Kev quav yeeb tshuaj lupus erythematosus

Kev tsim tshuaj lupus erythematosus yog ib qho kev tiv thaiv autoimmune uas yog chiv los ntawm kev tawm tsam los ntawm cov tshuaj.

Kev tsim tshuaj lupus erythematosus zoo sib xws tab sis tsis zoo ib yam rau cov kab mob lupus erythematosus (SLE). Nws yog qhov mob autoimmune. Qhov no txhais tau tias koj lub cev tawm tsam cov nqaij noj qab haus huv los ntawm kev ua yuam kev. Nws tshwm sim los ntawm kev fab tshuaj rau cov tshuaj. Cov mob uas cuam tshuam nrog cov tshuaj txiav tawm lupus thiab raug yuam los ntawm cov tshuaj ANCA vasculitis.

Cov tshuaj uas nquag paub uas ua rau tsim cov tshuaj lupus erythematosus yog:

• Isoniazid
• Hydralazine
• Procainamide
• Tumor-necrosis factor (TNF) alpha inhibitors (xws li etanercept, infliximab thiab adalimumab)
• Minocycline
• Quinidine

Lwm cov tshuaj siv tsis tshua zoo yuav ua rau tus mob. Cov no suav nrog:

• Tshuaj tiv thaiv qaug dab peg
• Capoten
• Chlorpromazine
• Methyldopa
• Sulfasalazine
• Levamisole, feem ntau yog cov dej ua paug ntawm yeeb dawb

Cov tshuaj tiv thaiv kab mob qog noj ntshav xws li pembrolizumab tuaj yeem ua rau ntau yam kev tiv thaiv autoimmune suav nrog kev siv tshuaj lupus.

Cov tsos mob ntawm kev quav yeeb tshuaj lupus zoo li tshwm sim tom qab noj cov tshuaj tsawg kawg 3 mus rau 6 lub hlis.

Cov tsos mob tuaj yeem suav nrog:

• Ua npaws
• Hnov mob siab (malaise)
• Mob tej pob txha
• Pob qij txha o
• Tsis qab los noj mov
• Pleuritic mob hauv siab
• Cov tawv nqaij ua pob rau ntawm thaj chaw raug tshav

Tus kws kho mob yuav kuaj xyuas lub cev thiab mloog koj lub hauv siab nrog lub taub hau tsom. Tus kws kho mob yuav hnov ​​lub suab hu ua lub plawv txhuam qhov muag lossis plev txhuam pleural.

Txoj kev kuaj ntawm daim tawv nqaij qhia pom pob.

Pob qij txha tej zaum yuav o tuaj thiab o.

Kev ntsuam xyuas uas yuav ua tau muaj xws li:

• Cov tshuaj tiv thaiv Antihistone
• Lub vaj huam sib luag Antinuclear antibody (ANA)
• Antineutrophil cytoplasmic antibody (ANCA) vaj huam sib luag
  
• Ua tiav cov ntshav suav (CBC) nrog kev sib txawv
• Cov vaj huam sib luag kev sib txuam
• Mob Lub Hlaus

Xoo fais fab hauv siab tuaj yeem pom tshwm sim ntawm pleuritis lossis mob pericarditis (mob ncig ncig ua rau mob ntsws lossis lub siab). Qhov ECG yuav qhia pom tias lub plawv cuam tshuam.

Feem ntau, cov tsos mob ploj mus li ntawm ob peb hnub mus rau ntau lub lis piam tom qab tsum cov tshuaj uas ua rau tus mob.

Kev kho mob yuav suav nrog:

• Nonsteroidal anti-inflammatory tshuaj (NSAIDs) los kho kev mob caj dab thiab pleurisy
• Corticosteroid cream los kho pob khaus tawv nqaij
• Cov tshuaj tiv thaiv kab mob (hydroxychloroquine) los kho cov tawv nqaij thiab mob caj dab

Yog tias tus mob cuam tshuam rau koj lub plawv, raum, lossis lub paj hlwb, koj tuaj yeem raug txhaj tshuaj ntau ntau ntawm corticosteroids (prednisone, methylprednisolone) thiab tshuaj tiv thaiv kab mob (azathioprine lossis cyclophosphamide). Qhov no tsis tshua muaj.

