me.

Kev Kho Mob PTT

Kev kho mob rau cov mob thrombotic thomox purpura yuav tsum tau pib sai li sai tau, vim tias nws ua rau neeg tuag taus rau ntau qhov xwm txheej, vim tias qhov tsim muaj thrombi tuaj yeem cuam tshuam cov hlab ntsha uas mus txog lub hlwb, txo ntshav khiav mus rau thaj av ntawd.

Cov kev kho mob ib txwm qhia los ntawm hematologist yog plasmapheresis, uas yog cov ntshav txheej txheem ua rau cov ntshav ntau dhau ntawm cov tshuaj tiv thaiv uas yuav ua rau cov kab mob no thiab dhau ntawm Ville Willebrand qhov xwm txheej, ntxiv rau kev txhawb nqa kev saib xyuas, xws li hemodialysis, piv txwv. , yog tias muaj mob raum. Nkag siab li cas plasmapheresis tiav lawm.

Ntxiv rau, kev siv cov corticosteroids thiab cov tshuaj tiv thaiv kab mob, piv txwv li, tej zaum yuav raug pom zoo los ntawm tus kws kho mob, txhawm rau txhawm rau ua kom muaj mob ntawm PTT thiab zam kom tsis txhob muaj kev cuam tshuam.