Thaum tus kab mob nquag, koj yuav tsum hnav khaub ncaws tiv thaiv thiab tsom iav tiv thaiv tiv thaiv tshav ntuj ntau.

Feem ntau, qhov teeb meem tshuaj lupus erythematosus tsis hnyav li SLE. Cov tsos mob feem ntau yuav ploj mus li ntawm ob peb hnub mus rau ntau lub lis piam tom qab koj tsum tsis noj tshuaj uas koj noj. Tsis tshua muaj, mob raum mob (nephritis) tuaj yeem txhim kho nrog cov tshuaj lupus tshwm sim los ntawm TNF inhibitors lossis nrog ANCA vasculitis vim hydralazine lossis levamisole. Kev mob ncauj plab yuav tsum tau kho nrog prednisone thiab tshuaj tiv thaiv kab mob.

Zam kev noj tshuaj uas ua rau muaj kev tawm tsam yav tom ntej. Cov tsos mob yuav zoo rov qab yog tias koj ua li ntawd.

Teeb meem yuav suav nrog:

• Kab mob
• Thrombocytopenia purpura - los ntshav ze rau ntawm daim tawv nqaij, tshwm sim los ntawm cov lej plasmaets tsawg ntawm cov ntshav
• Hemolytic anemia
• Myocarditis
• Mob rau hlwv
• Nees Qaum Ntuj

Hu rau koj tus kws khomob yog:

• Koj muaj cov tsos mob tshiab thaum noj ib yam tshuaj uas teev rau saum toj no.
• Koj cov tsos mob tsis tau zoo tom qab koj tsum tsis noj tshuaj uas ua rau tus mob.

Saib seb puas muaj cov tshuaj tiv thaiv yog tias koj tab tom noj ib yam tshuaj uas tuaj yeem ua qhov teeb meem no.

Lupus - qaug tshuaj

• Lupus, discoid - pom ntawm qhov mob txhab ntawm lub hauv siab
• Tshuaj tua kabmob

Benfaremo D, Manfredi L, Luchetti HLI, Gabrielli A. Musculoskeletal thiab mob rheumatic los ntawm kev kuaj mob hauv lub cev tiv thaiv kab mob: tshuaj xyuas cov ntawv nyeem. Curr Tshuaj Nyab XeebCov. 2018; 13 (3): 150-164. PMID: 29745339 www.ncbi.nlm.nih.gov/pubmed/29745339.

Dooley MA. Tshuaj muaj yees lupus. Hauv: Tsokos GC, ed. Cov kab ke Lupus ErythematosusCov. Cambridge, MA: Elsevier Kev Kawm Txuj Ci; 2016: chap 54.

Radhakrishnan J, Perazella MA. Cov tshuaj tiv thaiv kab mob glomerular: xav tau! Clin J Am Soc NairolCov. Xyoo 2015; 10 (7): 1287-1290. PMID: 25876771 www.ncbi.nlm.nih.gov/pubmed/25876771.

Richardson BC. Tshuaj muaj yees lupus. Hauv: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Pob tsuasCov. 7 tus ed. Philadelphia, PA: Elsevier; 2019: cha 141.

Rubin RL. Tshuaj muaj yees lupus. Tus Kws Paub Txog Opin Tshuaj Kev Nyab XeebCov. Xyoo 2015; 14 (3): 361-378. PMID: 25554102 www.ncbi.nlm.nih.gov/pubmed/25554102.

Vaglio A, Grayson PC, Fenaroli P, li al. Cov tshuaj lupus: cov tshuaj ib txwm thiab cov ntsiab lus tshiab. Autoimmun RevCov. 2018; 17 (9): 912-918. PMID: 30005854 www.ncbi.nlm.nih.gov/pubmed/30005854.